DK2822947T3 - Argininsalte af en tlr-7-agonist - Google Patents
Argininsalte af en tlr-7-agonist Download PDFInfo
- Publication number
- DK2822947T3 DK2822947T3 DK13708142.8T DK13708142T DK2822947T3 DK 2822947 T3 DK2822947 T3 DK 2822947T3 DK 13708142 T DK13708142 T DK 13708142T DK 2822947 T3 DK2822947 T3 DK 2822947T3
- Authority
- DK
- Denmark
- Prior art keywords
- salt
- arginine
- compound
- formula
- immunogen
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (15)
1. Argininsalt af 3-(5-amino-2-(2-methyl-4-(2-(2-(2- phosphonoethoxy)ethoxy)ethoxy)phenethyl)benzo[f][l,7]naphthyridin-8-yl)propionsyre.
2. Salt ifølge krav 1, hvor saltet har en 1:1 støkiometri af arginin til 3-(5-amino-2-(2-methyl-4-(2-(2-(2- phosphonoethoxy)ethoxy)ethoxy)phenethyl)benzo[f][l,7]naphthyridin-8-yl)propionsyre.
3. Salt ifølge et hvilket som helst af krav 1 til 2, hvor argininsaltet er et L-argininsalt.
4. Salt ifølge et hvilket som helst af krav 1 til 3, hvor saltet er hydreret.
5. Salt ifølge et hvilket som helst af krav 1 til 4, hvor saltet er et monohydrat.
6. Salt ifølge et hvilket som helst af krav 1 til 5, hvor saltet er et i alt væsentligt amorft fast stof.
7. Salt ifølge et hvilket som helst af krav 1 til 6 til anvendelse i terapi.
8. Anvendelse af saltet ifølge et hvilket som helst af krav 1 til 6 til fremstilling af et lægemiddel til anvendelse i terapi.
9. Salt til anvendelse eller anvendelse af et salt ifølge et hvilket som helst af krav 7 eller 8, hvor terapien er en fremgangsmåde til at rejse et immunrespons hos et subjekt.
10. Fremgangsmåde til fremstilling af argininsaltet ifølge et hvilket som helst af krav 1 til 6, omfattende trinnet af at bringe 3-(5-amino-2-(2-methyl-4-(2-(2-(2-phosphonoethoxy)ethoxy)ethoxy)phenethyl)benzo[f][l,7]naphthyridin-8-yl)propionsyre i kontakt med arginin i en solvent.
11. Sammensætning omfattende et argininsalt af 3-(5-amino-2-(2-methyl-4-(2-(2-(2-phosphonoethoxy)ethoxy)ethoxy)phenethyl)benzo[f][l,7]naphthyridin-8-yl)propionsyre og et uopløseligt metalsalt.
12. Sammensætning ifølge krav 11, yderligere omfattende et immunogen.
13. Sammensætning ifølge krav 12, hvor immunogenet er et overfladepolypeptid
14. Sammensætning ifølge krav 12, hvor immunogenet frembringer et immunrespons, som beskytter mod en virologisk sygdom, en bakteriel sygdom, en mykotisk sygdom, en parasitær sygdom, en auto-immun sygdom eller en tumor.
15. Fremgangsmåde til at fremstille et adjuvanskompleks, omfattende et trin med at blande et argininsalt af 3-(5-amino-2-(2-methyl-4-(2-(2-(2- phosphonoethoxy)ethoxy)ethoxy)phenethyl)benzo[f][l,7]naphthyridin-8-yl)propionsyre med et uopløseligt metalsalt, således at syren adsorberer til det uopløselige metalsalt for at danne komplekset.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261608011P | 2012-03-07 | 2012-03-07 | |
| PCT/EP2013/054548 WO2013131985A1 (en) | 2012-03-07 | 2013-03-07 | Immunologically useful arginine salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2822947T3 true DK2822947T3 (da) | 2016-09-19 |
Family
ID=47843276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13708142.8T DK2822947T3 (da) | 2012-03-07 | 2013-03-07 | Argininsalte af en tlr-7-agonist |
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| EP (1) | EP2822947B1 (da) |
| JP (1) | JP6325986B2 (da) |
| CN (1) | CN104203946B (da) |
| AU (1) | AU2013229466A1 (da) |
| CA (1) | CA2865759C (da) |
| CY (1) | CY1118091T1 (da) |
| DK (1) | DK2822947T3 (da) |
| ES (1) | ES2597755T3 (da) |
| HR (1) | HRP20161354T1 (da) |
| HU (1) | HUE030175T2 (da) |
| LT (1) | LT2822947T (da) |
| MX (1) | MX346678B (da) |
| PL (1) | PL2822947T3 (da) |
| PT (1) | PT2822947T (da) |
| RU (1) | RU2014140336A (da) |
| SI (1) | SI2822947T1 (da) |
| WO (1) | WO2013131985A1 (da) |
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| AU2010290896B2 (en) | 2009-09-02 | 2014-07-03 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions including TLR activity modulators |
| MX343914B (es) | 2010-09-01 | 2016-11-18 | Glaxosmithkline Biologicals Sa | Adsorcion de inmunopotenciadores en sales metalicas insolubles. |
| US20140112950A1 (en) | 2011-03-02 | 2014-04-24 | Manmohan Singh | Combination vaccines with lower doses of antigen and/or adjuvant |
| JP6345603B2 (ja) | 2012-03-08 | 2018-06-20 | ノバルティス アーゲー | 追加免疫ワクチンのアジュバント化された処方物 |
| AU2015238512B2 (en) | 2014-03-26 | 2018-02-01 | Glaxosmithkline Biologicals S.A. | Mutant staphylococcal antigens |
| EP3061826A1 (en) | 2015-02-27 | 2016-08-31 | Novartis AG | Flavivirus replicons |
| WO2021178306A1 (en) * | 2020-03-01 | 2021-09-10 | Dynavax Technologies Corporation | Coronavirus vaccines comprising a tlr9 agonist |
