DK2576534T3 - 1-Substitueret-carba-nukleosid prodrugs til antiviral behandling - Google Patents
1-Substitueret-carba-nukleosid prodrugs til antiviral behandlingInfo
- Publication number
- DK2576534T3 DK2576534T3 DK11725838.4T DK11725838T DK2576534T3 DK 2576534 T3 DK2576534 T3 DK 2576534T3 DK 11725838 T DK11725838 T DK 11725838T DK 2576534 T3 DK2576534 T3 DK 2576534T3
- Authority
- DK
- Denmark
- Prior art keywords
- carb
- substituted
- antiviral treatment
- nucleoside prodrugs
- nucleoside
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34959710P | 2010-05-28 | 2010-05-28 | |
| US35335110P | 2010-06-10 | 2010-06-10 | |
| US36604110P | 2010-07-20 | 2010-07-20 | |
| PCT/US2011/038253 WO2011150288A1 (en) | 2010-05-28 | 2011-05-26 | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
| US13/117,060 US8415308B2 (en) | 2010-05-28 | 2011-05-26 | 1′-substituted-carba-nucleoside prodrugs for antiviral treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2576534T3 true DK2576534T3 (da) | 2014-04-22 |
Family
ID=45375840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11725838.4T DK2576534T3 (da) | 2010-05-28 | 2011-05-26 | 1-Substitueret-carba-nukleosid prodrugs til antiviral behandling |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8415308B2 (da) |
| EP (1) | EP2576534B1 (da) |
| JP (4) | JP5837577B2 (da) |
| AR (1) | AR084389A1 (da) |
| CY (1) | CY1115479T1 (da) |
| DK (1) | DK2576534T3 (da) |
| ES (1) | ES2465265T3 (da) |
| HR (1) | HRP20140370T1 (da) |
| ME (1) | ME01882B (da) |
| PL (1) | PL2576534T3 (da) |
| PT (1) | PT2576534E (da) |
| RS (1) | RS53244B (da) |
| SI (1) | SI2576534T1 (da) |
| SM (1) | SMT201400048B (da) |
| TW (1) | TW201201815A (da) |
| UY (1) | UY33414A (da) |
| WO (1) | WO2011150288A1 (da) |
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| HRP20130048T1 (hr) | 2008-04-23 | 2013-02-28 | Gilead Sciences, Inc. | Karba-nukleozidni analozi za antivirusnu terapiju |
| WO2011035250A1 (en) | 2009-09-21 | 2011-03-24 | Gilead Sciences, Inc. | Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs |
| TW201201815A (en) * | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
| EA025311B1 (ru) | 2010-07-19 | 2016-12-30 | Гайлид Сайэнсиз, Инк. | Способы получения диастереомерно чистых фосфорамидатных пролекарств |
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| SI2709613T2 (sl) | 2011-09-16 | 2020-12-31 | Gilead Pharmasset LLC c/o Gilead Sciences, Inc. | Postopki za zdravljenje HCV |
| TW201331221A (zh) | 2011-10-14 | 2013-08-01 | Idenix Pharmaceuticals Inc | 嘌呤核苷酸化合物類之經取代的３’，５’－環磷酸酯及用於治療病毒感染之醫藥組成物 |
| EP2852604B1 (en) | 2012-05-22 | 2017-04-12 | Idenix Pharmaceuticals LLC | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
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| HUE029038T2 (en) | 2012-05-25 | 2017-01-30 | Janssen Sciences Ireland Uc | Uracil spirooxetan nucleosides |
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| SG11201502750UA (en) | 2012-10-08 | 2015-06-29 | Idenix Pharmaceuticals Inc | 2'-chloro nucleoside analogs for hcv infection |
| EP2909210A4 (en) * | 2012-10-17 | 2016-04-06 | Merck Sharp & Dohme | 2'-DISUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHOD FOR THE USE THEREOF FOR THE TREATMENT OF VIRUS DISEASES |
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| EP2970357B1 (en) | 2013-03-13 | 2025-01-01 | Idenix Pharmaceuticals LLC | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
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| UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
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-
2011
- 2011-05-25 TW TW100118301A patent/TW201201815A/zh unknown
- 2011-05-26 DK DK11725838.4T patent/DK2576534T3/da active
- 2011-05-26 ES ES11725838.4T patent/ES2465265T3/es active Active
- 2011-05-26 HR HRP20140370AT patent/HRP20140370T1/hr unknown
- 2011-05-26 ME MEP-2014-58A patent/ME01882B/me unknown
- 2011-05-26 US US13/117,060 patent/US8415308B2/en active Active
- 2011-05-26 PT PT117258384T patent/PT2576534E/pt unknown
- 2011-05-26 WO PCT/US2011/038253 patent/WO2011150288A1/en not_active Ceased
- 2011-05-26 SI SI201130154T patent/SI2576534T1/sl unknown
- 2011-05-26 JP JP2013512264A patent/JP5837577B2/ja active Active
- 2011-05-26 EP EP11725838.4A patent/EP2576534B1/en active Active
- 2011-05-26 RS RS20140150A patent/RS53244B/sr unknown
- 2011-05-26 PL PL11725838T patent/PL2576534T3/pl unknown
- 2011-05-27 UY UY0001033414A patent/UY33414A/es active IP Right Grant
- 2011-05-27 AR ARP110101821A patent/AR084389A1/es not_active Application Discontinuation
-
2014
- 2014-04-02 CY CY20141100249T patent/CY1115479T1/el unknown
- 2014-04-11 SM SM201400048T patent/SMT201400048B/xx unknown
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2015
- 2015-11-05 JP JP2015217492A patent/JP6193332B2/ja active Active
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2017
- 2017-08-09 JP JP2017154096A patent/JP2018012706A/ja active Pending
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2018
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Also Published As
| Publication number | Publication date |
|---|---|
| US8415308B2 (en) | 2013-04-09 |
| PL2576534T3 (pl) | 2014-07-31 |
| WO2011150288A1 (en) | 2011-12-01 |
| SMT201400048B (it) | 2014-05-07 |
| ME01882B (me) | 2014-12-20 |
| JP5837577B2 (ja) | 2015-12-24 |
| AR084389A1 (es) | 2013-05-15 |
| US20120020921A1 (en) | 2012-01-26 |
| JP2018162268A (ja) | 2018-10-18 |
| SI2576534T1 (sl) | 2014-06-30 |
| RS53244B (sr) | 2014-08-29 |
| JP2016094404A (ja) | 2016-05-26 |
| JP2018012706A (ja) | 2018-01-25 |
| PT2576534E (pt) | 2014-05-29 |
| EP2576534B1 (en) | 2014-03-19 |
| HRP20140370T1 (hr) | 2014-05-23 |
| TW201201815A (en) | 2012-01-16 |
| EP2576534A1 (en) | 2013-04-10 |
| CY1115479T1 (el) | 2017-01-04 |
| HK1182387A1 (en) | 2013-11-29 |
| JP6193332B2 (ja) | 2017-09-06 |
| JP2013528184A (ja) | 2013-07-08 |
| UY33414A (es) | 2011-12-30 |
| ES2465265T3 (es) | 2014-06-05 |
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