DK260687A - Immunoglobulin-konjugater og fremgangsmaade til fremstilling deraf - Google Patents

Immunoglobulin-konjugater og fremgangsmaade til fremstilling deraf

Info

Publication number
DK260687A
DK260687A DK260687A DK260687A DK260687A DK 260687 A DK260687 A DK 260687A DK 260687 A DK260687 A DK 260687A DK 260687 A DK260687 A DK 260687A DK 260687 A DK260687 A DK 260687A
Authority
DK
Denmark
Prior art keywords
procedures
preparing
immunoglobulin conjugates
conjugates
immunoglobulin
Prior art date
Application number
DK260687A
Other languages
English (en)
Other versions
DK260687D0 (da
Inventor
Bennett Coleman Laguzza
Cynthia Lynn Nichols
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK260687D0 publication Critical patent/DK260687D0/da
Publication of DK260687A publication Critical patent/DK260687A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK260687A 1986-05-27 1987-05-22 Immunoglobulin-konjugater og fremgangsmaade til fremstilling deraf DK260687A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86718386A 1986-05-27 1986-05-27

Publications (2)

Publication Number Publication Date
DK260687D0 DK260687D0 (da) 1987-05-22
DK260687A true DK260687A (da) 1987-11-28

Family

ID=25349292

Family Applications (1)

Application Number Title Priority Date Filing Date
DK260687A DK260687A (da) 1986-05-27 1987-05-22 Immunoglobulin-konjugater og fremgangsmaade til fremstilling deraf

Country Status (13)

Country Link
EP (1) EP0247792A3 (da)
JP (1) JPS62287000A (da)
KR (1) KR900006908B1 (da)
CN (1) CN87104430A (da)
AU (1) AU600727B2 (da)
CA (1) CA1288896C (da)
DK (1) DK260687A (da)
HU (1) HUT44033A (da)
IL (1) IL82579A0 (da)
NZ (1) NZ220441A (da)
PT (1) PT84932B (da)
SU (1) SU1561825A3 (da)
ZA (1) ZA873600B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8728856D0 (en) * 1987-12-10 1988-01-27 Bradwell A R Tumour-locating agents & method of locating tumours
PT89504A (pt) * 1988-01-27 1989-10-04 Lilly Co Eli Processo para a preparacao de conjugados de anticorpos com hidrazidas de vinca
US5006652A (en) * 1988-08-08 1991-04-09 Eli Lilly And Company Intermediates for antibody-vinca drug conjugates
US5010176A (en) * 1988-11-10 1991-04-23 Eli Lilly And Company Antibody-drug conjugates
CA2013600A1 (en) * 1989-04-04 1990-10-04 Michael J. Pikal Pharmaceutical formulations
AU648313B2 (en) * 1990-04-25 1994-04-21 Pharmacia & Upjohn Company Novel CC-1065 analogs
AU708475B2 (en) * 1995-10-18 1999-08-05 Merck & Co., Inc. Conjugates useful in the treatment of benign prostatic hyperplasia
EP1389209B1 (en) 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
WO2003097647A1 (en) 2002-05-15 2003-11-27 Endocyte, Inc. Vitamin-mitomycin conjugates
DK1592457T3 (da) 2003-01-27 2012-10-22 Endocyte Inc Folat-vinblastin-konjugat som lægemiddel
JP5149620B2 (ja) 2004-07-23 2013-02-20 エンドサイト，インコーポレイテッド ２価リンカーおよびその結合体
EP1863816B1 (en) 2005-03-16 2014-06-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
EP2382995A3 (en) 2005-08-19 2013-09-25 Endocyte, Inc. Ligand conjugates of Vinca alkaloids, analogs and derivatives
AU2006279304A1 (en) 2005-08-19 2007-02-22 Endocyte, Inc. Multi-drug ligand conjugates
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
CN104127878A (zh) 2007-03-14 2014-11-05 恩多塞特公司 结合配体连接的微管溶素递药缀合物
BRPI0812970A2 (pt) 2007-06-25 2019-09-24 Endocyte Inc conjugados contendo espaçadores hidrofílicos
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
EP2908818A4 (en) 2012-10-16 2016-07-13 Endocyte Inc CONJUGATES OF DRUG DELIVERY CONTAINING ARTIFICIAL AMINO ACIDS AND METHODS OF USE
CN108948128B (zh) * 2018-07-02 2021-10-01 中国科学技术大学 一种基于缺电子苯甲醛的无催化剂腙连接多肽或蛋白质化学修饰方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI820020L (fi) * 1981-01-12 1982-07-13 Lilly Industries Ltd Immunoglobulinkonjugater
EP0121388B1 (en) * 1983-03-30 1990-06-13 Lilly Industries Limited Immunoglobulin conjugates
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
ATE89567T1 (de) * 1985-11-12 1993-06-15 Wallone Region Konjugate von vinblastin und seine derivate, verfahren zur herstellung derselben und diese konjugate enthaltende pharmazeutische zusammensetzungen.

