DK258989A - Anvendelse af et xanthinderivat til inhibering af tnf og middel hertil - Google Patents

Anvendelse af et xanthinderivat til inhibering af tnf og middel hertil Download PDF

Info

Publication number: DK258989A
Authority: DK; Denmark
Prior art keywords: agents; inhibit tnf; derivative; xanthin; tnf
Prior art date: 1988-05-27

Application number

DK258989A

Other languages

English (en)

Other versions

DK258989D0 (da

Inventor

Heinz Haenel

Elmar Schrinner

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-27

Filing date

1989-05-26

Publication date

1989-11-28

1989-05-26 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-05-26 Publication of DK258989D0 publication Critical patent/DK258989D0/da

1989-11-28 Publication of DK258989A publication Critical patent/DK258989A/da

Links

LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title abstract 2
102000018594 Tumour necrosis factor Human genes 0.000 abstract 2
108050007852 Tumour necrosis factor Proteins 0.000 abstract 2
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 abstract 1
239000002451 tumor necrosis factor inhibitor Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Mycology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK258989A 1988-05-27 1989-05-26 Anvendelse af et xanthinderivat til inhibering af tnf og middel hertil DK258989A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3817955A DE3817955A1 (de)	1988-05-27	1988-05-27	Tnf-inhibitor enthaltendes arzneimittel

Publications (2)

Publication Number	Publication Date
DK258989D0 DK258989D0 (da)	1989-05-26
DK258989A true DK258989A (da)	1989-11-28

Family

ID=6355195

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK258989A DK258989A (da)	1988-05-27	1989-05-26	Anvendelse af et xanthinderivat til inhibering af tnf og middel hertil

Country Status (9)

Country	Link
US (1)	US5118500A (da)
EP (1)	EP0344586B1 (da)
JP (1)	JP3140021B2 (da)
AT (1)	ATE135225T1 (da)
DE (2)	DE3817955A1 (da)
DK (1)	DK258989A (da)
ES (1)	ES2086309T3 (da)
GR (1)	GR3020101T3 (da)
PT (1)	PT90660B (da)

Families Citing this family (44)

