DK2768986T3 - Plasma-mikrorna til detektionen af tidlig kolorektal cancer - Google Patents

Plasma-mikrorna til detektionen af tidlig kolorektal cancer Download PDF

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DK2768986T3
DK2768986T3 DK12852462.6T DK12852462T DK2768986T3 DK 2768986 T3 DK2768986 T3 DK 2768986T3 DK 12852462 T DK12852462 T DK 12852462T DK 2768986 T3 DK2768986 T3 DK 2768986T3
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colorectal
micrornas
plasma
sample
cancer
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DK12852462.6T
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I Cos Meritxell Gironella
Salvatella Juan Jose Lozano
I Garangou Antoni Castells
Maria Dolores Giraldez
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Hospital Clinic Barcelona
Centro De Investig Biomedica En Red De Enfermedades Hepaticas Y Digestivas Ciberehd
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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Claims (7)

1. Fremgangsmåde til at diagnosticere eller detektere kolorektal neoplasi hos et menneskeligt individ omfattende trinnene: a. at opnå en biologisk prøve valgt fra listen bestående af en plasmaprøve, en serumprøve og en blodprøve fra individet mistænkt for at lide af kolorektal neoplasi; b. at måle et overordnet ekspressionsmønster eller -niveau af en microRNA's biosignatur omfattende mindst microRNA miR15b opnået fra den/de biologisk(e) prøve(r) af individet; og c. at sammenligne det overordnede ekspressionsmønster af microRNA-biosignaturen fra den biologiske prøve af individet mistænkt for at lide af kolorektal neoplasi med det overordnede ekspressionsmønster af microRNA-biosignaturen fra en biologisk prøve af et normalt individ, hvor det normale individ er et sundt individ, som ikke lider af kolorektal neoplasi, og hvor overekspression af mindst miR15b indikerer kolorektal cancer.
2. Fremgangsmåden ifølge krav 1, yderligere omfattende analysen af mindst en af miR29a, miR19a, miR19b eller miR335 sammenlignet med ekspression fra det normale individ, hvor overekspression af miRNA miR15b i kombination med mindst en af miR29a, miR19a, miR19b eller miR335 indikerer kolorektal neoplasi.
3. Fremgangsmåden ifølge et hvilket som helst af kravene 1 eller 2, hvor fremgangsmåden er i stand til at detektere tidlig CRC (I-II) lige så akkurat som fremskreden CRC (stadie II-III), tumorer i højre side og læsioner i venstre side.
4. Fremgangsmåde til at stratificere en patient til en undergruppe i risiko for at lide af kolorektal neoplasi under anvendelse af fremgangsmåden ifølge et hvilket som helst af kravene 1 til 3.
5. Fremgangsmåde til at bestemme resistens over for eller modtagelighed for en kolorektal neoplasi terapeutisk plan under anvendelse af fremgangsmåden ifølge et hvilket som helst af kravene 1-3.
6. In v/fro-anvendelse af et kit til en diagnose af kolorektal neoplasi omfattende biomarkør-detekterende reagenser til at bestemme et differentieret ekspressionsniveau af mindst miR15b i en plasmaprøve, en serumprøve eller en blodprøve.
7. In v/fro-anvendelse af kittet ifølge krav 6, hvilket yderligere omfatter værktøjer, beholdere og reagenser nødvendige til at opnå prøver fra et individ valgt fra gruppen bestående afen plasmaprøve, en serumprøve eller en blodprøve.
DK12852462.6T 2011-10-21 2012-10-20 Plasma-mikrorna til detektionen af tidlig kolorektal cancer DK2768986T3 (da)

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US201161550148P 2011-10-21 2011-10-21
PCT/IB2012/003035 WO2013093635A2 (en) 2011-10-21 2012-10-20 Plasma micrornas for the detection of early colorectal cancer

