DK2807165T3 - Pyrimido[4,5-b]indol-derivater og anvendelse deraf i ekspansionen af hæmatopoietiske stamceller - Google Patents

Pyrimido[4,5-b]indol-derivater og anvendelse deraf i ekspansionen af hæmatopoietiske stamceller Download PDF

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Publication number
DK2807165T3
DK2807165T3 DK13740815.9T DK13740815T DK2807165T3 DK 2807165 T3 DK2807165 T3 DK 2807165T3 DK 13740815 T DK13740815 T DK 13740815T DK 2807165 T3 DK2807165 T3 DK 2807165T3
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hematopoitic
pyrimido
expansion
study cells
indol derivatives
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DK13740815.9T
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Guy Sauvageau
Yves Gareau
Rejean Ruel
Stéphane Gingras
Iman Fares
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Univ Montreal
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
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  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK13740815.9T 2012-01-27 2013-01-25 Pyrimido[4,5-b]indol-derivater og anvendelse deraf i ekspansionen af hæmatopoietiske stamceller DK2807165T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261591521P 2012-01-27 2012-01-27
PCT/CA2013/050052 WO2013110198A1 (en) 2012-01-27 2013-01-25 Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells

Publications (1)

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DK2807165T3 true DK2807165T3 (da) 2019-07-15

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Country Status (27)

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US (3) US9409906B2 (da)
EP (1) EP2807165B1 (da)
JP (1) JP6250556B2 (da)
KR (1) KR102098122B1 (da)
CN (1) CN104144931B (da)
AU (1) AU2013212457B2 (da)
BR (1) BR112014018524B1 (da)
CA (1) CA2862140C (da)
CY (1) CY1121799T1 (da)
DK (1) DK2807165T3 (da)
ES (1) ES2733946T3 (da)
FR (1) FR26C1003I1 (da)
HR (1) HRP20191189T1 (da)
HU (1) HUE044070T4 (da)
IL (1) IL233587B (da)
LT (2) LT2807165T (da)
NL (1) NL301363I2 (da)
NO (1) NO2026005I1 (da)
NZ (1) NZ627188A (da)
PL (1) PL2807165T3 (da)
PT (1) PT2807165T (da)
RS (1) RS59002B1 (da)
SG (1) SG11201404241SA (da)
SI (1) SI2807165T1 (da)
SM (1) SMT201900360T1 (da)
TR (1) TR201909582T4 (da)
WO (1) WO2013110198A1 (da)

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IL233587A0 (en) 2014-08-31
KR102098122B1 (ko) 2020-04-07
CA2862140C (en) 2020-04-21
HRP20191189T1 (hr) 2019-10-04
CY1121799T1 (el) 2020-07-31
NZ627188A (en) 2015-12-24
HK1203945A1 (en) 2015-11-06
SMT201900360T1 (it) 2019-07-11
LTPA2026503I1 (da) 2026-02-10
BR112014018524B1 (pt) 2023-03-28
HUE044070T2 (hu) 2019-09-30
KR20140121454A (ko) 2014-10-15
TR201909582T4 (tr) 2019-07-22
RS59002B1 (sr) 2019-08-30
FR26C1003I1 (fr) 2026-03-06
NO2026005I1 (no) 2026-01-21
AU2013212457A1 (en) 2014-09-18
PT2807165T (pt) 2019-07-12
US9409906B2 (en) 2016-08-09
AU2013212457B2 (en) 2017-02-16
BR112014018524A8 (pt) 2017-07-11
SG11201404241SA (en) 2014-08-28
WO2013110198A1 (en) 2013-08-01
US20170334904A1 (en) 2017-11-23
US10336747B2 (en) 2019-07-02
EP2807165A1 (en) 2014-12-03
PL2807165T3 (pl) 2019-09-30
JP2015504902A (ja) 2015-02-16
CN104144931B (zh) 2018-04-10
US20150011543A1 (en) 2015-01-08
EP2807165A4 (en) 2015-08-26
CA2862140A1 (en) 2013-08-01
LT2807165T (lt) 2019-07-25
HUE044070T4 (hu) 2019-12-30
ES2733946T3 (es) 2019-12-03
SI2807165T1 (sl) 2019-08-30
US20160222017A1 (en) 2016-08-04
CN104144931A (zh) 2014-11-12
BR112014018524A2 (pt) 2021-06-08
EP2807165B1 (en) 2019-05-15
NL301363I2 (nl) 2026-02-19
IL233587B (en) 2019-11-28
JP6250556B2 (ja) 2017-12-20

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