DK2804599T3 - Kombinationsterapi til behandling af kræft - Google Patents
Kombinationsterapi til behandling af kræft Download PDFInfo
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- DK2804599T3 DK2804599T3 DK13738179.4T DK13738179T DK2804599T3 DK 2804599 T3 DK2804599 T3 DK 2804599T3 DK 13738179 T DK13738179 T DK 13738179T DK 2804599 T3 DK2804599 T3 DK 2804599T3
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- Denmark
- Prior art keywords
- promoter
- cancer
- inhibitor
- melanin
- tyrosine
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- A—HUMAN NECESSITIES
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Claims (13)
1. Kombinationterapi omfattende: en tyrosinhydroxylaseinhibitor der er a-methyl-DL-tyrosin; en melaninpromotor der er melanotan II; en p450 3A4 promotor der er 5,5-diphenylhydantoin; og en leucinaminopeptidaseinhibitor der er rapamycin.
2. Tyrosinhydroxylaseinhibitor der er α-methyl-DL-tyrosin, til anvendelse til behandling af kræft i kombination med: en melaninpromotor der er melanotan II; en p450 3A4 promotor der er 5,5-diphenylhydantoin; og en leucinaminopeptidaseinhibitor der er rapamycin.
3. Melaninpromotor der er melanotan II, til anvendelse til behandling af kræft i kombination med: en tyrosinhydroxylaseinhibitor der er a-methyl-DL-tyrosin; en p450 3A4 promotor der er 5,5-diphenylhydantoin; og en leucinaminopeptidaseinhibitor der er rapamycin.
4. p450 3A4 promotor der er 5,5-diphenylhydantoin, til anvendelse til behandling af kræft i kombination med en tyrosinhydroxylaseinhibitor der er a-methyl-DL-tyrosin; en melaninpromotor der er melanotan II; og en leucinaminopeptidaseinhibitor der er rapamycin.
5. Leucinaminopeptidaseinhibitor der er rapamycin, til anvendelse til behandling af kræft i kombination med: en tyrosinhydroxylaseinhibitor der er a-methyl-DL-tyrosin; en melaninpromotor der er melanotan II; og en p450 3A4 promotor der er 5,5-diphenylhydantoin.
6. Tyrosinhydroxylaseinhibitoren, melaninpromotoren, p450 3A4 promotoren eller leucinaminopeptidaseinhibitoren til anvendelse ifølge et hvilket som helst af kravene 2-5, hvor kræften er valgt fra brystkræft, ikke-småcellet lungekræft, kræft i æggestokkene, livmoderhalskræft, kræft i bugspytkirtel, mavekræft, kræft i hjernen, leverkræft, testikel kræft, leukæmi eller lymfom.
7. Tyrosinhydroxylaseinhibitoren, melaninpromotoren, p450 3A4 promotoren eller leucinaminopeptidaseinhibitoren til anvendelse ifølge krav 6, hvor kræften er brystkræft.
8. Tyrosinhydroxylaseinhibitoren, melaninpromotoren, p450 3A4 promotoren eller leucinaminopeptidaseinhibitoren til anvendelse ifølge krav 6, hvor kræften er ikke-småcellet lungekræft.
9. Kombinationsteraien ifølge krav 1, endvidere omfattende D-leucin; eller tyrosinhydroxylaseinhibitoren, melaninpromotoren, p450 3A4 promotoren eller leucinaminopeptidaseinhibitoren til anvendelse ifølge et hvilket som helst af kravene 2-8, endvidere i kombination med D-leucin.
10. Kombinationsterapien ifølge krav 1 eller 9, endvidere omfattende en væksthormoninhibitor; eller tyrosinhydroxylaseinhibitoren, melaninpromotoren, p450 3A4 promotoren, eller leucinaminopeptidaseinhibitoren til anvendelse ifølge et hvilket som helst af kravene 2-9, endvidere i kombination med en væksthormoninhibitor.
11. Kombinationsterapien ifølge et hvilket som helst af kravene 1, 9 eller 10, endvidere omfattende melanin; eller tyrosinhydroxylaseinhibitoren, melaninpromotoren, p450 3A4 promotoren, eller leucinaminopeptidaseinhibitoren til anvendelse ifølge et hvilket som helst af kravene 2-10, endvidere i kombination med melanin.
12. Kombinationsterapien ifølge et hvilket som helst af kravene 1, 9-11; eller tyrosinhydroxylaseinhibitoren, melaninpromotoren, p450 3A4 promotoren eller leucinaminopeptidaseinhibitoren til anvendelse ifølge et hvilket som helst af kravene 2-11, hvor inhibitorerne og promotorerne er tilvejebragt i individuelle dosisformer.
