DK2845905T3 - Fremstilling af oligosaccharider - Google Patents
Fremstilling af oligosaccharider Download PDFInfo
- Publication number
- DK2845905T3 DK2845905T3 DK13183670.2T DK13183670T DK2845905T3 DK 2845905 T3 DK2845905 T3 DK 2845905T3 DK 13183670 T DK13183670 T DK 13183670T DK 2845905 T3 DK2845905 T3 DK 2845905T3
- Authority
- DK
- Denmark
- Prior art keywords
- oligosaccharides
- preparation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/20—Preparation of compounds containing saccharide radicals produced by the action of an exo-1,4 alpha-glucosidase, e.g. dextrose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/101—Plasmid DNA for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13183670.2A EP2845905B8 (en) | 2013-09-10 | 2013-09-10 | Production of oligosaccharides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2845905T3 true DK2845905T3 (da) | 2021-06-14 |
Family
ID=49117764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13183670.2T DK2845905T3 (da) | 2013-09-10 | 2013-09-10 | Fremstilling af oligosaccharider |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11427845B2 (da) |
| EP (3) | EP2845905B8 (da) |
| JP (3) | JP6894703B2 (da) |
| KR (1) | KR102335067B1 (da) |
| CN (5) | CN105722991A (da) |
| AU (1) | AU2014320757C1 (da) |
| BR (1) | BR112016005228A8 (da) |
| DK (1) | DK2845905T3 (da) |
| ES (1) | ES2875327T3 (da) |
| PL (1) | PL2845905T3 (da) |
| WO (1) | WO2015036138A1 (da) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2875327T3 (es) * | 2013-09-10 | 2021-11-10 | Chr Hansen Hmo Gmbh | Producción de oligosacáridos |
| PL2896628T3 (pl) | 2014-01-20 | 2019-03-29 | Jennewein Biotechnologie Gmbh | Sposób wydajnego oczyszczania obojętnych oligosacharydów ludzkiego mleka (HMO) z fermentacji mikrobiologicznej |
| WO2016157108A1 (en) * | 2015-03-31 | 2016-10-06 | Glycom A/S | Mixtures of human milk oligosaccharides comprising 3 '-o-sialyllactose |
| ES3011213T3 (en) | 2015-12-18 | 2025-04-07 | Glycom As | Fermentative production of oligosaccharides |
| US11312741B2 (en) | 2016-04-19 | 2022-04-26 | Glycom A/S | Separation of oligosaccharides from fermentation broth |
| US11419884B2 (en) | 2016-06-24 | 2022-08-23 | Glycom A/S | Compositions comprising HMOS, their production and use for the prevention and/or treatment of viral and/or bacterial infections |
| CN106190938B (zh) * | 2016-07-18 | 2019-05-14 | 南开大学 | 一种构建的重组大肠杆菌及生物合成3’-唾液乳糖的方法 |
| CA3030809A1 (en) | 2016-07-28 | 2018-02-01 | Fonterra Co-Operative Group Limited | Sialyloligosaccharide product and process |
| KR102593408B1 (ko) * | 2016-09-19 | 2023-10-25 | 프롤랙타 바이오사이언스, 인코포레이티드 | 정제된 인간 모유 올리고당 조성물 |
| ES2856749T3 (es) * | 2016-10-29 | 2021-09-28 | Chr Hansen Hmo Gmbh | Proceso para la producción de oligosacáridos fucosilados |
| FI3821712T3 (fi) | 2017-01-13 | 2023-01-13 | Parannetulla menetelmällä saatu hapatettu maitotuote | |
| JP2018140968A (ja) * | 2017-02-28 | 2018-09-13 | 日本食品化工株式会社 | １，６−アンヒドロ−β−Ｄ−グルコフラノース含有糖質の製造方法 |
| PL3375291T3 (pl) | 2017-03-17 | 2022-11-28 | Chr. Hansen HMO GmbH | Sposób hamowania izomeryzacji sacharydu redukującego po obróbce termicznej |
