DK2686421T3 - Generering af nk-celler og nk-celleforløbere - Google Patents
Generering af nk-celler og nk-celleforløbere Download PDFInfo
- Publication number
- DK2686421T3 DK2686421T3 DK12711984.0T DK12711984T DK2686421T3 DK 2686421 T3 DK2686421 T3 DK 2686421T3 DK 12711984 T DK12711984 T DK 12711984T DK 2686421 T3 DK2686421 T3 DK 2686421T3
- Authority
- DK
- Denmark
- Prior art keywords
- cells
- generation
- cell procedures
- procedures
- cell
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 210000000822 natural killer cell Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2011050193 | 2011-03-18 | ||
| EP11162866 | 2011-04-18 | ||
| PCT/NL2012/050165 WO2012128622A1 (en) | 2011-03-18 | 2012-03-16 | Generation of nk cells and nk-cell progenitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2686421T3 true DK2686421T3 (da) | 2021-03-08 |
Family
ID=45928983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12711984.0T DK2686421T3 (da) | 2011-03-18 | 2012-03-16 | Generering af nk-celler og nk-celleforløbere |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11118165B2 (da) |
| EP (1) | EP2686421B1 (da) |
| CA (1) | CA2830080C (da) |
| DK (1) | DK2686421T3 (da) |
| ES (1) | ES2856825T3 (da) |
| PL (1) | PL2686421T3 (da) |
| WO (1) | WO2012128622A1 (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015526088A (ja) * | 2012-08-13 | 2015-09-10 | アントフロゲネシス コーポレーション | ナチュラルキラー細胞及びその使用 |
| CN115137753A (zh) | 2013-02-05 | 2022-10-04 | 细胞结构公司 | 来自胎盘的自然杀伤细胞 |
| CN104509529A (zh) * | 2013-10-08 | 2015-04-15 | 康克韦斯特公司 | 用于储存和运输nk-92细胞系的方案和培养基 |
| US20160244716A1 (en) * | 2013-10-08 | 2016-08-25 | Hans G. Klingemann | Protocol and media for storage and transport of nk-92 cell line |
| KR101697473B1 (ko) | 2014-11-26 | 2017-01-18 | 주식회사 녹십자랩셀 | T 세포를 이용한 자연살해세포의 배양방법 |
| EA201890960A1 (ru) * | 2015-10-15 | 2018-10-31 | Селулэрити, Инк. | Натуральные киллеры и клетки ilc3 и их применение |
| US20190032013A1 (en) * | 2016-01-29 | 2019-01-31 | Tract Therapeutics, Inc. | Immune cell selection, expansion, and use |
| BR112018072701A2 (pt) | 2016-05-07 | 2019-02-19 | Celularity, Inc. | métodos de tratamento de leucemia mieloide aguda e mieloma múltiplo usando células exterminadoras naturais |
| GB201703476D0 (en) | 2017-03-03 | 2017-04-19 | Imp Innovations Ltd | Natural killer cells |
| GB201704953D0 (en) | 2017-03-28 | 2017-05-10 | Imp Innovations Ltd | Natural killer cells |
| JP6647240B2 (ja) * | 2017-05-12 | 2020-02-14 | 米満 吉和 | 高活性ｎｋ細胞、およびその利用 |
| EP3633029A4 (en) | 2017-05-26 | 2021-06-09 | Green Cross Lab Cell Corporation | METHOD OF DEVELOPING A NATURAL KILLER CELL USING A T-CELL |
| US11446329B2 (en) * | 2017-11-01 | 2022-09-20 | Restem Llc | Natural killer cell adoptive transfer therapy for the elimination of senescent PBMCs, reduction of inflammatory cytokines and treatment of IBS |
| KR102265437B1 (ko) * | 2017-11-24 | 2021-06-15 | 의료법인 성광의료재단 | Nk 배양용 조성물 및 이를 이용하여 nk 세포를 배양하는 방법 |
| IL276365B2 (en) | 2018-02-01 | 2023-10-01 | Nkmax Co Ltd | A method for the production of natural killer cells and a preparation for cancer treatment |
| CN108315299A (zh) * | 2018-02-13 | 2018-07-24 | 南京支云松生物科技有限公司 | 一种即用型异体nk细胞库网络储运应用系统 |
