DK2817519T3 - Fluidikmodul, indretning og fremgangsmåde til at pumpe en væske - Google Patents
Fluidikmodul, indretning og fremgangsmåde til at pumpe en væske Download PDFInfo
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- DK2817519T3 DK2817519T3 DK13705162.9T DK13705162T DK2817519T3 DK 2817519 T3 DK2817519 T3 DK 2817519T3 DK 13705162 T DK13705162 T DK 13705162T DK 2817519 T3 DK2817519 T3 DK 2817519T3
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- Prior art keywords
- fluid
- chamber
- compression chamber
- liquid
- fluid channel
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Links
- 239000012530 fluid Substances 0.000 title claims description 149
- 239000007788 liquid Substances 0.000 title claims description 84
- 238000005086 pumping Methods 0.000 title claims description 54
- 238000000034 method Methods 0.000 title claims description 31
- 230000006835 compression Effects 0.000 claims description 96
- 238000007906 compression Methods 0.000 claims description 96
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 230000000717 retained effect Effects 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 238000013022 venting Methods 0.000 description 6
- 230000001133 acceleration Effects 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 230000000630 rising effect Effects 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000011512 multiplexed immunoassay Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000011166 aliquoting Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000005184 irreversible process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010977 unit operation Methods 0.000 description 1
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04D—NON-POSITIVE-DISPLACEMENT PUMPS
- F04D17/00—Radial-flow pumps, e.g. centrifugal pumps; Helico-centrifugal pumps
- F04D17/08—Centrifugal pumps
- F04D17/10—Centrifugal pumps for compressing or evacuating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/71725—Feed mechanisms characterised by the means for feeding the components to the mixer using centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04F—PUMPING OF FLUID BY DIRECT CONTACT OF ANOTHER FLUID OR BY USING INERTIA OF FLUID TO BE PUMPED; SIPHONS
- F04F1/00—Pumps using positively or negatively pressurised fluid medium acting directly on the liquid to be pumped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0803—Disc shape
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Centrifugal Separators (AREA)
- Fluid-Pressure Circuits (AREA)
- Structures Of Non-Positive Displacement Pumps (AREA)
Claims (14)
1. Fluidikmodul (10; 50), der kan rotere om et rotationscenter (52), omfattende: et første kammer (60; 160), der omfatter et fluidudløb (66); et kompressionskammer (62; 162); et andet kammer (64; 164), der omfatter et fluidindløb (76); en første fluidkanal (68; 168) mellem fluidudløbet (66) i det første kammer (60; 160) og kompressionskammeret (62; 162); en anden fluidkanal (74; 174) mellem kompressionskammeret (62; 162) og fluidindløbet (76) i det andet kammer (64; 164), hvor en væske kan drives centrifugalt gennem den første fluidkanal fra det første kammer (62; 162) ind i kompressionskammeret (62; 162), hvor den anden fluidkanal (74; 174) omfatter mindst et parti, hvis begyndelse er beliggende længere udad radialt end dets ende, hvor et komprimerbart medium i kompressionskammeret (62; 162) ved rotation af fluidikmodulet (10; 50) kan holdes tilbage og komprimeres af en væske drevet fra det første kammer (60; 160) ind i kompressionskammeret (62; 162) af centifugalkraft, og hvor væske kan drives ind i det andet kammer (64; 164) fra kompressionskammeret (62; 162) gennem den anden fluidkanal (74; 174) ved en reduktion af rotationsfrekvensen og ved deraf følgende ekspansion af det komprimerbare medium, kendetegnet ved, at en strømningsmodstand i den anden fluidkanal (74; 174) for en strøm af væske fra kompressionskammeret (62; 162) til det andet kammer (64; 164) er mindre end en strømningsmodstand i den første fluidkanal (68; 168) for en strøm af væske fra kompressionskammeret (62; 162) til det første kammer (60).
2. Fluidikmodul (10; 50) ifølge krav 1, hvor et strømningstværsnit i den anden fluidkanal (74; 174) er større end et strømningstværsnit i den første fluidkanal (68; 168).
3. Fluidikmodul ifølge et af kravene 1 eller 2, hvor fluidindløbet (76) i det andet kammer (64; 164) er beliggende længere indad radialt end fluidudløbet (66) i det første kammer.
4. Fluidikmodul ifølge krav 3, hvor hele det andet kammer (64; 164) er beliggende længere indad radialt end det første kammer (60; 160).
5. Fluidikmodul ifølge et af kravene 1 eller 2, hvor den anden fluidkanal omfatter en sifon.
6. Fluidikmodul ifølge et hvilket som helst af kravene 1 til 5, hvor kompressionskammeret (62) omfatter et fluidindløb (70) og et fluidudløb (72), hvor den første fluidkanal (68) forbinder fluidudløbet (66) i det første kammer (60) med fluidindløbet (70) i kompressionskammeret (62), og den anden fluidkanal (74) forbinder fluidudløbet (72) i kompressionskammeret (62) med fluidindløbet (76) i det andet kammer (64).