| EP3645545A4 (en) | 2017-06-30 | 2021-05-05 | Glycom A/S | PURIFICATION OF OLIGOSACCHARIDES |
| EP3425052A1 (en) | 2017-07-07 | 2019-01-09 | Jennewein Biotechnologie GmbH | Fucosyltransferases and their use in producing fucosylated oligosaccharides |
| CN119655445A (zh) | 2017-07-12 | 2025-03-21 | 格礼卡姆股份公司 | 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物 |
| ES3039971T3 (en) | 2017-12-08 | 2025-10-28 | Chr Hansen Hmo Gmbh | Spray-dried 3-fucosyllactose |
| BR112020011242A2 (pt) | 2017-12-08 | 2020-11-17 | Jennewein Biotechnologie Gmbh | mistura seca por pulverização de oligossacarídeos de leite humano |
| PL3494806T3 (pl) | 2017-12-08 | 2025-10-06 | Chr. Hansen HMO GmbH | Suszona rozpyłowo lakto-n-fukopentaoza |
| PL3494805T3 (pl) | 2017-12-08 | 2025-10-06 | Chr. Hansen HMO GmbH | Suszone rozpyłowo tetrasacharydy |
| EP3494807A1 (en) | 2017-12-11 | 2019-06-12 | Jennewein Biotechnologie GmbH | Spray-dried sialyllactose |
| DK3524067T3 (da) | 2018-02-08 | 2025-05-19 | Chr Hansen Hmo Gmbh | Spraytørret blanding af modermælksoligosaccharider |
| CN112074196A (zh) * | 2018-05-07 | 2020-12-11 | 詹尼温生物技术有限责任公司 | 从微生物发酵获得的碳水化合物中纯化乳-N-新四糖(LNnT)的简单方法 |
| EP3569713A1 (en) * | 2018-05-16 | 2019-11-20 | Jennewein Biotechnologie GmbH | Use of glycosidases in the production of oligosaccharides |
| BR112020023639A2 (pt) * | 2018-05-23 | 2021-02-17 | Dsm Ip Assets B.V. | produção de oligossacarídeos |
| US10519475B1 (en) * | 2018-11-21 | 2019-12-31 | Amyris, Inc. | Biosynthesis of compounds in yeast |
| PT3897902T (pt) * | 2018-12-19 | 2023-12-06 | Glycom As | Separação de oligossacáridos |
| CN109735479B (zh) * | 2019-01-30 | 2022-04-01 | 光明乳业股份有限公司 | 一种合成2’-岩藻糖基乳糖的重组枯草芽孢杆菌及其构建方法与应用 |
| WO2020235946A1 (ko) * | 2019-05-21 | 2020-11-26 | 고려대학교 산학협력단 | 알파- 및 베타-1,4-글리코시드 결합을 모두 절단하는 효소의 용도 |
| PL3979827T3 (pl) * | 2019-06-04 | 2024-01-15 | N.V. Nutricia | Kompozycja żywieniowa zawierająca 2'fukozylolaktozę i 3'galaktozylolaktozę |
| CN114615896A (zh) | 2019-09-04 | 2022-06-10 | 杜邦营养生物科学有限公司 | 从包含人乳寡糖和相关组合物的溶液中去除消泡剂的方法 |
| AU2020354581A1 (en) | 2019-09-24 | 2022-03-03 | Prolacta Bioscience, Inc. | Compositions and methods for treatment of inflammatory and immune diseases |
| CN115279778B (zh) | 2020-03-12 | 2025-06-24 | 格礼卡姆股份公司 | 2’-fl的结晶 |
| US12077788B2 (en) * | 2020-08-10 | 2024-09-03 | Inbiose N.V. | Production of a mixture of neutral non-fucosylated oligosaccharides by a cell |
| CN116171328A (zh) * | 2020-08-10 | 2023-05-26 | 因比奥斯公司 | 藉由细胞培养或微生物发酵产生的不同寡糖的纯化混合物的制造方法 |
| CA3188645A1 (en) | 2020-08-14 | 2022-02-17 | Prolacta Bioscience, Inc. | Human milk oligosaccharide compositions for use with bacteriotherapies |
| MX2023008227A (es) | 2021-01-12 | 2023-07-20 | Prolacta Bioscience Inc | Regimenes de tratamiento simbiotico. |
| DK181562B1 (en) | 2021-11-11 | 2024-05-17 | Dsm Ip Assets Bv | Feed control system for a fermentation system, and related method |
| DK181566B1 (en) | 2021-12-21 | 2024-05-24 | Dsm Ip Assets Bv | Crystallization of LNnT |
| CN114107342B (zh) * | 2021-12-27 | 2024-01-26 | 黄山同兮生物科技有限公司 | 一种去除发酵液中乳糖的方法 |
| KR102616020B1 (ko) | 2021-12-31 | 2023-12-22 | 매일유업 주식회사 | 모유 올리고당 혼합물을 유효성분으로 포함하는 장관면역 개선용, 장 염증 예방 또는 개선용 조성물 |
