DK2482889T3 - Indretning til lægemiddelfremføringsanordning - Google Patents

Indretning til lægemiddelfremføringsanordning Download PDF

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Publication number
DK2482889T3
DK2482889T3 DK10759640.5T DK10759640T DK2482889T3 DK 2482889 T3 DK2482889 T3 DK 2482889T3 DK 10759640 T DK10759640 T DK 10759640T DK 2482889 T3 DK2482889 T3 DK 2482889T3
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Prior art keywords
piston rod
section
interaction
dose
drive mechanism
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DK10759640.5T
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English (en)
Inventor
Catherine Anne Macdonald
Robert Veasey
Christopher Jones
Garen Kouyoumjian
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Sanofi Aventis Deutschland
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2492—Ampoule holder connected to rest of syringe via snap connection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (17)

  1. - 1 -
    1. Genindstillelig drivmekanisme til en lægemiddelfremføringsanordning (1), der omfatter: 5 - en stempelstangsindretning (32), hvilken stempelstangsindretning (32) omfatter et styrespor (18), der løbet langs stempelstangsindretningen (32), hvilket styrespor (18) omfatter mindst én fremføringssektion (18A) og mindst én genindstillingssektion (18B), hvilken genindstillingssektion 10 (18B) er anbragt, så den fortsætter fremføringssektionen (18A), hvilken fremføringssektion (18A) omfatter mindst ét blokeringsmiddel (19), og - en interaktionsdel (23), hvilken interaktionsdel (23) er konfigureret til at samvirke med styresporet (18), 15 hvor stempelstangsindretningen (32) til fremføring af en dosis af et lægemiddel (24) er aksialt forskydelig i en dosisfremføringsretning væk fra en aksial startposition, idet interaktionsdelen (23) samvirker med fremføringssektionen (18A), og 20 hvor interaktionsdelen (23) til genindstilling af lægemiddelfremføringsanordningen (1) er konfigureret til at samvirke med genindstillingssektionen (18B), idet stempelstangsindretningen (32) forskydes aksialt mod den aksiale startposition, og blokeringsmidlet (19) forsættes i 25 forhold til interaktionsdelen (23) og passerer den aksiale position af interaktionsdelen (23), når stempelstangsindretningen (32) forskydes aksialt mod den aksiale startposition, og er kendetegnet ved, at blokeringsmidlet (19) passerer 30 interaktionsdelen (23), når stempelstangsindretningen (32) forskydes i dosisfremføringsretningen, idet aksial forskydning af stempelstangsindretningen (32) mod den aksiale startposition forhindres ved mekanisk interaktion mellem blokeringsmidlet (19) og interaktionsdelen (23), når 35 interaktionsdelen (23) samvirker med fremføringssektionen (18A).
  2. 2. Genindstillelig drivmekanisme ifølge krav 1, - Δ - hvor genindstillingssektionen (18B) er anbragt, så den danner en kontinuert omkreds med fremføringssektionen (18A).
  3. 3. Genindstillelig drivmekanisme ifølge krav 1 eller krav 2, 5 hvor blokeringsmidlet (19), når interaktionsdelen (23) samvirker med genindstillingssektionen (23), vinkelforsættes fra interaktionsdelen (23).
  4. 4. Genindstillelig drivmekanisme ifølge et hvilket som helst 10 af ovennævnte krav, hvor genindstillingssektionen (18B) strækker sig aksialt langs fremføringssektionen (18A).
  5. 5. Genindstillelig drivmekanisme ifølge et hvilket som helst 15 af ovennævnte krav, hvor genindstillingssektionen (18B) er vinkelforskudt i forhold til fremføringssektionen (18A) og vinkelforskydningen mellem genindstillingssektionen (18B) og fremføringssektionen (18A) falder i den aksiale retning væk fra den aksiale 20 startposition.
  6. 6. Genindstillelig drivmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor fremføringssektionen (18A) er forbundet til 25 genindstillingssektionen (18B) via en vinkeludvidende forbindelsesregion (25) af styresporet (18).
  7. 7. Genindstillelig drivmekanisme ifølge krav 6, hvor stempelstangsindretningen er roterbar (32) til 30 genindstilling af drivmekanismen, således at forbindelsesregionen (25) passerer interaktionsdelen (23), og interaktionsdelen (23) føres ind i mekanisk samvirkning med genindstillingssektionen (18B).
