DK2854883T3 - Biomatrix-hydrogeler og fremgangsmåder til anvendelse deraf - Google Patents

Biomatrix-hydrogeler og fremgangsmåder til anvendelse deraf Download PDF

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Publication number
DK2854883T3
DK2854883T3 DK13728251.3T DK13728251T DK2854883T3 DK 2854883 T3 DK2854883 T3 DK 2854883T3 DK 13728251 T DK13728251 T DK 13728251T DK 2854883 T3 DK2854883 T3 DK 2854883T3
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Denmark
Prior art keywords
hydroges
biomatrix
procedures
biomatrix hydroges
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Application number
DK13728251.3T
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English (en)
Inventor
Nir Altschuler
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Cartiheal 2009 Ltd
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Publication of DK2854883T3 publication Critical patent/DK2854883T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Materials For Medical Uses (AREA)
DK13728251.3T 2012-05-17 2013-04-29 Biomatrix-hydrogeler og fremgangsmåder til anvendelse deraf DK2854883T3 (da)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261648087P 2012-05-17 2012-05-17
US201261648089P 2012-05-17 2012-05-17
US201361763981P 2013-02-13 2013-02-13
US201361763985P 2013-02-13 2013-02-13
US201361764496P 2013-02-13 2013-02-13
US201361764467P 2013-02-13 2013-02-13
US201361773219P 2013-03-06 2013-03-06
US201361773228P 2013-03-06 2013-03-06
PCT/IL2013/050364 WO2013171736A1 (en) 2012-05-17 2013-04-29 Biomatrix hydrogels and methods of use thereof

Publications (1)

Publication Number Publication Date
DK2854883T3 true DK2854883T3 (da) 2019-07-15

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DK13728251.3T DK2854883T3 (da) 2012-05-17 2013-04-29 Biomatrix-hydrogeler og fremgangsmåder til anvendelse deraf

Country Status (6)

