DK282786A - Ergolinderivater, fremgangsmaade til fremstilling deraf og forbindelser til anvendelse som mellemprodukter ved fremgangsmaaden samtfarmaceutiske praeparater - Google Patents

Ergolinderivater, fremgangsmaade til fremstilling deraf og forbindelser til anvendelse som mellemprodukter ved fremgangsmaaden samtfarmaceutiske praeparater Download PDF

Info

Publication number: DK282786A
Authority: DK; Denmark
Prior art keywords: sub; intermediates; relationships; procedures; production
Prior art date: 1985-06-19

Application number

DK282786A

Other languages

English (en)

Other versions

DK171117B1 (da

DK282786D0 (da

Inventor

Luigi Bernardi

Sergio Mantegani

Aldemio Temperilli

Gabriella Traquandi

Alessandro Rossi

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-19

Filing date

1986-06-17

Publication date

1986-12-20

1986-06-17 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1986-06-17 Publication of DK282786D0 publication Critical patent/DK282786D0/da

1986-12-20 Publication of DK282786A publication Critical patent/DK282786A/da

1996-06-17 Application granted granted Critical

1996-06-17 Publication of DK171117B1 publication Critical patent/DK171117B1/da

Links

AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title 2
239000000543 intermediate Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000004521 1,3,4-thiadiazol-2-yl group Chemical group S1C(=NN=C1)* 0.000 abstract 1
-1 2-thiazolyl Chemical group 0.000 abstract 1
239000004215 Carbon black (E152) Substances 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229930195733 hydrocarbon Natural products 0.000 abstract 1
150000002430 hydrocarbons Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 abstract 1
125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Emergency Protection Circuit Devices (AREA)
Control Of Electric Motors In General (AREA)
Diaphragms For Electromechanical Transducers (AREA)

DK282786A 1985-06-19 1986-06-17 Ergolinderivater, fremgangsmåde til fremstilling deraf, forbindelser til anvendelse som mellemprodukter ved fremgangsmåden samt farmaceutiske præparater indeholdende ergolinderivaterne DK171117B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB858515528A GB8515528D0 (en)	1985-06-19	1985-06-19	Ergoline derivatives
GB8515528		1985-06-19

Publications (3)

Publication Number	Publication Date
DK282786D0 DK282786D0 (da)	1986-06-17
DK282786A true DK282786A (da)	1986-12-20
DK171117B1 DK171117B1 (da)	1996-06-17

Family

ID=10580992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK282786A DK171117B1 (da)	1985-06-19	1986-06-17	Ergolinderivater, fremgangsmåde til fremstilling deraf, forbindelser til anvendelse som mellemprodukter ved fremgangsmåden samt farmaceutiske præparater indeholdende ergolinderivaterne

Country Status (19)

Country	Link
US (1)	US4746666A (da)
EP (1)	EP0206206B1 (da)
JP (1)	JPH0717639B2 (da)
KR (1)	KR920010074B1 (da)
AT (1)	ATE46510T1 (da)
AU (1)	AU584431B2 (da)
CA (1)	CA1285277C (da)
DE (2)	DE3665715D1 (da)
DK (1)	DK171117B1 (da)
ES (1)	ES8707247A1 (da)
FI (1)	FI83869C (da)
GB (1)	GB8515528D0 (da)
GR (1)	GR861538B (da)
HU (1)	HU196397B (da)
IE (1)	IE59020B1 (da)
IL (1)	IL79119A (da)
NZ (1)	NZ216545A (da)
PT (1)	PT82767B (da)
ZA (1)	ZA864481B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9006772D0 (en) *	1990-03-27	1990-05-23	Erba Carlo Spa	4-piperidinyl-ergoline derivatives
PT628042E (pt) *	1992-12-24	2002-01-30	Pharmacia & Upjohn Spa	Derivados de ergolina serotoninergicos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU92970A (en) *	1969-05-13	1978-02-28	Farmaceutici Italia	Process for preparing lumilysergic acid derivatives
DE2802023A1 (de) *	1977-01-28	1978-08-03	Sandoz Ag	Neue ergotderivate, ihre herstellung und verwendung
FI76085C (fi) *	1981-07-21	1988-09-09	Erba Farmitalia	Foerfarande foer framstaellning av ergolinderivat.
GB2112382B (en) *	1981-11-06	1985-03-06	Erba Farmitalia	Ergoline derivatives
EP0091652B1 (en) *	1982-04-13	1986-02-26	FARMITALIA CARLO ERBA S.p.A.	Ergoline derivatives, process for producing the ergoline derivatives and pharmaceutical compositions containing them
PH21123A (en) *	1983-04-28	1987-07-27	Erba Farmitalia	Ergoline derivatives
IT1173489B (it) *	1984-03-27	1987-06-24	Inverni Della Beffa Spa	Procedimento di preparazione di 1-metil-10alfa-metossilumilisergolo e di suci esteri,e intermedi per la loro preparazione
IT1213206B (it) *	1984-08-07	1989-12-14	Inverni Della Beffa Spa	Procedimento per la preparazione di derivati del lisergolo.

