DK2508207T3 - Nanopartikler ladet med kemoterapeutisk antitumormiddel - Google Patents

Nanopartikler ladet med kemoterapeutisk antitumormiddel

Info

Publication number
DK2508207T3
DK2508207T3 DK11305364.9T DK11305364T DK2508207T3 DK 2508207 T3 DK2508207 T3 DK 2508207T3 DK 11305364 T DK11305364 T DK 11305364T DK 2508207 T3 DK2508207 T3 DK 2508207T3
Authority
DK
Denmark
Prior art keywords
antitumor agent
nanoparticles charged
chemotherapeutic antitumor
chemotherapeutic
nanoparticles
Prior art date
Application number
DK11305364.9T
Other languages
English (en)
Inventor
Emilia Pisani
Sophie Lebel-Binay
Valerie Polard
Original Assignee
Bioalliance Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioalliance Pharma filed Critical Bioalliance Pharma
Application granted granted Critical
Publication of DK2508207T3 publication Critical patent/DK2508207T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5138Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82BNANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Manufacturing & Machinery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK11305364.9T 2011-03-31 2011-03-31 Nanopartikler ladet med kemoterapeutisk antitumormiddel DK2508207T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11305364.9A EP2508207B1 (en) 2011-03-31 2011-03-31 Nanoparticles loaded with chemotherapeutic antitumoral Drug

Publications (1)

Publication Number Publication Date
DK2508207T3 true DK2508207T3 (da) 2013-07-29

Family

ID=44513370

Family Applications (2)

Application Number Title Priority Date Filing Date
DK11305364.9T DK2508207T3 (da) 2011-03-31 2011-03-31 Nanopartikler ladet med kemoterapeutisk antitumormiddel
DK12713673.7T DK2691116T3 (da) 2011-03-31 2012-03-30 Nanopartikler ladet med kemoterapeutisk antitumorlægemiddel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK12713673.7T DK2691116T3 (da) 2011-03-31 2012-03-30 Nanopartikler ladet med kemoterapeutisk antitumorlægemiddel

Country Status (26)

Country Link
US (2) US9763874B2 (da)
EP (2) EP2508207B1 (da)
JP (1) JP5523638B2 (da)
KR (1) KR101578273B1 (da)
CN (2) CN103379920A (da)
AU (1) AU2012233666B2 (da)
BR (1) BR112013019105A2 (da)
CA (1) CA2822177C (da)
CY (1) CY1117868T1 (da)
DK (2) DK2508207T3 (da)
ES (2) ES2424476T3 (da)
HR (2) HRP20160708T1 (da)
HU (1) HUE028465T2 (da)
IL (1) IL227466A (da)
ME (1) ME02470B (da)
MX (1) MX344704B (da)
MY (1) MY162339A (da)
PH (1) PH12013501513A1 (da)
PL (1) PL2508207T3 (da)
PT (1) PT2508207E (da)
RS (1) RS52880B (da)
RU (1) RU2616494C2 (da)
SG (1) SG193453A1 (da)
SI (1) SI2691116T1 (da)
SM (1) SMT201600197B (da)
WO (1) WO2012131018A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2508207T3 (pl) 2011-03-31 2013-09-30 Bioalliance Pharma Nanocząsteczki zawierające chemioterapeutyczny lek przeciwnowotworowy
EP2875072B1 (en) * 2012-07-17 2017-03-15 Dow Global Technologies LLC Composition comprising an organic liquid diluent and a cellulose ether of very low viscosity
US9925192B2 (en) 2014-02-28 2018-03-27 Merck Sharp & Dohme Corp. Method for treating cancer
EP3131542A1 (en) * 2014-04-18 2017-02-22 Pfizer Inc. Methods of treating cancers with therapeutic nanoparticles
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
US9402834B2 (en) 2014-10-21 2016-08-02 Ions Pharmaceutical S.À R.L. Human therapeutic agents
US9907786B2 (en) * 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
US20240285592A1 (en) * 2015-05-13 2024-08-29 Ankh Life Sciences Limited Human therapeutic agents
JP6938462B2 (ja) 2015-07-28 2021-09-22 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System 治療用化合物の脳への一方向送達のためのインプラント組成物
WO2017046037A1 (en) 2015-09-14 2017-03-23 Onxeo Nanoparticles loaded with active ingredients, their process of preparation and their uses
CA3015241A1 (en) * 2016-02-22 2017-08-31 Onxeo Combination therapies comprising immuno-oncology agents and belinostat
NO342271B1 (en) * 2016-09-29 2018-04-30 Sintef Tto As A new drug delivery system for treatment of cancer
US10646540B2 (en) * 2016-11-18 2020-05-12 City Of Hope Peptide inhibitors of twist
CN106511365A (zh) * 2016-12-17 2017-03-22 郑州郑先医药科技有限公司 一种治疗肝硬化的西药组合物
CN118652192A (zh) 2017-05-24 2024-09-17 德克萨斯州大学系统董事会 用于抗体药物缀合物的接头
BR112020019452A2 (pt) * 2018-03-27 2021-01-05 Sintef Tto As Nanopartículas de poli (alquil cianoacrilato) para uso em tratamento de câncer
US12433846B2 (en) 2019-03-27 2025-10-07 Sintef Tto As Drug delivery system for treatment of cancer
WO2020207655A1 (en) 2019-04-10 2020-10-15 Sintef Tto As Nanoparticles comprising copolymeric or homopolymeric compounds which comprise cyanoacrylate subunits
MX2019015508A (es) 2019-12-18 2021-06-21 Univ Guadalajara Nanopartículas para el tratamiento del cáncer.
US12129265B2 (en) 2020-07-21 2024-10-29 Ankh Life Sciences Limited Therapeutic agents and uses thereof
CN119792282B (zh) * 2024-12-27 2025-11-04 上海交通大学医学院附属瑞金医院 去氢骆驼蓬碱在制备抗病毒药物中的应用

