DK2521736T3 - Humaniserede antistoffer - Google Patents
Humaniserede antistoffer Download PDFInfo
- Publication number
- DK2521736T3 DK2521736T3 DK11700015T DK11700015T DK2521736T3 DK 2521736 T3 DK2521736 T3 DK 2521736T3 DK 11700015 T DK11700015 T DK 11700015T DK 11700015 T DK11700015 T DK 11700015T DK 2521736 T3 DK2521736 T3 DK 2521736T3
- Authority
- DK
- Denmark
- Prior art keywords
- humanized antibodies
- humanized
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/467—Igs with modifications in the FR-residues only
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29202810P | 2010-01-04 | 2010-01-04 | |
| GB1000064.4A GB2476681B (en) | 2010-01-04 | 2010-01-04 | Humanized camelid VH, VK and VL immunoglobulin domains |
| PCT/EP2011/050071 WO2011080350A1 (en) | 2010-01-04 | 2011-01-04 | Humanized antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2521736T3 true DK2521736T3 (da) | 2019-10-28 |
Family
ID=41795980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11700015T DK2521736T3 (da) | 2010-01-04 | 2011-01-04 | Humaniserede antistoffer |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8835607B2 (da) |
| EP (1) | EP2521736B1 (da) |
| JP (2) | JP6250284B2 (da) |
| CN (2) | CN105801696A (da) |
| AU (1) | AU2011203408C1 (da) |
| CA (1) | CA2784767C (da) |
| DK (1) | DK2521736T3 (da) |
| GB (1) | GB2476681B (da) |
| IL (1) | IL220404A (da) |
| WO (1) | WO2011080350A1 (da) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013021562B1 (pt) | 2011-03-16 | 2023-01-10 | Argenx Bvba | Anticorpos para cd70 |
| CA2835094C (en) * | 2011-05-06 | 2020-12-22 | David Gearing | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| WO2012163519A1 (en) * | 2011-05-27 | 2012-12-06 | Dutalys | Antibodies with improved folding stability |
| EP2773660A2 (en) * | 2011-11-03 | 2014-09-10 | Argen-X B.V. | Chimeric human-camel antigens and their use |
| US10040870B2 (en) | 2012-08-31 | 2018-08-07 | Argenx Bvba | Highly diverse combinatorial antibody libraries |
| AU2013310924B2 (en) | 2012-08-31 | 2017-08-03 | Argenx Bvba | Method for producing antibody molecules having inter-species, intra-target cross-reactivity |
| EP2719706A1 (en) | 2012-10-15 | 2014-04-16 | Universität Zürich | Bispecific HER2 ligands for cancer therapy |
| EP2906591A1 (en) | 2012-10-15 | 2015-08-19 | Universität Zürich | Bispecific her2 ligands for cancer therapy |
| MX2015009547A (es) | 2013-01-28 | 2015-11-25 | Evec Inc | Anticuerpo anti-hmgb1 humanizado o fragmento de union al antigeno del mismo. |
| WO2015063331A1 (en) * | 2013-11-04 | 2015-05-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Synthetic single domain antibody |
| EP2883883A1 (en) | 2013-12-16 | 2015-06-17 | Cardio3 Biosciences S.A. | Therapeutic targets and agents useful in treating ischemia reperfusion injury |
| GB201414823D0 (en) | 2014-08-20 | 2014-10-01 | Argen X Bv | Multispecific antibodies |
| US10391168B1 (en) | 2014-08-22 | 2019-08-27 | University Of Bern | Anti-CD70 combination therapy |
| EP3297672B1 (en) | 2015-05-21 | 2021-09-01 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| HRP20251020T1 (hr) | 2016-05-20 | 2025-10-24 | Harpoon Therapeutics, Inc. | Proteini s jednolančanim varijabilnim fragmentom koji vežu cd3 |
