DK261283A - Antimikrobielle disulfid-prolaegemidler - Google Patents

Antimikrobielle disulfid-prolaegemidler Download PDF

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Publication number
DK261283A
DK261283A DK261283A DK261283A DK261283A DK 261283 A DK261283 A DK 261283A DK 261283 A DK261283 A DK 261283A DK 261283 A DK261283 A DK 261283A DK 261283 A DK261283 A DK 261283A
Authority
DK
Denmark
Prior art keywords
antimicrobial
prolagents
disulfid
alanyl
physico
Prior art date
Application number
DK261283A
Other languages
English (en)
Other versions
DK261283D0 (da
Inventor
Charles Gilvarg
William Dennis Kingsbury
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of DK261283D0 publication Critical patent/DK261283D0/da
Publication of DK261283A publication Critical patent/DK261283A/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/70Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06086Dipeptides with the first amino acid being basic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/29Polyamino acid or polypeptide with an uninterrupted series of peptide repeating units

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK261283A 1982-06-08 1983-06-08 Antimikrobielle disulfid-prolaegemidler DK261283A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/386,365 US4427582A (en) 1982-06-08 1982-06-08 Antimicrobial disulfide prodrugs

Publications (2)

Publication Number Publication Date
DK261283D0 DK261283D0 (da) 1983-06-08
DK261283A true DK261283A (da) 1983-12-09

Family

ID=23525295

Family Applications (1)

Application Number Title Priority Date Filing Date
DK261283A DK261283A (da) 1982-06-08 1983-06-08 Antimikrobielle disulfid-prolaegemidler

Country Status (12)

Country Link
US (1) US4427582A (da)
EP (1) EP0128249B1 (da)
JP (1) JPS595150A (da)
AT (1) ATE36166T1 (da)
AU (1) AU562703B2 (da)
DE (1) DE3377578D1 (da)
DK (1) DK261283A (da)
ES (1) ES523048A0 (da)
GR (1) GR77483B (da)
IE (1) IE55428B1 (da)
PT (1) PT76786B (da)
ZA (1) ZA833350B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA832844B (en) * 1982-05-18 1984-03-28 Smithkline Beckman Corp Oligopeptide prodrugs
ES2039402T3 (es) * 1986-10-24 1993-10-01 Pfrimmer Kabi Gmbh & Co. Kg Empleo de peptidos n,n'-bis-l-aminoacido-l-cistina en preparados de aminoacidos para alimentacion oral y parenteral.
US6423519B1 (en) * 1998-07-15 2002-07-23 Gpc Biotech Inc. Compositions and methods for inhibiting fungal growth
US20070219250A1 (en) * 2003-11-28 2007-09-20 Romi Singh Pharmaceutical Compositions of Nateglinide
FR2976944A1 (fr) 2011-06-21 2012-12-28 Centre Nat Rech Scient Prodrogues peptidiques
CN105722851A (zh) * 2013-04-28 2016-06-29 秦刚 一种新型的连接子及其制备方法和用途
KR102917231B1 (ko) 2021-03-08 2026-01-26 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. 항체 면역 작용제 접합체 및 이의 적용

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE448631B (sv) 1978-04-28 1987-03-09 Toyo Jozo Kk Disulfidforening av en berare med s-s-utbytesreaktivitet
US4258193A (en) 1978-07-13 1981-03-24 Toyo Jozo Kabushiki Kaisha Disulfide derivatives having S--S exchange reactivity
US4284624A (en) 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides

Also Published As

Publication number Publication date
JPS595150A (ja) 1984-01-12
ES8504692A1 (es) 1985-04-16
US4427582A (en) 1984-01-24
EP0128249A3 (en) 1985-10-09
DE3377578D1 (en) 1988-09-08
IE831330L (en) 1983-12-08
EP0128249A2 (en) 1984-12-19
PT76786B (en) 1985-12-13
DK261283D0 (da) 1983-06-08
ATE36166T1 (de) 1988-08-15
GR77483B (da) 1984-09-24
AU1446283A (en) 1983-12-15
IE55428B1 (en) 1990-09-12
EP0128249B1 (en) 1988-08-03
ES523048A0 (es) 1985-04-16
AU562703B2 (en) 1987-06-18
ZA833350B (en) 1984-04-25
PT76786A (en) 1983-06-01

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