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Publication number Priority date Publication date Assignee Title
US4310667A (en) 1976-04-22 1982-01-12 Agence Nationale De Valorisation De La Recherche (Anvar) 2-N Quaternary ammonium salt derivatives of 9-hydroxy ellipticine
FR2775435B1 (fr) 1998-02-27 2000-05-26 Bioalliance Pharma Nanoparticules comprenant au moins un polymere et au moins un compose apte a complexer un ou plusieurs principes actifs
EP2430923A1 (en) * 2002-06-05 2012-03-21 Genentech, Inc. Compositions and methods for liver growth and liver protection
US20040202665A1 (en) * 2002-07-01 2004-10-14 Janette Lazarovits Compositions and methods for therapeutic treatment
JP5201763B2 (ja) * 2007-02-28 2013-06-05 昇一 城武 異なる平均粒径サイズの粒子からなる混合微粒子カプセルの製造方法
US20090061009A1 (en) * 2007-08-29 2009-03-05 Joseph Schwarz Composition and Method of Treatment of Bacterial Infections
EP2050747A1 (en) 2007-10-12 2009-04-22 BioAlliance Pharma Dimers of harmol or of its derivatives and uses thereof
CA2703149A1 (en) * 2007-10-26 2009-04-30 Pfizer Products Inc. Idarubicin for the treatment of lymphoma in a dog
US20110003710A1 (en) * 2008-02-28 2011-01-06 John Hopkins University Selectin ligands useful in the diagnosis and treatment of cancer
EP2153821A1 (en) * 2008-08-06 2010-02-17 BioAlliance Pharma Oral formulations of camptothecin derivatives
PL2508207T3 (pl) 2011-03-31 2013-09-30 Bioalliance Pharma Nanocząsteczki zawierające chemioterapeutyczny lek przeciwnowotworowy

Also Published As

Publication number Publication date
RS52880B (sr) 2014-02-28
EP2691116B8 (en) 2016-06-01
EP2691116B1 (en) 2016-03-23
JP5523638B2 (ja) 2014-06-18
ME02470B (me) 2017-02-20
ES2577955T3 (es) 2016-07-19
IL227466A0 (en) 2013-09-30
AU2012233666B2 (en) 2014-01-16
AU2012233666A1 (en) 2013-07-11
PH12013501513A1 (en) 2019-06-03
MX2013007581A (es) 2013-11-01
SG193453A1 (en) 2013-10-30
EP2691116A1 (en) 2014-02-05
PT2508207E (pt) 2013-07-22
EP2508207B1 (en) 2013-05-08
WO2012131018A1 (en) 2012-10-04
RU2013128934A (ru) 2015-01-10
MX344704B (es) 2017-01-03
ES2424476T3 (es) 2013-10-02
BR112013019105A2 (pt) 2019-04-02
CA2822177A1 (en) 2012-10-04
CN103379920A (zh) 2013-10-30
US20140024610A1 (en) 2014-01-23
RU2616494C2 (ru) 2017-04-17
KR101578273B1 (ko) 2015-12-16
HUE028465T2 (en) 2016-12-28
HRP20130702T1 (en) 2013-09-30
HRP20160708T1 (hr) 2016-07-15
MY162339A (en) 2017-06-15
IL227466A (en) 2016-12-29
SI2691116T1 (sl) 2016-10-28
CY1117868T1 (el) 2017-05-17
HK1192841A1 (zh) 2014-09-05
SMT201600197B (it) 2016-08-31
EP2508207A1 (en) 2012-10-10
KR20130114240A (ko) 2013-10-16
US20170333341A1 (en) 2017-11-23
CN105233301A (zh) 2016-01-13
JP2014503577A (ja) 2014-02-13
US9763874B2 (en) 2017-09-19
DK2691116T3 (da) 2016-07-04
PL2508207T3 (pl) 2013-09-30
CA2822177C (en) 2016-02-16

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