DK2686421T3 - Generering af nk-celler og nk-celleforløbere - Google Patents
Generering af nk-celler og nk-celleforløbere Download PDFInfo
- Publication number
- DK2686421T3 DK2686421T3 DK12711984.0T DK12711984T DK2686421T3 DK 2686421 T3 DK2686421 T3 DK 2686421T3 DK 12711984 T DK12711984 T DK 12711984T DK 2686421 T3 DK2686421 T3 DK 2686421T3
- Authority
- DK
- Denmark
- Prior art keywords
- cells
- generation
- cell procedures
- procedures
- cell
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 210000000822 natural killer cell Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL2011050193 | 2011-03-18 | ||
| EP11162866 | 2011-04-18 | ||
| PCT/NL2012/050165 WO2012128622A1 (en) | 2011-03-18 | 2012-03-16 | Generation of nk cells and nk-cell progenitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2686421T3 true DK2686421T3 (da) | 2021-03-08 |
Family
ID=45928983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12711984.0T DK2686421T3 (da) | 2011-03-18 | 2012-03-16 | Generering af nk-celler og nk-celleforløbere |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11118165B2 (da) |
| EP (1) | EP2686421B1 (da) |
| CA (1) | CA2830080C (da) |
| DK (1) | DK2686421T3 (da) |
| ES (1) | ES2856825T3 (da) |
| PL (1) | PL2686421T3 (da) |
| WO (1) | WO2012128622A1 (da) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114134113A (zh) * | 2012-08-13 | 2022-03-04 | 人类起源公司 | 自然杀伤细胞及其用途 |
| US9763983B2 (en) | 2013-02-05 | 2017-09-19 | Anthrogenesis Corporation | Natural killer cells from placenta |
| CN104509529A (zh) * | 2013-10-08 | 2015-04-15 | 康克韦斯特公司 | 用于储存和运输nk-92细胞系的方案和培养基 |
| WO2015054299A1 (en) * | 2013-10-08 | 2015-04-16 | Conkwest, Inc. | Protocol and media for storage and transport of nk-92 cell line |
| KR101697473B1 (ko) | 2014-11-26 | 2017-01-18 | 주식회사 녹십자랩셀 | T 세포를 이용한 자연살해세포의 배양방법 |
| IL258666B2 (en) * | 2015-10-15 | 2024-09-01 | Celularity Inc | Natural killer cells and ILC3 cells and their use |
| US20190032013A1 (en) * | 2016-01-29 | 2019-01-31 | Tract Therapeutics, Inc. | Immune cell selection, expansion, and use |
| JP2019519486A (ja) | 2016-05-07 | 2019-07-11 | セルラリティ インコーポレイテッド | ナチュラルキラー細胞を使用して急性骨髄性白血病および多発性骨髄腫を処置する方法 |
| GB201703476D0 (en) | 2017-03-03 | 2017-04-19 | Imp Innovations Ltd | Natural killer cells |
| GB201704953D0 (en) | 2017-03-28 | 2017-05-10 | Imp Innovations Ltd | Natural killer cells |
| JP6647240B2 (ja) | 2017-05-12 | 2020-02-14 | 米満 吉和 | 高活性ｎｋ細胞、およびその利用 |
| EP3633029A4 (en) | 2017-05-26 | 2021-06-09 | Green Cross Lab Cell Corporation | METHOD OF DEVELOPING A NATURAL KILLER CELL USING A T-CELL |
| US11446329B2 (en) * | 2017-11-01 | 2022-09-20 | Restem Llc | Natural killer cell adoptive transfer therapy for the elimination of senescent PBMCs, reduction of inflammatory cytokines and treatment of IBS |
| KR102265437B1 (ko) * | 2017-11-24 | 2021-06-15 | 의료법인 성광의료재단 | Nk 배양용 조성물 및 이를 이용하여 nk 세포를 배양하는 방법 |
| CA3089853A1 (en) | 2018-02-01 | 2019-08-08 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| CN108315299A (zh) * | 2018-02-13 | 2018-07-24 | 南京支云松生物科技有限公司 | 一种即用型异体nk细胞库网络储运应用系统 |