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US (6) US20130102487A1 (da)
EP (2) EP2944700B1 (da)
JP (2) JP6159727B2 (da)
KR (2) KR101900872B1 (da)
CN (2) CN104651521B (da)
AU (1) AU2012356317B2 (da)
BR (2) BR122015004941B1 (da)
CA (1) CA2852850C (da)
DK (2) DK2768986T3 (da)
ES (2) ES2662401T3 (da)
HU (2) HUE035614T2 (da)
IN (1) IN2015DN01855A (da)
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NO (1) NO3051026T3 (da)
PL (2) PL2944700T3 (da)
PT (2) PT2944700T (da)
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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2628355B2 (ja) 1987-09-22 1997-07-09 バクスター、インターナショナル、インコーポレイテッド 生理学的測定装置のための光ファイバープローブコネクター
CA2825522A1 (en) 2011-01-26 2012-08-02 Cepheid Methods of detecting lung cancer
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
CN104781421B (zh) 2012-09-04 2020-06-05 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
ES2660989T3 (es) 2013-12-28 2018-03-27 Guardant Health, Inc. Métodos y sistemas para detectar variantes genéticas
WO2019217478A1 (en) * 2018-05-09 2019-11-14 Dermtech, Inc. Novel gene classifiers and uses thereof in autoimmune diseases
CA2939343A1 (en) 2014-02-18 2015-08-27 Baylor Research Institute Mir-320e and colorectal cancer
CN118813801A (zh) 2014-06-13 2024-10-22 东丽株式会社 大肠癌的检测试剂盒或装置以及检测方法
WO2016034715A2 (fr) * 2014-09-05 2016-03-10 Prestizia Methode de prediction de l'evolution clinique du cancer colorectal
CN104313142B (zh) * 2014-10-16 2016-02-03 上海交通大学医学院附属仁济医院 miRNA-30a作为标记分子在制备诊断试剂中的用途
CN104388541B (zh) * 2014-10-21 2017-07-04 复旦大学附属肿瘤医院 miR‑1914*和miR‑1915的用途
CN104372004B (zh) * 2014-12-04 2018-04-27 广东医学院 一个与心肌梗死易感相关的miR-27a基因单核苷酸多态位点的检测方法及其应用
WO2016144265A1 (en) * 2015-03-09 2016-09-15 Agency For Science, Technology And Research Method of determining the risk of developing breast cancer by detecting the expression levels of micrornas (mirnas)
EP3147370A1 (en) * 2015-09-28 2017-03-29 Rheinische Friedrich-Wilhelms-Universität Bonn Exosomal microrna in serum as an indicator for the activation of brown and beige fat tissue (bat)
SG11201805119QA (en) 2015-12-17 2018-07-30 Guardant Health Inc Methods to determine tumor gene copy number by analysis of cell-free dna
EP3529376A4 (en) * 2016-08-18 2020-08-12 Nham Tran BIOMARKERS FOR ORAL, PHARYNX AND THROAT CANCER
EP3327135A1 (en) * 2016-11-28 2018-05-30 Advanced Marker Discovery, S.L. In vitro method for identifying colorectal adenomas or colorectal cancer
CN106950370A (zh) * 2017-01-25 2017-07-14 上海市第十人民医院 血液微小核酸大肠癌诊断分子组合
CN107254522A (zh) * 2017-06-09 2017-10-17 中山大学附属第三医院 miR‑664a‑5p的检测试剂在制备肝癌诊断试剂/试剂盒中的应用
CN107236799B (zh) * 2017-06-15 2020-06-09 昆明医科大学第六附属医院 一种肾纤维化miRNA标记物
CN107326092B (zh) * 2017-08-25 2021-07-20 深圳市恩普电子技术有限公司 大肠癌相关的miRNA作为生物标志物的应用及大肠癌检测试剂盒
CN107746886B (zh) * 2017-09-11 2019-10-01 朱伟 一种与结直肠癌辅助诊断相关的血浆miRNA标志物及其应用
WO2019144183A1 (en) * 2018-01-23 2019-08-01 La Trobe University Biomarkers of colorectal cancer
CA3090785A1 (en) 2018-02-14 2019-08-22 John Daniel Dobak Iii Novel gene classifiers and uses thereof in non-melanoma skin cancers
CN110205367B (zh) * 2018-02-28 2022-06-21 伽蓝（集团）股份有限公司 一种筛选保护皮肤细胞端粒的活性物的方法
CN114438214B (zh) * 2018-06-27 2023-12-22 深圳华大生命科学研究院 结直肠癌肿瘤标志物及其检测方法与装置
CN109557311B (zh) * 2018-12-13 2022-02-15 中南大学湘雅医院 结直肠癌诊断标志物及结直肠癌的检测产品及其应用
KR102275465B1 (ko) * 2019-01-18 2021-07-09 사회복지법인 삼성생명공익재단 전이성 대장암 치료물질 스크리닝 방법
US20220145398A1 (en) * 2019-03-11 2022-05-12 The Chinese University Of Hong Kong Mirna markers for colorectal cancer
JP7727970B2 (ja) * 2019-07-15 2025-08-22 インスティテュ ディンベスティガシオンス ビオメディクス アウグスト ピ イ スニェール（イデイベーアーペーエセ） 結腸直腸癌および／またはその前癌段階の診断またはスクリーニングのための非侵襲的方法
CN110438227A (zh) * 2019-07-29 2019-11-12 广州中昱医学生物科技有限公司 miR-17-92在结直肠癌诊断中的用途
AU2020325690A1 (en) 2019-08-02 2022-03-03 Fundació De Recerca Clinic Barcelona-Institut D’Investigacions Biomèdiques August Pi I Sunyer CAR T-cells against BCMA for the treatment of Multiple myeloma
CN112080568A (zh) * 2020-09-27 2020-12-15 扬州大学 一种与湖羊肌肉细胞增殖相关的miRNA标志物及其检测引物和应用
WO2023032452A1 (ja) * 2021-08-31 2023-03-09 国立大学法人大阪大学 ２型糖尿病・大腸がんを検査する方法
US20230083456A1 (en) * 2021-09-08 2023-03-16 GeneGenieDx Corporation Compositions and methods for diagnosing colorectal cancer
CN113981096A (zh) * 2021-11-30 2022-01-28 无锡市疾病预防控制中心 一种用于诊断结直肠癌的血浆miRNA标志物及其应用
CN114672560B (zh) * 2022-01-12 2025-09-26 北京艾克伦医疗科技有限公司 通过外泌体miRNA标志物鉴定结直肠癌状态的检测试剂盒和方法
EP4526473A2 (en) 2022-05-20 2025-03-26 Novigenix SA Biomarkers for colorectal neoplasia
CN119144728B (zh) * 2024-11-19 2025-04-29 四川大学华西医院 原发性肝癌的MicroRNA标志物的引物、试剂盒和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
GB0415277D0 (en) * 2004-07-07 2004-08-11 Colonix Ltd Apparatus and method for sampling mucosal surfaces
US7939255B2 (en) 2006-07-03 2011-05-10 Catholic University Industry Academy Cooperation Foundation Diagnostic methods for colorectal cancer
US8343719B2 (en) * 2006-10-30 2013-01-01 Research Foundation Of State University Of New York Microrna as biomarker in cancer
US8252538B2 (en) 2006-11-01 2012-08-28 The Ohio State University MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma
WO2009059026A1 (en) * 2007-10-30 2009-05-07 Veridex, Llc Process for monitoring colorectal cancer
CN101424640B (zh) * 2007-11-02 2012-07-25 江苏命码生物科技有限公司 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法
WO2009111643A2 (en) * 2008-03-06 2009-09-11 Asuragen, Inc. Microrna markers for recurrence of colorectal cancer
MX2010012542A (es) * 2008-05-16 2010-12-21 Veridex Llc Metodos para evaluar el cancer colorrectal y composiciones para usar en el.
WO2010004562A2 (en) 2008-07-09 2010-01-14 Rosetta Genomics Ltd. Methods and compositions for detecting colorectal cancer
WO2010056337A2 (en) * 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
US9074206B2 (en) * 2008-11-13 2015-07-07 Fudan University Compositions and methods for micro-RNA expression profiling of colorectal cancer
WO2010126355A1 (en) * 2009-04-29 2010-11-04 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam Means and methods for counteracting, preventing and/or determining heart failure, or a risk of heart failure
EP2336353A1 (en) * 2009-12-17 2011-06-22 febit holding GmbH miRNA fingerprints in the diagnosis of diseases
US20100317533A1 (en) 2009-06-05 2010-12-16 British Columbia Cancer Agency Branch Biomarkers of cancer metastasis
WO2011012136A1 (en) 2009-07-28 2011-02-03 Exiqon A/S A method for classifying a human cell sample as cancerous
CN101988060A (zh) * 2009-07-30 2011-03-23 江苏命码生物科技有限公司 结直肠癌检测标记物及其检测方法、试剂盒和生物芯片
WO2011044541A2 (en) * 2009-10-09 2011-04-14 Baylor Research Institute Identification of micrornas (mirnas) in fecal samples as biomarkers for gastroenterological cancers
WO2011076142A1 (en) 2009-12-24 2011-06-30 Fudan University Compositions and methods for microrna expession profiling in plasma of colorectal cancer
WO2011076147A1 (en) 2009-12-24 2011-06-30 Fudan University Plasma-based micro-rna biomarkers and methods for early detection of colorectal cancer
US20140148348A1 (en) 2010-01-13 2014-05-29 Christine Kuslich Dectection of gastrointestinal disorders
CN102985563A (zh) * 2010-06-23 2013-03-20 香港中文大学 结肠直肠癌的微rna标志物

