DK2756077T3 - ENDOGLYCOSIDASE FROM THE STREPTOCOCCUS PYOGENES AND METHODS OF USING IT - Google Patents

ENDOGLYCOSIDASE FROM THE STREPTOCOCCUS PYOGENES AND METHODS OF USING IT Download PDF

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Publication number
DK2756077T3
DK2756077T3 DK12756523.2T DK12756523T DK2756077T3 DK 2756077 T3 DK2756077 T3 DK 2756077T3 DK 12756523 T DK12756523 T DK 12756523T DK 2756077 T3 DK2756077 T3 DK 2756077T3
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asp
leu
thr
gly
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DK12756523.2T
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Danish (da)
English (en)
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Mattias Collin
Maria Allhorn
Jonathan Sjögren
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Genovis Ab
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01096Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/56944Streptococcus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK12756523.2T 2011-09-13 2012-09-12 ENDOGLYCOSIDASE FROM THE STREPTOCOCCUS PYOGENES AND METHODS OF USING IT DK2756077T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201115841A GB201115841D0 (en) 2011-09-13 2011-09-13 Protein and method
PCT/EP2012/067841 WO2013037824A1 (en) 2011-09-13 2012-09-12 Endoglycosidase from streptococcus pyogenes and methods using it

Publications (1)

Publication Number Publication Date
DK2756077T3 true DK2756077T3 (en) 2017-07-03

Family

ID=44908522

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12756523.2T DK2756077T3 (en) 2011-09-13 2012-09-12 ENDOGLYCOSIDASE FROM THE STREPTOCOCCUS PYOGENES AND METHODS OF USING IT

Country Status (20)

Country Link
US (1) US9493752B2 (2)
EP (1) EP2756077B1 (2)
JP (1) JP6076349B2 (2)
KR (1) KR102001427B1 (2)
CN (1) CN103946377B (2)
AU (1) AU2012307461B2 (2)
BR (1) BR112014005816A2 (2)
CA (1) CA2848230C (2)
DK (1) DK2756077T3 (2)
EA (1) EA028490B8 (2)
ES (1) ES2627334T3 (2)
GB (2) GB201115841D0 (2)
IL (1) IL231410A0 (2)
IN (1) IN2014CN02163A (2)
MX (1) MX347727B (2)
PL (1) PL2756077T3 (2)
PT (1) PT2756077T (2)
SG (1) SG11201400505YA (2)
WO (1) WO2013037824A1 (2)
ZA (1) ZA201401840B (2)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1343895B1 (en) * 2000-12-21 2008-06-18 ID Biomedical Corporation Streptococcus pyogenes antigens and corresponding dna fragments
FI2911699T4 (fi) 2012-10-23 2025-12-09 Synaffix Bv Muokattu vasta-aine, vasta-ainekonjugaatti ja menetelmä niiden valmistamiseksi
PL2991683T3 (pl) 2013-05-02 2020-03-31 Glykos Finland Oy Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem
EP3057618B1 (en) 2013-10-14 2022-12-14 SynAffix B.V. Glycoengineered antibody, antibody-conjugate and methods for their preparation
WO2015057066A1 (en) 2013-10-14 2015-04-23 Synaffix B.V. Glycoengineered antibody, antibody-conjugate and methods for their preparation
EP2935608A1 (en) 2013-10-14 2015-10-28 SynAffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
EP3058083B1 (en) 2013-10-14 2018-04-11 SynAffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
GB201318490D0 (en) * 2013-10-18 2013-12-04 Genovis Ab Method
CN106660967A (zh) 2014-01-24 2017-05-10 西纳福克斯股份有限公司 (杂)芳基1,3‑偶极化合物与(杂)环炔的环加成方法
EP3160513B1 (en) 2014-06-30 2020-02-12 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
GB201413240D0 (en) * 2014-07-25 2014-09-10 Hansa Medical Ab Method
EP3177633B1 (en) 2014-08-04 2022-07-20 SynAffix B.V. Process for the modification of a glycoprotein using a beta-(1,4)-n-acetylgalactosaminyltransferase or a mutant thereof
GB201502306D0 (en) * 2015-02-12 2015-04-01 Hansa Medical Ab Protein
GB201502305D0 (en) * 2015-02-12 2015-04-01 Hansa Medical Ab Protein
CN107810273B (zh) 2015-04-23 2022-09-27 西纳福克斯股份有限公司 用为或衍生自β-(1,4)-N-乙酰半乳糖胺转移酶的糖基转移酶修饰糖蛋白的方法
EP3402815B1 (en) 2016-01-15 2023-12-06 University of Maryland, College Park Endo-s2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins
ES2877754T3 (es) 2016-02-04 2021-11-17 Genovis Ab Nuevas proteasas estreptocócicas
WO2018039373A1 (en) * 2016-08-24 2018-03-01 Cho Pharma Inc Endoglycosidase mutants for glycoprotein remodeling and methods of using it
DK3630968T3 (da) 2017-05-26 2024-07-29 Genovis Ab Enzymer til glycananalyse
US20210228738A1 (en) 2017-07-17 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins
WO2019243672A1 (en) 2018-06-19 2019-12-26 Glykos Biomedical Oy Conjugate
US20210138080A1 (en) 2018-06-29 2021-05-13 Glykos Biomedical Oy Conjugates
US20230038373A1 (en) 2019-12-18 2023-02-09 Glykos Biomedical Oy Stabile conjugate
CN111044731B (zh) * 2019-12-19 2021-05-07 北京科技大学 脉冲温育免疫反应分离富集多肽药物中肽类杂质的方法
IL294321B1 (en) 2020-01-09 2026-04-01 Mersana Therapeutics Inc Antibody-drug conjugates are attached at a specific site with linkers that include peptides.
CN120078887A (zh) * 2020-09-21 2025-06-03 上海宝济药业股份有限公司 一种药物组合及其应用
JP2024501894A (ja) 2021-01-04 2024-01-16 メルサナ セラピューティクス インコーポレイテッド B7h4ターゲティング抗体-薬物コンジュゲートおよびその使用方法
EP4079848A1 (en) 2021-04-22 2022-10-26 Genovis Ab Immunoglobulin cleaving enzyme
CN115873833B (zh) * 2022-11-08 2024-08-16 上海泰昶生物技术有限公司 生产免疫球蛋白g降解酶的工程菌株和工艺
CN117165643B (zh) * 2023-08-17 2025-10-28 山东大学 一种糖苷内切酶在水解高甘露糖型n-糖蛋白中的应用
TW202519652A (zh) * 2023-11-10 2025-05-16 大陸商上海齊魯製藥研究中心有限公司 新型Endo S2突變體酶
TW202540414A (zh) * 2024-03-01 2025-10-16 大陸商上海齊魯製藥研究中心有限公司 新型Endo S2突變體酶
WO2025248500A1 (en) 2024-05-31 2025-12-04 Janssen Biotech, Inc. Antibody drug conjugates that target enpp3
GB202413764D0 (en) 2024-09-18 2024-10-30 Genovis Ab Immunoglobulin proteases and their uses