| WO2019182392A1 (ko) * | 2018-03-23 | 2019-09-26 | 주식회사 녹십자랩셀 | 자연살해세포의 제조방법 |
| GB201810486D0 (en) | 2018-06-26 | 2018-08-08 | Imperial Innovations Ltd | Natural killer cells |
| CN113383069B (zh) | 2018-11-14 | 2024-12-13 | Gc细胞治疗 | 使用转化的t细胞培养脐带血来源的自然杀伤细胞的方法 |
| AU2019456283B2 (en) | 2019-07-08 | 2023-06-08 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| WO2021015615A1 (en) * | 2019-07-22 | 2021-01-28 | Glycostem Therapeutics B.V. | Low density cell culture |
| EP4032972A4 (en) * | 2019-09-18 | 2024-07-24 | Slbigen Inc. | GENETICALLY MODIFIED NK CELL LINE TRANSDUCED WITH A GENE ENCODING A NEW CHIMERIC ANTIGEN RECEPTOR AND ITS USE |
| EP4114415A1 (en) | 2020-03-06 | 2023-01-11 | Sorrento Therapeutics, Inc. | Innate immunity killer cells targeting psma positive tumor cells |
| CN111286488B (zh) * | 2020-03-10 | 2021-04-02 | 河南侨创生命科技有限公司 | 一种自然杀伤细胞体外培养方法 |
| US11547726B2 (en) * | 2020-03-26 | 2023-01-10 | Honed Life Sciences, Llc | Enhancement of production of NK cells from stem cells |
| US12236422B2 (en) * | 2022-01-05 | 2025-02-25 | Mastercard International Incorporated | Computer-implemented methods and systems for authentic user-merchant association and services |
| GB202217507D0 (en) * | 2022-11-23 | 2023-01-04 | Imperial College Innovations Ltd | Natural killer cells |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1941027B1 (en) * | 2005-09-28 | 2014-08-20 | IPD-Therapeutics B.V. | Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics. |
| CN101506356A (zh) * | 2006-08-23 | 2009-08-12 | 比内克斯有限公司 | 用于免疫治疗的活化淋巴细胞的制备方法 |
| PL2142642T3 (pl) * | 2007-03-27 | 2017-10-31 | Ipd Therapeutics B V | Sposoby i środki do proliferacji komórek macierzystych oraz następczego wytwarzania i ekspansji komórek progenitorowych, jak również wytwarzania komórek efektorowych jako leków klinicznych |
| CA2785627C (en) | 2009-12-29 | 2020-02-18 | Gamida-Cell Ltd. | Methods for enhancing natural killer cell proliferation and activity |
| AU2010347018A1 (en) * | 2010-02-24 | 2012-09-20 | Ingo Schmidt-Wolf | Method for the generation of a CIK cell and NK cell population |
| KR20180086204A (ko) | 2015-11-05 | 2018-07-30 | 글리코스템 떼라퓨틱스 비.브이. | 면역치료법에 사용하기 위한 조성물 |
-
2012
- 2012-03-16 ES ES12711984T patent/ES2856825T3/es active Active
- 2012-03-16 EP EP12711984.0A patent/EP2686421B1/en active Active
- 2012-03-16 PL PL12711984T patent/PL2686421T3/pl unknown
- 2012-03-16 US US14/005,168 patent/US11118165B2/en active Active
- 2012-03-16 WO PCT/NL2012/050165 patent/WO2012128622A1/en not_active Ceased
- 2012-03-16 DK DK12711984.0T patent/DK2686421T3/da active
- 2012-03-16 CA CA2830080A patent/CA2830080C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012128622A1 (en) | 2012-09-27 |
| ES2856825T3 (es) | 2021-09-28 |
| EP2686421A1 (en) | 2014-01-22 |
| CA2830080C (en) | 2021-10-26 |
| US20140080148A1 (en) | 2014-03-20 |
| EP2686421B1 (en) | 2020-12-23 |
| US11118165B2 (en) | 2021-09-14 |
| PL2686421T3 (pl) | 2021-05-31 |
| CA2830080A1 (en) | 2012-09-27 |
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