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US5672347A (en) *	1984-07-05	1997-09-30	Genentech, Inc.	Tumor necrosis factor antagonists and their use
US4965271A (en) *	1986-12-31	1990-10-23	Hoechst Roussel Pharmaceuticals, Inc.	Method of inhibiting the activity of leukocyte derived cytokines
US5196429A (en) *	1986-12-31	1993-03-23	Hoechst-Roussel Pharmaceuticals Inc.	Method of inhibiting the activity of leukocyte derived cytokines
US5272153A (en) *	1986-12-31	1993-12-21	Hoechst-Roussel Pharmaceuticals, Inc.	Method of inhibiting the activity of leukocyte derived cytokines
US5196430A (en) *	1986-12-31	1993-03-23	Hoechst-Roussel Pharmaceuticals Inc.	Method of inhibiting the activity of leukocyte derived cytokines
US6541610B1 (en)	1989-09-05	2003-04-01	Immunex Corporation	Fusion proteins comprising tumor necrosis factor receptor
DE59010908D1 (de)	1989-09-12	2000-08-10	Hoffmann La Roche	TNF-bindende Proteine
DE4019571A1 (de) *	1990-06-20	1992-01-02	Hoechst Ag	Pharmazeutische kombinationspraeparate enthaltend cephalosporin- und xanthinderivate und deren verwendung
AU9084991A (en) *	1990-11-01	1992-05-26	Board Of Regents, The University Of Texas System	Antifungal activity of and prevention of drug induced nephrotoxicity by methylxanthine analogues
US5958413A (en) *	1990-11-01	1999-09-28	Celltech Limited	Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor
NZ240644A (en) *	1990-11-21	1994-08-26	Smithkline Beecham Corp	Use of xanthine derivatives to inhibit the production of tumour necrosis factor (tnf)
EP0493682A3 (en) *	1990-11-30	1992-11-19	Hoechst-Roussel Pharmaceuticals Incorporated	Use of xanthines for the preparation of a medicament effective for inhibiting the effects of allograft reaction in humans
US6420374B1 (en)	1990-11-30	2002-07-16	Fred Hutchinson Cancer Research Center	Use of xanthines as immunosuppressants and to inhibit allograft reactions
US5856115A (en) *	1991-05-24	1999-01-05	Fred Hutchinson Cancer Research Center	Assay for identification therapeutic agents
US5795859A (en) *	1991-07-05	1998-08-18	Peptide Technology Limited	Peptide which abrogates TNF and/or LPS toxicity
ES2038546B1 (es) *	1991-11-08	1994-02-16	Andromaco Lab	Procedimiento de obtencion de un producto de naturaleza polipeptidica con actividad inhibidora de la hiperproduccion del factor de necrosis tumoral.
ATE230990T1 (de) *	1992-03-04	2003-02-15	Cell Therapeutics Inc	Enantiomere hydroxylierte xanthinverbindungen
US5648357A (en) *	1992-03-04	1997-07-15	Cell Therapeutics, Inc.	Enatiomerically pure hydroxylated xanthine compounds
US5580873A (en) *	1992-03-04	1996-12-03	Cell Therapeutics, Inc.	Enatiomerically pure hydroxylated xanthine compounds to treat proliferative vascular diseases
EP0670730B1 (en) *	1992-03-30	2003-06-04	Immunex Corporation	Fusion protein comprising two tumor necrosis factor receptors
PL173978B1 (pl) *	1992-07-13	1998-05-29	Nika Health Products Ltd	Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej
US6183742B1 (en)	1992-07-13	2001-02-06	Nika Health Products, Limited	Applications of lysozyme dimer
US5817662A (en) *	1992-11-09	1998-10-06	Cell Therapeutics, Inc.	Substituted amino alkyl compounds
US5804584A (en) *	1992-11-16	1998-09-08	Cell Therapeutics, Inc.	Therapeutic compounds containing a monocyclic five- to six- membered ring structure having one to two nitrogen atoms
US6693105B1 (en)	1992-11-16	2004-02-17	Cell Therapeutics, Inc.	Hydroxyl-containing compounds
US5795897A (en) *	1992-11-18	1998-08-18	Cell Therapeutics, Inc.	Oxohexyl methylxanthine compounds
WO1994015605A1 (en) *	1993-01-14	1994-07-21	Cell Therapeutics, Inc.	Acetal or ketal substituted therapeutic compounds
WO1994016704A1 (en) *	1993-01-19	1994-08-04	Cell Therapeutics, Inc.	Oxime-substituted therapeutic compounds
AU1090795A (en) *	1993-11-12	1995-05-29	Cell Therapeutics, Inc.	Method for preventing tissue injury from hypoxia
AU1967495A (en) *	1994-02-18	1995-09-04	Cell Therapeutics, Inc.	Intracellular signalling mediators
US6103730A (en) *	1994-03-24	2000-08-15	Cell Therapeutics, Inc.	Amine substituted compounds
US5807861A (en) *	1994-03-24	1998-09-15	Cell Therapeutics, Inc.	Amine substituted xanthinyl compounds
US5801182A (en) *	1994-03-24	1998-09-01	Cell Therapeutics, Inc.	Amine substituted compounds
US6010711A (en) *	1996-01-26	2000-01-04	University Of Rochester	Methods, articles and compositions for the pharmacologic inhibition of bone resorption with phosphodiesterase inhibitors
DE19707655A1 (de) *	1997-02-26	1998-08-27	Hoechst Ag	Kombinationspräparat zur Anwendung bei Demenz
US6123937A (en) *	1997-03-14	2000-09-26	Nika Health Products, Limited	Applications of lysozyme dimer
US20030207901A1 (en) *	1999-07-27	2003-11-06	Cell Therapeutics, Inc.	Hydroxyl-containing compounds
EP2241328A1 (en) *	2000-05-12	2010-10-20	Immunex Corporation	Interleukin-1 inhibitors in the treatment of diseases
RU2184544C1 (ru) *	2000-12-08	2002-07-10	Институт иммунологии	Противоаллергический препарат
US7101978B2 (en) *	2003-01-08	2006-09-05	Applied Molecular Evolution	TNF-α binding molecules
US7892563B2 (en) *	2003-05-20	2011-02-22	Wyeth Holdings Corporation	Methods for treatment of severe acute respiratory syndrome (SARS)
US7435799B2 (en) *	2004-01-08	2008-10-14	Applied Molecular Evolution	TNF-α binding molecules
AU2005229009A1 (en) *	2004-03-23	2005-10-13	Amgen, Inc.	Monoclonal antibodies specific for human OX40L (CD 134L)
US20220023343A1 (en)	2018-11-19	2022-01-27	Board Of Regents, The University Of Texas System	Suicide gene

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4879111A (en) *	1986-04-17	1989-11-07	Cetus Corporation	Treatment of infections with lymphokines