| KR102530742B1 (ko) | 2016-05-20 | 2023-05-09 | 하푼 테라퓨틱스, 인크. | 단일 도메인 혈청 알부민 결합 단백질 |
| GB201611123D0 (en) | 2016-06-27 | 2016-08-10 | Euremab Srl | Anti met antibodiesand uses thereof |
| WO2018007999A1 (en) | 2016-07-08 | 2018-01-11 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
| WO2018011405A1 (en) | 2016-07-15 | 2018-01-18 | Universität Zürich | Il-13ralpha1 antibodies for use in treatment of atopic inflammation, sepsis and neutropenia |
| GB201612337D0 (en) | 2016-07-15 | 2016-08-31 | Argen-X N V | Ant-il-22r antibodies |
| CA3036564A1 (en) | 2016-09-23 | 2018-03-29 | Elstar Therapeutics, Inc. | Multispecific antibody molecules comprising lambda and kappa light chains |
| KR102275008B1 (ko) * | 2016-11-23 | 2021-07-13 | 하푼 테라퓨틱스, 인크. | 전립선 특이 막 항원 결합 단백질 |
| JP7215997B2 (ja) | 2016-11-23 | 2023-01-31 | ハープーン セラピューティクス，インク． | 前立腺特異的膜抗原（ｐｓｍａ）を標的とする三重特異性タンパク質と使用方法 |
| WO2018160754A2 (en) | 2017-02-28 | 2018-09-07 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
| CA3058290A1 (en) | 2017-04-18 | 2018-10-25 | Universite Libre De Bruxelles | Biomarkers and targets for proliferative diseases |
| WO2018193427A1 (en) | 2017-04-21 | 2018-10-25 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
| SG10202107880XA (en) | 2017-05-12 | 2021-09-29 | Harpoon Therapeutics Inc | Mesothelin binding proteins |
| US10730954B2 (en) | 2017-05-12 | 2020-08-04 | Harpoon Therapeutics, Inc. | MSLN targeting trispecific proteins and methods of use |
| CA3078969A1 (en) | 2017-10-13 | 2019-04-18 | Harpoon Therapeutics, Inc. | Trispecific proteins and methods of use |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| CN111315772A (zh) | 2017-10-31 | 2020-06-19 | 斯塔顿生物技术有限公司 | 抗apoc3抗体及其使用方法 |
| CN111448217A (zh) * | 2017-12-22 | 2020-07-24 | 阿根思公司 | 双特异性抗原结合构建体 |
| IT201800000535A1 (it) | 2018-01-03 | 2019-07-03 | Procedimenti per la cura del cancro. | |
| GB201800649D0 (en) | 2018-01-16 | 2018-02-28 | Argenx Bvba | CD70 Combination Therapy |
| US12037382B2 (en) | 2018-02-05 | 2024-07-16 | Stichting Vu | Inverse agonistic anti-US28 antibodies |
| GB201802487D0 (en) | 2018-02-15 | 2018-04-04 | Argenx Bvba | Cytokine combination therapy |
| WO2019161386A1 (en) * | 2018-02-19 | 2019-08-22 | New York University | Alpha-synuclein single domain antibodies |
| US11655293B2 (en) | 2018-02-22 | 2023-05-23 | Universitat Zurich | Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT |
| EP3623382A1 (en) | 2018-09-14 | 2020-03-18 | Universität Zürich | Ligands to gm-csf or gm-csf-receptor for use in leukemia in a patient having undergone allo-hct |
| JP7390729B2 (ja) | 2018-03-23 | 2023-12-04 | ユニヴェルシテ リブル ドゥ ブリュッセル | Ｗｎｔシグナル伝達アゴニスト分子 |
| MX2020012217A (es) | 2018-05-14 | 2021-03-02 | Harpoon Therapeutics Inc | Porción de unión para activación condicional de moléculas de inmunoglobulina. |
| WO2019238966A1 (en) | 2018-06-15 | 2019-12-19 | Universität Bern | LIGANDS TO LIGHT OR ITS RECEPTOR LTßR FOR USE IN HAEMATOLOGIC MALIGNANCIES |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| CN119306844A (zh) | 2018-09-25 | 2025-01-14 | 哈普恩治疗公司 | Dll3结合蛋白及使用方法 |
| KR20210075080A (ko) | 2018-10-08 | 2021-06-22 | 유니베르시태트 취리히 | Her2-결합 사량체 폴리펩티드 |
