DK2851084T3 - Modulation af Vps10p-domæne-receptorer til behandlingen af kardiovaskulær sygdom - Google Patents

Modulation af Vps10p-domæne-receptorer til behandlingen af kardiovaskulær sygdom Download PDF

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DK2851084T3
DK2851084T3 DK14192407.6T DK14192407T DK2851084T3 DK 2851084 T3 DK2851084 T3 DK 2851084T3 DK 14192407 T DK14192407 T DK 14192407T DK 2851084 T3 DK2851084 T3 DK 2851084T3
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Anders Nykjaer
Mads Fuglsang Kjølby
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H Lundbeck As
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Claims (8)

  1. J.
    1. Antistof til anvendelse i en fremgangsmåde til behandling og/eller forebyggelse af abnorme plasma-lipidkoncentrationer hos et dyr, hvor nævnte antistof er en antagonist og nævnte antistof er i stand til at binde til en receptor af Sortilin, for derved at inhibere aktiviteten af nævnte Sortilin-receptor.
  2. 2. Antistoffet ifølge krav 1, hvor nævnte antistof er i stand til at inhibere binding af ApoB til nævnte Sortilin-receptor.
  3. 3. Antistoffet ifølge et hvilket som helst af de foregående krav, hvor dyret er et menneske.
  4. 4. Antistoffet ifølge krav 1, hvor nævnte antistof er valgt fra gruppen bestående af: polyklonale antistoffer, monoklonale antistoffer, humaniserede antistoffer, enkelt-kædede antistoffer, rekombinante antistoffer.
  5. 5. Antistoffet ifølge et hvilket som helst af kravene 1-6, hvor antistoffet er rettet mod den ekstracellulære del af Sortilin.
  6. 6. Antagonisten ifølge et hvilket som helst af de foregående krav, hvor antagonisten binder en aminosyrerest af bindingsstedet omfattende aminosyrerester R325, S316, Y351, 1353, K260, 1327, F314, F350 til M363, S305, F306, T398 til G400, I303-G309, Q349-A356, Y395 og T402 af SEQ ID NO. 1.
  7. 7. Antagonisten ifølge et hvilket som helst af de foregående krav, hvor antagonisten binder en aminosyrerest af bindingsstedet omfattende aminosyrerester L572, L114, V112, R109 til Sill, S115 til G118, T570, G571, W586, W597, T168-I174, L572, A573 og S584 til F588 af SEQ ID NO. 1.
  8. 8. Anvendelsen ifølge krav 1, hvor abnorme plasmalipidkoncentrationer er i primær hyperlipoproteinæmi, kombineret hyperlipidæmi, endogen Hyperlipæmi, familiær hypertriglyceridæmi, atherosklerose, hjerneblødning (slagtilfælde), cerebrovaskulær sygdom, koronarsklerose, hyperkolesterolæmi, hyperlipidæmi, myokardieinfarkt (hjerteanfald) og veneblodprop.
DK14192407.6T 2008-05-22 2009-05-20 Modulation af Vps10p-domæne-receptorer til behandlingen af kardiovaskulær sygdom DK2851084T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5538508P 2008-05-22 2008-05-22
DKPA200800711 2008-05-22
EP09749511.3A EP2282728B1 (en) 2008-05-22 2009-05-20 Modulation of the Vps10p-domain receptors.

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DK2851084T3 true DK2851084T3 (da) 2018-07-30

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DK14192407.6T DK2851084T3 (da) 2008-05-22 2009-05-20 Modulation af Vps10p-domæne-receptorer til behandlingen af kardiovaskulær sygdom
DK09749511.3T DK2282728T3 (da) 2008-05-22 2009-05-20 Modulation at Vps10p-domæne-receptorer

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US (2) US9084745B2 (da)
EP (2) EP2282728B1 (da)
DK (2) DK2851084T3 (da)
ES (2) ES2680222T3 (da)
WO (1) WO2009140972A2 (da)

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WO2014071128A1 (en) 2012-11-02 2014-05-08 The Brigham And Women's Hospital, Inc. Macrophage-derived matrix vesicles: an alternative mechanism for microcalcification in atherosclerotic plaques
JP2016513712A (ja) * 2013-03-14 2016-05-16 ジェローム， ジェイ． シェンターク， カイロミクロンへの分子の取り込みのためのコレストソーム小胞
WO2016164608A1 (en) * 2015-04-07 2016-10-13 Alector Llc Methods of screening for sortilin binding antagonists
EP3991748A3 (en) 2015-04-07 2022-08-24 Alector LLC Anti-sortilin antibodies and methods of use thereof
CA3018859A1 (en) * 2017-12-01 2019-06-01 Turun Yliopisto Treatment of her2-dependent cancers by sorl1 inhibition
SMT202300110T1 (it) 2018-07-13 2023-05-12 Alector Llc Anticorpi anti-sortilina e relativi metodi di uso
CN109580504B (zh) * 2018-10-19 2021-10-26 东软威特曼生物科技(南京)有限公司 一种脂蛋白胆固醇测定试剂及试剂盒
SE545408C2 (en) 2021-12-02 2023-09-05 Sortina Pharma Ab Sortilin inhibitors
US12387615B2 (en) * 2022-10-21 2025-08-12 The Boeing Company System and method for detecting and avoiding conflicts along a current route of a vehicle

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ES2680222T3 (es) 2018-09-05
US20150299304A1 (en) 2015-10-22
US9084745B2 (en) 2015-07-21
EP2851084B1 (en) 2018-05-02
US20110166036A1 (en) 2011-07-07
HK1208802A1 (en) 2016-03-18
ES2533787T3 (es) 2015-04-14
EP2282728A2 (en) 2011-02-16
WO2009140972A2 (en) 2009-11-26
WO2009140972A3 (en) 2010-06-17
DK2282728T3 (da) 2015-04-20
EP2851084A1 (en) 2015-03-25
EP2282728B1 (en) 2015-02-25

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