| US20220280482A1 (en) * | 2021-03-06 | 2022-09-08 | Mind Medicine, Inc. | Formulations of psilocin that have enhanced stability |
| GB202215414D0 (en) | 2022-10-18 | 2022-11-30 | Glaxosmithkline Biologicals Sa | Vaccine |
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| US6699474B1 (en) | 1990-08-20 | 2004-03-02 | Erich Hugo Cerny | Vaccine and immunserum against drugs of abuse |
| EP0967279B1 (en) | 1992-03-02 | 2008-01-02 | Novartis Vaccines and Diagnostics S.r.l. | Helicobacter pylori cytotoxin useful for vaccines and diagnostics |
| FR2718452B1 (fr) | 1994-04-06 | 1996-06-28 | Pf Medicament | Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation. |
| DE69529219T2 (de) | 1994-07-01 | 2003-11-06 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Helicobacter proteine und impstoffe |
| GB2324093A (en) | 1996-01-04 | 1998-10-14 | Rican Limited | Helicobacter pylori bacterioferritin |
| GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
| CA2414884A1 (en) | 2000-07-03 | 2002-01-10 | Chiron S.P.A. | Immunisation against chlamydia pneumoniae |
| FR2827605B1 (fr) | 2001-07-20 | 2004-07-16 | Pf Medicament | Nouveaux peptides derives de la proteine g du vrs et leur utilisation dans un vaccin |
| EP2168596B1 (en) | 2001-12-12 | 2012-05-23 | Novartis Vaccines and Diagnostics S.r.l. | Immunisation against chlamydia trachomatis |
| GB0211118D0 (en) | 2002-05-15 | 2002-06-26 | Polonelli Luciano | Vaccines |
| CN1809380B (zh) | 2002-10-11 | 2010-05-12 | 启龙有限公司 | 广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 |
| CA2526106A1 (en) | 2003-06-26 | 2005-01-13 | Chiron Corporation | Immunogenic compositions for chlamydia trachomatis |
| BRPI0508365A (pt) | 2004-03-02 | 2007-07-24 | Chiron Corp | composições imunogênicas para chlamydia pneumoniae |
| SI2351772T1 (sl) | 2005-02-18 | 2016-11-30 | Glaxosmithkline Biologicals Sa | Proteini in nukleinske kisline iz Escherichia coli povezane z meningitisom/sepso |
| JP2008530245A (ja) | 2005-02-18 | 2008-08-07 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド | 尿路病原性菌株由来の抗原 |
| US8133973B2 (en) | 2005-05-12 | 2012-03-13 | Novartis Vaccines And Diagnostics, S.R.L. | Immunogenic compositions for Chlamydia trachomatis |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
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| EP2586790A3 (en) | 2006-08-16 | 2013-08-14 | Novartis AG | Immunogens from uropathogenic Escherichia coli |
| BR122016015627A2 (pt) | 2007-10-19 | 2018-10-30 | Novartis Ag | kit, composição antigênica liofilizada e método para preparação de uma composição imunogênica |
| NZ612315A (en) | 2009-04-14 | 2014-10-31 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| US8609106B2 (en) | 2009-06-01 | 2013-12-17 | Novartis Ag | Combinations of pneumococcal RrgB clades |
| CA2765112A1 (en) * | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
| JP2013502918A (ja) | 2009-08-27 | 2013-01-31 | ノバルティス アーゲー | 髄膜炎菌ｆＨＢＰ配列を含むハイブリッドポリペプチド |
| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
| AU2010290896B2 (en) * | 2009-09-02 | 2014-07-03 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions including TLR activity modulators |
| MX343914B (es) | 2010-09-01 | 2016-11-18 | Glaxosmithkline Biologicals Sa | Adsorcion de inmunopotenciadores en sales metalicas insolubles. |
| WO2012103421A1 (en) | 2011-01-27 | 2012-08-02 | Novartis Ag | Adjuvant nanoemulsions with crystallisation inhibitors |
| BR112014004782A2 (pt) * | 2011-09-01 | 2017-03-21 | Novartis Ag | formulações adjuvantes de antígenos de staphylococcus aureus |
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Also Published As
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| MX346678B (es) | 2017-03-29 |
| CA2865759C (en) | 2020-07-21 |
| SI2822947T1 (sl) | 2016-10-28 |
| HUE030175T2 (en) | 2017-04-28 |
| RU2014140336A (ru) | 2016-04-27 |
| HRP20161354T1 (hr) | 2016-12-02 |
| CN104203946B (zh) | 2017-03-22 |
| US9320748B2 (en) | 2016-04-26 |
| ES2597755T3 (es) | 2017-01-20 |
| EP2822947A1 (en) | 2015-01-14 |
| CA2865759A1 (en) | 2013-09-12 |
| CN104203946A (zh) | 2014-12-10 |
| US20150125475A1 (en) | 2015-05-07 |
| MX2014010423A (es) | 2014-09-22 |
| PT2822947T (pt) | 2016-09-26 |
| EP2822947B1 (en) | 2016-08-03 |
| JP6325986B2 (ja) | 2018-05-16 |
| CY1118091T1 (el) | 2017-06-28 |
| LT2822947T (lt) | 2016-10-10 |
| AU2013229466A1 (en) | 2014-09-04 |
| JP2015511957A (ja) | 2015-04-23 |
| PL2822947T3 (pl) | 2017-01-31 |
| WO2013131985A1 (en) | 2013-09-12 |
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