| WO2020080941A1 (en) | 2018-10-16 | 2020-04-23 | Umc Utrecht Holding B.V. | Anti- low-density lipoprotein receptor-related protein 5/6 antibodies |
| WO2020104627A1 (en) | 2018-11-21 | 2020-05-28 | Universität Zürich | Photochemically induced conjugation of radiometals to small molecules, peptides and nanoparticles in a simultaneous one-pot reaction |
| WO2020232303A1 (en) | 2019-05-14 | 2020-11-19 | Harpoon Therapeutics, Inc. | EpCAM BINDING PROTEINS AND METHODS OF USE |
| BR112022016550A2 (pt) | 2020-02-21 | 2022-11-16 | Harpoon Therapeutics Inc | Proteínas de ligação a flt3 e métodos de uso |
| US12692306B2 (en) | 2020-08-18 | 2026-07-28 | Universität Zürich | CD25-biased anti-IL-2 antibody |
| WO2022136344A1 (en) | 2020-12-21 | 2022-06-30 | Université Libre de Bruxelles | Modulation of prdm12 for use in treatment of pain conditions |
| WO2022154664A1 (en) | 2021-01-15 | 2022-07-21 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Inducers of senescence, in combination with a selective death receptor 5 (dr5) agonist, for use in a method of treating cancer |
| JPWO2023008404A1 (da) * | 2021-07-26 | 2023-02-02 | ||
| IL310612A (en) | 2021-08-05 | 2024-04-01 | Immunos Therapeutics Ag | HLA-B57 is different with increased expression levels |
| MX2024001691A (es) | 2021-08-05 | 2024-04-19 | Immunos Therapeutics Ag | Medicamentos de combinación que comprenden proteínas de fusión de antígeno leucocitario de humano (hla). |
| WO2023021006A1 (en) | 2021-08-16 | 2023-02-23 | Universität Zürich | Il-1 targeting agents for treatment of pitiyriasis rubra pilaris |
| WO2023036849A1 (en) | 2021-09-07 | 2023-03-16 | ETH Zürich | Identifying and predicting future coronavirus variants |
| WO2023104933A1 (en) * | 2021-12-07 | 2023-06-15 | new/era/mabs GmbH | Camelid antibodies for use in therapy and diagnosis |
| EP4260907A1 (en) | 2022-04-11 | 2023-10-18 | Universität Zürich | Agents for treatment of endometriosis and other benign gynecological neoplasms |
| WO2024006975A1 (en) * | 2022-07-01 | 2024-01-04 | Bristol-Myers Squibb Company | Methods for antibody humanization |
| EP4612180A1 (en) | 2022-10-31 | 2025-09-10 | Stichting Amsterdam UMC | Single domain anti-cd169 antibodies |
| WO2024097665A2 (en) * | 2022-10-31 | 2024-05-10 | Twist Bioscience Corporation | Machine learning for antibody optimization |
| US20260176369A1 (en) | 2022-11-08 | 2026-06-25 | Stichting Amsterdam UMC | Activation Inducible Antigen Receptors for Adoptive Immunotherapy |
| JP2026514293A (ja) | 2023-02-08 | 2026-05-08 | イムノス セラピューティクス アーゲー | β２ミクログロブリン、ＨＬＡ重鎖ポリペプチド及びＣＤ４７－ＳＩＲＰαの阻害剤の融合タンパク質 |
| WO2025008519A1 (en) | 2023-07-05 | 2025-01-09 | Universität Bern | Il-1ra blockers for treatment and prevention of sepsis |
| WO2025021293A1 (en) | 2023-07-25 | 2025-01-30 | Universität Zürich | Disruption of rbr1 expression in plant cells |
| WO2025101525A1 (en) * | 2023-11-06 | 2025-05-15 | Beijing Starmab Biomed Technology Ltd | Monospecific and multi-specific antibodies |
| EP4631501A1 (en) | 2024-04-09 | 2025-10-15 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Combinations of a calcium homeostasis disruptor with a death receptor 5 agonist for treating cancer |