| CN116042562B (zh) * | 2022-03-11 | 2023-10-20 | 山东恒鲁生物科技有限公司 | 重组酵母菌及其应用 |
| CN115011535A (zh) * | 2022-05-10 | 2022-09-06 | 南通励成生物工程有限公司 | 一种以葡萄糖为碳源合成2’-岩藻糖基乳糖的菌株及其构建方法和应用 |
| KR20240002283A (ko) * | 2022-06-28 | 2024-01-05 | 주식회사 삼양사 | 2’-푸코실락토오스 제조방법 |
| EP4577061A1 (en) | 2022-08-25 | 2025-07-02 | DSM IP Assets B.V. | Hybrid method for producing complex hmos |
| EP4623089A1 (en) | 2022-11-25 | 2025-10-01 | DSM IP Assets B.V. | Two-strain system for producing oligosaccharides |
| WO2024130119A2 (en) | 2022-12-16 | 2024-06-20 | Prolacta Bioscience, Inc. | Synbiotic compositions for short chain fatty acid production |
| WO2025114343A2 (en) | 2023-11-29 | 2025-06-05 | Frieslandcampina Nederland B.V. | Process for the production of human milk oligosaccharides |
| WO2026104582A1 (en) | 2024-11-14 | 2026-05-21 | Chr. Hansen A/S | Process for the purification of human milk oligosaccharides using mutant alternative β-galactosidase enzymes |
| WO2026104581A1 (en) * | 2024-11-14 | 2026-05-21 | Chr. Hansen A/S | MUTANT β-GALACTOSIDASE ENZYMES FOR THE DEGRADATION OF LACTOBIONIC ACID |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5995895A (ja) * | 1982-11-22 | 1984-06-02 | Meiji Seika Kaisha Ltd | フラクトオリゴ糖の精製法 |
| JPS6391092A (ja) | 1986-10-07 | 1988-04-21 | Yakult Honsha Co Ltd | オリゴ糖の製造法 |
| JPH0695895A (ja) | 1990-11-19 | 1994-04-08 | Internatl Business Mach Corp <Ibm> | アプリケーシヨンプログラム装置及びその方法 |
| JPH05276969A (ja) * | 1992-04-03 | 1993-10-26 | Nippon Shinyaku Co Ltd | 高純度マルトオリゴ糖の製法 |
| JPH07274990A (ja) | 1994-04-15 | 1995-10-24 | Mitsubishi Kasei Eng Co | 環状イヌロオリゴ糖の精製方法 |
| JP3095643B2 (ja) * | 1994-11-17 | 2000-10-10 | 明治製菓株式会社 | 高濃度糖混合液からの高純度オリゴ糖類の製造法 |
| JP4238028B2 (ja) * | 2000-11-16 | 2009-03-11 | 株式会社林原生物化学研究所 | α−イソマルトシル転移酵素活性を有するポリペプチド |
| US20080145899A1 (en) * | 2004-09-17 | 2008-06-19 | Neose Technologies Inc | Production of Oligosaccharides By Microorganisms |
| ES2626080T3 (es) | 2007-04-16 | 2017-07-21 | Momenta Pharmaceuticals, Inc. | Caracterización de N-glicanos utilizando exoglicosidasas |
| KR100945306B1 (ko) | 2007-12-31 | 2010-03-03 | 주식회사 삼양제넥스 | 고순도 갈락토올리고당의 제조방법 |
| WO2009113030A2 (en) * | 2008-03-12 | 2009-09-17 | Tata Chemicals Ltd. | Process for the production of galactooligosaccharides by free cells |
| WO2010070104A1 (en) * | 2008-12-19 | 2010-06-24 | Jennewein Biotechnologie Gmbh | Synthesis of fucosylated compounds |
| MX2011013231A (es) * | 2009-06-08 | 2012-01-20 | Jennewein Biotechnologie Gmbh | Sintesis de hmo. |
| IT1395068B1 (it) * | 2009-08-07 | 2012-09-05 | Inalco Spa | Processo per la produzione di galatto-oligosaccaridi ultrapuri |
| CN101870992A (zh) * | 2010-06-21 | 2010-10-27 | 天津科技大学 | 利用基因工程菌耦合发酵合成gdp-岩藻糖的方法 |
| EP2439264B1 (en) | 2010-10-11 | 2015-06-03 | Jennewein Biotechnologie GmbH | Novel fucosyltransferases and their applications |
| EP2479263B1 (en) * | 2011-01-20 | 2013-11-27 | Jennewein Biotechnologie GmbH | Novel Fucosyltransferases and their applications |
| EP2675899A4 (en) * | 2011-02-16 | 2014-09-10 | Glycosyn LLC | BIOSYNTHESIS OF HUMAN MILK OLIGOSACCHARIDES IN MANIPULATED BACTERIA |