  8. 8. Genindstillelig drivmekanisme ifølge krav 6 eller krav 7, hvor en overgang fra fremføringssektionen (18A) til genindstillingssektionen (18B) er blokeret fra siden via forbindelsesregionen (25). - G -
  9. 9. Genindstillelig drivmekanisme ifølge krav 7 eller 8, hvor en sektionsseparator (29) er anbragt i forbindelsesregionen (25), hvilken sektionsseparator (29) 5 blokerer rotation af stempelstangsindretningen (32) i den retning, der ville føre interaktionsdelen (23) tilbage til interaktion med fremføringssektionen (18A) via forbindelsesregionen (25).
  10. 10. Genindstillelig drivmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor fremføringssektionen (18A) udgår skråt i forhold til den længdegående hovedakse (28) af stempelstangsindretningen (32), og genindstillingssektionen (18B) udgår mindre skråt i forhold 15 til den længdegående hovedakse (28) af stempelstangsindretningen (32) end fremføringssektionen (18A).
  11. 11. Genindstillelig drivmekanisme ifølge et hvilket som helst af ovennævnte krav, 20 hvor fremføringssektionen (18A) og interaktionsdelen (23) definerer en rotationsvinkel, hvormed stempelstangsindretningen (32) roteres ved mekanisk interaktion mellem interaktionsdelen (23) og fremføringssektionen (18A), når stempelstangsindretningen (32) 25 forskydes aksialt til fremføring af en dosis.
  12. 12. Genindstillelig drivmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor stempelstangsindretningen (32), når den er flyttet 30 tilbage til den aksiale startposition, er roterbar, så den kan føre interaktionsdelen (23) i mekanisk samvirkning med fremføringssektionen (18A) eller en anden fremføringssektion (18A).
  13. 13. Genindstillelig drivmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor drivmekanismen omfatter en drivdel (5) , hvilken drivdel (5) er konfigureret til at drive den aksiale forskydning af - 4 - stempelstangsindretningen (32) i dosisfremføringsretningen ved hjælp af mekanisk interaktion mellem en interaktionsflade (17) på stempelstangsindretningen (32) og et drivtræk (15) på drivdelen (5), og hvor stempelstangsindretningen (32) til 5 genindstilling af lægemiddelfremføringsanordningen (1) er konfigureret, så den er roterbar, således at interaktionsfladen (17) vinkelforskydes i forhold til drivtrækket (15), så interaktionsfladen (17) kan passere den aksiale position af drivtrækket (15) med en vinkelforsætning. 10
  14. 14. Genindstillelig drivmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor fremføringssektionen (18A) omfatter et antal dosissektioner, idet to tilgrænsende dosissektioner adskilles 15 af blokeringsmidlet (19).
  15. 15. Genindstillelig drivmekanisme ifølge krav 13 eller 14, hvor styresporet (18) er tilvejebragt på en ydre overflade af stempelstangsindretningen (32), og interaktionsfladen (17) er 20 tilvejebragt på en indre overflade af stempelstangsindretningen (32).
  16. 16. Genindstillelig drivmekanisme ifølge et hvilket som helst af ovennævnte krav, 25 hvor fremføringssektionen (18A) strækker sig i vinkelretningen med mindre end 360 grader over dens samlede aksiale udstrækning.
  17. 17. Genindstillelig drivmekanisme ifølge krav 14, hvor 30 dosissektionerne omfatter en rampe, og rampen fortrinsvis skråner opad i retningen af blokeringsmidlet (19).
DK10759640.5T 2009-09-30 2010-09-29 Indretning til lægemiddelfremføringsanordning DK2482889T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09171743 2009-09-30
PCT/EP2010/064401 WO2011039210A1 (en) 2009-09-30 2010-09-29 Assembly for a drug delivery device

Publications (1)

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DK2482889T3 true DK2482889T3 (da) 2016-05-17

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US (1) US9463278B2 (da)
EP (1) EP2482889B1 (da)
JP (1) JP5749724B2 (da)
CA (1) CA2773013A1 (da)
DK (1) DK2482889T3 (da)
WO (1) WO2011039210A1 (da)

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WO2011039210A1 (en) 2011-04-07
EP2482889B1 (en) 2016-02-10
US9463278B2 (en) 2016-10-11
US20120283653A1 (en) 2012-11-08
JP5749724B2 (ja) 2015-07-15
EP2482889A1 (en) 2012-08-08
JP2013506449A (ja) 2013-02-28

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