DK2501384T3 - Fremgangsmåde til behandling af proliferative lidelser og andre patologiske tilstande formidlede af BCR-ABL, C-KIT, DDR1, DDR2, eller PDGF-R-kinaseaktivitet - Google Patents
Fremgangsmåde til behandling af proliferative lidelser og andre patologiske tilstande formidlede af BCR-ABL, C-KIT, DDR1, DDR2, eller PDGF-R-kinaseaktivitet Download PDFInfo
- Publication number
- DK2501384T3 DK2501384T3 DK10781781.9T DK10781781T DK2501384T3 DK 2501384 T3 DK2501384 T3 DK 2501384T3 DK 10781781 T DK10781781 T DK 10781781T DK 2501384 T3 DK2501384 T3 DK 2501384T3
- Authority
- DK
- Denmark
- Prior art keywords
- nilotinib
- formula
- treatment
- pyrimidylaminobenzamide
- pharmaceutically acceptable
- Prior art date
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- 238000011282 treatment Methods 0.000 title claims description 22
- 230000000694 effects Effects 0.000 title claims description 11
- 230000001575 pathological effect Effects 0.000 title claims description 9
- 230000002062 proliferating effect Effects 0.000 title claims description 8
- -1 DDR2 Proteins 0.000 title claims description 6
- 102100036725 Epithelial discoidin domain-containing receptor 1 Human genes 0.000 title description 9
- 101710131668 Epithelial discoidin domain-containing receptor 1 Proteins 0.000 title description 9
- 108091008606 PDGF receptors Proteins 0.000 title description 9
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 title description 8
- 230000001404 mediated effect Effects 0.000 title description 7
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- 150000003839 salts Chemical class 0.000 claims description 11
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- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 7
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
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- 240000000560 Citrus x paradisi Species 0.000 description 3
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- YCBPQSYLYYBPDW-UHFFFAOYSA-N 4-methyl-n-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide;hydrate;hydrochloride Chemical compound O.Cl.C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 YCBPQSYLYYBPDW-UHFFFAOYSA-N 0.000 description 1
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- VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical compound [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
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- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
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Claims (3)
1. Pyrimidylaminobenzamid af formlen (I)
(i), hvor Py betegner 3-pyridyl, Ri repræsenterer hydrogen, R2 repræsenterer 5-(4-methyl-1 H-imidazol-1-yl)-3-(trifluormethyl)-phenyl; og R4 repræsenterer methyl; eller et farmaceutisk acceptabelt salt deraf, til behandling af en proliferativ lidelse eller anden patologisk tilstand valgt blandt melanom, især melanom omfattende c-KIT-mutationer, brystcancer, tyktarmscancer, lungecancer, prostatacancer eller Kaposi's sarcom, gastrointestinale stromatumorer (GIST), akut myeloid leukæmi (AML), leukæmi, som reagerer på en inhibering af Abl-tyrosinkinaseaktiviteten, kronisk myeloid leukæmi (CML), Philadelphia chromosom-positiv akut lymfoblastisk leukæmi (Ph+ ALL), mesothelioma, systemisk mastocytose, hypereosinofil syndrom (HES), fibrose, leverfibrose, nyrefibrose, rheumatoid arthritis, polyarthritis, sclerodermi, lupus erythematosus, graft versus host-sygdom, neurofibromatose, pulmonal hypertension, pulmonal arteriel hypertension, Alzheimer's sygdom, seminom, dysgerminom og psoriasis, hvor forbindelsen af formel (I) eller et farmaceutisk acceptabelt salt deraf og eventuelt, farmaceutisk acceptable bærere, indgives oralt dispergeret i æblemos.
2. Pyrimidylaminobenzamid af formlen (I) til anvendelse i overensstemmelse med krav 1 i form af dets monohydrochlorid-monohydratsalt.
