DK2525863T3 - Fremgangsmåde og anordning til forbedring af glykæmisk styring - Google Patents
Fremgangsmåde og anordning til forbedring af glykæmisk styring Download PDFInfo
- Publication number
- DK2525863T3 DK2525863T3 DK11734450.7T DK11734450T DK2525863T3 DK 2525863 T3 DK2525863 T3 DK 2525863T3 DK 11734450 T DK11734450 T DK 11734450T DK 2525863 T3 DK2525863 T3 DK 2525863T3
- Authority
- DK
- Denmark
- Prior art keywords
- insulin
- data
- dose
- value
- values
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 35
- 230000002641 glycemic effect Effects 0.000 title description 2
- 206010022489 Insulin Resistance Diseases 0.000 claims description 190
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 180
- 229940125396 insulin Drugs 0.000 claims description 90
- 102000004877 Insulin Human genes 0.000 claims description 89
- 108090001061 Insulin Proteins 0.000 claims description 89
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 49
- 239000008103 glucose Substances 0.000 claims description 49
- 239000008280 blood Substances 0.000 claims description 25
- 210000004369 blood Anatomy 0.000 claims description 25
- 150000001720 carbohydrates Chemical class 0.000 claims description 11
- 235000014633 carbohydrates Nutrition 0.000 claims description 11
- 238000004590 computer program Methods 0.000 claims description 7
- 230000006870 function Effects 0.000 claims description 6
- 230000000007 visual effect Effects 0.000 claims description 5
- 238000012377 drug delivery Methods 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 238000011161 development Methods 0.000 description 24
- 230000018109 developmental process Effects 0.000 description 24
- 230000001019 normoglycemic effect Effects 0.000 description 14
- 238000005259 measurement Methods 0.000 description 13
- 230000000875 corresponding effect Effects 0.000 description 8
- 230000001419 dependent effect Effects 0.000 description 8
- 230000007246 mechanism Effects 0.000 description 8
- 238000004891 communication Methods 0.000 description 7
- 230000008859 change Effects 0.000 description 6
- 206010012601 diabetes mellitus Diseases 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 238000004364 calculation method Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 235000012054 meals Nutrition 0.000 description 5
- 230000000737 periodic effect Effects 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 230000036760 body temperature Effects 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 210000003722 extracellular fluid Anatomy 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000013528 artificial neural network Methods 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002996 emotional effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000037081 physical activity Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 108010065920 Insulin Lispro Proteins 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- 102000052651 Pancreatic hormone Human genes 0.000 description 1
- 101800001268 Pancreatic hormone Proteins 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 229940123452 Rapid-acting insulin Drugs 0.000 description 1
- 108010026951 Short-Acting Insulin Proteins 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- WNRQPCUGRUFHED-DETKDSODSA-N humalog Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(O)=O)C1=CC=C(O)C=C1.C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 WNRQPCUGRUFHED-DETKDSODSA-N 0.000 description 1
- 230000003345 hyperglycaemic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 229960004717 insulin aspart Drugs 0.000 description 1
- 229960002068 insulin lispro Drugs 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 238000007477 logistic regression Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000010801 machine learning Methods 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 206010062198 microangiopathy Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- VOMXSOIBEJBQNF-UTTRGDHVSA-N novorapid Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(O)=O)C1=CC=C(O)C=C1.C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 VOMXSOIBEJBQNF-UTTRGDHVSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000004025 pancreas hormone Substances 0.000 description 1
- 229940032957 pancreatic hormone Drugs 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 238000007637 random forest analysis Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1413—Modular systems comprising interconnecting elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards
- A61M2205/505—Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/201—Glucose concentration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Optics & Photonics (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Primary Health Care (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Claims (18)
1. Fremgangsmåde til anbefaling af en insulindosis tilpasset til anvendelse med en insulinindgivelsesanordning, hvilken fremgangsmåde omfatter: modtagelse af blodglucose- (BG) data, der indbefatter et koncentrationsniveau for kropsglucose; bestemmelse af en insulinsensitivitets- (IS) værdi svarende til BG-dataene; og bestemmelse af en insulindosis baseret på den bestemte IS-værdi, hvor insulindosen bestemmes ud fra følgende ligning: Anbefalet bolus = (Carbs/CIR) + (CBG-TBG)/IS - RI hvor: Carbs er mængden af carbohydrater, der skal indtages; CIR er forholdet mellem carbohydrat og insulin; CBG er det aktuelle blodgluc o seniveau; TBG er målblodglucoseniveauet; IS insulinsensitivitetsværdien bestemt svarende til BG-dataene; og RI er det resterende insulin, der er tilbage i en patients krop, kendetegnet ved, at: insulinsensitivitets- (IS) værdibestemmelsen indbefatter valg af IS-værdien fra en tabel/skema, hvori IS-værdier svarer til koncentrationsniveauerne for kropsglucose.
