DK2563935T3 - In situ-hybridiseringsfremgangsmåde og -buffer - Google Patents
In situ-hybridiseringsfremgangsmåde og -bufferInfo
- Publication number
- DK2563935T3 DK2563935T3 DK11721993.1T DK11721993T DK2563935T3 DK 2563935 T3 DK2563935 T3 DK 2563935T3 DK 11721993 T DK11721993 T DK 11721993T DK 2563935 T3 DK2563935 T3 DK 2563935T3
- Authority
- DK
- Denmark
- Prior art keywords
- buffer
- situ hybridization
- hybridization method
- situ
- hybridization
- Prior art date
Links
- 238000007901 in situ hybridization Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34359610P | 2010-04-30 | 2010-04-30 | |
| PCT/DK2011/050136 WO2011134474A1 (en) | 2010-04-30 | 2011-04-28 | In situ hybridization method and buffer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2563935T3 true DK2563935T3 (da) | 2014-06-23 |
Family
ID=44116204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11721993.1T DK2563935T3 (da) | 2010-04-30 | 2011-04-28 | In situ-hybridiseringsfremgangsmåde og -buffer |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9212390B2 (da) |
| EP (1) | EP2563935B1 (da) |
| DK (1) | DK2563935T3 (da) |
| ES (1) | ES2465948T3 (da) |
| SG (1) | SG184938A1 (da) |
| WO (1) | WO2011134474A1 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2563935B1 (en) * | 2010-04-30 | 2014-04-16 | Exiqon A/S | In situ hybridization method and buffer. |
| WO2017041005A1 (en) | 2015-09-03 | 2017-03-09 | Abbott Molecular Inc. | Hybridization buffers comprising an alkyl diester |
| US10457981B2 (en) | 2016-01-08 | 2019-10-29 | Abbott Molecular Inc. | Hybridization buffers |
| SG11202003888VA (en) | 2017-11-03 | 2020-05-28 | Fluidigm Canada Inc | Reagents and methods for elemental imaging mass spectrometry of biological samples |
| WO2019169304A1 (en) * | 2018-03-02 | 2019-09-06 | Mirna Analytics Llc | Biomarker detection in pulmonary hypertension |
| US12000838B2 (en) | 2018-04-27 | 2024-06-04 | Standard Biotools Canada Inc. | Reagents and methods for elemental mass spectrometry of biological samples |
| EP3807922A4 (en) | 2018-06-18 | 2022-03-23 | Fluidigm Canada Inc. | HIGH RESOLUTION IMAGING DEVICE AND METHOD |
| CN109211903B (zh) * | 2018-08-31 | 2020-06-30 | 华中科技大学 | 一种对相变的原位观察结果进行定量分析的方法及应用 |
| CA3140663A1 (en) | 2019-06-18 | 2020-12-24 | Paul Corkum | Improved mass cytometry |
| EP4573209A2 (en) * | 2022-08-16 | 2025-06-25 | GLC Biotechnology, Inc. | Nucleic acid probe compositions for enriching, extracting, and/or detecting a variant target nucleic acid in a sample |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990002173A1 (en) | 1988-08-31 | 1990-03-08 | Research Development Foundation | One-step in situ hybridization assay |
| ATE153706T1 (de) | 1988-08-31 | 1997-06-15 | Aprogenex Inc | Manuelles in situ hybridisierungsverfahren |
| US5521061A (en) | 1992-07-17 | 1996-05-28 | Aprogenex, Inc. | Enhancement of probe signal in nucleic acid-mediated in-situ hybridization studies |
| US5693473A (en) * | 1994-08-12 | 1997-12-02 | Myriad Genetics, Inc. | Linked breast and ovarian cancer susceptibility gene |
| US5750340A (en) * | 1995-04-07 | 1998-05-12 | University Of New Mexico | In situ hybridization solution and process |