| WO2019182392A1 (ko) * | 2018-03-23 | 2019-09-26 | 주식회사 녹십자랩셀 | 자연살해세포의 제조방법 |
| GB201810486D0 (en) | 2018-06-26 | 2018-08-08 | Imperial Innovations Ltd | Natural killer cells |
| AU2019381526B2 (en) | 2018-11-14 | 2023-02-23 | Green Cross Lab Cell Corporation | Method for culturing cord blood-derived natural killer cells using transformed T-cells |
| AU2019456283B2 (en) | 2019-07-08 | 2023-06-08 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| CN114402065A (zh) * | 2019-07-22 | 2022-04-26 | 格雷克斯迪姆医疗私人有限公司 | 低密度细胞培养 |
| EP4032972A4 (en) * | 2019-09-18 | 2024-07-24 | Slbigen Inc. | GENETICALLY MODIFIED NK CELL LINE TRANSDUCED WITH A GENE ENCODING A NEW CHIMERIC ANTIGEN RECEPTOR AND ITS USE |
| EP4114415A1 (en) | 2020-03-06 | 2023-01-11 | Sorrento Therapeutics, Inc. | Innate immunity killer cells targeting psma positive tumor cells |
| CN111286488B (zh) * | 2020-03-10 | 2021-04-02 | 河南侨创生命科技有限公司 | 一种自然杀伤细胞体外培养方法 |
| US11547726B2 (en) * | 2020-03-26 | 2023-01-10 | Honed Life Sciences, Llc | Enhancement of production of NK cells from stem cells |
| CN113913384A (zh) * | 2020-07-09 | 2022-01-11 | 杭州优凯瑞医药科技有限公司 | 一种制备靶点特异性nk细胞的方法及其应用 |
| US12236422B2 (en) * | 2022-01-05 | 2025-02-25 | Mastercard International Incorporated | Computer-implemented methods and systems for authentic user-merchant association and services |
| GB202217507D0 (en) * | 2022-11-23 | 2023-01-04 | Imperial College Innovations Ltd | Natural killer cells |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1941027T3 (pl) * | 2005-09-28 | 2015-01-30 | Ipd Therapeutics B V | Metody i środki do proliferacji komórek macierzystych oraz wytwarzania i ekspansji komórek progenitorowych, a także produkcji komórek efektorowych jako leków klinicznych |
| WO2008023874A1 (en) * | 2006-08-23 | 2008-02-28 | Binex Co., Ltd. | Manufacturing method of activated lymphocytes for immunotherapy |
| US9193953B2 (en) * | 2007-03-27 | 2015-11-24 | Ipd-Therapeutics B.V. | Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells |
| EP3184109B1 (en) | 2009-12-29 | 2020-11-18 | Gamida-Cell Ltd. | Methods for enhancing natural killer cell proliferation and activity |
| US20130059379A1 (en) * | 2010-02-24 | 2013-03-07 | Ingo Schmidt-Wolf | Method for the generation of a cik cell and nk cell population |
| CA3003923A1 (en) | 2015-11-05 | 2017-05-11 | Glycostem Therapeutics B.V. | Composition for use in immunotherapy |
-
2012
- 2012-03-16 WO PCT/NL2012/050165 patent/WO2012128622A1/en not_active Ceased
- 2012-03-16 PL PL12711984T patent/PL2686421T3/pl unknown
- 2012-03-16 EP EP12711984.0A patent/EP2686421B1/en active Active
- 2012-03-16 DK DK12711984.0T patent/DK2686421T3/da active
- 2012-03-16 CA CA2830080A patent/CA2830080C/en active Active
- 2012-03-16 US US14/005,168 patent/US11118165B2/en active Active
- 2012-03-16 ES ES12711984T patent/ES2856825T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012128622A1 (en) | 2012-09-27 |
| EP2686421B1 (en) | 2020-12-23 |
| CA2830080A1 (en) | 2012-09-27 |
| US20140080148A1 (en) | 2014-03-20 |
| CA2830080C (en) | 2021-10-26 |
| ES2856825T3 (es) | 2021-09-28 |
| EP2686421A1 (en) | 2014-01-22 |
| US11118165B2 (en) | 2021-09-14 |
| PL2686421T3 (pl) | 2021-05-31 |
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