2. Fremgangsmåde ifølge krav 1, hvor BG-dataene omfatter BG-niveau.
3. Fremgangsmåde ifølge krav 2, hvor BG-dataene endvidere omfatter BG-tendens.
4. Fremgangsmåde ifølge krav 1, hvor modtagelse af BG-data indbefatter mindst én af: modtagelse af en indlæsning fra en bruger og modtagelse af et signal fra en glucosemonitor.
5. Fremgangsmåde ifølge krav 1, der endvidere omfatter visuel visning af IS-værdier som en funktion af BG-data.
6. Fremgangsmåde ifølge krav 5, hvor visuel visning indbefatter visning af en graf eller en tabel, der viser match mellem IS-værdier og BG-dataene.
7. Fremgangsmåde ifølge krav 1, der endvidere omfatter visuel visning af IS-værdier i form af et interval.
8. Fremgangsmåde ifølge krav 1, der endvidere omfatter hentning fra en hukommelse af IS-værdien svarende til BG-dataene.
9. Fremgangsmåde ifølge krav 1, hvor insulindosen indbefatter mindst én af en boluskomponent og en basal komponent.
10. Fremgangsmåde ifølge krav 1, der endvidere omfatter tilvejebringelse af en insulinpumpe med en processor, der har en dosisvejlederapplikation, der fungerer derpå, hvilken dosisvejleder er konfigureret til at bestemme IS-værdien og insulindosen.
11. Computerprogram, der omfatter instruktioner til udførelse af fremgangsmådens trin ifølge et hvilket som helst af krav 1 til 10, når computerprogrammet udføres på en egnet computerenhed.
12. Computerlæsbart medium, hvorpå der er kodet et computerprogram ifølge krav 11.
13. Lægemiddelindgivelsesanordning, der omfatter midler tilpasset til at udføre fremgangsmådens trin ifølge et hvilket som helst af kravene 1 til 10.
14. Lægemiddelindgivelsesanordning ifølge krav 13, der omfatter: en pumpe til indgivelse af lægemidlet i en brugers krop; indlæsningsmidler til modtagelse af mindst én af blodglucose- (BG) data og insulinsensitivitets- (IS) værdier; en processor med en dosisvejlederapplikation, der fungerer derpå, konfigureret til at bestemme IS-værdien baseret på BG-dataene; en hukommelse til lagring af BG-dataene og IS-værdien; og et display til visning af udlæsning forbundet med IS-værdien.
15. Anordning ifølge krav 14, hvor BG-dataene modtages fra en kontinuerlig glucosemonitor (CGM).
16. Anordning ifølge krav 14, hvor dosisvejlederen genererer en anbefalet insulindosis forbundet med IS-værdien.
17. Anordning ifølge krav 14, hvor indlæsningsmidlerne indbefatter én eller flere af: mindst én knap/kontakt, et tastatur, en berørings skærm, en stemmekommando, et glucometer og en CGM.