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GB0130228D0 (en) 2001-12-18 2002-02-06 Hansa Medica Ab Protein
GB0624874D0 (en) * 2006-12-13 2007-01-24 Hansa Medical Ab Treatment
CN102584989B (zh) * 2007-09-14 2015-05-13 季诺维斯公司 用于解离Fcgamma-受体-IgG复合物及纯化与检测IgG的方法和试剂盒
GB0821100D0 (en) 2008-11-18 2008-12-24 Hansa Medical Ab Antibodies
JP2013506404A (ja) 2009-10-02 2013-02-28 ロシュ グリクアート アーゲー 抗体における非フコシル化の検出法

Also Published As

Publication number Publication date
CA2848230C (en) 2020-03-24
ZA201401840B (en) 2018-05-30
EP2756077B1 (en) 2017-03-29
GB2509284A (en) 2014-06-25
KR20140081813A (ko) 2014-07-01
IL231410A0 (en) 2014-04-30
PT2756077T (pt) 2017-06-21
CN103946377B (zh) 2016-10-05
IN2014CN02163A (2) 2015-05-29
ES2627334T3 (es) 2017-07-27
GB201115841D0 (en) 2011-10-26
EA028490B1 (ru) 2017-11-30
SG11201400505YA (en) 2014-04-28
JP6076349B2 (ja) 2017-02-08
US20140302519A1 (en) 2014-10-09
NZ622172A (en) 2016-04-29
AU2012307461B2 (en) 2016-08-18
JP2014531205A (ja) 2014-11-27
CA2848230A1 (en) 2013-03-21
CN103946377A (zh) 2014-07-23
WO2013037824A1 (en) 2013-03-21
MX2014002906A (es) 2014-10-17
GB201406321D0 (en) 2014-05-21
MX347727B (es) 2017-05-10
EP2756077A1 (en) 2014-07-23
AU2012307461A1 (en) 2014-03-27
PL2756077T3 (pl) 2017-09-29
BR112014005816A2 (pt) 2020-12-29
KR102001427B1 (ko) 2019-07-18
US9493752B2 (en) 2016-11-15
EA201490447A1 (ru) 2014-09-30
EA028490B8 (ru) 2018-01-31

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