3. Pyrimidylaminobenzamid af formlen (I) elleret pyrimidylaminobenzamid af formlen (I) i form af dets monohydrochlorid-monohydratsalt til anvendelse i overensstemmelse med krav 1, hvor den patologiske tilstand vælges blandt CML og Ph+ ALL.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26181209P | 2009-11-17 | 2009-11-17 | |
| PCT/US2010/056926 WO2011062927A1 (en) | 2009-11-17 | 2010-11-17 | Method of treating proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2501384T3 true DK2501384T3 (da) | 2016-05-17 |
| DK2501384T4 DK2501384T4 (da) | 2024-01-02 |
Family
ID=43513643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10781781.9T DK2501384T4 (da) | 2009-11-17 | 2010-11-17 | Fremgangsmåde til behandling af proliferative lidelser og andre patologiske tilstande formidlede af BCR-ABL, C-KIT, DDR1, DDR2, eller PDGF-R-kinaseaktivitet |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US9061029B2 (da) |
| EP (1) | EP2501384B2 (da) |
| JP (2) | JP5829615B2 (da) |
| KR (1) | KR101743315B1 (da) |
| CN (1) | CN102612368B (da) |
| AR (1) | AR079029A1 (da) |
| AU (1) | AU2010322102B2 (da) |
| BR (1) | BR112012011693A2 (da) |
| CA (1) | CA2779490C (da) |
| CL (1) | CL2012001270A1 (da) |
| CO (1) | CO6551690A2 (da) |
| DK (1) | DK2501384T4 (da) |
| EC (1) | ECSP12011903A (da) |
| ES (1) | ES2572128T5 (da) |
| FI (1) | FI2501384T4 (da) |
| GT (1) | GT201200150A (da) |
| HR (1) | HRP20160472T4 (da) |
| HU (1) | HUE027307T2 (da) |
| IL (1) | IL219727A (da) |
| JO (1) | JO3634B1 (da) |
| MA (1) | MA33738B1 (da) |
| ME (1) | ME02413B (da) |
| MX (1) | MX2012005694A (da) |
| MY (1) | MY169956A (da) |
| NZ (1) | NZ599968A (da) |
| PE (1) | PE20121476A1 (da) |
| PH (1) | PH12012500965A1 (da) |
| PL (1) | PL2501384T5 (da) |
| RS (1) | RS54747B2 (da) |
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Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2776130A1 (en) | 2011-11-07 | 2014-09-17 | Institut National de la Sante et de la Recherche Medicale (INSERM) | A ddr1 antagonist or an inhibitor of ddr1 gene expression for use in the prevention or treatment of crescentic glomerulonephritis |
| AR090835A1 (es) | 2012-04-24 | 2014-12-10 | Chugai Pharmaceutical Co Ltd | Derivados de quinazolindiona |
| CA2871237A1 (en) | 2012-04-24 | 2013-10-31 | Chugai Seiyaku Kabushiki Kaisha | Benzamide derivative |
| CA2911040C (en) | 2012-05-02 | 2021-11-16 | Georgetown University | Treating an .alpha.-synucleinopathy with tyrosine kinase inhibitors |
| PE20161416A1 (es) * | 2012-05-15 | 2017-01-08 | Novartis Ag | Derivados de benzamida para la inhibicion de la actividad abl1, abl2 y bcr-abl1 |
| US20140080772A1 (en) * | 2012-09-06 | 2014-03-20 | The Board Of Regents Of The University Of Texas System | Treatments for melanoma |
| US9561245B2 (en) | 2012-09-06 | 2017-02-07 | The Board Of Regents Of The University Of Texas System | Combination treatments for melanoma |
| US9572828B2 (en) | 2013-07-18 | 2017-02-21 | The Board Of Regents Of The University Of Texas System | Treatment for melanoma |
| US10005739B2 (en) | 2013-10-23 | 2018-06-26 | Chugai Seiyaku Kabushiki Kaisha | Quinazolinone and isoquinolinone derivative |
| HK1248208A1 (zh) * | 2015-08-31 | 2018-10-12 | 东丽株式会社 | 尿素衍生物和其用途 |
| CN108103186B (zh) * | 2018-02-28 | 2021-07-02 | 固安博健生物技术有限公司 | 诊断类风湿性关节炎和骨关节炎的分子标志物 |
| TWI831259B (zh) | 2018-06-15 | 2024-02-01 | 漢達生技醫藥股份有限公司 | 包含達沙替尼十二烷基硫酸鹽組合物的膠囊 |
| CN120040470A (zh) | 2018-11-20 | 2025-05-27 | 乔治敦大学 | 用于治疗神经退行性、肌退行性和溶酶体贮积病症的组合物和方法 |
| WO2020144650A1 (en) * | 2019-01-10 | 2020-07-16 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of prostate cancer |
| EP4096791A1 (en) | 2020-01-31 | 2022-12-07 | Nanocopoeia LLC | Amorphous nilotinib microparticles and uses thereof |
| WO2021222739A1 (en) | 2020-04-30 | 2021-11-04 | Nanocopoeia, Llc | Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib |
| MX2023003556A (es) | 2020-09-29 | 2023-06-13 | Shenzhen Pharmacin Co Ltd | Composiciones farmaceuticas. |
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| ES2337995T3 (es) | 2002-06-28 | 2010-05-03 | Nippon Shinyaku Co., Ltd. | Derivado de amida. |
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| CA2493764C (en) * | 2002-08-01 | 2011-05-24 | Aesgen, Inc. | Improved treatment of cancer with glutamine |
| CA2606716C (en) * | 2005-05-02 | 2013-07-23 | Novartis Ag | Use of pyrimidylaminobenzamide derivatives for the treatment of systematic mastocytosis |
| SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
| GT200600316A (es) | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
| GT200600315A (es) | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida | |
| EP1923053A1 (en) | 2006-09-27 | 2008-05-21 | Novartis AG | Pharmaceutical compositions comprising nilotinib or its salt |
| KR100925559B1 (ko) * | 2007-10-26 | 2009-11-05 | 한국과학기술연구원 | 악티노마이신 ｄ를 유효성분으로 하는 ｄｄｒ과 콜라겐결합 저해제 |
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