DK2500730T3 - Opløselig urokinase-plasminogen-aktivatorreceptor (suPAR) som diagnostisk markør for en lavgrad-inflammation - Google Patents

Opløselig urokinase-plasminogen-aktivatorreceptor (suPAR) som diagnostisk markør for en lavgrad-inflammation Download PDF

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Publication number
DK2500730T3
DK2500730T3 DK12164660.8T DK12164660T DK2500730T3 DK 2500730 T3 DK2500730 T3 DK 2500730T3 DK 12164660 T DK12164660 T DK 12164660T DK 2500730 T3 DK2500730 T3 DK 2500730T3
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Denmark
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supar
risk
years
marker
cancer
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DK12164660.8T
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English (en)
Inventor
Jesper Eugen-Olsen
Steen B Haugaard
Ove Andersen
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Hvidovre Hospital
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Publication of DK2500730T3 publication Critical patent/DK2500730T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7095—Inflammation

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (9)

1. Fremgangsmåde til diagnosticering af lavgrad inflammation i et tilsyneladende raskt pattedyrindivid, såsom et menneske-individ, omfattende: (a) udføre en in w'tro-måling af niveauet af en markør i form af opløselig urokinase-plasminogen-aktivatorreceptor (suPAR) og/eller D2D3-kløv-ningsprodukter af suPAR, i én eller flere prøver indeholdende en biologisk væske opnået fra individet, og (b) anvende den ene eller flere målte værdier opnået som en faktor i diagnosen af lavgrad inflammation.
2. Fremgangsmåde til forudsigelse af risikoen for at udvikle en lavgrad-inflammation-relateret sygdom, i et pattedyr-individ, såsom et menneske-individ, omfattende at: (a) udføre en in w'fro-måling af niveauet af en markør i form af (i) opløselig urokinase-plasminogen-aktivatorreceptor (suPAR), og/eller (ii) D2D3 kløvningsprodukter af suPAR i én eller flere prøver indeholdende en biologisk væske opnået fra individet, og (b) anvende den målte værdi opnået som en faktor til at forudse risikoen for at udvikle en lavgrad-inflammations-relateret sygdom.
3. Fremgangsmåde ifølge krav 1 eller 2, hvor den biologiske væske er blodserum, blodplasma eller urin.
4. Fremgangsmåde ifølge krav 1 eller 2, hvor mere end én af prøverne omfatter et biologisk væske der er blevet afledt fra individet ved mere end et tidspunkt.
5. Fremgangsmåde ifølge krav 4, yderligere sammenligne niveauet af markøren ved ét eller flere tidspunkter for at bedømme virkningen af et profylaktisk forløb og/eller behandling.
6. Fremgangsmåde ifølge krav 5, hvor det profylaktiske forløb omfatter fysisk motion.
7. Fremgangsmåde ifølge krav 5 eller 6, hvor et fald i niveauet af markøren på mindst 10% og/eller 1 ng/ml angiver virkning.
8. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor in wfro-målingen er et ELISA-assay.
9. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor fremgangsmåden yderligere omfatter at udføre en glucosetolerencetest, eller teste TNF-alfa, IL-6, leukocyttælling, fastende plasma-glucose eller fastende blod-glucose, blodtryk, kolesterol, C-reaktiv protein- og/eller triglyceridniveauer.
DK12164660.8T 2006-12-22 2007-12-21 Opløselig urokinase-plasminogen-aktivatorreceptor (suPAR) som diagnostisk markør for en lavgrad-inflammation DK2500730T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87683806P 2006-12-22 2006-12-22
DKPA200601709 2006-12-22
US94707407P 2007-06-29 2007-06-29
DKPA200700956 2007-06-29
EP07858108.9A EP2115478B1 (en) 2006-12-22 2007-12-21 Soluble urokinase plasminogen activator receptor (suPAR) as predictive marker for cardiovascular diseases

Publications (1)

Publication Number Publication Date
DK2500730T3 true DK2500730T3 (da) 2018-05-28

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DK07858108.9T DK2115478T3 (da) 2006-12-22 2007-12-21 Opløselig urokinase-plasminogen-aktivatorreceptor (suPAR) som prædiktiv markør for cardiovaskulære sygdomme
DK12164660.8T DK2500730T3 (da) 2006-12-22 2007-12-21 Opløselig urokinase-plasminogen-aktivatorreceptor (suPAR) som diagnostisk markør for en lavgrad-inflammation

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DK07858108.9T DK2115478T3 (da) 2006-12-22 2007-12-21 Opløselig urokinase-plasminogen-aktivatorreceptor (suPAR) som prædiktiv markør for cardiovaskulære sygdomme

Country Status (15)

Country Link
US (2) US8815519B2 (da)
EP (2) EP2115478B1 (da)
AU (1) AU2007337996B2 (da)
CA (1) CA2674521C (da)
CY (1) CY1120296T1 (da)
DK (2) DK2115478T3 (da)
ES (2) ES2456043T3 (da)
GB (1) GB2461410C (da)
HU (1) HUE037758T2 (da)
LT (1) LT2500730T (da)
PL (1) PL2500730T3 (da)
PT (1) PT2500730T (da)
SI (1) SI2500730T1 (da)
TR (1) TR201807733T4 (da)
WO (1) WO2008077958A2 (da)

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CA2779958A1 (en) * 2008-11-06 2010-05-14 University Of Miami Role of soluble upar in the pathogenesis of proteinuric kidney disease
US8349256B2 (en) * 2008-11-21 2013-01-08 Sysmex Corporation Blood cell analyzer, blood cell analyzing method, and computer program product
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WO2020206129A1 (en) * 2019-04-02 2020-10-08 The Regents Of The University Of Michigan Use of soluble urokinase plasminogen activator receptor levels in the management of patients with cardiovascular disease
CN111128398B (zh) * 2020-03-30 2020-08-14 广州地理研究所 一种基于人口迁徙大数据的流行病感染人数估算方法
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CN112630442A (zh) * 2020-11-03 2021-04-09 浙江大学 一种血浆可溶性尿激酶型纤溶酶原激活物受体及其应用
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Publication number Publication date
GB0912351D0 (en) 2009-08-26
HUE037758T2 (hu) 2018-09-28
LT2500730T (lt) 2018-05-10
ES2456043T3 (es) 2014-04-21
US9645157B2 (en) 2017-05-09
GB2461410C (en) 2018-06-20
CA2674521C (en) 2022-06-14
WO2008077958A2 (en) 2008-07-03
SI2500730T1 (en) 2018-08-31
PL2500730T3 (pl) 2018-08-31
EP2500730B1 (en) 2018-03-07
WO2008077958A3 (en) 2009-04-02
CA2674521A1 (en) 2008-07-03
EP2115478B1 (en) 2014-01-22
US20100098705A1 (en) 2010-04-22
DK2115478T3 (da) 2014-03-10
AU2007337996A1 (en) 2008-07-03
EP2115478A2 (en) 2009-11-11
US8815519B2 (en) 2014-08-26
GB2461410B (en) 2011-06-29
TR201807733T4 (tr) 2018-06-21
EP2500730A1 (en) 2012-09-19
GB2461410A (en) 2010-01-06
PT2500730T (pt) 2018-05-28
ES2670711T3 (es) 2018-05-31
CY1120296T1 (el) 2019-07-10
AU2007337996B2 (en) 2013-03-14
US20140370527A1 (en) 2014-12-18

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