DK2700708T3 - Forbedring af T-cellestimulerende evne for humane antigenpræsenterende celler in vitro og in vivo og anvendelse heraf i vaccination - Google Patents

Forbedring af T-cellestimulerende evne for humane antigenpræsenterende celler in vitro og in vivo og anvendelse heraf i vaccination Download PDF

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DK2700708T3
DK2700708T3 DK13181345.3T DK13181345T DK2700708T3 DK 2700708 T3 DK2700708 T3 DK 2700708T3 DK 13181345 T DK13181345 T DK 13181345T DK 2700708 T3 DK2700708 T3 DK 2700708T3
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cells
mrna
dcs
trimix
specific
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DK13181345.3T
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Kris Maria Magdalena Thielemans
Aude Bonehill
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Univ Brussel Vrije
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4242—Transcription factors, e.g. SOX or c-MYC
    • A61K40/4243—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/42—Cancer antigens
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    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/428—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C12N2510/00—Genetically modified cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Claims (6)

1. Vaccine, der omfatter ét eller flere mRNA- eller DNA-molekyler, der koder for samtlige af dc funktionelle immunstimulcrcndc proteiner CD40L, CD70 og caTLR4 (konstitutivt aktivt TLR4) til anvendelse i frembringelse af et immunrespons mod en tumor hos en person, kendetegnet ved, at vaccinen indgives via intratumoral injektion.
2. Vaccine til anvendelse ifølge krav 1, der endvidere omfatter et tumorantigen; eller RNA-eller DNA-molekyler, der koder for tumorantigenet.
3. Vaccine til anvendelse ifølge et hvilket som helst af kravene 1 til 2, hvor de mRNA- eller DNA-molekyler, der koder for de immunstimulerende proteiner, er en del af et enkelt mRNA-eller DNA-molekyle; og hvor det enkelte mRNA- eller DNA-molekyle kan udtrykke de immunstimulerende proteiner samtidigt.
4. Vaccine til anvendelse ifølge krav 3, hvor de mRNA- eller DNA-molekyler, der koder for de immunstimulerende proteiner, er frasepareret i det enkelte mRNA- eller DNA-molekyle af et internt ribosomindgangssted (IRES) eller en selvfraspaltelig 2a-peptidkodende sekvens.
5. Vaccine til anvendelse ifølge et hvilket som helst af kravene 1 til 4, der endvidere omfatter mRNA- eller DNA-molekyler, der koder for ét eller flere af proteinerne udvalgt fra gruppen bestående af: IL-12p70, CCR7 og 4-1 BBL.
6. Vaccine til anvendelse ifølge et hvilket som helst af kravene 1 til 5, hvor mRNA’et er beskyttet ved liposomindkapsling; protaminbeskyttelse; lipid-, kationiske eller polykationiske sammensætninger; boble-liposomation; polyethylenimin- (PEI) beskyttelse og/eller liposomladetmikroboblebeskyttelse.
DK13181345.3T 2012-08-23 2013-08-22 Forbedring af T-cellestimulerende evne for humane antigenpræsenterende celler in vitro og in vivo og anvendelse heraf i vaccination DK2700708T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13/593,393 US20130108663A1 (en) 2007-09-14 2012-08-23 Enhancing the t-cell stimulatory capacity of human antigen presenting cells in vitro and in vivo and their use in vaccination

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DK2700708T3 true DK2700708T3 (da) 2017-10-23

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DK13181345.3T DK2700708T3 (da) 2012-08-23 2013-08-22 Forbedring af T-cellestimulerende evne for humane antigenpræsenterende celler in vitro og in vivo og anvendelse heraf i vaccination

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US (1) US20130108663A1 (da)
EP (3) EP2700708B1 (da)
DK (1) DK2700708T3 (da)
ES (1) ES2643943T3 (da)
HU (1) HUE034907T2 (da)
PL (1) PL2700708T3 (da)
PT (1) PT2700708T (da)

