DK2616486T3 - Faktor viii-varianter med nedsat cellulær optagelse - Google Patents
Faktor viii-varianter med nedsat cellulær optagelse Download PDFInfo
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- DK2616486T3 DK2616486T3 DK11769805.0T DK11769805T DK2616486T3 DK 2616486 T3 DK2616486 T3 DK 2616486T3 DK 11769805 T DK11769805 T DK 11769805T DK 2616486 T3 DK2616486 T3 DK 2616486T3
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- Prior art keywords
- leu
- ser
- glu
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Claims (12)
1. Rekombinant FVIII-variant med FVIII-aktivitet, hvor varianten omfatter 2-10 substitutioner af overfladetilgængelige, positivt ladede aminosyrerester i FVIII Cl-foden og/eller C2-foden, hvor de overfladetilgængelige ladede aminosyrerester er substitueret med alanin eller glutamin, og hvor substitutionerne resulterer i nedsat cellulær optagelse af FVIII-varianten, og hvor varianten omfatter en R2215-substitution kombineret med en K2092-sub stitution.
2. Rekombinant FVIII-variant ifølge krav 1, hvor FVIII-varianten omfatter en K2092A-sub stitution.
3. Rekombinant FVIII-variant ifølge et hvilket som helst af kravene 1-2, hvor varianten omfatter en R2215A-substitution.
4. Rekombinant FVIII-variant ifølge et hvilket som helst af de foregående krav, hvor varianten endvidere omfatter en substitution af R2090.
5. Rekombinant FVIII-variant ifølge et hvilket som helst af de foregående krav, hvor varianten endvidere omfatter en substitution af K2065.
6. Rekombinant FVIII-variant ifølge et hvilket som helst af de foregående krav, hvor varianten endvidere omfatter en K2065-substitution kombineret med en substitution af K2249.
7. Rekombinant FVIII-variant ifølge et hvilket som helst af de foregående krav, hvor varianten har nedsat LRP-binding.
8. Rekombinant FVIII-variant ifølge et hvilket som helst af de foregående krav, hvor varianten har nedsat immunogenicitet.
9. Rekombinant FVIII-variant ifølge et hvilket som helst af de foregående krav, hvor FVIII-varianten er konjugeret til en del med forlængende halveringstid.
10. Rekombinant FVIII-variant ifølge et hvilket som helst af de foregående krav, hvor varianten endvidere omfatter F2093A-mutationen.
11. Farmaceutisk sammensætning, der omfatter en rekombinant FVIII-variant ifølge et hvilket som helst af de foregående krav.
12. Rekombinant FVIII-variant ifølge et hvilket som helst af kravene 1-10 eller farmaceutisk sammensætning ifølge krav 11 til anvendelse i behandling af hæmofili.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10176731 | 2010-09-15 | ||
| US38473110P | 2010-09-21 | 2010-09-21 | |
| EP11173768 | 2011-07-13 | ||
| US201161507666P | 2011-07-14 | 2011-07-14 | |
| PCT/EP2011/065913 WO2012035050A2 (en) | 2010-09-15 | 2011-09-14 | Factor viii variants having a decreased cellular uptake |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2616486T3 true DK2616486T3 (da) | 2019-03-18 |
Family
ID=65721669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11769805.0T DK2616486T3 (da) | 2010-09-15 | 2011-09-14 | Faktor viii-varianter med nedsat cellulær optagelse |
Country Status (3)
| Country | Link |
|---|---|
| DK (1) | DK2616486T3 (da) |
| ES (1) | ES2712575T3 (da) |
| LT (1) | LT2616486T (da) |
-
2011
- 2011-09-14 DK DK11769805.0T patent/DK2616486T3/da active
- 2011-09-14 LT LTEP11769805.0T patent/LT2616486T/lt unknown
- 2011-09-14 ES ES11769805T patent/ES2712575T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2712575T3 (es) | 2019-05-13 |
| LT2616486T (lt) | 2019-03-25 |
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