18. Anordning ifølge krav 14, der endvidere indbefatter mindst én kanyle, der kan indføres subkutant for indgivelse af den anbefalede insulindosis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29654010P | 2010-01-20 | 2010-01-20 | |
| PCT/IL2011/000061 WO2011089600A1 (en) | 2010-01-20 | 2011-01-20 | A method and device for improving glycemic control |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2525863T3 true DK2525863T3 (da) | 2019-01-21 |
Family
ID=44306454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11734450.7T DK2525863T3 (da) | 2010-01-20 | 2011-01-20 | Fremgangsmåde og anordning til forbedring af glykæmisk styring |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9457145B2 (da) |
| EP (1) | EP2525863B1 (da) |
| DK (1) | DK2525863T3 (da) |
| ES (1) | ES2704845T3 (da) |
| WO (1) | WO2011089600A1 (da) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8417311B2 (en) | 2008-09-12 | 2013-04-09 | Optiscan Biomedical Corporation | Fluid component analysis system and method for glucose monitoring and control |
| EP3868284A1 (en) | 2007-10-10 | 2021-08-25 | Optiscan Biomedical Corporation | Fluid component analysis system and method for glucose monitoring and control |
| US7959598B2 (en) | 2008-08-20 | 2011-06-14 | Asante Solutions, Inc. | Infusion pump systems and methods |
| WO2013173499A2 (en) | 2012-05-15 | 2013-11-21 | Minor James M | Diagnostic methods and devices for monitoring chronic glycemia |
| US11798685B2 (en) | 2012-05-15 | 2023-10-24 | James M. Minor | Diagnostic methods and devices for controlling acute glycemia |
| US9364609B2 (en) * | 2012-08-30 | 2016-06-14 | Medtronic Minimed, Inc. | Insulin on board compensation for a closed-loop insulin infusion system |
| US9833191B2 (en) | 2012-11-07 | 2017-12-05 | Bigfoot Biomedical, Inc. | Computer-based diabetes management |
| CN105339943B (zh) | 2013-06-21 | 2019-01-01 | 费森尤斯维尔公司 | 用于对患者的胰岛素施用进行控制的方法及控制设备 |
| US9561324B2 (en) | 2013-07-19 | 2017-02-07 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
| GB2523989B (en) | 2014-01-30 | 2020-07-29 | Insulet Netherlands B V | Therapeutic product delivery system and method of pairing |
| US9486580B2 (en) | 2014-01-31 | 2016-11-08 | Aseko, Inc. | Insulin management |
| US9233204B2 (en) | 2014-01-31 | 2016-01-12 | Aseko, Inc. | Insulin management |
| AU2015274894B2 (en) | 2014-06-10 | 2018-11-15 | Bigfoot Biomedical, Inc. | Insulin delivery systems and methods |
| JP6989262B2 (ja) | 2014-10-27 | 2022-01-05 | アセコー インコーポレイテッド | 皮下外来患者管理 |
| US11081226B2 (en) | 2014-10-27 | 2021-08-03 | Aseko, Inc. | Method and controller for administering recommended insulin dosages to a patient |
| US10307535B2 (en) * | 2014-12-19 | 2019-06-04 | Medtronic Minimed, Inc. | Infusion devices and related methods and systems for preemptive alerting |
| US10265031B2 (en) | 2014-12-19 | 2019-04-23 | Medtronic Minimed, Inc. | Infusion devices and related methods and systems for automatic alert clearing |
| US10737024B2 (en) | 2015-02-18 | 2020-08-11 | Insulet Corporation | Fluid delivery and infusion devices, and methods of use thereof |
| CA2993275C (en) | 2015-08-20 | 2022-06-21 | Aseko, Inc. | Diabetes management therapy advisor |
| DE102015222853A1 (de) * | 2015-11-19 | 2017-05-24 | Siemens Healthcare Gmbh | Verfahren zum automatischen Ermitteln eines Kontrastmittel-Injektionsprotokolls |
| WO2017123525A1 (en) | 2016-01-13 | 2017-07-20 | Bigfoot Biomedical, Inc. | User interface for diabetes management system |
| US10610643B2 (en) | 2016-01-14 | 2020-04-07 | Bigfoot Biomedical, Inc. | Occlusion resolution in medication delivery devices, systems, and methods |
| US10780223B2 (en) | 2016-01-14 | 2020-09-22 | Bigfoot Biomedical, Inc. | Adjusting insulin delivery rates |
| US12383166B2 (en) | 2016-05-23 | 2025-08-12 | Insulet Corporation | Insulin delivery system and methods with risk-based set points |
