DK2658536T3 - Gemcaben og derivater til behandling af pancreatitis - Google Patents
Gemcaben og derivater til behandling af pancreatitis Download PDFInfo
- Publication number
- DK2658536T3 DK2658536T3 DK11810759.8T DK11810759T DK2658536T3 DK 2658536 T3 DK2658536 T3 DK 2658536T3 DK 11810759 T DK11810759 T DK 11810759T DK 2658536 T3 DK2658536 T3 DK 2658536T3
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- Prior art keywords
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- administered
- gemcabene
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- OSGPYAHSKOGBFY-KMHHXCEHSA-A mipomersen sodium Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].N1([C@H]2C[C@@H]([C@H](O2)COP([O-])(=O)S[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP([O-])(=O)S[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=O)S[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C(C)=C2)=O)COP([O-])(=O)S[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=O)S[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP([O-])(=O)S[C@@H]2[C@H](O[C@H](C2)N2C3=NC=NC(N)=C3N=C2)COP([O-])(=O)S[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)S[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)S[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)S[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)S[C@H]2[C@H]([C@@H](O[C@@H]2CO)N2C3=C(C(NC(N)=N3)=O)N=C2)OCCOC)N2C(N=C(N)C(C)=C2)=O)OCCOC)N2C(N=C(N)C(C)=C2)=O)OCCOC)N2C(NC(=O)C(C)=C2)=O)OCCOC)N2C(N=C(N)C(C)=C2)=O)OCCOC)SP([O-])(=O)OC[C@H]2O[C@H](C[C@@H]2SP([O-])(=O)OC[C@H]2O[C@H](C[C@@H]2SP([O-])(=O)OC[C@H]2O[C@H](C[C@@H]2SP([O-])(=O)OC[C@@H]2[C@H]([C@H]([C@@H](O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OCCOC)SP([O-])(=O)OC[C@H]2[C@@H]([C@@H]([C@H](O2)N2C(N=C(N)C(C)=C2)=O)OCCOC)SP([O-])(=O)OC[C@H]2[C@@H]([C@@H]([C@H](O2)N2C3=NC=NC(N)=C3N=C2)OCCOC)SP([O-])(=O)OC[C@H]2[C@@H]([C@@H]([C@H](O2)N2C(N=C(N)C(C)=C2)=O)OCCOC)SP([O-])(=O)OC[C@H]2[C@H](O)[C@@H]([C@H](O2)N2C(N=C(N)C(C)=C2)=O)OCCOC)N2C(N=C(N)C(C)=C2)=O)N2C(NC(=O)C(C)=C2)=O)N2C(NC(=O)C(C)=C2)=O)C=C(C)C(N)=NC1=O OSGPYAHSKOGBFY-KMHHXCEHSA-A 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 229940124641 pain reliever Drugs 0.000 description 1
- 210000000277 pancreatic duct Anatomy 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000002616 plasmapheresis Methods 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 229960002965 pravastatin Drugs 0.000 description 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229960000672 rosuvastatin Drugs 0.000 description 1
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 description 1
- 102200092203 rs3135506 Human genes 0.000 description 1
- 229960001852 saquinavir Drugs 0.000 description 1
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000010009 steroidogenesis Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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- 238000001356 surgical procedure Methods 0.000 description 1
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- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960000838 tipranavir Drugs 0.000 description 1
- SUJUHGSWHZTSEU-FYBSXPHGSA-N tipranavir Chemical compound C([C@@]1(CCC)OC(=O)C([C@H](CC)C=2C=C(NS(=O)(=O)C=3N=CC(=CC=3)C(F)(F)F)C=CC=2)=C(O)C1)CC1=CC=CC=C1 SUJUHGSWHZTSEU-FYBSXPHGSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (14)
1. Forbindelse med formlen o o (CHj)4-O-(CH^—- H3C CHa HSC CH3 5 eller et farmaceutisk acceptabelt salt eller hydrat deraf til anvendelse til reducering af en persons risiko for udvikling af pancreatitis, hvor personen har et triglyceridniveau i blodet på 500 mg/dl eller højere, og hvor den administrerede mængde af forbindelsen er mellem 150 og 600 mg/dag. 10
2. Forbindelse til anvendelse ifølge krav 1, hvor personen har et triglyceridniveau i blodet på 1000 mg/dl eller højere.
3. Forbindelse til anvendelse ifølge krav 1 eller 2, hvor 15 personen har et LDL-kolesterolniveau, der er højere end 100 mg/dl.