1988
- 1988-05-27 DE DE3817955A patent/DE3817955A1/de not_active Withdrawn
1989
- 1989-05-24 PT PT90660A patent/PT90660B/pt not_active IP Right Cessation
- 1989-05-24 EP EP89109312A patent/EP0344586B1/de not_active Expired - Lifetime
- 1989-05-24 DE DE58909621T patent/DE58909621D1/de not_active Expired - Fee Related
- 1989-05-24 AT AT89109312T patent/ATE135225T1/de not_active IP Right Cessation
- 1989-05-24 ES ES89109312T patent/ES2086309T3/es not_active Expired - Lifetime
- 1989-05-25 US US07/356,734 patent/US5118500A/en not_active Expired - Lifetime
- 1989-05-26 JP JP01131708A patent/JP3140021B2/ja not_active Expired - Fee Related
- 1989-05-26 DK DK258989A patent/DK258989A/da not_active Application Discontinuation
1996
- 1996-05-30 GR GR960401467T patent/GR3020101T3/el unknown

Also Published As

Publication number	Publication date
DK258989D0 (da)	1989-05-26
JP3140021B2 (ja)	2001-03-05
DE58909621D1 (de)	1996-04-18
US5118500A (en)	1992-06-02
GR3020101T3 (en)	1996-08-31
ATE135225T1 (de)	1996-03-15
DE3817955A1 (de)	1989-11-30
PT90660B (pt)	1994-10-31
ES2086309T3 (es)	1996-07-01
JPH0219327A (ja)	1990-01-23
EP0344586A3 (en)	1990-05-16
EP0344586B1 (de)	1996-03-13
PT90660A (pt)	1989-11-30
EP0344586A2 (de)	1989-12-06

Legal Events

Date	Code	Title	Description
2000-01-17	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK258989D0 (da)	1989-05-26	Anvendelse af et xanthinderivat til inhibering af tnf og middel hertil
DK162472C (da)	1992-05-11	Laegemiddelform til afgivelse af et terapeutisk middel i periodontallommen og dens omgivelser
DE3873879D1 (de)	1992-09-24	Nicht-sedative antihistaminica enthaltende husten-/schnupfenmittel.
DK72284D0 (da)	1984-02-16	Farmaceutisk middel med metabolisk og energetisk virkning til anvendelse i kardial- og vaskulaerterapi
DK543189A (da)	1990-05-02	Lysyloxidaseinhibitorer og deres anvendelse
ZA882884B (en)	1988-10-27	Cough/cold mixtures comprising non-sedating antihistamine drugs
DK648487A (da)	1988-08-19	Spiro-substituerede glutaramid-derivater og deres medicinske anvendelse samt farmaceutiske praeparater indeholdende disse forbindelser
DK99790A (da)	1990-06-18	Indretning til opbevaring, blanding og afgivelse af to forskellige fluida
LU88576I2 (fr)	1995-03-21	RISPERIDONE et ses sels pharmaceutiquement acceptables (Risperdal R)
DK462486D0 (da)	1986-09-29	Farmaceutisk tablet indeholdende cefuroxim-axetil
ES2137935T3 (es)	2000-01-01	Preparaciones farmaceuticas que contienen una anticitoquina.
DE3483713D1 (de)	1991-01-17	Hydroxypyridon-derivate und sie enthaltende pharmazeutische zubereitungen.
MX9405383A (es)	1995-01-31	Imidazo(4,5-c) piridin-4-aminas.
DK108888A (da)	1988-09-03	Farmaceutisk tablet, farmaceutisk granulat og fremgangsmaader til fremstilling af henholdsvis denne tablet og dette granulat
DK453584D0 (da)	1984-09-21	Pyridinderivater til medicinsk anvendelse og farmaceutiske praeparater indeholdende pyridinderivater
DK326989D0 (da)	1989-06-30	Alminoalkylaminocarbonylaminodiolaminosyrederivater og deres anvendelse som renininhibitorer
DK610284D0 (da)	1984-12-19	2-phenyl-imidazolderivater, deres fremstilling og laegemidler indeholdende disse forbindelser
DK40487A (da)	1987-07-28	Heterocycliske lipoxygenaseinhibitorer og farmaceutisk acceptable salte deraf
DE68917499D1 (de)	1994-09-22	Catechol-Derivate und sie enthaltende pharmazeutische Präparate.
DK522788D0 (da)	1988-09-20	Amidinoderivater og farmaceutiske praeparater med indhold af saadanne forbindelser
DK0563060T3 (da)	1999-11-08	Anvendelse af IL-4 og TNF til fremstilling af et lægemiddel til behandling af tumorceller
DK360189D0 (da)	1989-07-20	S-adenosyl-methionin-decarboxylase-inhibitorer, deres fremstilling og anvendelse
DK259586D0 (da)	1986-06-02	Farmaceutisk tablet
DK449989A (da)	1990-03-14	Quinolinderivater, deres fremstilling og laegemidler indeholdende disse derivater
DK35889D0 (da)	1989-01-27	Vitamin d3 derivater og farmaceutiske praeparater indeholdende disse forbindelser