| US11462313B2 (en) * | 2016-08-17 | 2022-10-04 | Novo Nordisk A/S | Systems and methods for adjusting a basal/bolus ratio in an insulin regimen |
| US11282598B2 (en) * | 2016-08-25 | 2022-03-22 | Novo Nordisk A/S | Starter kit for basal insulin titration |
| US10765807B2 (en) | 2016-09-23 | 2020-09-08 | Insulet Corporation | Fluid delivery device with sensor |
| CN110012675B (zh) | 2016-11-29 | 2024-02-27 | 诺和诺德股份有限公司 | 用于基础率滴定的起始套件 |
| US11096624B2 (en) | 2016-12-12 | 2021-08-24 | Bigfoot Biomedical, Inc. | Alarms and alerts for medication delivery devices and systems |
| EP3568860B1 (en) | 2017-01-13 | 2025-12-10 | Insulet Corporation | Insulin delivery methods, systems and devices |
| US10758675B2 (en) | 2017-01-13 | 2020-09-01 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| EP3568862B1 (en) | 2017-01-13 | 2026-03-18 | Insulet Corporation | System and method for adjusting insulin delivery |
| US10583250B2 (en) | 2017-01-13 | 2020-03-10 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| US10500334B2 (en) | 2017-01-13 | 2019-12-10 | Bigfoot Biomedical, Inc. | System and method for adjusting insulin delivery |
| WO2018132765A1 (en) | 2017-01-13 | 2018-07-19 | Mazlish Bryan | Insulin delivery methods, systems and devices |
| CA3059985C (en) | 2017-05-05 | 2023-08-08 | Eli Lilly And Company | Closed loop control of physiological glucose |
| EP3438858A1 (en) | 2017-08-02 | 2019-02-06 | Diabeloop | Closed-loop blood glucose control systems and methods |
| CA3085930A1 (en) | 2017-12-21 | 2019-06-27 | Eli Lilly And Company | Closed loop control of physiological glucose |
| USD928199S1 (en) | 2018-04-02 | 2021-08-17 | Bigfoot Biomedical, Inc. | Medication delivery device with icons |
| US11147919B2 (en) * | 2018-04-23 | 2021-10-19 | Medtronic Minimed, Inc. | Methodology to recommend and implement adjustments to a fluid infusion device of a medication delivery system |
| US11158413B2 (en) | 2018-04-23 | 2021-10-26 | Medtronic Minimed, Inc. | Personalized closed loop medication delivery system that utilizes a digital twin of the patient |
| CN118750687A (zh) | 2018-05-04 | 2024-10-11 | 英赛罗公司 | 基于控制算法的药物输送系统的安全约束 |
| US12562251B1 (en) | 2018-05-09 | 2026-02-24 | Bigfoot Biomedical, Inc. | Computing architecture for assuring the provenance of medication therapy related parameters, and related systems, methods and devices |
| JP2021528758A (ja) | 2018-06-22 | 2021-10-21 | イーライ リリー アンド カンパニー | インスリンとプラムリンタイドの送達システム、方法、およびデバイス |
| JP2022501139A (ja) | 2018-09-28 | 2022-01-06 | インスレット コーポレイション | 人工膵臓システム用活動モード |
| US11565039B2 (en) | 2018-10-11 | 2023-01-31 | Insulet Corporation | Event detection for drug delivery system |
| USD920343S1 (en) | 2019-01-09 | 2021-05-25 | Bigfoot Biomedical, Inc. | Display screen or portion thereof with graphical user interface associated with insulin delivery |
| US11986629B2 (en) | 2019-06-11 | 2024-05-21 | Medtronic Minimed, Inc. | Personalized closed loop optimization systems and methods |
| US11801344B2 (en) | 2019-09-13 | 2023-10-31 | Insulet Corporation | Blood glucose rate of change modulation of meal and correction insulin bolus quantity |
| US11935637B2 (en) | 2019-09-27 | 2024-03-19 | Insulet Corporation | Onboarding and total daily insulin adaptivity |
| US11957875B2 (en) | 2019-12-06 | 2024-04-16 | Insulet Corporation | Techniques and devices providing adaptivity and personalization in diabetes treatment |
| US11833329B2 (en) | 2019-12-20 | 2023-12-05 | Insulet Corporation | Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns |
| JP7512395B2 (ja) | 2020-01-06 | 2024-07-08 | インスレット コーポレイション | 持続する残差に基づく食事および／または運動行為の予測 |
| EP4100958A1 (en) | 2020-02-03 | 2022-12-14 | Insulet Corporation | Use of fuzzy logic in predicting user behavior affecting blood glucose concentration |
