DK2555807T3 - Skabelon-øceller og små øcelleklynger til behandling af diabetes - Google Patents

Skabelon-øceller og små øcelleklynger til behandling af diabetes Download PDF

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Publication number
DK2555807T3
DK2555807T3 DK11714194T DK11714194T DK2555807T3 DK 2555807 T3 DK2555807 T3 DK 2555807T3 DK 11714194 T DK11714194 T DK 11714194T DK 11714194 T DK11714194 T DK 11714194T DK 2555807 T3 DK2555807 T3 DK 2555807T3
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Denmark
Prior art keywords
skabelon
ecles
clines
treating diabetes
ecl
Prior art date
Application number
DK11714194T
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English (en)
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DK2555807T5 (da
Inventor
Cory Berkland
Lisa A Stehno-Bittel
Teruna Siahaan
Karthik Ramachandran
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Univ Kansas
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Publication of DK2555807T3 publication Critical patent/DK2555807T3/da
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3882—Hollow organs, e.g. bladder, esophagus, urether, uterus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography
    • C12N2535/10—Patterned coating

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Botany (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
DK11714194.5T 2010-04-06 2011-03-31 Skabelon-øceller og små øcelleklynger til behandling af diabetes DK2555807T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/798,529 US8735154B2 (en) 2006-10-30 2010-04-06 Templated islet cells and small islet cell clusters for diabetes treatment
PCT/US2011/030775 WO2011126921A2 (en) 2010-04-06 2011-03-31 Templated islet cells and small islet cell clusters for diabetes treatment

Publications (2)

Publication Number Publication Date
DK2555807T3 true DK2555807T3 (da) 2019-11-11
DK2555807T5 DK2555807T5 (da) 2022-01-03

Family

ID=44515145

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11714194.5T DK2555807T5 (da) 2010-04-06 2011-03-31 Skabelon-øceller og små øcelleklynger til behandling af diabetes

Country Status (10)

Country Link
US (2) US8735154B2 (da)
EP (1) EP2555807B9 (da)
JP (1) JP5956422B2 (da)
CN (1) CN102958543B (da)
AU (1) AU2011238540B2 (da)
BR (1) BR112012025172B1 (da)
CA (1) CA2795243C (da)
DK (1) DK2555807T5 (da)
MX (1) MX2012011644A (da)
WO (1) WO2011126921A2 (da)

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US8735154B2 (en) * 2006-10-30 2014-05-27 The University Of Kansas Templated islet cells and small islet cell clusters for diabetes treatment
EP2286822A1 (en) 2009-08-17 2011-02-23 Universiteit Twente Diabetes treatment
US8895048B2 (en) 2010-04-06 2014-11-25 The University Of Kansas Templated islet cells and small islet cell clusters for diabetes treatment
CA2842695C (en) * 2011-07-27 2021-01-12 University Of Kansas Method of evaluating a xenobiotic for biological activity using one or more divots
DK2838992T3 (da) * 2012-04-20 2018-02-05 Biolamina Ab Opretholdelse af differentierede celler med lamininer
US20150320836A1 (en) * 2012-07-06 2015-11-12 The Regents Of The University Of California Cryopreservation of cells inside a macro-encapsulation device
DK2909311T3 (da) 2012-10-18 2020-10-12 Univ Kansas Forbedret pålidelighed hos tests under anvendelse af en platform med flere fordybninger og flercellede klynger med flere kilder
JP6145257B2 (ja) * 2012-10-18 2017-06-07 株式会社クラレ エストロゲン活性を評価する方法
CN105555950B (zh) 2013-06-13 2021-03-05 奥尔吉尼西丝有限公司 细胞群体、转分化的方法及其使用方法
WO2015040176A1 (en) * 2013-09-19 2015-03-26 Beta-Cell Nv Method for the treatment of diabetes mellitus
US20160106722A1 (en) 2014-10-21 2016-04-21 Life Plus, LLC Human therapeutic agents
DK3188721T3 (da) 2014-10-21 2019-08-12 Ankh Life Sciences Ltd Humane terapeutika
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
WO2016181220A2 (en) 2015-05-13 2016-11-17 Ions Pharmaceutical S.À R.L. Therapeutic compositions and methods of use thereof
WO2017194711A1 (en) 2016-05-11 2017-11-16 Animal Cell Therapy - Act Production of a canine beta cell line from an immature pancreas
US10597639B2 (en) 2016-10-20 2020-03-24 Washington University 3D-printed scaffold device for cell transplantation
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
SG11201911256UA (en) 2017-05-08 2020-01-30 Orgenesis Ltd Transdifferentiated cell populations and methods of use thereof
WO2018220623A1 (en) * 2017-05-29 2018-12-06 Orgenesis Ltd. Compositions and methods for providing cell replacement therapy
WO2019092135A1 (en) 2017-11-08 2019-05-16 Animal Cell Therapy - Act Production of canine pancreatic islets from an immature pancreas
CN111269873A (zh) * 2018-12-05 2020-06-12 中国科学院大连化学物理研究所 一种基于微坑芯片的3d胰岛细胞血管化微球构建方法
US12129265B2 (en) 2020-07-21 2024-10-29 Ankh Life Sciences Limited Therapeutic agents and uses thereof
CN114870093B (zh) * 2022-05-07 2023-04-07 四川大学 基于数字光处理的3d打印组织工程胰岛及其制备方法和用途

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US20080103606A1 (en) * 2006-10-30 2008-05-01 Cory Berkland Templated islet cells and small islet cell clusters for diabetes treatment
US8735154B2 (en) * 2006-10-30 2014-05-27 The University Of Kansas Templated islet cells and small islet cell clusters for diabetes treatment
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Also Published As

Publication number Publication date
MX2012011644A (es) 2013-02-11
WO2011126921A3 (en) 2012-01-19
US20140219997A1 (en) 2014-08-07
EP2555807A2 (en) 2013-02-13
JP2013524787A (ja) 2013-06-20
CN102958543B (zh) 2016-01-13
CA2795243C (en) 2019-06-11
CN102958543A (zh) 2013-03-06
JP5956422B2 (ja) 2016-07-27
BR112012025172B1 (pt) 2018-08-28
WO2011126921A2 (en) 2011-10-13
AU2011238540B2 (en) 2014-12-04
US8735154B2 (en) 2014-05-27
DK2555807T5 (da) 2022-01-03
EP2555807B1 (en) 2019-07-31
US20100233239A1 (en) 2010-09-16
EP2555807B9 (en) 2021-12-08
BR112012025172A2 (pt) 2017-06-27
CA2795243A1 (en) 2011-10-13
AU2011238540A1 (en) 2012-11-29

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