13. Kombinationsterapien ifølge et hvilket som helst af kravene 1, 9-11; eller tyrosinhydroxylaseinhibitoren, melaninpromotoren, p450 3A4 promotoren eller leucinaminopeptidaseinhibitoren til anvendelse ifølge et hvilket som helst af kravene 2-11, hvor inhibitorerne og promotorerne er tilvejebragt i en enkelt dosisform.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| US201261587420P | 2012-01-17 | 2012-01-17 | |
| US13/371,076 US8481498B1 (en) | 2012-01-17 | 2012-02-10 | Pharmaceutical compositions and methods |
| US201261702994P | 2012-09-19 | 2012-09-19 | |
| PCT/US2013/021714 WO2013109610A1 (en) | 2012-01-17 | 2013-01-16 | Pharmaceutical compositions and methods |
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| DK2804599T3 true DK2804599T3 (da) | 2019-02-04 |
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| DK13738179.4T DK2804599T3 (da) | 2012-01-17 | 2013-01-16 | Kombinationsterapi til behandling af kræft |
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Families Citing this family (18)
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| PH12014501639B1 (en) * | 2012-01-17 | 2023-02-22 | Tyme Inc | Pharmaceutical compositions and methods |
| US20130183263A1 (en) | 2012-01-17 | 2013-07-18 | Steven Hoffman | Pharmaceutical compositions and methods |
| US10646552B2 (en) | 2012-01-17 | 2020-05-12 | Tyme, Inc. | Pharmaceutical compositions and methods |
| US10272068B2 (en) | 2012-01-17 | 2019-04-30 | Tyme, Inc. | Pharmaceutical compositions and methods |
| US9585841B2 (en) * | 2013-10-22 | 2017-03-07 | Tyme, Inc. | Tyrosine derivatives and compositions comprising them |
| US9724657B2 (en) | 2013-10-22 | 2017-08-08 | Tyme, Inc. | High-speed centrifugal mixing devices and methods of use |
| US9687528B2 (en) | 2014-12-23 | 2017-06-27 | Steven Hoffman | Transdermal formulations |
| AU2015371253B2 (en) * | 2014-12-23 | 2020-07-23 | Steven Hoffman | Transdermal formulations |
| EP3429583A1 (en) * | 2016-03-15 | 2019-01-23 | Tyme, Inc. | Pharmaceutical compositions for the treatment of cancer |
| CN109562116A (zh) * | 2016-05-18 | 2019-04-02 | 迪美公司 | 在癌症治疗中的双氢睾酮及双氢睾酮衍生物和促进剂 |
| JP2019537608A (ja) * | 2016-11-15 | 2019-12-26 | タイム，インコーポレーテッド | 癌の処置のための医薬組成物および方法 |
| AU2017368135A1 (en) * | 2016-11-30 | 2019-06-13 | Tyme, Inc. | Tyrosine derivatives and compositions comprising them |
| CN110769855A (zh) * | 2017-04-21 | 2020-02-07 | 史蒂文·霍夫曼 | 用于治疗视网膜病变的组合物和方法 |
| WO2020232227A1 (en) * | 2019-05-14 | 2020-11-19 | Tyme, Inc. | Compositions and methods for treating cancer |
| CN114599352A (zh) * | 2019-10-15 | 2022-06-07 | 迪美公司 | 用于治疗癌症的α-甲基-DL-酪氨酸烷基酯 |
| IL294803A (en) * | 2020-01-17 | 2022-09-01 | Tyme Inc | Tyrosine derivatives for modulating cancer |
| US10905698B1 (en) | 2020-05-14 | 2021-02-02 | Tyme, Inc. | Methods of treating SARS-COV-2 infections |
| CN116783212A (zh) * | 2020-12-02 | 2023-09-19 | 霍夫曼技术有限责任公司 | 用于调节非人哺乳动物中的癌症的组合物和方法 |
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| US5073541A (en) * | 1987-11-18 | 1991-12-17 | Administrators Of The Tulane Educational Fund | Treatment of small cell lung cancer with somatostatin analogs |
| DE3823735A1 (de) * | 1988-07-13 | 1989-03-02 | Ernst Hajek | Verwendung von d-leucin (rechtsdrehende (alpha)-amino-isocapronsaeure) als wirkstoff zur bekaempfung maligner tumoren des schleimhautepithels des gesamten intestinaltraktes einschliesslich pankreas und gallenblase |
| US5225435A (en) | 1990-05-18 | 1993-07-06 | Yale University | Soluble melanin |
| IT1291633B1 (it) | 1997-04-22 | 1999-01-11 | Pharmaconsult S A S | Uso dell'alfa-metil-p-tirosina per inibire la produzione di melanina nei melanociti dell'iride |
| NZ506839A (en) * | 1998-03-09 | 2003-05-30 | Zealand Pharma As | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
| CA2341903A1 (en) * | 1998-08-21 | 2000-03-02 | The Children's Medical Center Corporation | Use of melanin for inhibition of angiogenesis and macular degeneration |
| JP2002128304A (ja) | 2000-10-20 | 2002-05-09 | Nec Eng Ltd | 給紙装置 |
| JP5074661B2 (ja) * | 2002-12-26 | 2012-11-14 | 味の素株式会社 | 肝癌発生・進展抑制剤 |
| DE602005014442D1 (de) * | 2005-03-11 | 2009-06-25 | Gpc Biotech Ag | Antiproliferative Kombinations-Therapie mit Satraplatin oder JM118 und Docetaxel |
| EP2056808A4 (en) * | 2006-08-28 | 2009-12-23 | Univ California | Small molecule potentiator of hormonal therapy for breast cancer |
| JP5073541B2 (ja) | 2007-05-09 | 2012-11-14 | ルネサスエレクトロニクス株式会社 | 半導体記憶装置 |
| EP2190453A2 (en) * | 2007-09-11 | 2010-06-02 | Mondobiotech Laboratories AG | Use of trp6-triptorelin and d-leu6-leuprolide as therapeutic agents |
| US8110578B2 (en) * | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
| AU2011241175A1 (en) * | 2010-04-16 | 2012-11-29 | Davos Life Science Pte. Ltd. | Synergistic interaction of at least one Vitamin E component and tyrosinase inhibitors for dermatological applications |
| PH12014501639B1 (en) * | 2012-01-17 | 2023-02-22 | Tyme Inc | Pharmaceutical compositions and methods |
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