DK2880155T3 - Anvendelse af den reduktive glycinvej til generering af formatotrofiske og autotrofiske mikroorganismer - Google Patents

Anvendelse af den reduktive glycinvej til generering af formatotrofiske og autotrofiske mikroorganismer Download PDF

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DK2880155T3
DK2880155T3 DK13759023.8T DK13759023T DK2880155T3 DK 2880155 T3 DK2880155 T3 DK 2880155T3 DK 13759023 T DK13759023 T DK 13759023T DK 2880155 T3 DK2880155 T3 DK 2880155T3
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Denmark
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formatotrophic
organisms
glycine
road
generating
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DK13759023.8T
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English (en)
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Arren Bar-Even
Ron Milo
Elad Noor
Oren Yishai
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Yeda Res & Dev
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
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    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01002—Formate dehydrogenase (1.2.1.2)
    • C—CHEMISTRY; METALLURGY
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    • C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
    • C12Y105/01005—Methylenetetrahydrofolate dehydrogenase (NADP+) (1.5.1.5)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
    • C12Y105/01015—Methylenetetrahydrofolate dehydrogenase (NAD+) (1.5.1.15)
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    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04009—Methenyltetrahydrofolate cyclohydrolase (3.5.4.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
    • C12Y603/04003—Formate--tetrahydrofolate ligase (6.3.4.3)

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
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  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Electromagnetism (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK13759023.8T 2012-07-29 2013-07-29 Anvendelse af den reduktive glycinvej til generering af formatotrofiske og autotrofiske mikroorganismer DK2880155T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261676962P 2012-07-29 2012-07-29
PCT/IL2013/050643 WO2014020599A1 (en) 2012-07-29 2013-07-29 Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms

Publications (1)

Publication Number Publication Date
DK2880155T3 true DK2880155T3 (da) 2019-07-15

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DK13759023.8T DK2880155T3 (da) 2012-07-29 2013-07-29 Anvendelse af den reduktive glycinvej til generering af formatotrofiske og autotrofiske mikroorganismer

Country Status (5)

Country Link
US (2) US10155933B2 (da)
EP (2) EP3594331A1 (da)
DK (1) DK2880155T3 (da)
ES (1) ES2730377T3 (da)
WO (1) WO2014020599A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3594331A1 (en) 2012-07-29 2020-01-15 Yeda Research and Development Co. Ltd. Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms
US20150050708A1 (en) * 2013-03-15 2015-02-19 Genomatica, Inc. Microorganisms and methods for producing butadiene and related compounds by formate assimilation
US10053712B2 (en) 2013-12-10 2018-08-21 Yeda Research And Development Co. Ltd. Use of enzymes which catalyze pyruvate synthesis from formate and acetyl-CoA and bacteria expressing same
KR102000755B1 (ko) * 2016-12-27 2019-07-17 한국과학기술원 외부 유전자가 도입된 재조합 미생물 및 상기 미생물을 이용하여 개미산과 이산화탄소로부터 유용물질을 제조하는 방법
WO2018124475A2 (ko) * 2016-12-27 2018-07-05 한국과학기술원 외부 유전자가 도입된 재조합 미생물 및 상기 미생물을 이용하여 개미산과 이산화탄소로부터 유용물질을 제조하는 방법
IL267579B2 (en) * 2016-12-27 2024-12-01 Korea Advanced Inst Sci & Tech Recombinant microorganism having heterologous genes introduced thereto and method for producing useful material from formic acid and carbon dioxide using same microorganism
WO2021084526A1 (en) 2019-10-31 2021-05-06 Yeda Research And Development Co. Ltd. Engineered autotrophic bacteria for co2 conversion to organic materials
AU2020402138A1 (en) * 2019-12-10 2022-07-14 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Novel genetically engineered microorganism capable of growing on formate, methanol, methane or CO2
US20230357704A1 (en) * 2022-05-03 2023-11-09 Alliance For Sustainable Energy, Llc Photobioconversion of electrocatalysis-derived formate

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Also Published As

Publication number Publication date
US10377994B2 (en) 2019-08-13
WO2014020599A1 (en) 2014-02-06
US20190032027A1 (en) 2019-01-31
EP3594331A1 (en) 2020-01-15
EP2880155B1 (en) 2019-04-17
ES2730377T3 (es) 2019-11-11
US20150218528A1 (en) 2015-08-06
EP2880155A1 (en) 2015-06-10
US10155933B2 (en) 2018-12-18

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