| US11551802B2 (en) | 2020-02-11 | 2023-01-10 | Insulet Corporation | Early meal detection and calorie intake detection |
| US11547800B2 (en) | 2020-02-12 | 2023-01-10 | Insulet Corporation | User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system |
| US11986630B2 (en) | 2020-02-12 | 2024-05-21 | Insulet Corporation | Dual hormone delivery system for reducing impending hypoglycemia and/or hyperglycemia risk |
| US11324889B2 (en) * | 2020-02-14 | 2022-05-10 | Insulet Corporation | Compensation for missing readings from a glucose monitor in an automated insulin delivery system |
| US12495994B2 (en) | 2020-02-20 | 2025-12-16 | Insulet Corporation | Meal bolus subcategories in model based insulin therapy |
| US11607493B2 (en) | 2020-04-06 | 2023-03-21 | Insulet Corporation | Initial total daily insulin setting for user onboarding |
| US12121700B2 (en) | 2020-07-22 | 2024-10-22 | Insulet Corporation | Open-loop insulin delivery basal parameters based on insulin delivery records |
| US12569619B2 (en) | 2020-09-21 | 2026-03-10 | Insulet Corporation | Techniques for determining automated insulin delivery dosages |
| EP4221588A1 (en) | 2020-09-30 | 2023-08-09 | Insulet Corporation | Secure wireless communications between a glucose monitor and other devices |
| US12128215B2 (en) | 2020-09-30 | 2024-10-29 | Insulet Corporation | Drug delivery device with integrated optical-based glucose monitor |
| EP3985681A1 (en) * | 2020-10-13 | 2022-04-20 | Diabeloop | Computerized system for the repeated determination of a set of at least one control parameters of a medical device |
| US11160925B1 (en) | 2021-01-29 | 2021-11-02 | Insulet Corporation | Automatic drug delivery system for delivery of a GLP-1 therapeutic |
| US12431229B2 (en) | 2021-03-10 | 2025-09-30 | Insulet Corporation | Medicament delivery device with an adjustable and piecewise analyte level cost component to address persistent positive analyte level excursions |
| US11904140B2 (en) | 2021-03-10 | 2024-02-20 | Insulet Corporation | Adaptable asymmetric medicament cost component in a control system for medicament delivery |
| US12592306B2 (en) | 2021-04-28 | 2026-03-31 | Insulet Corporation | Devices and methods for initialization of drug delivery devices using measured analyte sensor information |
| US12496398B2 (en) | 2021-05-28 | 2025-12-16 | Insulet Corporation | Threshold based automatic glucose control response |
| US12406760B2 (en) | 2021-06-07 | 2025-09-02 | Insulet Corporation | Exercise safety prediction based on physiological conditions |
| US12514980B2 (en) | 2021-06-30 | 2026-01-06 | Insulet Corporation | Adjustment of medicament delivery by a medicament delivery device based on menstrual cycle phase |
| US12521486B2 (en) | 2021-07-16 | 2026-01-13 | Insulet Corporation | Method for modification of insulin delivery during pregnancy in automatic insulin delivery systems |
| EP4409581A1 (en) | 2021-09-27 | 2024-08-07 | Insulet Corporation | Techniques enabling adaptation of parameters in aid systems by user input |
| US11439754B1 (en) | 2021-12-01 | 2022-09-13 | Insulet Corporation | Optimizing embedded formulations for drug delivery |
| EP4243030A1 (en) | 2022-03-09 | 2023-09-13 | Insulet Corporation | Adjusting medicament delivery parameters in an open loop medicament delivery mode |
| US20230337949A1 (en) * | 2022-04-22 | 2023-10-26 | Beta Bionics, Inc. | Ambulatory medicament pump with distress notifications |
| CN120457493A (zh) | 2023-01-06 | 2025-08-08 | 英赛罗公司 | 自动或手动启动的随餐推注输送及随后的自动安全约束放宽 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7404796B2 (en) * | 2004-03-01 | 2008-07-29 | Becton Dickinson And Company | System for determining insulin dose using carbohydrate to insulin ratio and insulin sensitivity factor |
| US20040077996A1 (en) | 2002-10-22 | 2004-04-22 | Jasperson Keith E. | Drug infusion system with multiple medications |
