DK2473172T3 - Bisphosphonatsammensætninger og fremgangsmåder til behandling af hjerteinsufficiens - Google Patents
Bisphosphonatsammensætninger og fremgangsmåder til behandling af hjerteinsufficiens Download PDFInfo
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- DK2473172T3 DK2473172T3 DK10814383.5T DK10814383T DK2473172T3 DK 2473172 T3 DK2473172 T3 DK 2473172T3 DK 10814383 T DK10814383 T DK 10814383T DK 2473172 T3 DK2473172 T3 DK 2473172T3
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- Prior art keywords
- bisphosphonate
- heart failure
- pharmaceutically effective
- use according
- administration
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (11)
1. Bisphosphonat eller farmaceutisk effektivt salt deraf til anvendelse i behandling eller forebyggelse af hjerteinsufficiens hos et individ, hvori bisphosphonatet er beregnet til intravenøs eller oral administration ved en dosis på fra ca. 40 pg/kg til ca. 125 pg/kg, hvor individet oplever forbedret kardiel ejektionsfraktion.
2. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 1, hvor bisphosphonatet er zoledronsyre.
3. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 2, hvor doseringen er årlig eller halvårlig for administration til individet.
4. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 2, hvor individet har en stigning i ejektionsfraktion på fra ca. 10 % til 20 % efter administration af zoledronsyren.
5. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 2, hvor zoledronsyren er beregnet til administration efter en dosis vitamin D.
6. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 1, hvor mindst ét andet terapeutisk middel udvalgt fra gruppen bestående af nitrater, beta-adrenerge blokkere, angiotensinkonverterende enzyminhibitorer, calciumkanalantagonister, antihypertensive midler, kolesterolsænkende midler, diuretika, ACE-inhibitorer, hjerteglycosider, non-peptid angiotensin Il-antagonister, Ilb/IIIa-antagonister og aspirin endvidere er beregnet til yderligere administration til patienten.
7. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 1, hvor hjerteinsufficiens er en følge af mindst én af følgende tilstande: hypertension, iskæmisk hjertesygdom, eksponering for en kardiotoksisk forbindelse, stråleterapi, myocarditis, thyroideasygdom, virusinfektion, stofmisbrug, alkoholmisbrug, pericarditis, atherosklerose, karsygdom, hypertrofisk kardiomyopati, akut myokardieinfarkt, ventrikulær systolisk dysfunktion, ventrikulær diastolisk dysfunktion, koronar bypasskirurgi, fald i kontraktion af venstre ventrikel, en stigning i inflammatoriske cytokiner eller en genetisk defekt.
8. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 1, hvor bisphosphonatet er beregnet til administration forud for diagnosen på hjerteinsufficiens hos individet.
9. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 1, hvor bisphosphonatet er beregnet til administration efter diagnose af hjerteinsufficiens hos individet.
10. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 7, hvor bisphosphonatet er beregnet til administration samtidig med en kardiotoksisk forbindelse eller stråleterapi.
11. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 1, hvor bisphosphonatforbindelsen er udvalgt fra gruppen bestående af zoledronsyre, risedronat, alendronat, cimadronat, clodronat, tiludronat, etidronat, ibandronat, piridronat eller pamidronat.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23879709P | 2009-09-01 | 2009-09-01 | |
| PCT/US2010/047417 WO2011028737A2 (en) | 2009-09-01 | 2010-09-01 | Bisphosphonate compositions and methods for treating heart failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2473172T3 true DK2473172T3 (da) | 2015-06-15 |
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ID=43649931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10814383.5T DK2473172T3 (da) | 2009-09-01 | 2010-09-01 | Bisphosphonatsammensætninger og fremgangsmåder til behandling af hjerteinsufficiens |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9867838B2 (da) |
| EP (1) | EP2473172B1 (da) |
| CN (2) | CN105920023A (da) |
| DK (1) | DK2473172T3 (da) |
| ES (1) | ES2537216T3 (da) |
| HR (1) | HRP20150496T1 (da) |