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PT2922554T (pt) 2012-11-26 2022-06-28 Modernatx Inc Arn modificado nas porções terminais
EP3434774A1 (en) 2013-01-17 2019-01-30 ModernaTX, Inc. Signal-sensor polynucleotides for the alteration of cellular phenotypes
AU2016251687C1 (en) 2015-04-22 2023-07-27 CureVac SE RNA containing composition for treatment of tumor diseases
WO2016193300A1 (en) 2015-06-01 2016-12-08 Medigene Immunotherapies Gmbh Method for generating antibodies against t cell receptor
AU2016273213B2 (en) 2015-06-01 2019-03-14 Medigene Immunotherapies Gmbh T cell receptor library
EP3359670B2 (en) 2015-10-05 2024-02-14 ModernaTX, Inc. Methods for therapeutic administration of messenger ribonucleic acid drugs
TWI752930B (zh) * 2015-12-23 2022-01-21 德商梅迪基因免疫治療公司 抗原特異性ｔｃｒ的新生成
SMT202200310T1 (it) 2015-12-23 2022-09-14 Modernatx Inc Metodi di utilizzo dei polinucleotidi codificanti il ligando di ox40
KR20240144261A (ko) 2017-02-28 2024-10-02 사노피 치료적 rna
US12042527B2 (en) 2019-01-08 2024-07-23 Modernatx, Inc. Use of mRNAs encoding OX40L, IL-23 and IL-36gamma in combination with immune checkpoint blockade for treating particular cancers
US20220143161A1 (en) * 2019-03-13 2022-05-12 Etherna Immunotherapies Nv Mrna vaccine
US20220362360A1 (en) * 2019-04-26 2022-11-17 Etherna Immunotherapies Nv Mrna formulation
WO2020260685A1 (en) * 2019-06-27 2020-12-30 Etherna Immunotherapies Nv Combination therapy
BR112022015666A2 (pt) * 2020-02-14 2022-09-27 Etherna Immunotherapies Nv Vacinas intranasais de mrna
IL308310A (en) * 2021-05-10 2024-01-01 Nykode Therapeutics ASA Co-expression of immune-stimulating structures and compounds
CN114457117B (zh) * 2022-01-11 2023-06-02 深圳市珈钰生物科技有限公司 树突细胞肿瘤疫苗和其用途
CA3172967A1 (en) 2022-09-13 2024-03-13 Universite Laval Monoglycerol acrylate based polymer and uses thereof

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US20030099932A1 (en) * 1998-05-12 2003-05-29 Lorens James B. Retroviral vectors with separation sequences
US20030202963A1 (en) * 2000-10-12 2003-10-30 Cornell Research Foundation, Inc. Method of treating cancer
DE10162480A1 (de) * 2001-12-19 2003-08-07 Ingmar Hoerr Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
AU2003256240A1 (en) * 2002-08-29 2004-03-19 National University Of Singapore Recombinant nucleic acid useful for inducing protective immune response against allergens
DE10335833A1 (de) * 2003-08-05 2005-03-03 Curevac Gmbh Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie
PT2201100E (pt) * 2007-09-14 2016-06-03 Univ Brussel Vrije Aperfeiçoamento da capacidade estimulatória de células t das células que apresentam antígeno humano e o seu uso na vacinação

Also Published As

Publication number Publication date
EP3255143A3 (en) 2018-02-28
EP2700708A2 (en) 2014-02-26
EP3255143A2 (en) 2017-12-13
EP3255143A9 (en) 2018-11-14
ES2643943T3 (es) 2017-11-27
EP2700708A3 (en) 2014-04-16
PT2700708T (pt) 2017-10-25
EP3453754A1 (en) 2019-03-13
US20130108663A1 (en) 2013-05-02
HUE034907T2 (hu) 2018-03-28
PL2700708T3 (pl) 2018-01-31
EP2700708B1 (en) 2017-08-02

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