7. Fluidikmodul ifølge et hvilket som helst af kravene 1 til 6, hvor kompressionskammeret (162) omfatter en fluidåbning (163), der er fluidisk forbundet med et kanalafsnit (165), som den første fluidkanal (168) og den anden fluidkanal (174) fører ind i.
8. Fluidikmodul ifølge et hvilket som helst af kravene 1 til 7, hvor den første fluidkanal (68; 168) omfatter en ventil, der repræsenterer en lavere strømningsmodstand for en strøm af fluid fra det første kammer (60; 160) til kompressionskammeret (62; 162) end i den modsatte retning.
9. Indretning til at pumpe en væske, omfattende: et fluidikmodul (10; 50) ifølge et hvilket som helst af kravene 1 til 8, et drev (20), der er indrettet til: at udsætte fluidikmodulet (10; 50) for sådan en rotationsfrekvens i en første fase, at væske drives fra det første kammer (60; 160) gennem den første fluidkanal (68; 168) ind i kompressionskammeret (62; 162), hvor et komprimerbart medium således holdes tilbage og komprime-res, hvor fyldningsniveauer af væsken i den første fluidkanal (68; 168), kompressionskammeret (62; 162) og den anden fluidkanal (74; 174) indtager en tilstand af ligevægt; og at reducere rotationsfrekvensen i en anden fase således, at det komprimerbare medium i kompressionskammeret (62; 162) vil ekspandere og derved drive væske fra kompressionskammeret (62; 162) gennem den anden fluidkanal ind i det andet kammer.
10. Indretning ifølge krav 9, der endvidere omfatter et organ til at støtte ekspansion af det komprimerbare medium efter reduktion af rotationsfrekvensen.
11. Indretning ifølge krav 10, hvor organet til at støtte omfatter mindst en af en trykkilde til at frembringe et tryk i kompressionskammeret (62; 162), en varmekilde til at opvarme det komprimerbare medium og et organ til at fremkalde gasudvikling som følge af kemiske reaktioner.
12. Fremgangsmåde til at pumpe en væske, omfattende: at indføre en væske i det første kammer (60; 160) af et fluidikmodul (10; 50) ifølge et hvilket som helst af kravene 1 til 8; at udsætte fluidikmodulet (10; 50) for en rotationsfrekvens for at drive væske fra det første kammer (60; 160) gennem den første fluidkanal (68; 168) ind i kompressionskammeret (62; 162), hvor det komprimerbare medium holdes tilbage og komprimeres i kompressionskammeret (62; 162), og fyldningsniveauer af væsken i den første fluidkanal (68; 168), kompressionskammeret (62; 162) og den anden fluidkanal (74; 174) indtager en tilstand af ligevægt; og at reducere rotationsfrekvensen, hvor det komprimerbare medium i kompressionskammeret (62; 162) ekspanderer, og væske derved drives fra kompressionskammeret gennem den anden fluidkanal (74; 174) ind i det andet kammer.
13. Fremgangsmåde ifølge krav 12, der endvidere omfatter at støtte ekspansionen af det komprimerbare medium efter reduktion af rotationsfrekvensen.
14. Fremgangsmåde ifølge krav 13, hvor støtten omfatter mindst en af udsættelse af det komprimerbare medium for et tryk, opvarmning af det komprimerbare medium og fremkaldelse af gasudvikling i kompressionskammeret.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102012202775.0A DE102012202775B4 (de) | 2012-02-23 | 2012-02-23 | Fluidikmodul, vorrichtung und verfahren zum pumpen einer flüssigkeit |
| PCT/EP2013/053243 WO2013124258A1 (en) | 2012-02-23 | 2013-02-19 | Fluidics module, device and method for pumping a liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2817519T3 true DK2817519T3 (da) | 2016-10-10 |
Family
ID=47740950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13705162.9T DK2817519T3 (da) | 2012-02-23 | 2013-02-19 | Fluidikmodul, indretning og fremgangsmåde til at pumpe en væske |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10001125B2 (da) |
| EP (1) | EP2817519B1 (da) |
| CN (1) | CN104169590B (da) |
| DE (1) | DE102012202775B4 (da) |
| DK (1) | DK2817519T3 (da) |
| ES (1) | ES2585397T3 (da) |
| IN (1) | IN2014KN01672A (da) |
| PL (1) | PL2817519T3 (da) |
| WO (1) | WO2013124258A1 (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012131598A1 (en) | 2011-03-28 | 2012-10-04 | Biosurfit, S.A. | Liquid switching, dosing and pumping |