| HU (1) | HUE025737T2 (da) |
| PL (1) | PL2473172T3 (da) |
| PT (1) | PT2473172E (da) |
| SI (1) | SI2473172T1 (da) |
| SM (1) | SMT201500124B (da) |
| WO (1) | WO2011028737A2 (da) |
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| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| WO2013074587A1 (en) * | 2011-11-16 | 2013-05-23 | Duke University | Bishophonate compositions and methods for treating and/or reducing cardiac dysfunction |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| EP4132535A4 (en) * | 2020-04-06 | 2024-04-24 | Duke University | COMPOSITIONS AND METHODS FOR TREATING INFECTION-INDUCED CARDIOMYOPATHY |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2405254C2 (de) | 1974-02-04 | 1982-05-27 | Henkel KGaA, 4000 Düsseldorf | Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper |
| DE3428524A1 (de) | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4639338A (en) | 1984-08-06 | 1987-01-27 | Ciba-Geigy Corporation | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate |
| EP0243173B1 (en) | 1986-04-24 | 1991-06-26 | Fujisawa Pharmaceutical Co., Ltd. | New diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
| DE3623397A1 (de) | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US5057505A (en) | 1986-11-21 | 1991-10-15 | Ciba-Geigy Corporation | Substituted aminomethanediphosphonic acids and use in medicaments |
| ES2038692T4 (es) | 1986-11-21 | 2012-02-10 | Novartis Ag | Procedimiento para la obtencion de acidos alcanodifosfonicos substituidos. |
| GB8808138D0 (en) | 1988-04-07 | 1988-05-11 | Leo Pharm Prod Ltd | Chemical compounds |
| AU8495091A (en) | 1990-08-21 | 1992-03-17 | Upjohn Company, The | Bisphosphonic acid derivatives as anti-arthritic agents |
| US5157027A (en) | 1991-05-13 | 1992-10-20 | E. R. Squibb & Sons, Inc. | Bisphosphonate squalene synthetase inhibitors and method |
| WO1992021355A1 (en) | 1991-05-28 | 1992-12-10 | The Procter & Gamble Company | Calcium, trace mineral, vitamin d and drug therapy combinations |
| AU670337B2 (en) | 1992-11-30 | 1996-07-11 | Novartis Ag | Use of certain methanebisphosphonic acid derivatives in fracture healing |
| EP0600834A1 (en) | 1992-11-30 | 1994-06-08 | Ciba-Geigy Ag | Use of methanebisphosphonic acid derivatives for the manufacture of a medicament for fracture healing |
| US5403829A (en) | 1993-03-24 | 1995-04-04 | Leiras Oy | Use of bisphosphonates in endo-osteal bone surgery |
| FI92465C (fi) | 1993-04-14 | 1994-11-25 | Risto Tapani Lehtinen | Menetelmä endo-osteaalisten materiaalien käsittelemiseksi |
| US5646134A (en) | 1994-04-21 | 1997-07-08 | Merck & Co., Inc. | Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices |
| GB9408775D0 (en) | 1994-05-04 | 1994-06-22 | Ciba Geigy Ag | Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration |
| US6117856A (en) | 1996-02-14 | 2000-09-12 | Binderman; Itzhak | Topical bisphosphonates for prevention of bone resorption |
| DE19738005A1 (de) * | 1997-08-30 | 1999-03-04 | Bayer Ag | Verwendung von substituierten 1,1-Bisphosphonaten |
| WO1999038998A1 (en) | 1998-01-29 | 1999-08-05 | Merck & Co., Inc. | Methods of identifying modulators of kinases responsive to stress |
| US6984400B2 (en) | 1998-07-14 | 2006-01-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of treating restenosis using bisphosphonate nanoparticles |
| JP2003519183A (ja) | 2000-01-04 | 2003-06-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 心臓および動脈の石灰化を抑制する低用量ビスホスホネートの使用 |
| AU2001239953A1 (en) * | 2000-03-01 | 2001-09-12 | University Of South Florida | Methods of modulating cell-adhesion mediated drug resistance |
| GB0012209D0 (en) | 2000-05-19 | 2000-07-12 | Novartis Ag | Organic compounds |
| DK1296689T3 (da) | 2000-06-20 | 2005-11-28 | Novartis Ag | Fremgangsmåde til indgivelse af bisphosphonater |
| BR0209365A (pt) * | 2001-05-02 | 2004-06-08 | Novartis Ag | Usos farmacêuticos de bisfosfonatos |
| US20030064965A1 (en) | 2001-10-02 | 2003-04-03 | Jacob Richter | Method of delivering drugs to a tissue using drug-coated medical devices |
| WO2003086415A1 (en) | 2002-04-05 | 2003-10-23 | Merck & Co., Inc. | Method for inhibiting bone resorption with an alendronate and vitamin d formulation |