Country Link
US (1) US10342897B2 (da)
EP (1) EP2854883B1 (da)
DK (1) DK2854883T3 (da)
HU (1) HUE046178T2 (da)
SI (1) SI2854883T1 (da)
WO (1) WO2013171736A1 (da)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180228621A1 (en) 2004-08-09 2018-08-16 Mark A. Reiley Apparatus, systems, and methods for the fixation or fusion of bone
JP5795577B2 (ja) 2009-06-15 2015-10-14 カルティヒール（２００９）リミティド 組織修復のための固形形態
US10363140B2 (en) 2012-03-09 2019-07-30 Si-Bone Inc. Systems, device, and methods for joint fusion
HK1205902A1 (zh) 2012-03-09 2015-12-31 Si-Bone, Inc 結合植入物
ES2964578T3 (es) 2012-05-04 2024-04-08 Si Bone Inc Implante fenestrado
BR112015019509A2 (pt) 2013-02-13 2017-07-18 Cartiheal 2009 Ltd substratos sólidos para atenuar ou prevenir a adesão e vascularização de tecidos e células
US9936983B2 (en) 2013-03-15 2018-04-10 Si-Bone Inc. Implants for spinal fixation or fusion
US11147688B2 (en) 2013-10-15 2021-10-19 Si-Bone Inc. Implant placement
US10478309B2 (en) 2014-01-10 2019-11-19 Mbp (Mauritius) Ltd Method for producing osteosynthesis devices, osteosynthesis devices and implants made of semi-synthetic hybrid material obtained by structural modification of the components of a natural marine biomaterial
CN103877614A (zh) * 2014-02-26 2014-06-25 同济大学 一种组织工程骨软骨修复的双层复合支架及其制备方法
US10166033B2 (en) 2014-09-18 2019-01-01 Si-Bone Inc. Implants for bone fixation or fusion
EP3193752B1 (en) 2014-09-18 2020-07-22 SI-Bone, Inc. Matrix implant
BR112017018857A2 (pt) * 2015-03-12 2018-04-24 Timplast Int Llc composição para a degradação de plástico
CA2973549A1 (en) * 2015-05-06 2016-11-10 Cartiheal (2009) Ltd Solid substrates, tools for use with same and uses thereof for promoting cell and tissue growth
EP3461462B1 (en) * 2015-05-06 2023-06-21 Cartiheal (2009) Ltd. Optimized solid substrates
FR3037801B1 (fr) * 2015-06-23 2017-08-11 Jd Invest Materiau semi-synthetique pulverulent, obtenu par modification de la composition d'un biomateriau naturel marin, son procede de fabrication, ses applications
ES2914684T3 (es) 2015-08-19 2022-06-15 Univ Iowa Res Found Terapia preventiva para la artrosis postraumática
KR101795747B1 (ko) 2016-01-15 2017-11-08 고려대학교 산학협력단 비연속적 시료 분획 및 통합유닛과 이를 구비한 이중 온라인 다기능 액체크로마토그래피 장치
US11583613B2 (en) 2016-03-03 2023-02-21 University of Pittsburgh—of the Commonwealth System of Higher Education Hydrogel systems for skeletal interfacial tissue regeneration applied to epiphyseal growth plate repair
CN106046397A (zh) * 2016-06-28 2016-10-26 深圳市阳光之路生物材料科技有限公司 一种关节润滑材料及其制备方法
CN106267363B (zh) * 2016-09-18 2019-06-14 辽宁聚高智造科技有限公司 一种人造骨
MX2019012005A (es) * 2017-04-06 2020-02-12 Univ Carnegie Mellon Fabricación de aditivo basada en interfaz líquido-líquido.
WO2018218305A1 (en) * 2017-06-02 2018-12-06 The University Of Western Australia Method for manufacturing a calcified tissue substitute
EP3687422A4 (en) 2017-09-26 2021-09-22 SI-Bone, Inc. SYSTEMS AND PROCESSES FOR DECORTICATION OF THE SACROILIAC JOINT
RU2676478C1 (ru) * 2017-10-12 2018-12-29 Федеральное государственное бюджетное образовательное учреждение высшего образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ приготовления пломбировочной массы для закрытия дефекта кости
CN111787886A (zh) 2018-01-02 2020-10-16 卡尔蒂希尔(2009)公司 用于促进细胞和组织生长的优化固体基质的植入工具和方案
ES3068401T3 (en) 2018-03-20 2026-05-29 Univ Pittsburgh Commonwealth Sys Higher Education Regeneration of vital tooth pulp
US20190298528A1 (en) * 2018-03-28 2019-10-03 Derek P. LINDSEY Threaded implants and methods of use across bone segments
US12440604B2 (en) 2018-06-13 2025-10-14 University of Pittsburgh—of the Commonwealth System of Higher Education Bone regeneration in compromised wounds
IL261820B2 (en) 2018-09-16 2024-08-01 Cartiheal 2009 Ltd Optimized cage systems promoting bone repair and fusion
US11369419B2 (en) 2019-02-14 2022-06-28 Si-Bone Inc. Implants for spinal fixation and or fusion
EP4613244A3 (en) 2019-02-14 2025-11-12 SI-Bone Inc. Implants for spinal fixation and or fusion
WO2020176660A1 (en) * 2019-02-26 2020-09-03 Mirrorme3D Systems and methods for postoperative soft tissue care
CN110151362A (zh) * 2019-03-13 2019-08-23 上海交通大学医学院附属第九人民医院 一种3d打印的节段性骨缺损修复装置及其制备方法
US20240325606A1 (en) * 2019-04-12 2024-10-03 Eosvision (Suzhou) Biomedical Technology Co., Ltd Collagen-based hydrogels, corneal implants, filler glue and uses thereof
WO2020263989A1 (en) 2019-06-24 2020-12-30 University Of Iowa Research Foundation Jnk inhibitors as anticancer agents
EP4054548A4 (en) * 2019-11-04 2023-12-13 RevBio, Inc. Adhesive compositions comprising therapeutics
AU2020386985A1 (en) 2019-11-21 2022-06-02 Si-Bone Inc. Rod coupling assemblies for bone stabilization constructs
WO2021108590A1 (en) 2019-11-27 2021-06-03 Si-Bone, Inc. Bone stabilizing implants and methods of placement across si joints
JP2023504571A (ja) 2019-12-09 2023-02-03 エスアイ－ボーン・インコーポレイテッド 仙腸関節安定化インプラント及び埋込方法
US11904006B2 (en) 2019-12-11 2024-02-20 University Of Iowa Research Foundation Poly(diaminosulfide) particle-based vaccine