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RU2014120427A (ru) 2015-11-27
WO2013093635A2 (en) 2013-06-27
DK2944700T3 (da) 2018-01-22
IN2015DN01855A (da) 2015-07-10
CN104145024A (zh) 2014-11-12
KR20150036804A (ko) 2015-04-07
JP2014530619A (ja) 2014-11-20
CA2852850A1 (en) 2013-06-27
US20150087525A1 (en) 2015-03-26
WO2013093635A3 (en) 2013-09-06
RU2662975C1 (ru) 2018-07-31
HUE039522T2 (hu) 2019-01-28
US20130102487A1 (en) 2013-04-25
JP6203209B2 (ja) 2017-09-27
JP6159727B2 (ja) 2017-07-05
EP2944700A1 (en) 2015-11-18
KR20140097195A (ko) 2014-08-06
MX357550B (es) 2018-07-13
HUE035614T2 (en) 2018-05-28
PL2768986T3 (pl) 2018-12-31
BR112014009643A2 (pt) 2017-12-12
CN104651521A (zh) 2015-05-27
ES2662401T3 (es) 2018-04-06
EP2768986A2 (en) 2014-08-27
PL2944700T3 (pl) 2018-05-30
ES2688693T3 (es) 2018-11-06
EP2768986B1 (en) 2018-06-27
KR101900872B1 (ko) 2018-09-20
AU2012356317B2 (en) 2016-04-07
CN104651521B (zh) 2021-08-27
US20180355439A1 (en) 2018-12-13
RU2611189C2 (ru) 2017-02-21
BR122015004941B1 (pt) 2021-09-28
PT2768986T (pt) 2018-10-23
KR101912731B1 (ko) 2018-10-29
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