4. Forbindelse til anvendelse ifølge krav 3, hvor personen har et LDL-kolesterolniveau, der er højere end 250 mg/dl. 20
5. Forbindelse til anvendelse ifølge krav 1, hvor den administrerede mængde af forbindelsen er 150, 300 eller 600 mg/dag.
6. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1-5, hvor forbindelsen administreres en gang dagligt.
7. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1-6, hvor forbindelsen administreres i kombination med 30 et middel, der er udvalgt blandt: et kolesterolsænkende middel, en kolesterolabsorptionshæmmer, en galdesyrekompleksdanner eller en ApoB-syntesehæmmer.
8. Forbindelse til anvendelse ifølge krav 7, hvor midlet er 35 et statin.
9. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1-8, hvor forbindelsen administreres i kombination med en proteasehæmmer.
10. Forbindelse til anvendelse ifølge et hvilket som helst af 5 kravene 1-9, hvor forbindelsen er gemcaben.
11. Forbindelse til anvendelse ifølge krav 10, hvor den administrerede mængde af gemcaben er 150 eller 300 mg/dag.
12. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1-9, hvor forbindelsen administreres som et vandfrit monocalciumsalt, hvor det vandfri monocalciumsalt har formlen Λ λ -c> V (CH2)4 O (CH2)4—o- h3c ch3 h3c ch3
13. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1-9, hvor forbindelsen er et hydrat af 0 j? HO//^—(CH2)4---0-(CH^-y^OH HSC C Ha HjC C Ha
14. Forbindelse til anvendelse ifølge et hvilket som helst af 20 kravene 1-9, hvor forbindelsen er et hydrat af monocalciumsaltet af Λ——λ h3c ch3 h3c ch3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061427236P | 2010-12-27 | 2010-12-27 | |
| PCT/US2011/066736 WO2012092103A1 (en) | 2010-12-27 | 2011-12-22 | Gemcabene and derivatives for treating pancreatitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2658536T3 true DK2658536T3 (da) | 2017-01-09 |
Family
ID=45498140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11810759.8T DK2658536T3 (da) | 2010-12-27 | 2011-12-22 | Gemcaben og derivater til behandling af pancreatitis |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8846761B2 (da) |
| EP (2) | EP3170495B1 (da) |
| JP (3) | JP2014509305A (da) |
| CN (2) | CN103442707A (da) |
| AU (1) | AU2011352449B2 (da) |
| CA (1) | CA2822921C (da) |
| DK (1) | DK2658536T3 (da) |
| ES (1) | ES2608177T3 (da) |
| HK (1) | HK1250484A1 (da) |
| HU (1) | HUE031004T2 (da) |
| MX (1) | MX337593B (da) |
| PL (1) | PL2658536T3 (da) |
| PT (1) | PT2658536T (da) |
| WO (1) | WO2012092103A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016077832A2 (en) | 2014-11-14 | 2016-05-19 | Gemphire Therapeutics Inc. | PROCESSES AND INTERMEDIATES FOR PREPARING α,ω-DICARBOXYLIC ACID-TERMINATED DIALKANE ETHERS |
| AU2016348638A1 (en) * | 2015-11-06 | 2018-06-07 | Gemphire Therapeutics Inc. | Gemcabene combinations for the treatment of cardiovascular disease |
| EP3612171A4 (en) | 2017-04-18 | 2020-10-21 | Gemphire Therapeutics Inc. | GEMCABENE, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, COMPOSITIONS THEREOF AND PROCEDURES FOR THE USE OF THE SAME |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3737289A (en) | 1988-06-06 | 1990-01-05 | Okamoto, Shosuke | Agent for treating pancreatitis or the like |
| US5648387A (en) | 1995-03-24 | 1997-07-15 | Warner-Lambert Company | Carboxyalkylethers, formulations, and treatment of vascular diseases |