RU2729929C1 (ru) * 2020-02-18 2020-08-13 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) Временный имплантат для пациентов с инфицированными дефектами в челюстно-лицевой области и способ их лечения с использованием такого имплантата
EP3896048A1 (en) * 2020-04-17 2021-10-20 Institut National De La Sante Et De La Recherche Medicale - Inserm Formulation comprising a phosphocalcic cement and a physical and/or covalent hydrogel of polysaccharides, printable and having ductile mechanical properties for bone regeneration/bone repair
TR202013434A2 (tr) * 2020-08-26 2020-10-21 Saadet Atsü Osteoartrit tedavisinde hyaluronikasit- kollagenle enkapsülenen mezenkimal kök hücre-trombositten zengin plazma ve kondrosit içeren ürün-yöntem
JP2023553120A (ja) 2020-12-09 2023-12-20 エスアイ－ボーン・インコーポレイテッド 仙腸関節安定化インプラントおよびインプラント方法
EP4301340A4 (en) 2021-03-05 2025-01-15 Georgia Tech Research Corporation THERMOSENSITIVE HYDROGELS RELEASING MICELLES AS THERAPEUTIC DELIVERY SYSTEM
CN113181430A (zh) * 2021-04-12 2021-07-30 北京冬曦既驾科技咨询有限公司 增材制造医用陶瓷浆料及其制成的医疗用品
US20250043142A1 (en) * 2021-12-02 2025-02-06 Omya International Ag In situ mineralization of 3d printed metastable calcium species
WO2023102533A1 (en) 2021-12-03 2023-06-08 Si-Bone Inc. Fusion cages and methods for sacro-iliac joint stabilization
CN114317439B (zh) * 2021-12-23 2024-04-16 北京基石生命科技有限公司 一种培养肿瘤类器官的方法
CN114452443A (zh) * 2021-12-24 2022-05-10 佛山科学技术学院 用于制备关节软骨支架的组合物及其制备方法与应用
CN115386544B (zh) * 2022-08-23 2024-01-05 广东唯泰生物科技有限公司 用于间充质干细胞培养的水凝胶、培养基及其制备方法
CN115554470B (zh) * 2022-08-30 2024-02-09 吉林大学 一种具有骨质疏松微环境调节功能的关节假体界面及其制备方法与应用
WO2024254205A2 (en) * 2023-06-05 2024-12-12 University Of Vermont And State Agricultural College Methods of processing dairy liquids using gelling agents, and related methods, gelling agents, and products
AU2024325368A1 (en) 2023-08-15 2026-03-12 Si-Bone Inc. Pelvic stabilization implants, methods of use and manufacture
WO2026044030A1 (en) * 2024-08-21 2026-02-26 Board Of Regents Of The University Of Nebraska Systems and methods for electrotaxis treatment of tissues
CN120530862B (zh) * 2025-06-05 2026-08-04 广东省农业科学院蔬菜研究所 一种穴盘育苗基质及其制备方法和应用
CN121313947B (zh) * 2025-09-26 2026-07-17 武汉大学 一种数字化血浆基质骨块的制备方法及应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188373A (en) 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4352883A (en) 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4495174A (en) 1982-06-21 1985-01-22 Research Corporation Anesthetic polyorganophosphazenes
US4440921A (en) 1982-06-21 1984-04-03 Research Corporation Coupling of polyorganophosphazenes to carboxylic acid
US4474753A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Topical drug delivery system utilizing thermosetting gels
US4474752A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4880622A (en) 1986-05-20 1989-11-14 Research Corporation Technologies, Inc. Water-soluble phosphazene polymers having pharmacological applications
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5902441A (en) 1996-09-04 1999-05-11 Z Corporation Method of three dimensional printing
US6506217B1 (en) * 1999-03-29 2003-01-14 Arnett Facial Reconstruction Courses, Inc. Moldable post-implantation bone filler and method
EP1347790A1 (de) * 2000-12-29 2003-10-01 Basf Aktiengesellschaft Aborbierende zusammensetzungen
GB0103754D0 (en) 2001-02-15 2001-04-04 Vantico Ltd Three-dimensional structured printing
US20030143283A1 (en) * 2002-01-28 2003-07-31 Andrew Tofe Bone repair material
EP2514445B1 (en) * 2003-10-22 2018-07-18 Encelle, Inc. Bioactive hydrogel compositions for the regeneration of connective tissue
US20060198863A1 (en) * 2005-03-03 2006-09-07 Musculoskeletal Transplant Foundation Ceramic composition for filling bone defects
US20090028954A1 (en) * 2006-12-22 2009-01-29 Mathys Ag Bettlach Precursor for the preparation of a pasty bone replacement material by admixture of a liquid
WO2009066283A2 (en) 2007-11-19 2009-05-28 Ben Gurion University Of The Negev Research And Development Authority Calcium-mediated effects of coral and methods of use thereof
HUE043110T2 (hu) 2008-11-20 2019-08-28 Cartiheal 2009 Ltd Szilárd formák szövetjavításhoz
JP5795577B2 (ja) 2009-06-15 2015-10-14 カルティヒール（２００９）リミティド 組織修復のための固形形態
EP2833933B1 (en) 2012-04-05 2020-10-14 Cartiheal (2009) Ltd Multi-phasic solid implants for tissue repair
WO2014072982A2 (en) 2012-11-12 2014-05-15 Cartiheal (2009) Ltd. Tools and systems for solid form and graft implantation
BR112015019509A2 (pt) 2013-02-13 2017-07-18 Cartiheal 2009 Ltd substratos sólidos para atenuar ou prevenir a adesão e vascularização de tecidos e células
CA2973549A1 (en) 2015-05-06 2016-11-10 Cartiheal (2009) Ltd Solid substrates, tools for use with same and uses thereof for promoting cell and tissue growth

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WO2013171736A1 (en) 2013-11-21
SI2854883T1 (sl) 2019-08-30
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HUE046178T2 (hu) 2020-02-28
US20150147397A1 (en) 2015-05-28
EP2854883A1 (en) 2015-04-08

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