| WO2026068859A1 (en) | 2024-09-30 | 2026-04-02 | Université Libre de Bruxelles | Wnt signaling agonist molecules in the treatment of a bone-related disease or disorder |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US648213A (en) | 1899-12-06 | 1900-04-24 | Frederick Meukert Jr | Vehicle-shaft. |
| NZ243706A (en) | 1991-07-25 | 1994-08-26 | Idec Pharma Corp | Recombinant monkey antibodies, pharmaceutical compositions |
| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| AU2003208946A1 (en) * | 2002-02-28 | 2003-09-16 | Eli Lilly And Company | Anti-interleukin-1 beta analogs |
| US20090130123A1 (en) * | 2004-06-15 | 2009-05-21 | Erol Fikrig | Antibodies to west nile virus polypeptides |
| WO2008070344A2 (en) * | 2006-10-27 | 2008-06-12 | Lpath, Inc. | Compositions and methods for binding sphingosine-1-phosphate |
| US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2160409A1 (en) * | 2007-05-24 | 2010-03-10 | Ablynx N.V. | Amino acid sequences directed against growth factor receptors and polypeptides comprising the same for the treatment of diseases and disorders associated with growth factors and their receptors |
| AU2008270274B2 (en) * | 2007-07-03 | 2012-06-28 | Ablynx N.V. | Providing improved immunoglobulin sequences by mutating CDR and/or FR positions |
| AU2009245724A1 (en) * | 2008-05-09 | 2009-11-12 | Ablynx N.V. | Amino acid sequences directed against integrins and uses thereof |
| GB2461546B (en) * | 2008-07-02 | 2010-07-07 | Argen X Bv | Antigen binding polypeptides |
-
2010
- 2010-01-04 GB GB1000064.4A patent/GB2476681B/en active Active
-
2011
- 2011-01-04 EP EP11700015.8A patent/EP2521736B1/en active Active
- 2011-01-04 CA CA2784767A patent/CA2784767C/en active Active
- 2011-01-04 DK DK11700015T patent/DK2521736T3/da active
- 2011-01-04 CN CN201610178075.8A patent/CN105801696A/zh active Pending
- 2011-01-04 WO PCT/EP2011/050071 patent/WO2011080350A1/en not_active Ceased
- 2011-01-04 AU AU2011203408A patent/AU2011203408C1/en active Active
- 2011-01-04 US US12/984,402 patent/US8835607B2/en active Active
- 2011-01-04 CN CN2011800121871A patent/CN102858800A/zh active Pending
- 2011-01-04 JP JP2012546465A patent/JP6250284B2/ja active Active
-
2012
- 2012-06-14 IL IL220404A patent/IL220404A/en active IP Right Grant
-
2014
- 2014-07-28 US US14/444,352 patent/US9540437B2/en active Active
-
2016
- 2016-06-01 JP JP2016109758A patent/JP2016216461A/ja active Pending
- 2016-11-30 US US15/365,569 patent/US20170145088A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150057436A1 (en) | 2015-02-26 |
| CN105801696A (zh) | 2016-07-27 |
| EP2521736A1 (en) | 2012-11-14 |
| JP2013516165A (ja) | 2013-05-13 |
| GB201000064D0 (en) | 2010-02-17 |
| US20110165621A1 (en) | 2011-07-07 |
| AU2011203408C1 (en) | 2015-10-15 |
| JP6250284B2 (ja) | 2017-12-27 |
| JP2016216461A (ja) | 2016-12-22 |
| WO2011080350A1 (en) | 2011-07-07 |
| EP2521736B1 (en) | 2019-09-11 |
| US20170145088A1 (en) | 2017-05-25 |
| AU2011203408B2 (en) | 2015-05-28 |
| CA2784767C (en) | 2022-05-31 |
| US9540437B2 (en) | 2017-01-10 |
| IL220404A (en) | 2017-05-29 |
| AU2011203408A1 (en) | 2012-07-12 |
| CA2784767A1 (en) | 2011-07-07 |
| US8835607B2 (en) | 2014-09-16 |
| GB2476681B (en) | 2012-04-04 |
| GB2476681A (en) | 2011-07-06 |
| CN102858800A (zh) | 2013-01-02 |
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