DK2473172T3 - Bisphosphonatsammensætninger og fremgangsmåder til behandling af hjerteinsufficiens - Google Patents
Bisphosphonatsammensætninger og fremgangsmåder til behandling af hjerteinsufficiens Download PDFInfo
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- DK2473172T3 DK2473172T3 DK10814383.5T DK10814383T DK2473172T3 DK 2473172 T3 DK2473172 T3 DK 2473172T3 DK 10814383 T DK10814383 T DK 10814383T DK 2473172 T3 DK2473172 T3 DK 2473172T3
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- Prior art keywords
- bisphosphonate
- heart failure
- pharmaceutically effective
- use according
- administration
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (11)
1. Bisphosphonat eller farmaceutisk effektivt salt deraf til anvendelse i behandling eller forebyggelse af hjerteinsufficiens hos et individ, hvori bisphosphonatet er beregnet til intravenøs eller oral administration ved en dosis på fra ca. 40 pg/kg til ca. 125 pg/kg, hvor individet oplever forbedret kardiel ejektionsfraktion.
2. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 1, hvor bisphosphonatet er zoledronsyre.
3. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 2, hvor doseringen er årlig eller halvårlig for administration til individet.
4. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 2, hvor individet har en stigning i ejektionsfraktion på fra ca. 10 % til 20 % efter administration af zoledronsyren.
5. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 2, hvor zoledronsyren er beregnet til administration efter en dosis vitamin D.
6. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 1, hvor mindst ét andet terapeutisk middel udvalgt fra gruppen bestående af nitrater, beta-adrenerge blokkere, angiotensinkonverterende enzyminhibitorer, calciumkanalantagonister, antihypertensive midler, kolesterolsænkende midler, diuretika, ACE-inhibitorer, hjerteglycosider, non-peptid angiotensin Il-antagonister, Ilb/IIIa-antagonister og aspirin endvidere er beregnet til yderligere administration til patienten.
7. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 1, hvor hjerteinsufficiens er en følge af mindst én af følgende tilstande: hypertension, iskæmisk hjertesygdom, eksponering for en kardiotoksisk forbindelse, stråleterapi, myocarditis, thyroideasygdom, virusinfektion, stofmisbrug, alkoholmisbrug, pericarditis, atherosklerose, karsygdom, hypertrofisk kardiomyopati, akut myokardieinfarkt, ventrikulær systolisk dysfunktion, ventrikulær diastolisk dysfunktion, koronar bypasskirurgi, fald i kontraktion af venstre ventrikel, en stigning i inflammatoriske cytokiner eller en genetisk defekt.
8. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 1, hvor bisphosphonatet er beregnet til administration forud for diagnosen på hjerteinsufficiens hos individet.
9. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 1, hvor bisphosphonatet er beregnet til administration efter diagnose af hjerteinsufficiens hos individet.
10. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 7, hvor bisphosphonatet er beregnet til administration samtidig med en kardiotoksisk forbindelse eller stråleterapi.
11. Bisphosphonat eller farmaceutisk effektivt salt til anvendelse ifølge krav 1, hvor bisphosphonatforbindelsen er udvalgt fra gruppen bestående af zoledronsyre, risedronat, alendronat, cimadronat, clodronat, tiludronat, etidronat, ibandronat, piridronat eller pamidronat.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23879709P | 2009-09-01 | 2009-09-01 | |
| PCT/US2010/047417 WO2011028737A2 (en) | 2009-09-01 | 2010-09-01 | Bisphosphonate compositions and methods for treating heart failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2473172T3 true DK2473172T3 (da) | 2015-06-15 |
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ID=43649931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10814383.5T DK2473172T3 (da) | 2009-09-01 | 2010-09-01 | Bisphosphonatsammensætninger og fremgangsmåder til behandling af hjerteinsufficiens |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9867838B2 (da) |
| EP (1) | EP2473172B1 (da) |
| CN (2) | CN105920023A (da) |
| DK (1) | DK2473172T3 (da) |
| ES (1) | ES2537216T3 (da) |
| HR (1) | HRP20150496T1 (da) |
| HU (1) | HUE025737T2 (da) |
| PL (1) | PL2473172T3 (da) |
