DK2654858T3 - Injektionsanordning med dosisindstillingsmekanisme med maksimaldosisstop - Google Patents
Injektionsanordning med dosisindstillingsmekanisme med maksimaldosisstop Download PDFInfo
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- DK2654858T3 DK2654858T3 DK11802702.8T DK11802702T DK2654858T3 DK 2654858 T3 DK2654858 T3 DK 2654858T3 DK 11802702 T DK11802702 T DK 11802702T DK 2654858 T3 DK2654858 T3 DK 2654858T3
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- RWHUEXWOYVBUCI-ITQXDASVSA-N nafarelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 RWHUEXWOYVBUCI-ITQXDASVSA-N 0.000 description 1
- 229960002333 nafarelin Drugs 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 229960004532 somatropin Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 241001223854 teleost fish Species 0.000 description 1
- 229960003813 terlipressin Drugs 0.000 description 1
- BENFXAYNYRLAIU-QSVFAHTRSA-N terlipressin Chemical compound NCCCC[C@@H](C(=O)NCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CN)CSSC1 BENFXAYNYRLAIU-QSVFAHTRSA-N 0.000 description 1
- CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical compound [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Claims (6)
1. Dosisindstillingsmekanisme til en lægemiddelfremføringsanordning, hvilken mekanisme omfatter: et hus (11), en dosisindstillingsdel (4, 5), der er bevægelig i forhold til huset (11) til indstilling af en dosis, en drivmuffe (3), der er mindst delvist placeret inde i huset (11) og bevæges langs en spiralformet bane med en rotationskomponent og en translationskomponent i en første aksial retning i forhold til huset (11) under dosisindstilling, en stempelstang (2) til dosisdispensering, hvor stempelstangen (2) ikke er i direkte kontakt med dosisindstillingsdelen (4, 5) , hvor stempelstangen (2) er i direkte kontakt med drivmuffen (3), og hvor drivmuffen (3) er indskudt mellem dosisindstillingsdelen (4, 5) og stempelstangen (2), hvor dosisindstillingsdelen (4, 5) og drivmuffen (3) er afkoblet under dosisdispensering, således at dosisindstillingsdelen (4, 5) er fri til at rotere i forhold til drivmuffen (3), der er kendetegnet ved, at huset (11) og drivmuffen (3) er forsynet med modsvarende stopmidler (9a, 12), som omfatter et fremspring (9a) eller en indskæring formet på drivmuffen (3) og et modsvarende stopelement (12) formet på huset (11), hvilke stopmidler er indrettet til at begrænse bevægelsen af drivmuffen (3) i den første aksiale retning under dosisindstilling til derved definering en maksimal indstillelig dosis.
2. Dosisindstillingsmekanisme ifølge krav 1, hvor huset (11) har et første fremspring (12), og drivmuffen (3) har et andet fremspring (9a), og hvor afstanden mellem det første og andet fremspring (9a, 12) definerer den maksimale indstillelige dosis.
3. Dosisindstillingsmekanisme ifølge et hvilket som helst af kravene 1 til 2, hvor dosisindstillingsdelen (4, 5) og drivmuffen (3) er koblet under dosisindstilling, og hvor dosisindstillingsdelen (4, 5) og drivmuffen (3) roteres sammen under dosisindstilling.
4. Dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor stopmidlerne (12) er tilvejebragt på indersiden af det rørformede hus (11) og på ydersiden af drivmuffen (3).
5. Dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor dosisindstillingsdelen (4, 5) og stempelstangen (2) er afkoblet under dosisdispensering, således at dosisindstillingsdelen (4, 5) og stempelstangen (2) har mulighed for at bevæge sig i forhold til hinanden under dosisdispensering.
6. Dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav, der yderligere omfatter et reservoir, der indeholder et medikament, fortrinsvis insulin, hvilket reservoir er fastgjort til huset (11).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10196230 | 2010-12-21 | ||
| PCT/EP2011/073078 WO2012084720A1 (en) | 2010-12-21 | 2011-12-16 | Injection device with dose setting mechanism having maximum dose stop |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2654858T3 true DK2654858T3 (da) | 2017-09-25 |
Family
ID=43919786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11802702.8T DK2654858T3 (da) | 2010-12-21 | 2011-12-16 | Injektionsanordning med dosisindstillingsmekanisme med maksimaldosisstop |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9789259B2 (da) |
| EP (1) | EP2654858B1 (da) |
| JP (1) | JP5961186B2 (da) |
| CN (1) | CN103379932B (da) |
| AR (1) | AR084355A1 (da) |
| AU (1) | AU2011347652B2 (da) |
| BR (1) | BR112013015330A2 (da) |
| CA (1) | CA2821658A1 (da) |
| DK (1) | DK2654858T3 (da) |
| ES (1) | ES2639620T3 (da) |
| HU (1) | HUE036313T2 (da) |
| IL (1) | IL227023A (da) |
| PL (1) | PL2654858T3 (da) |
| TW (1) | TWI527605B (da) |