| US20060205692A1 (en) | 2002-05-11 | 2006-09-14 | Montes Imber F | 1,1-and 1,2-Bisphosphonates as apoliprotein e modulators |
| US20050026871A1 (en) | 2002-07-17 | 2005-02-03 | Moshe Flashner-Barak | Method of increasing bioavailability of alendronate or other bis-phosphonate by predose administration of vitamin D derivative |
| TWI344367B (en) * | 2002-09-16 | 2011-07-01 | Novartis Ag | Use of zoledronic acid or a pharmaceutically acceptable salt or hydrate thereof in the preparation of a medicament for the treatment of osteoporosis post hip fracture |
| US20060166937A1 (en) | 2002-10-15 | 2006-07-27 | Prescott Margaret F | Bisphosphonates for the treatment of atherosclerosis and device comprising them |
| KR20050090435A (ko) * | 2002-12-30 | 2005-09-13 | 셀진 코포레이션 | 플루오로알콕시-치환된 1,3-디히드로-이소인돌릴 화합물 및그의 제약학적 용도 |
| JP4621202B2 (ja) | 2003-06-27 | 2011-01-26 | バイオレスト リミテッド | 急性冠症候群を治療する方法 |
| US20060051407A1 (en) | 2003-06-27 | 2006-03-09 | Yoram Richter | Method of treating ischemia-reperfusion injury |
| US10517883B2 (en) * | 2003-06-27 | 2019-12-31 | Zuli Holdings Ltd. | Method of treating acute myocardial infarction |
| US20050119230A1 (en) * | 2003-09-18 | 2005-06-02 | Alexandra Glausch | Pharmaceutical products comprising bisphosphonated |
| AU2004273672A1 (en) | 2003-09-19 | 2005-03-31 | Wisconsin Alumni Research Foundation | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin D derivatives and a bisphosphonate |
| GB0327742D0 (en) * | 2003-11-28 | 2003-12-31 | Isis Innovation | Novel uses of known drugs |
| WO2006019843A1 (en) | 2004-07-15 | 2006-02-23 | Nanobac Life Sciences | Methods and compositions for the administration of calcium chelators, bisphosphonates and/or citrate compounds and their pharmaceutical uses |
| US20060069068A1 (en) | 2004-07-15 | 2006-03-30 | Nanobac Pharmaceuticals, Inc. | Methods and compositions for the treatment of diseases characterized by pathological calcification |
| US7473684B2 (en) * | 2005-09-16 | 2009-01-06 | Selamine Limited | Bisphosphonate formulation |
| BRPI0710503A2 (pt) * | 2006-04-07 | 2011-08-16 | Merrion Res Iii Ltd | uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral |
| EP1925621A1 (en) * | 2006-11-27 | 2008-05-28 | Novartis AG | Crystalline forms of zoledronic acid |
| US20080146489A1 (en) | 2006-12-15 | 2008-06-19 | Pacetti Stephen D | Regional delivery of therapeutic agents for the treatment of vascular diseases |
| US20100144679A1 (en) | 2007-03-21 | 2010-06-10 | Duke University | Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture |
| CN101945853B (zh) * | 2007-12-21 | 2014-08-20 | 配体药物公司 | 选择性雄激素受体调节剂(sarm)及其应用 |
| CN101259133A (zh) * | 2008-03-28 | 2008-09-10 | 王洪 | 唑来磷酸用于制备预防及治疗骨质疏松症的药物 |
| EP2288378A4 (en) | 2008-04-16 | 2011-12-14 | Univ Utah Res Found | PHARMACOLOGICAL TARGETING OF VEGETABLE ILLNESS |
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- 2010-09-01 US US13/393,248 patent/US9867838B2/en active Active
- 2010-09-01 CN CN201610268687.6A patent/CN105920023A/zh active Pending
- 2010-09-01 EP EP10814383.5A patent/EP2473172B1/en active Active
- 2010-09-01 SI SI201030934T patent/SI2473172T1/sl unknown
- 2010-09-01 HR HRP20150496TT patent/HRP20150496T1/hr unknown
- 2010-09-01 PL PL10814383T patent/PL2473172T3/pl unknown
- 2010-09-01 HU HUE10814383A patent/HUE025737T2/en unknown
- 2010-09-01 PT PT108143835T patent/PT2473172E/pt unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| US9867838B2 (en) | 2018-01-16 |
| WO2011028737A3 (en) | 2011-07-14 |
| WO2011028737A8 (en) | 2012-05-18 |
| EP2473172A4 (en) | 2013-01-16 |
| EP2473172A2 (en) | 2012-07-11 |
| SMT201500124B (it) | 2015-07-09 |
| CN105920023A (zh) | 2016-09-07 |
| HUE025737T2 (en) | 2016-05-30 |
| US20120208786A1 (en) | 2012-08-16 |
| EP2473172B1 (en) | 2015-04-08 |
| HRP20150496T1 (hr) | 2015-08-14 |
| PT2473172E (pt) | 2015-06-25 |
| CN102639137A (zh) | 2012-08-15 |
| ES2537216T3 (es) | 2015-06-03 |
| WO2011028737A2 (en) | 2011-03-10 |
| PL2473172T3 (pl) | 2015-08-31 |
| SI2473172T1 (sl) | 2015-07-31 |
| US20180125869A1 (en) | 2018-05-10 |
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