DK2655604T3 - Adenovirus serotype-26- og serotype-35-filovirusvacciner - Google Patents
Adenovirus serotype-26- og serotype-35-filovirusvacciner Download PDFInfo
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- DK2655604T3 DK2655604T3 DK11849865.8T DK11849865T DK2655604T3 DK 2655604 T3 DK2655604 T3 DK 2655604T3 DK 11849865 T DK11849865 T DK 11849865T DK 2655604 T3 DK2655604 T3 DK 2655604T3
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Claims (11)
1. Første og anden rekombinant adenovirusvektor, der hver omfatter en nukleinsyre, der koder for et antigent filovirusprotein, hvor den første adenovirusvektor omfatter et adenovirus-26-capsidprotein, og hvor den anden adenovirusvektor omfatter et adenovirus-35-capsidprotein, til anvendelse til inducering af et immunrespons hos et individ mod filovirusantigenet ved administrering til individet som en initialvaccination af en immunologisk effektiv mængde af den første rekombinante adenovirusvektor; efterfulgt af administrering til individet som en boostervaccination af en immunologisk effektiv mængde af den anden adenovirusvektor, hvor de antigene filovirusproteiner, der kodes af den første og anden rekombinante adenovirusvektor, har mindst én fælles antigen determinant.
2. Rekombinante adenovirusvektorer til anvendelse ifølge krav 1, hvor adenovirusvektorerne administreres intramuskulært.
3. Rekombinante adenovirusvektorer til anvendelse ifølge krav 1 eller krav 2, hvor det antigene filovirusprotein er et glycoprotein.
4. Rekombinante adenovirusvektorer til anvendelse ifølge et hvilket som helst af kravene 1-2, hvor det antigene filovirusprotein er fra et Ebola-virus.
5. Rekombinante adenovirusvektorer til anvendelse ifølge krav 4, hvor Ebola-virusset er af arten Zaire.
6. Rekombinante adenovirusvektorer til anvendelse ifølge krav 5, hvor det antigene filovirusprotein kodes af en polynukleotidsekvens ifølge SEQ ID NO: 1.
7. Rekombinante adenovirusvektorer til anvendelse ifølge krav 4, hvor Ebola-virusset er af arten Sudan/Gulu.
8. Rekombinante adenovirusvektorer til anvendelse ifølge krav 7, hvor det antigene filovirusprotein kodes af en polynukleotidsekvens ifølge SEQ ID NO: 2.
9. Rekombinante adenovirusvektorer til anvendelse ifølge krav 7, hvor det antigene filovirusprotein kodes af en polynukleotidsekvens ifølge SEQ ID NO: 3.
10. Rekombinante adenovirusvektorer til anvendelse ifølge et hvilket som helst af kravene 1-3, hvor det antigene filovirusprotein er fra Marburg-virus.
11. Rekombinante adenovirusvektorer til anvendelse ifølge krav 10, hvor det antigene filovirusprotein kodes af en polynukleotidsekvens ifølge SEQ ID NO: 4.