| BR112013029208A2 (pt) * | 2011-05-13 | 2017-02-14 | Glycom As | método para preparar um ou mais oligossarídeos de leite humano ou derivados ou precursores dos mesmos, uso de oligossacarídeos, e, composto |
| DK2728009T3 (da) * | 2012-10-31 | 2017-11-06 | Jennewein Biotechnologie Gmbh | Fremgangsmåde til fremstilling af monosaccharider |
| ES2875327T3 (es) * | 2013-09-10 | 2021-11-10 | Chr Hansen Hmo Gmbh | Producción de oligosacáridos |
-
2013
- 2013-09-10 ES ES13183670T patent/ES2875327T3/es active Active
- 2013-09-10 DK DK13183670.2T patent/DK2845905T3/da active
- 2013-09-10 EP EP13183670.2A patent/EP2845905B8/en active Active
- 2013-09-10 PL PL13183670T patent/PL2845905T3/pl unknown
- 2013-09-10 EP EP19184573.4A patent/EP3572520A1/en active Pending
- 2013-09-10 EP EP19184576.7A patent/EP3572521A1/en active Pending
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2014
- 2014-07-04 CN CN201480061563.XA patent/CN105722991A/zh active Pending
- 2014-07-04 CN CN201910957839.7A patent/CN110643658A/zh active Pending
- 2014-07-04 WO PCT/EP2014/064280 patent/WO2015036138A1/en not_active Ceased
- 2014-07-04 CN CN201910957609.0A patent/CN110628842A/zh active Pending
- 2014-07-04 CN CN202410094161.5A patent/CN118028397A/zh active Pending
- 2014-07-04 AU AU2014320757A patent/AU2014320757C1/en active Active
- 2014-07-04 KR KR1020167008748A patent/KR102335067B1/ko active Active
- 2014-07-04 BR BR112016005228A patent/BR112016005228A8/pt not_active Application Discontinuation
- 2014-07-04 JP JP2016541849A patent/JP6894703B2/ja active Active
- 2014-07-04 CN CN202410094021.8A patent/CN118028396A/zh active Pending
-
2016
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2019
- 2019-08-23 JP JP2019152702A patent/JP7389584B2/ja active Active
- 2019-08-23 JP JP2019152682A patent/JP6992029B2/ja active Active
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2022
- 2022-07-22 US US17/814,333 patent/US11981947B2/en active Active
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|---|---|
| PL2845905T3 (pl) | 2021-09-27 |
| EP3572521A1 (en) | 2019-11-27 |
| US20220389468A1 (en) | 2022-12-08 |
| BR112016005228A2 (da) | 2017-09-05 |
| CN118028397A (zh) | 2024-05-14 |
| CN110628842A (zh) | 2019-12-31 |
| EP2845905B1 (en) | 2021-05-19 |
| EP2845905A1 (en) | 2015-03-11 |
| JP2019213553A (ja) | 2019-12-19 |
| US20220403433A1 (en) | 2022-12-22 |
| JP2016530888A (ja) | 2016-10-06 |
| US20160186223A1 (en) | 2016-06-30 |
| JP7389584B2 (ja) | 2023-11-30 |
| EP2845905B8 (en) | 2021-07-14 |
| EP3572520A1 (en) | 2019-11-27 |
| WO2015036138A1 (en) | 2015-03-19 |
| KR102335067B1 (ko) | 2021-12-03 |
| KR20160065111A (ko) | 2016-06-08 |
| AU2014320757B2 (en) | 2018-04-19 |
| BR112016005228A8 (pt) | 2022-11-08 |
| CN110643658A (zh) | 2020-01-03 |
| US11981947B2 (en) | 2024-05-14 |
| US12123040B2 (en) | 2024-10-22 |
| ES2875327T3 (es) | 2021-11-10 |
| CN118028396A (zh) | 2024-05-14 |
| AU2014320757C1 (en) | 2018-07-19 |
| JP6894703B2 (ja) | 2021-06-30 |
| CN105722991A (zh) | 2016-06-29 |
| US11427845B2 (en) | 2022-08-30 |
| JP2019213552A (ja) | 2019-12-19 |
| AU2014320757A1 (en) | 2016-04-28 |
| JP6992029B2 (ja) | 2022-01-13 |
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