| WO2005113036A1 (en) | 2004-05-13 | 2005-12-01 | The Regents Of The University Of California | Method and apparatus for glucose control and insulin dosing for diabetics |
| US7935104B2 (en) | 2005-11-07 | 2011-05-03 | Medingo, Ltd. | Systems and methods for sustained medical infusion and devices related thereto |
| US7704226B2 (en) * | 2005-11-17 | 2010-04-27 | Medtronic Minimed, Inc. | External infusion device with programmable capabilities to time-shift basal insulin and method of using the same |
| EP1993637A2 (en) | 2006-02-15 | 2008-11-26 | Medingo Ltd. | Systems and methods for sensing analyte and dispensing therapeutic fluid |
| CN102743179B (zh) | 2006-12-22 | 2016-03-16 | F·霍夫曼-拉罗氏股份公司 | 带体内电化学分析物感测的流体传输 |
| EP2139540A1 (en) | 2007-03-19 | 2010-01-06 | Medingo Ltd. | User interface for selecting bolus doses in a drug delivery device |
| EP2174248B1 (en) | 2007-06-25 | 2016-10-05 | Roche Diabetes Care GmbH | A method system and device for assessing insulin sensitivity |
| EP2023256A1 (en) * | 2007-08-02 | 2009-02-11 | Novo Nordisk A/S | Drug administration monitoring |
| JP2011504129A (ja) | 2007-11-21 | 2011-02-03 | メディンゴ・リミテッド | アナライト監視及び流体分注システム |
| CN103336853B (zh) * | 2008-04-04 | 2017-03-01 | 海吉雅有限公司 | 用于优化患者的胰岛素剂量方案的系统 |
| EP3639869A1 (en) | 2008-04-09 | 2020-04-22 | Roche Diabetes Care GmbH | Systems, devices and methods for fluid delivery |
| WO2009133558A2 (en) | 2008-04-29 | 2009-11-05 | Medingo Ltd. | A method for selecting bolus doses and bolus delivery patterns in a drug delivery device |
| WO2009139846A1 (en) | 2008-05-12 | 2009-11-19 | Department Of Veterans Affairs | Automated system and method for diabetes control |
| ES2647063T3 (es) | 2009-09-18 | 2017-12-19 | F. Hoffmann-La Roche Ag | Dispositivos, sistemas y métodos para cuantificar dosis de bolo de acuerdo con parámetros del usuario |
-
2011
- 2011-01-20 EP EP11734450.7A patent/EP2525863B1/en active Active
- 2011-01-20 US US13/574,165 patent/US9457145B2/en active Active
- 2011-01-20 WO PCT/IL2011/000061 patent/WO2011089600A1/en not_active Ceased
- 2011-01-20 ES ES11734450T patent/ES2704845T3/es active Active
- 2011-01-20 DK DK11734450.7T patent/DK2525863T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2525863A4 (en) | 2014-08-13 |
| EP2525863A1 (en) | 2012-11-28 |
| US9457145B2 (en) | 2016-10-04 |
| ES2704845T3 (es) | 2019-03-20 |
| EP2525863B1 (en) | 2018-12-05 |
| US20130030358A1 (en) | 2013-01-31 |
| WO2011089600A1 (en) | 2011-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2525863B1 (en) | A method and device for improving glycemic control | |
| EP2475356B1 (en) | Devices, systems and methods for adjusting fluid delivery parameters | |
| EP2174128B1 (en) | Method and device for assessing carbohydrate-to-insulin ratio | |
| JP6262222B2 (ja) | 閉ループコントローラのための手動ボーラス投与又は食事イベント管理方法及びシステム | |
| EP2477613B1 (en) | Devices, systems and methods for quantifying bolus doses according to user parameters | |
| EP2445407B1 (en) | A method and device for improving glycemic control based on residual insulin | |
| US20080234663A1 (en) | Method for Selecting Bolus Doses in a Drug Delivery System | |
| WO2012019746A1 (en) | Method and system for improving glycemic control | |
| Agarwal et al. | Diabetes technology in people with type 2 diabetes: novel indications | |
| WO2009007970A1 (en) | Systems and methods for glycemic control during pump disconnection | |
| WO2010092572A1 (en) | Insulin delivery safety | |
| KR20230113361A (ko) | 자동 약물 전달 시스템을 위한 간단한 식사 알림을위한 디바이스 및 방법 | |
| WO2024059597A1 (en) | Incorporation of additional sensors into adaptation of aid systems | |
| HK1241778A1 (en) | Devices, systems and methods for quantifying bolus doses according to user parameters | |
| HK1173675A (en) | Devices, systems and methods for quantifying bolus doses according to user parameters |