| WO (1) | WO2012084720A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014253256A1 (en) * | 2013-04-10 | 2015-09-24 | Sanofi | Automatic drug injection device with reverse wound flat spiral spring drive mechanism |
| WO2014166904A1 (en) * | 2013-04-10 | 2014-10-16 | Sanofi | Hand-held drug injection device and dose setting limiter mechanism therefor |
| EP2983741B1 (en) * | 2013-04-10 | 2020-06-03 | Sanofi | Pen-type drug injection device and dose setting limiter mechanism therefor |
| JP6448624B2 (ja) | 2013-05-27 | 2019-01-09 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物送達デバイス用の駆動アセンブリ、および薬物送達デバイス |
| US20160296710A1 (en) * | 2013-09-03 | 2016-10-13 | Sanofi | Drive assembly for a drug delivery device and drug delivery device comprising a drive assembly |
| EP2891503A1 (en) * | 2014-01-02 | 2015-07-08 | Sanofi-Aventis Deutschland GmbH | Assembly for a drug delivery device |
| AR102193A1 (es) * | 2014-10-09 | 2017-02-08 | Sanofi Sa | Manguito impulsor, dispositivo de administración de fármacos y método para ensamblar un dispositivo de administración de fármacos |
| CN110382021B (zh) * | 2017-02-24 | 2021-06-01 | 群康生技股份有限公司 | 具有剂量控制功能的注射推进机构 |
| WO2022214624A1 (en) * | 2021-04-07 | 2022-10-13 | Medmix Switzerland Ag | Drug delivery device with balancing weight |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6003736A (en) * | 1997-06-09 | 1999-12-21 | Novo Nordisk A/S | Device for controlled dispensing of a dose of a liquid contained in a cartridge |
| GB2375965B (en) | 2000-01-28 | 2004-09-01 | Novo Nordisk As | A dose setting limiter |
| EP2275158B1 (en) * | 2001-05-16 | 2013-01-23 | Eli Lilly and Company | Medication injector apparatus |
| EP1545663B1 (en) | 2002-10-01 | 2006-08-30 | Becton Dickinson and Company | Medication delivery pen |
| US9205197B2 (en) * | 2003-03-03 | 2015-12-08 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device dose setting mechanism |
| GB0304822D0 (en) * | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
| TR201903984T4 (tr) * | 2003-08-12 | 2019-04-22 | Lilly Co Eli | Mekanik avantaja yönelik üçlü vida dişine sahip ilaç dağıtım aparatı. |
| WO2006014425A1 (en) | 2004-07-02 | 2006-02-09 | Biovalve Technologies, Inc. | Methods and devices for delivering glp-1 and uses thereof |
| JP5175556B2 (ja) * | 2005-02-28 | 2013-04-03 | ノボ・ノルデイスク・エー／エス | 最大投与量の事前設定が可能な、注入デバイスのための投与量設定機構 |
| EP1923084A1 (en) * | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Dosing and drive mechanism for drug delivery device |
| DE202008011175U1 (de) * | 2008-08-18 | 2010-01-07 | Haselmeier Gmbh | Injektionsgerät |
| EP2193816A1 (en) * | 2008-12-02 | 2010-06-09 | Sanofi-Aventis Deutschland GmbH | Medication delivery device |
| CN102413854B (zh) | 2009-02-26 | 2013-08-28 | Shl集团有限责任公司 | 剂量设定机构 |
| AR076624A1 (es) | 2009-06-02 | 2011-06-22 | Sanofi Aventis Deutschland | Suministro de dos o mas medicametos por medio de una unica seleccion de dosis y una unica interfaz de dispensacion |
-
2011
- 2011-12-16 BR BR112013015330A patent/BR112013015330A2/pt not_active IP Right Cessation
- 2011-12-16 HU HUE11802702A patent/HUE036313T2/hu unknown
- 2011-12-16 CA CA2821658A patent/CA2821658A1/en not_active Abandoned
- 2011-12-16 DK DK11802702.8T patent/DK2654858T3/da active
- 2011-12-16 ES ES11802702.8T patent/ES2639620T3/es active Active
- 2011-12-16 US US13/994,628 patent/US9789259B2/en not_active Expired - Fee Related
- 2011-12-16 CN CN201180067891.7A patent/CN103379932B/zh not_active Expired - Fee Related
- 2011-12-16 PL PL11802702T patent/PL2654858T3/pl unknown
- 2011-12-16 AU AU2011347652A patent/AU2011347652B2/en not_active Ceased
- 2011-12-16 EP EP11802702.8A patent/EP2654858B1/en not_active Not-in-force
- 2011-12-16 WO PCT/EP2011/073078 patent/WO2012084720A1/en not_active Ceased
- 2011-12-16 JP JP2013545222A patent/JP5961186B2/ja not_active Expired - Fee Related
- 2011-12-19 AR ARP110104763A patent/AR084355A1/es not_active Application Discontinuation
- 2011-12-19 TW TW100147029A patent/TWI527605B/zh not_active IP Right Cessation
-
2013
- 2013-06-18 IL IL227023A patent/IL227023A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011347652B2 (en) | 2015-03-26 |
| ES2639620T3 (es) | 2017-10-27 |
| TW201238619A (en) | 2012-10-01 |
| HUE036313T2 (hu) | 2018-06-28 |
| CA2821658A1 (en) | 2012-06-28 |
| BR112013015330A2 (pt) | 2016-09-20 |
| CN103379932A (zh) | 2013-10-30 |
| IL227023A (en) | 2016-07-31 |
| JP2014502530A (ja) | 2014-02-03 |
| JP5961186B2 (ja) | 2016-08-02 |
| US9789259B2 (en) | 2017-10-17 |
| PL2654858T3 (pl) | 2017-11-30 |
| US20130267911A1 (en) | 2013-10-10 |
| TWI527605B (zh) | 2016-04-01 |
| EP2654858A1 (en) | 2013-10-30 |
| AR084355A1 (es) | 2013-05-08 |
| AU2011347652A1 (en) | 2013-05-02 |
| EP2654858B1 (en) | 2017-06-14 |
| WO2012084720A1 (en) | 2012-06-28 |
| CN103379932B (zh) | 2015-08-05 |
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