| PT (1) | PT2473172E (da) |
| SI (1) | SI2473172T1 (da) |
| SM (1) | SMT201500124B (da) |
| WO (1) | WO2011028737A2 (da) |
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| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| CA2856030A1 (en) * | 2011-11-16 | 2013-05-23 | Duke University | Bisphosphonate compositions and methods for treating and/or reducing cardiac dysfunction |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US20230149430A1 (en) * | 2020-04-06 | 2023-05-18 | Duke University | Compositions and methods for the treatment of infection-induced cardiomyopathy |
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| DE2405254C2 (de) | 1974-02-04 | 1982-05-27 | Henkel KGaA, 4000 Düsseldorf | Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper |
| DE3428524A1 (de) | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
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| US20050119230A1 (en) * | 2003-09-18 | 2005-06-02 | Alexandra Glausch | Pharmaceutical products comprising bisphosphonated |
| KR20060058134A (ko) | 2003-09-19 | 2006-05-29 | 화이자 프로덕츠 인코포레이티드 | 2-알킬리덴-19-노르-비타민 디 유도체 및비스포스포네이트의 조합을 포함하는 약학 조성물 및 방법 |
| GB0327742D0 (en) * | 2003-11-28 | 2003-12-31 | Isis Innovation | Novel uses of known drugs |
| WO2006019843A1 (en) | 2004-07-15 | 2006-02-23 | Nanobac Life Sciences | Methods and compositions for the administration of calcium chelators, bisphosphonates and/or citrate compounds and their pharmaceutical uses |
| US20060069068A1 (en) | 2004-07-15 | 2006-03-30 | Nanobac Pharmaceuticals, Inc. | Methods and compositions for the treatment of diseases characterized by pathological calcification |
| US7473684B2 (en) * | 2005-09-16 | 2009-01-06 | Selamine Limited | Bisphosphonate formulation |
| WO2007117706A2 (en) * | 2006-04-07 | 2007-10-18 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| EP1925621A1 (en) * | 2006-11-27 | 2008-05-28 | Novartis AG | Crystalline forms of zoledronic acid |
| US20080146489A1 (en) | 2006-12-15 | 2008-06-19 | Pacetti Stephen D | Regional delivery of therapeutic agents for the treatment of vascular diseases |
| WO2008116133A1 (en) | 2007-03-21 | 2008-09-25 | Duke University | Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture |
| JP5539221B2 (ja) * | 2007-12-21 | 2014-07-02 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）およびその使用 |
| CN101259133A (zh) * | 2008-03-28 | 2008-09-10 | 王洪 | 唑来磷酸用于制备预防及治疗骨质疏松症的药物 |
| WO2009148709A1 (en) | 2008-04-16 | 2009-12-10 | University Of Utah Research Foundation | Pharmacological targeting of vascular malformations |
-
2010
- 2010-09-01 PT PT108143835T patent/PT2473172E/pt unknown
- 2010-09-01 CN CN201610268687.6A patent/CN105920023A/zh active Pending
- 2010-09-01 CN CN2010800472182A patent/CN102639137A/zh active Pending
- 2010-09-01 HU HUE10814383A patent/HUE025737T2/en unknown
- 2010-09-01 HR HRP20150496TT patent/HRP20150496T1/hr unknown
- 2010-09-01 ES ES10814383.5T patent/ES2537216T3/es active Active
- 2010-09-01 PL PL10814383T patent/PL2473172T3/pl unknown
- 2010-09-01 SI SI201030934T patent/SI2473172T1/sl unknown
- 2010-09-01 DK DK10814383.5T patent/DK2473172T3/da active
- 2010-09-01 WO PCT/US2010/047417 patent/WO2011028737A2/en not_active Ceased
- 2010-09-01 US US13/393,248 patent/US9867838B2/en active Active
- 2010-09-01 EP EP10814383.5A patent/EP2473172B1/en active Active
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2015
- 2015-05-26 SM SM201500124T patent/SMT201500124B/xx unknown
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2018
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2537216T3 (es) | 2015-06-03 |
| EP2473172A4 (en) | 2013-01-16 |
| EP2473172B1 (en) | 2015-04-08 |
| WO2011028737A2 (en) | 2011-03-10 |
| WO2011028737A3 (en) | 2011-07-14 |
| PT2473172E (pt) | 2015-06-25 |
| SI2473172T1 (sl) | 2015-07-31 |
| EP2473172A2 (en) | 2012-07-11 |
| US20180125869A1 (en) | 2018-05-10 |
| CN102639137A (zh) | 2012-08-15 |
| PL2473172T3 (pl) | 2015-08-31 |
| CN105920023A (zh) | 2016-09-07 |
| SMT201500124B (it) | 2015-07-09 |
| US20120208786A1 (en) | 2012-08-16 |
| US9867838B2 (en) | 2018-01-16 |
| WO2011028737A8 (en) | 2012-05-18 |
| HUE025737T2 (en) | 2016-05-30 |
| HRP20150496T1 (hr) | 2015-08-14 |
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