| JP2001502881A (ja) * | 1995-05-18 | 2001-03-06 | アボツト・ラボラトリーズ | 高分子ペプチドプローブ及びその使用 |
| US6043060A (en) | 1996-11-18 | 2000-03-28 | Imanishi; Takeshi | Nucleotide analogues |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| CA2303299C (en) | 1997-09-12 | 2016-02-23 | Exiqon A/S | Oligonucleotide analogues |
| US6225285B1 (en) * | 1998-03-11 | 2001-05-01 | Exelixis Pharmaceuticals, Inc. | Semaphorin K1 |
| AU3516899A (en) * | 1998-05-04 | 1999-11-23 | Dako A/S | Method and probes for the detection of chromosome aberrations |
| DE69942309D1 (de) | 1998-05-18 | 2010-06-10 | Igenex Inc | In situ hybridisierungsverfahren zur entdeckung von zielnukleinsäuren |
| EP1161439B1 (en) | 1999-03-18 | 2010-04-21 | Exiqon A/S | Xylo-lna analogues |
| DK1163250T3 (da) | 1999-03-24 | 2006-11-13 | Exiqon As | Forbedret syntese af [2.2.1]bicyclonukleosider |
| NZ514348A (en) | 1999-05-04 | 2004-05-28 | Exiqon As | L-ribo-LNA analogues |
| AU5429000A (en) | 1999-06-25 | 2001-01-31 | Sankyo Company Limited | Novel bicyclonucleoside derivatives |
| JP4151751B2 (ja) | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
| US7521479B2 (en) | 2001-04-16 | 2009-04-21 | Panacea Pharmaceuticals, Inc. | Methods of treating prion disease in mammals |
| WO2003020739A2 (en) | 2001-09-04 | 2003-03-13 | Exiqon A/S | Novel lna compositions and uses thereof |
| US20070099196A1 (en) | 2004-12-29 | 2007-05-03 | Sakari Kauppinen | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs |
| US8758990B2 (en) | 2005-07-28 | 2014-06-24 | Id-Fish Technology, Inc. | Methods for detecting and differentiating Mycobacterium genus and Mycobacterium avium complex in a sample or culture |
| EP1966390A1 (en) | 2005-12-29 | 2008-09-10 | Exiqon A/S | Detection of tissue origin of cancer |
| DK2666859T3 (da) | 2006-04-03 | 2019-04-08 | Roche Innovation Ct Copenhagen As | FARMACEUTISK SAMMENSÆTNING, DER OMFATTER ANTI-miRNA-ANTISENSE-OLIGONUKLEOTIDER |
| JP5733977B2 (ja) * | 2008-05-19 | 2015-06-10 | 株式会社セリッシュエフディー | ＲＮＡｉｎｓｉｔｕハイブリダイゼーション |
| EP2563935B1 (en) * | 2010-04-30 | 2014-04-16 | Exiqon A/S | In situ hybridization method and buffer. |
| EP2968220B1 (en) * | 2013-03-15 | 2021-05-05 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
-
2011
- 2011-04-28 EP EP11721993.1A patent/EP2563935B1/en active Active
- 2011-04-28 SG SG2012077590A patent/SG184938A1/en unknown
- 2011-04-28 DK DK11721993.1T patent/DK2563935T3/da active
- 2011-04-28 ES ES11721993.1T patent/ES2465948T3/es active Active
- 2011-04-28 WO PCT/DK2011/050136 patent/WO2011134474A1/en not_active Ceased
- 2011-04-28 US US13/695,427 patent/US9212390B2/en active Active
-
2015
- 2015-12-04 US US14/960,000 patent/US10023912B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2563935B1 (en) | 2014-04-16 |
| WO2011134474A1 (en) | 2011-11-03 |
| EP2563935A1 (en) | 2013-03-06 |
| US9212390B2 (en) | 2015-12-15 |
| SG184938A1 (en) | 2012-11-29 |
| US20130164750A1 (en) | 2013-06-27 |
| US10023912B2 (en) | 2018-07-17 |
| US20160160278A1 (en) | 2016-06-09 |
| ES2465948T3 (es) | 2014-06-09 |
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