DK2665486T3 - Sammensætninger til modulering af gamma-c-cytokin-aktivitet - Google Patents

Sammensætninger til modulering af gamma-c-cytokin-aktivitet Download PDF

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Publication number
DK2665486T3
DK2665486T3 DK12736203.6T DK12736203T DK2665486T3 DK 2665486 T3 DK2665486 T3 DK 2665486T3 DK 12736203 T DK12736203 T DK 12736203T DK 2665486 T3 DK2665486 T3 DK 2665486T3
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cytokin
compositions
activity
modulating gamma
modulating
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DK12736203.6T
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English (en)
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Yutaka Tagaya
Nazli Azimi
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Bioniz Llc
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    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
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DK12736203.6T 2011-01-18 2012-01-17 Sammensætninger til modulering af gamma-c-cytokin-aktivitet DK2665486T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161433890P 2011-01-18 2011-01-18
US201161527049P 2011-08-24 2011-08-24
PCT/US2012/021566 WO2012099886A1 (en) 2011-01-18 2012-01-17 Compositions and mehthods for modulating gamma-c-cytokine activity

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DK2665486T3 true DK2665486T3 (da) 2020-03-09

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DK19206731.2T DK3636274T3 (da) 2011-01-18 2012-01-17 Sammensætninger til modulering af gamma-c-cytokin-aktivitet
DK12736203.6T DK2665486T3 (da) 2011-01-18 2012-01-17 Sammensætninger til modulering af gamma-c-cytokin-aktivitet

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US (10) US9133244B2 (da)
EP (3) EP2665486B1 (da)
JP (4) JP6395379B2 (da)
CN (2) CN109021069A (da)
AU (3) AU2012207456C1 (da)
BR (1) BR112013018046B1 (da)
CA (1) CA2824515C (da)
CY (1) CY1122846T1 (da)
DK (2) DK3636274T3 (da)
ES (2) ES2989085T3 (da)
FI (1) FI3636274T3 (da)
HR (1) HRP20200470T1 (da)
LT (1) LT2665486T (da)
PL (2) PL3636274T3 (da)
PT (2) PT2665486T (da)
RS (1) RS60050B1 (da)
SI (1) SI2665486T1 (da)
SM (1) SMT202000142T1 (da)
WO (1) WO2012099886A1 (da)

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HRP20200470T1 (hr) 2011-01-18 2020-10-02 Bioniz, Llc Pripravci za modulaciju aktivnosti gama-c-citokina
US9959384B2 (en) 2013-12-10 2018-05-01 Bioniz, Llc Methods of developing selective peptide antagonists
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CN119684428A (zh) * 2015-10-09 2025-03-25 比奥尼斯治疗公司 调节γC-细胞因子活性
JP2019518786A (ja) * 2016-05-06 2019-07-04 牧林 王 インターロイキンの組み合せ及びその使用
WO2018187499A1 (en) * 2017-04-07 2018-10-11 Bioniz, Llc Stable modulators of gamma-c-cytokine activity
CN112566664B (zh) * 2018-07-19 2023-08-25 国立大学法人东京大学 Htlv-1相关性脊髓病(ham)治疗或预防剂、及ham的治疗方法
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CN113710229B (zh) 2019-02-25 2026-01-06 芝加哥大学 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物
EP3976182A4 (en) * 2019-05-03 2023-01-18 Bioniz, LLC MODULATION OF THE EFFECTS OF GAMMA CYTOKINE SIGNALING FOR THE TREATMENT OF ALOPECIA AND ALOPECIA-ASSOCIATED DISORDERS
KR20220020879A (ko) 2019-06-12 2022-02-21 에스크진 파마, 아이엔씨. 새로운 il-15 프로드럭 및 이를 사용하는 방법
KR102265435B1 (ko) * 2019-08-20 2021-06-15 주식회사 케어젠 피부 미백 활성을 갖는 펩타이드 및 이의 용도
KR20220110207A (ko) 2019-11-05 2022-08-05 메디카인 인코포레이티드 IL-2RβγC 결합 화합물
MX2022005404A (es) 2019-11-05 2022-09-09 Medikine Inc Compuestos de fijación a il-2r e il-7r dual.
WO2021142471A1 (en) 2020-01-11 2021-07-15 AskGene Pharma, Inc. Novel masked cytokines and methods of use thereof
IL295304A (en) 2020-02-03 2022-10-01 Medikine Inc Il-7 receptor alpha gamma c binding compounds, compositions comprising same and uses thereof
JP2023512687A (ja) 2020-02-03 2023-03-28 メディカイン、インコーポレイテッド IL-7Rα結合化合物
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EP4172175A4 (en) * 2020-06-24 2024-07-24 Bioniz Therapeutics, Inc. Antagonistic peptide targeting il-2, il-9, and il-15 signaling for the treatment of cytokine-release syndrome and cytokine storm associated disorders
EP4212163A4 (en) 2020-09-08 2024-09-18 Dexon Pharmaceuticals Inc. CYTOKINE STORM INHIBITOR, METHOD FOR USING CYTOKINE STORM INHIBITOR, AND METHOD FOR SCREENING CYTOKINE INHIBITOR
JP2024511387A (ja) 2021-03-16 2024-03-13 シートムエックス セラピューティクス,インコーポレイテッド マスクした活性化可能サイトカイン構成体ならびに関連する組成物及び方法
JP6974892B1 (ja) 2021-05-27 2021-12-01 デクソンファーマシューティカルズ株式会社 癌悪液質の改善剤および癌悪液質の改善方法
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