| US20020103252A1 (en) | 1997-12-12 | 2002-08-01 | Bisgaier Charles Larry | Statin-carboxyalkylether combinations |
| US20030105154A1 (en) * | 2001-10-24 | 2003-06-05 | Bisgaier Charles Larry | Statin-carboxyalkylether combinations |
| US6861555B2 (en) | 2000-01-25 | 2005-03-01 | Warner-Lambert Company | Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith |
| MXPA01009893A (es) | 1999-04-01 | 2003-07-28 | Esperion Therapeutics Inc | Compuestos con eter, composiciones y usos de estos. |
| IL155215A0 (en) | 2000-10-11 | 2003-11-23 | Esperion Therapeutics Inc | Ether compounds and compositions for cholesterol management and related uses |
| US6645170B2 (en) | 2001-03-05 | 2003-11-11 | Bioject Medical Technologies, Inc. | Simplified disposable needle-free injection apparatus and method |
| US20040229954A1 (en) * | 2003-05-16 | 2004-11-18 | Macdougall Diane Elaine | Selective manipulation of triglyceride, HDL and LDL parameters with 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt |
| US7345190B2 (en) | 2003-11-12 | 2008-03-18 | Ssv Therapeutics, Inc. | Carnitine conjugates as dual prodrugs and uses thereof |
-
2011
- 2011-12-22 DK DK11810759.8T patent/DK2658536T3/da active
- 2011-12-22 PL PL11810759T patent/PL2658536T3/pl unknown
- 2011-12-22 MX MX2013007310A patent/MX337593B/es active IP Right Grant
- 2011-12-22 US US13/334,384 patent/US8846761B2/en active Active
- 2011-12-22 CN CN2011800630388A patent/CN103442707A/zh active Pending
- 2011-12-22 CN CN201710858297.9A patent/CN107648210A/zh active Pending
- 2011-12-22 EP EP16192597.9A patent/EP3170495B1/en active Active
- 2011-12-22 PT PT118107598T patent/PT2658536T/pt unknown
- 2011-12-22 HU HUE11810759A patent/HUE031004T2/en unknown
- 2011-12-22 EP EP11810759.8A patent/EP2658536B1/en active Active
- 2011-12-22 ES ES11810759.8T patent/ES2608177T3/es active Active
- 2011-12-22 AU AU2011352449A patent/AU2011352449B2/en not_active Ceased
- 2011-12-22 JP JP2013546406A patent/JP2014509305A/ja not_active Withdrawn
- 2011-12-22 WO PCT/US2011/066736 patent/WO2012092103A1/en not_active Ceased
- 2011-12-22 CA CA2822921A patent/CA2822921C/en active Active
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2015
- 2015-09-10 JP JP2015178843A patent/JP6207560B2/ja active Active
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2017
- 2017-09-04 JP JP2017169145A patent/JP2018027953A/ja active Pending
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2018
- 2018-08-01 HK HK18109899.3A patent/HK1250484A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3170495A1 (en) | 2017-05-24 |
| CA2822921C (en) | 2018-07-17 |
| AU2011352449B2 (en) | 2015-06-18 |
| US20120165411A1 (en) | 2012-06-28 |
| CN107648210A (zh) | 2018-02-02 |
| WO2012092103A1 (en) | 2012-07-05 |
| PL2658536T3 (pl) | 2017-04-28 |
| AU2011352449A1 (en) | 2013-07-11 |
| CN103442707A (zh) | 2013-12-11 |
| US8846761B2 (en) | 2014-09-30 |
| JP6207560B2 (ja) | 2017-10-04 |
| HK1250484A1 (zh) | 2018-12-21 |
| PT2658536T (pt) | 2016-12-22 |
| JP2018027953A (ja) | 2018-02-22 |
| EP2658536B1 (en) | 2016-10-19 |
| ES2608177T3 (es) | 2017-04-06 |
| MX337593B (es) | 2016-03-11 |
| HUE031004T2 (en) | 2017-06-28 |
| EP2658536A1 (en) | 2013-11-06 |
| EP3170495B1 (en) | 2023-04-26 |
| JP2014509305A (ja) | 2014-04-17 |
| MX2013007310A (es) | 2013-10-25 |
| JP2016028075A (ja) | 2016-02-25 |
| CA2822921A1 (en) | 2012-07-05 |
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