1985
- 1985-06-19 GB GB858515528A patent/GB8515528D0/en active Pending
1986
- 1986-06-03 ES ES555671A patent/ES8707247A1/es not_active Expired
- 1986-06-07 KR KR1019860004522A patent/KR920010074B1/ko not_active Expired
- 1986-06-13 GR GR861538A patent/GR861538B/el unknown
- 1986-06-16 PT PT82767A patent/PT82767B/pt not_active IP Right Cessation
- 1986-06-16 EP EP86108201A patent/EP0206206B1/en not_active Expired
- 1986-06-16 AT AT86108201T patent/ATE46510T1/de not_active IP Right Cessation
- 1986-06-16 AU AU58896/86A patent/AU584431B2/en not_active Ceased
- 1986-06-16 ZA ZA864481A patent/ZA864481B/xx unknown
- 1986-06-16 FI FI862561A patent/FI83869C/fi not_active IP Right Cessation
- 1986-06-16 DE DE8686108201T patent/DE3665715D1/de not_active Expired
- 1986-06-16 US US06/874,413 patent/US4746666A/en not_active Expired - Fee Related
- 1986-06-16 IL IL79119A patent/IL79119A/xx not_active IP Right Cessation
- 1986-06-16 DE DE198686108201T patent/DE206206T1/de active Pending
- 1986-06-16 NZ NZ216545A patent/NZ216545A/xx unknown
- 1986-06-17 JP JP61139413A patent/JPH0717639B2/ja not_active Expired - Lifetime
- 1986-06-17 DK DK282786A patent/DK171117B1/da not_active IP Right Cessation
- 1986-06-17 IE IE159986A patent/IE59020B1/en not_active IP Right Cessation
- 1986-06-17 HU HU862549A patent/HU196397B/hu not_active IP Right Cessation
- 1986-06-18 CA CA000511866A patent/CA1285277C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU5889686A (en)	1986-12-24
KR920010074B1 (ko)	1992-11-13
DE3665715D1 (en)	1989-10-26
IE59020B1 (en)	1993-12-15
IL79119A (en)	1989-06-30
NZ216545A (en)	1989-06-28
DE206206T1 (de)	1987-05-21
AU584431B2 (en)	1989-05-25
IE861599L (en)	1986-12-19
IL79119A0 (en)	1986-09-30
ES555671A0 (es)	1987-07-16
PT82767A (en)	1986-07-01
ES8707247A1 (es)	1987-07-16
JPS61291587A (ja)	1986-12-22
FI862561L (fi)	1986-12-20
HU196397B (en)	1988-11-28
GB8515528D0 (en)	1985-07-24
ZA864481B (en)	1987-02-25
EP0206206B1 (en)	1989-09-20
DK171117B1 (da)	1996-06-17
PT82767B (pt)	1989-01-17
US4746666A (en)	1988-05-24
FI83869C (fi)	1991-09-10
DK282786D0 (da)	1986-06-17
KR870000333A (ko)	1987-02-17
ATE46510T1 (de)	1989-10-15
CA1285277C (en)	1991-06-25
FI83869B (fi)	1991-05-31
EP0206206A1 (en)	1986-12-30
JPH0717639B2 (ja)	1995-03-01
FI862561A0 (fi)	1986-06-16
HUT41778A (en)	1987-05-28
GR861538B (en)	1986-10-14

Legal Events

Date	Code	Title	Description
1996-06-17	B1	Patent granted (law 1993)
1998-02-16	PBP	Patent lapsed

Publication	Publication Date	Title
AU554206B2 (en)	1986-08-14	1-alkyl-2-aminotetralin derivatives
AU599792B2 (en)	1990-07-26	Anti-parkinsonian indolone derivatives
ES8802053A1 (es)	1988-03-16	Un procedimiento para la preparacion de nuevas piranopiridinas
ES551005A0 (es)	1987-11-01	Un procedimiento para preparar derivados de tironina
IE890153L (en)	1989-07-20	Dideoxydidehydrocarbocylic nucleosides
AU4536389A (en)	1990-05-24	Anti-antherosclerotic diaryl compounds
ES2111352T3 (es)	1998-03-01	Uso de diester fosfato para el tratamiento de enfermedades retinianas.
ATE39482T1 (de)	1989-01-15	N-(1-ethyl-2-pyrrolidinylmethyl)-benzamidderivate, verfahren und zwischenprodukte zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen.
AU584431B2 (en)	1989-05-25	Ergoline derivatives
EP0272596A3 (en)	1990-03-28	Theophyllinemethyldithiolan and theophyllinemethyldithianyl derivates, a method for their preparation and pharmaceutical compositions in which they are included
ES2036539T3 (es)	1993-06-01	Un procedimiento para preparar derivados de ergolina.
DE69000806D1 (de)	1993-03-11	Indol-derivate.
FI860098A0 (fi)	1986-01-09	Nya piperazinderivat, foerfarande foer deras framstaellning och farmaceutiska kompositioner som innehaoller dessa foereningar som aktiv ingrediens.
IT8520150A0 (it)	1985-03-29	Nuovi derivati ad attivita'terapeutica, procedimento per laloro preparazione e relative composizioni farmaceutiche.