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| US42295410P | 2010-12-14 | 2010-12-14 | |
| PCT/US2011/064944 WO2012082918A1 (en) | 2010-12-14 | 2011-12-14 | Adenovirus serotype 26 and serotype 35 filovirus vaccines |
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| HUE065565T2 (hu) | 2014-09-03 | 2024-06-28 | Bavarian Nordic As | Módszerek és készítmények filovírus fertõzés elleni védõ immunitás elõidézésére |
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| PT3390430T (pt) | 2015-12-15 | 2019-11-20 | Janssen Vaccines & Prevention Bv | Antígenos, vetores, composições para o vírus da imunodeficiência humana e métodos da sua utilização |
| WO2017143174A1 (en) | 2016-02-18 | 2017-08-24 | International Flavors & Fragrances Inc. | Polyurea capsule compositions |
| ES2876160T3 (es) | 2016-03-18 | 2021-11-12 | Int Flavors & Fragrances Inc | Microcápsulas de sílice y métodos para prepararlas |
| JP6595132B2 (ja) | 2016-06-16 | 2019-10-23 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | Ｈｉｖワクチン製剤 |
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| CN110958887B (zh) | 2017-06-15 | 2023-10-31 | 扬森疫苗与预防公司 | 编码hiv抗原的痘病毒载体及其使用方法 |
| US20190022212A1 (en) | 2017-07-21 | 2019-01-24 | Beth Israel Deaconess Medical Center, Inc. | Methods for safe induction of cross-clade immunity against human immunodeficiency virus infection in human |
| JP7311489B2 (ja) * | 2017-07-28 | 2023-07-19 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 異種ｒｅｐＲＮＡ免疫化のための方法および組成物 |
| BR112020007884A2 (pt) | 2017-11-20 | 2020-11-03 | Janssen Pharmaceuticals, Inc. | método de proporcionar uma administração segura de vetores adenovirais que codificam um antígeno de vírus zika |
| CN111741766A (zh) | 2017-12-19 | 2020-10-02 | 杨森科学爱尔兰无限公司 | 用于诱导针对乙型肝炎病毒(hbv)的免疫应答的方法和组合物 |
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| EA037291B9 (ru) * | 2020-08-22 | 2021-11-24 | федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома sars-cov-2 (варианты) |
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| EP4154974A1 (en) | 2021-09-23 | 2023-03-29 | International Flavors & Fragrances Inc. | Biodegradable microcapsules |
| WO2023047349A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized coronavirus spike protein fusion proteins |
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| WO2024061753A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized trimeric class i fusion proteins |
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| US6852324B1 (en) * | 1997-12-23 | 2005-02-08 | The United States Of America As Represented By The Department Of Health And Human Services | Immunization for ebola virus infection |
| US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| WO2003028632A2 (en) | 2001-10-01 | 2003-04-10 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The | Development of a preventive vaccine for filovirus infection in primates |
| KR101021387B1 (ko) | 2002-04-25 | 2011-03-14 | 크루셀 홀란드 비.브이. | 아데노바이러스 벡터를 생산하기 위한 수단 및 방법 |
| DK1497440T3 (da) | 2002-04-25 | 2008-12-01 | Crucell Holland Bv | Stabile adenovirale vektorer og fremgangsmåder til propagering deraf |
| EP1553983A2 (en) * | 2002-10-23 | 2005-07-20 | Crucell Holland B.V. | New settings for recombinant adenoviral-based vaccines |
| WO2005012538A2 (en) * | 2003-08-01 | 2005-02-10 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Accelerated vaccination |
| AU2005289439B2 (en) * | 2004-09-27 | 2011-12-01 | Crucell Holland B.V. | Optimized vaccines to provide protection against Ebola and other viruses |
| BRPI0516048A (pt) | 2004-10-13 | 2008-08-19 | Crucell Holland B V E Beth Isr | batelada de um adenovìrus recombinante defectivo em replicação baseado em um sorotipo do subgrupo c |
| JP4843613B2 (ja) * | 2004-10-13 | 2011-12-21 | クルセル ホランド ベー ヴェー | 改良されたアデノウイルスベクターおよびその使用方法 |
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| US20100143302A1 (en) | 2006-03-16 | 2010-06-10 | Crucell Holland B.V. | Recombinant Adenoviruses Based on Serotype 26 and 48, and Use Thereof |
| US20090110695A1 (en) * | 2006-03-27 | 2009-04-30 | Menzo Jans Emko Havenga | Compositions Comprising a Recombinant Adenovirus and an Adjuvant |
| WO2009092113A2 (en) * | 2008-01-19 | 2009-07-23 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for the delivery of vaccines to disrupted epithelium |
| DK2655604T3 (da) | 2010-12-14 | 2018-08-06 | Us Gov Health & Human Services | Adenovirus serotype-26- og serotype-35-filovirusvacciner |
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| CA2821289A1 (en) | 2012-06-21 |
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| US20140017278A1 (en) | 2014-01-16 |
| EA201390866A1 (ru) | 2014-05-30 |
| JP2014503206A (ja) | 2014-02-13 |
| AU2011343798B2 (en) | 2016-07-14 |
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