| DE102012202775B4 (de) * | 2012-02-23 | 2016-08-25 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Fluidikmodul, vorrichtung und verfahren zum pumpen einer flüssigkeit |
| DE102013218978B3 (de) * | 2013-09-20 | 2014-11-06 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Vorrichtung und Verfahren, die Rückschlüsse über die Viskosität einer Probe ermöglichen |
| DE102013219929B4 (de) | 2013-10-01 | 2015-07-30 | Albert-Ludwigs-Universität Freiburg | Fluidikmodul, Vorrichtung und Verfahren zum Aliquotieren einer Flüssigkeit |
| DE102013220064B3 (de) * | 2013-10-02 | 2014-12-24 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Vorrichtung und verfahren zum bewegen einer festphase in eine mehrzahl von kammern |
| EP2952257A1 (en) * | 2014-06-06 | 2015-12-09 | Roche Diagnostics GmbH | Rotatable cartridge for processing and analyzing a biological sample |
| DE102014211121A1 (de) | 2014-06-11 | 2015-12-17 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Fluidikmodul, vorrichtung und verfahren zum handhaben von flüssigkeit |
| CN105675894B (zh) * | 2014-11-20 | 2017-10-20 | 绍兴普施康生物科技有限公司 | 气体式微流体检测装置及其运作方法 |
| DE212016000165U1 (de) * | 2015-08-07 | 2018-04-16 | Poc Medical Systems Inc. | Mikrofluidikvorrichtungen |
| CN107427829A (zh) | 2015-12-16 | 2017-12-01 | 拜奥塞菲特公司 | 用于处理液体的方法和装置 |
| DE102016207845B4 (de) | 2016-05-06 | 2018-04-12 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Fluidhandhabungsvorrichtung und Verfahren zur Fluidhandhabung |
| CN105842468B (zh) * | 2016-05-13 | 2017-12-22 | 绍兴普施康生物科技有限公司 | 一种微流控化学发光免疫检测装置及其使用方法 |
| DE102016208972A1 (de) * | 2016-05-24 | 2017-11-30 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Fluidikmodul, Vorrichtung und Verfahren zum biochemischen Prozessieren einer Flüssigkeit unter Verwendung von mehreren Temperaturzonen |
| CN107949437A (zh) * | 2016-06-09 | 2018-04-20 | 拜奥塞菲特公司 | 用于旋转地驱动液流的液体处理装置及使用该装置的方法 |
| US10639635B2 (en) | 2016-10-07 | 2020-05-05 | Biosurfit, SA | Device and method for handling liquid |
| US9909975B1 (en) | 2016-10-07 | 2018-03-06 | Biosurfit, S.A. | Device for rotation about an axis of rotation to drive liquid flow within the device comprising a first element, a second element and the radially outer wall of a cavity define a detection chamber |
| DE102016121764B4 (de) * | 2016-11-14 | 2026-02-12 | Testo SE & Co. KGaA | Mikrofluidische Verarbeitungskammer, Testträger und zugehöriges Verfahren zur Prozessierung einer Flüssigkeit in einem Testträger |
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| DE102017204002B4 (de) * | 2017-03-10 | 2019-05-23 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Zentrifugo-pneumatisches schalten von flüssigkeit |
| CN107796933A (zh) * | 2017-10-10 | 2018-03-13 | 绍兴普施康生物科技有限公司 | 微流控离心盘片及凝血检测方法 |
| IT201800006083A1 (it) | 2018-06-06 | 2019-12-06 | Dispositivo microfluidico per la concentrazione di particelle tramite centrifugazione, e relativo dispositivo di centrifugazione e/o rilevazione | |
| CA3133632A1 (en) | 2019-03-19 | 2020-09-24 | Monika Ursula Helga Bruggemann | Means and methods for accurately assessing clonal immunoglobulin (ig)/t cell receptor (tr) gene rearrangements. |
| CN109946469B (zh) * | 2019-04-11 | 2024-03-26 | 石家庄禾柏生物技术股份有限公司 | 一种向碟片中心方向输送液体的装置 |
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2012
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2013
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- 2013-02-19 IN IN1672KON2014 patent/IN2014KN01672A/en unknown
- 2013-02-19 ES ES13705162.9T patent/ES2585397T3/es active Active
- 2013-02-19 PL PL13705162T patent/PL2817519T3/pl unknown
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|---|---|
| US20140356129A1 (en) | 2014-12-04 |
| US10563656B2 (en) | 2020-02-18 |
| US20180291912A1 (en) | 2018-10-11 |
| EP2817519A1 (en) | 2014-12-31 |
| DE102012202775B4 (de) | 2016-08-25 |
| PL2817519T3 (pl) | 2017-02-28 |
| CN104169590B (zh) | 2016-06-01 |
| ES2585397T3 (es) | 2016-10-05 |
| IN2014KN01672A (da) | 2015-10-23 |
| DE102012202775A1 (de) | 2013-08-29 |
| WO2013124258A1 (en) | 2013-08-29 |
| EP2817519B1 (en) | 2016-07-13 |
| US10001125B2 (en) | 2018-06-19 |
| CN104169590A (zh) | 2014-11-26 |
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