DK245182A - Fremgangsmaade til fremstilling af 1,7-dihydropyrrolo (3,4-e)-(1,4)diazepin-2(1h)-on-derivater - Google Patents

Fremgangsmaade til fremstilling af 1,7-dihydropyrrolo (3,4-e)-(1,4)diazepin-2(1h)-on-derivater Download PDF

Info

Publication number: DK245182A
Authority: DK; Denmark
Prior art keywords: sub; diazepin; preparing; hydrogen; dihydropyrrolo
Prior art date: 1981-06-04

Application number

DK245182A

Other languages

English (en)

Other versions

DK160307C (da

DK160307B (da

Inventor

L Mariani

G Tarzia

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-06-04

Filing date

1982-06-01

Publication date

1982-12-05

1982-06-01 Application filed by Lepetit Spa filed Critical Lepetit Spa

1982-12-05 Publication of DK245182A publication Critical patent/DK245182A/da

1991-02-25 Publication of DK160307B publication Critical patent/DK160307B/da

1991-07-29 Application granted granted Critical

1991-07-29 Publication of DK160307C publication Critical patent/DK160307C/da

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
230000000049 anti-anxiety effect Effects 0.000 abstract 1
230000001773 anti-convulsant effect Effects 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
229960003965 antiepileptics Drugs 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

DK245182A 1981-06-04 1982-06-01 Analogifremgangsmaade til fremstilling af 1,7-dihydropyrrolooe3,4-eaaoe1,4aadiazepin-2(1h)-on-derivater DK160307C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8117184		1981-06-04
GB8117184		1981-06-04

Publications (3)

Publication Number	Publication Date
DK245182A true DK245182A (da)	1982-12-05
DK160307B DK160307B (da)	1991-02-25
DK160307C DK160307C (da)	1991-07-29

Family

ID=10522285

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK245182A DK160307C (da)	1981-06-04	1982-06-01	Analogifremgangsmaade til fremstilling af 1,7-dihydropyrrolooe3,4-eaaoe1,4aadiazepin-2(1h)-on-derivater

Country Status (14)

Country	Link
US (1)	US4402970A (da)
EP (1)	EP0066762B1 (da)
JP (1)	JPS57212184A (da)
AT (1)	ATE16594T1 (da)
AU (1)	AU551695B2 (da)
CA (1)	CA1178583A (da)
DE (1)	DE3267543D1 (da)
DK (1)	DK160307C (da)
ES (1)	ES8307809A1 (da)
GR (1)	GR76455B (da)
IE (1)	IE53343B1 (da)
IL (1)	IL65896A (da)
PH (1)	PH18767A (da)
ZA (1)	ZA823701B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4508730A (en) *	1982-09-08	1985-04-02	Gruppo Lepetit S.P.A.	1,7-Dihydro-pyrrolo[3,4-e][1,4]diazepin-2(3H)-one derivatives a process for preparing them and their use as anticonvulsant and anti-anxiety agents
US4517195A (en) *	1984-07-02	1985-05-14	Hoechst-Roussel Pharmaceuticals Inc.	Pyrrolo[1,2-b][1,2,5]triazepines and pharmaceutical compositions thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1295563B (de) *	1963-05-29	1969-05-22	American Home Prod	Verfahren zur Herstellung von 5-Phenyl-7-chlor-1, 2-dihydro-3H-1, 4-benzodiazepinon-(2)-4-oxyd
NL298071A (da) *	1963-06-04
US3553207A (en) *	1968-12-16	1971-01-05	Parke Davis & Co	Phenylpyrazolodiazepinone compounds
US3553210A (en) *	1968-12-16	1971-01-05	Parke Davis & Co	3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5(1h)-one, 7-oxide compounds
GB1433103A (en) *	1974-03-20	1976-04-22	Lepetit Spa	Pharmacologically active pyrrolodiazepines

1982
- 1982-05-17 GR GR68184A patent/GR76455B/el unknown
- 1982-05-20 AU AU83870/82A patent/AU551695B2/en not_active Ceased
- 1982-05-22 DE DE8282104487T patent/DE3267543D1/de not_active Expired
- 1982-05-22 AT AT82104487T patent/ATE16594T1/de active
- 1982-05-22 EP EP82104487A patent/EP0066762B1/en not_active Expired
- 1982-05-24 US US06/381,272 patent/US4402970A/en not_active Expired - Fee Related
- 1982-05-27 IL IL65896A patent/IL65896A/xx unknown
- 1982-05-27 ZA ZA823701A patent/ZA823701B/xx unknown
- 1982-05-31 PH PH27383A patent/PH18767A/en unknown
- 1982-06-01 DK DK245182A patent/DK160307C/da not_active IP Right Cessation
- 1982-06-03 IE IE1336/82A patent/IE53343B1/en not_active IP Right Cessation
- 1982-06-03 CA CA000404438A patent/CA1178583A/en not_active Expired
- 1982-06-03 ES ES512811A patent/ES8307809A1/es not_active Expired
- 1982-06-03 JP JP57095597A patent/JPS57212184A/ja active Granted

Also Published As

Publication number	Publication date
DE3267543D1 (de)	1986-01-02
US4402970A (en)	1983-09-06
AU551695B2 (en)	1986-05-08
IE53343B1 (en)	1988-10-26
CA1178583A (en)	1984-11-27
EP0066762A2 (en)	1982-12-15
DK160307C (da)	1991-07-29
IE821336L (en)	1982-12-04
DK160307B (da)	1991-02-25
ES512811A0 (es)	1983-08-01
JPS57212184A (en)	1982-12-27
IL65896A (en)	1985-08-30
ATE16594T1 (de)	1985-12-15
JPH0378397B2 (da)	1991-12-13
PH18767A (en)	1985-09-20
AU8387082A (en)	1982-12-09
GR76455B (da)	1984-08-10
ES8307809A1 (es)	1983-08-01
EP0066762A3 (en)	1983-04-27
EP0066762B1 (en)	1985-11-21
ZA823701B (en)	1983-03-30

Legal Events

Date	Code	Title	Description
1993-02-22	PBP	Patent lapsed

Publication	Publication Date	Title
NO834187L (no)	1984-05-18	Benzodiazepinreseptoraktive forbindelser og fremgangsmaate til fremstilling av disse
DK160307C (da)	1991-07-29	Analogifremgangsmaade til fremstilling af 1,7-dihydropyrrolooe3,4-eaaoe1,4aadiazepin-2(1h)-on-derivater
DK240283A (da)	1984-11-28	Beta-carbolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling af samme
IE780918L (en)	1978-11-06	3, 5-disubstituted-1h-1, 2, 4-triazoles.
DK394483A (da)	1984-03-09	Fremgangsmaade til fremstilling af 1,7-dihydropyrrol(3,4-e)-(1,4)diazepin-2(3h)-on-derivater
DE3576822D1 (de)	1990-05-03	Pyrrolo(1,2-b)(1,2,5)triazepine, verfahren und zwischenprodukte zu ihrer herstellung und ihre anwendung als arzneimittel.
FR2507184B1 (fr)	1985-10-25	Derives du type pyrrolo (3,4-e) (1,4) diazepin-2 (1h)-one utilisables comme agents anxiolytiques et anticonvulsivants, et procede pour leur preparation