Also Published As

Publication number Publication date
DK260687D0 (da) 1987-05-22
NZ220441A (en) 1989-09-27
IL82579A0 (en) 1987-11-30
ZA873600B (en) 1988-12-28
JPS62287000A (ja) 1987-12-12
PT84932A (en) 1987-06-01
CA1288896C (en) 1991-09-10
AU7334987A (en) 1987-12-03
EP0247792A3 (en) 1989-07-12
CN87104430A (zh) 1988-05-11
AU600727B2 (en) 1990-08-23
PT84932B (pt) 1990-02-08
EP0247792A2 (en) 1987-12-02
HUT44033A (en) 1988-01-28
KR900006908B1 (ko) 1990-09-24
KR870011132A (ko) 1987-12-21
SU1561825A3 (ru) 1990-04-30

Similar Documents

Publication Publication Date Title
DK665187A (da) Immunoglobulin-konjugater og fremgangsmaade til fremstilling heraf
DK664887A (da) 3-substituerede 3-aroyloxy-propanaminer og fremgangsmaade til fremstilling deraf
DK260687D0 (da) Immunoglobulin-konjugater og fremgangsmaade til fremstilling deraf
DK166087D0 (da) Proteiner og fremgangsmaade til fremstilling deraf
DK8787D0 (da) Indolderivater og fremgangsmaade til fremstilling deraf
DK522487D0 (da) Imidazopyridinforbindelse og fremgangsmaade til fremstilling deraf
DK3687A (da) Polypeptider og fremgangsmaade til fremstilling deraf
DK134288D0 (da) Kemo-radio-immuno-konjugat og fremgangsmaade til fremstilling heraf
DK335986A (da) Poly-4-aminopropyl-2-carboxamidoderivat og fremgangsmaade til fremstilling deraf
DK315085A (da) Isoinsolinyl-alkyl-piperaziner og fremgangsmaade til fremstilling deraf
DK477287A (da) Pyrido-benzoxadiazin-derivater og fremgangsmaade til fremstilling deraf
DK203087D0 (da) Proteiner og fremgangsmaade til fremstilling deraf
DK397788D0 (da) Polyarylalkan-oligomer-praeparater og fremgangsmaade til fremstilling deraf
DK32989A (da) Immunoglobulin-konjugater og fremgangsmaade til fremstilling deraf
NO873197D0 (no) Bedoevelsespreparat og fremgangsmaate for anvendelse av dette.
DK362987A (da) Hexahydroarylquinolizin og fremgangsmaade til fremstilling deraf
DK401385A (da) 7-oxomitosan-derivater og fremgangsmaade til fremstilling deraf
DK487688D0 (da) Benzofuranderivater og fremgangsmaade til fremstilling deraf
DK446685D0 (da) Carbapenemderivater og fremgangsmaade til fremstilling deraf
DK624588D0 (da) 4-demethoxy-anthracyclin-derivater og fremgangsmaade til fremstilling deraf
DK129689D0 (da) Ifosfamid-mesna-lyofilisat og fremgangsmaade til fremstilling deraf
DK182585D0 (da) Fosfomycinderivat og fremgangsmaade til fremstilling deraf
DK160087A (da) Katalysatorkomponent og fremgangsmaade til fremstilling deraf
DK290187D0 (da) Peptidderivater og fremgangsmaade til fremstilling deraf
DK319188A (da) Glycerolacetalaminoacylat og fremgangsmaade til fremstilling deraf

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment