DK2968010T3 - Personlig auditiv somato-sensorisk stimulering for behandling af tinnitus - Google Patents
Personlig auditiv somato-sensorisk stimulering for behandling af tinnitus Download PDFInfo
- Publication number
- DK2968010T3 DK2968010T3 DK14765204.4T DK14765204T DK2968010T3 DK 2968010 T3 DK2968010 T3 DK 2968010T3 DK 14765204 T DK14765204 T DK 14765204T DK 2968010 T3 DK2968010 T3 DK 2968010T3
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- DK
- Denmark
- Prior art keywords
- tinnitus
- stimulation
- bimodal
- attack
- auditory
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/12—Audiometering
- A61B5/128—Audiometering evaluating tinnitus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M21/02—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; ELECTRIC HEARING AIDS; PUBLIC ADDRESS SYSTEMS
- H04R25/00—Electric hearing aids
- H04R25/75—Electric tinnitus maskers providing an auditory perception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0072—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with application of electrical currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/361—Phantom sensations, e.g. tinnitus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Acoustics & Sound (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Psychology (AREA)
- Biophysics (AREA)
- Audiology, Speech & Language Pathology (AREA)
- Signal Processing (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Medical Informatics (AREA)
- Pathology (AREA)
- Multimedia (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (15)
1. Et system til behandling af en auditiv tilstand hos en person, systemet omfatter en processor (14) og et lager (16); og et bimodalt stimulerings system (70-1, 900)konfigureret til at generere et hørligt stimulerings signal med et første angrebspunkt og en første angrebsperiode, påbegynde stimuli, og/eller længerevarende påvirkning, genere et somatosensorisk stimulerings signal til at stimulere et somatosensorisk system hos en person, det somatosensoriske stimulerings signal har et andet angrebspunkt og en anden angrebsperiode, påbegynde stimuli, og/eller længerevarende påvirkning, kendetegnet ved, at systemet er konfigureret til at etablere en indstillings rækkefølge og indstillings forskel mellem det første angrebspunkt og det andet angrebspunkt for at reducere tinnitus, hvori den første angrebsperiode og den anden angrebsperiode skal bibeholdes asynkront for at reducere tinnitus således at påbegyndelsen af den første angrebsperiode ikke overlapper påbegyndelsen af den anden angrebsperiode.
2. Systemet ifølge patentkrav 1, hvori det bimodale stimulerings system er yderligere konfigureret til (i) at ændre indstillings rækkefølgen mellem det første angrebspunkt og det andet angrebspunkt for at fastsætte en ønsket reduktion af tinnitus, eller (ii) justere indstillingen mellem det første angrebspunkt og det andet angrebspunkt for at fastsætte en ønsket reduktion af tinnitus.
3. Systemet ifølge patentkrav 1, hvori det bimodale stimulerings system er yderligere konfigureret til anvendelse af det somatosensoriske stimulerings signal hos personen ved at anvende stimulering (i) af personens hjerne for at stimulere det somatosensoriske system, (ii) af personens trigeminus nerve ved ansigts stimulering eller personens cervikal spinal nerve for at stimulere det somatosensoriske system, (iii) til personens dybe hjerne region for at stimulere det somatosensoriske system, eller (iv) til personens ansigts overflade struktur eller personens hals overflade struktur for at stimulere det somatosensoriske system.
4. Systemet ifølge patentkrav 1, hvori det bimodale stimulerings system er yderligere konfigureret til at: bestemme en indstillings profil til personen, hvis indstillings profil indeholder indstillings data fra forskellige indstillings ordrer og indstillings differencer mellem det første angrebspunkt og det andet angrebspunkt og indeholder registreret tinnitus data fra de forskellige indstillings ordrer og indstillings forskelle; og lagre indstillings profilen for adgang til at bestemme en foreslået tinnitus behandlings kur med det auditive stimulerings signal og det somatosensoriske stimulerings signal.
5. Systemet ifølge patentkrav 1, hvori det bimodale stimulering system er yderligere konfigureret til at: bestemme en indledende indstillings profil for personen, indstillings profilen indeholder en indledende indstillings ordre og indstillings difference for det første angrebspunkt og det andet angrebspunkt og er beregnet til at reducere tinnitus efter angrebet.
6. Systemet ifølge patentkrav 1, hvori det bimodale stimulerings system er yderligere konfigureret til at: modtage en indikation af tinnitus angrebet og automatisk starte indstillings ordren og indstillings differencen mellem det første angrebspunkt og det andet angrebspunkt for at reducere tinnitusen.
7. Systemet ifølge patentkrav 1, hvori det bimodale stimulerings system er yderligere konfigureret til at: justere over en tidsperiode indstillings ordren og indstillings differencen mellem det første angrebspunkt og det andet angrebspunkt for at bestemme en tinnitus reduktions profil over en tidsperiode; og lagre tinnitus reduktions profilen.
8. Systemet ifølge patentkrav 1, hvori det bimodale stimulerings system er yderligere konfigureret til at tilvejebringe indstillings ordren og indstillings differencen mellem det første angrebspunkt og det andet angrebspunkt ved at: give adgang til tinnitus reduktions profilen; og bestemme indstillings ordren og indstillings differencen fra tinnitus reduktions profilen.
9. Systemet ifølge patentkrav 1, hvori det bimodale stimulerings system er yderligere konfigureret til bestemmelse af indstillings ordren og indstillings differencen mellem det første angrebspunkt og det andet angrebspunkt ved: bestemmelse af behandlingstid; at give adgang til tinnitus reduktions profilen; bestemmelse af indstillings ordren og indstillings differencen svarende til behandlingstiden fra tinnitus reduktions profilen; og anvende det frembragte auditive stimulerings signal og somatosensoriske stimulerings signal baseret på den identificerede tilsvarende indstillings ordre og indstillings difference, hvori den identificerede behandlings tid er en nuværende tid eller en fremtidig tid.
10. Systemet ifølge patentkrav 1, hvori det bimodale stimulerings system er yderligere konfigureret (i) for at justere den første angrebsperiode og/eller den anden angrebsperiode til reducering af tinnitus, (ii) til periodisk justering af den første angrebsperiode og/eller den anden angrebsperiode til reducering af tinnitus, eller (iii) til justering af indstillings ordren og indstillings differencen mellem den første angrebsperiode og den anden angrebsperiode til selektivt at øge eller formindske brænd hyppigheden i en bestemt neuron.
11. Systemet ifølge patentkrav 1, hvori den auditive tilstand er tinnitus eller hyperacusis.
12. Et computer læsbart lagrings medium lagret med et sæt instruktioner som kan udføres af en processor til behandling af en auditiv tilstand hos en person, instruktionerne indeholder: instruktioner til skabelse af et hørligt stimulerings signal med et første angrebspunkt og en første angrebsperiode, påbegynde stimuli, og/eller varighed; instruktioner til skabelse af et somatosensorisk stimulerings signal til at stimulere et somatosensorisk system hos en person, det somatosensoriske stimulerings signal har et andet angrebspunkt og en anden angrebsperiode, påbegynde stimuli, og/eller varighed; og instruktioner til etablering af en indstillings ordre og indstillings difference mellem det første angrebspunkt og det andet angrebspunkt til at reducere tinnitus, hvori den første angrebsperiode og den anden angrebsperiode skal bibeholdes asynkront for at reducere tinnitus således at påbegyndelsen af den første angrebsperiode ikke overlapper påbegyndelsen af den anden angrebsperiode.
13. Det computer læsbare lagrings medium ifølge patentkrav 12, hvori den auditive tilstand er tinnitus eller hyperacusis.
14. Det computer læsbare lagrings medium ifølge patentkrav 12, hvis instruktioner endvidere omfatter: instruktioner til bestemmelse af optimale parameter værdier til et hørlig stimulerings signal og et somatosensorisk stimulerings signal til ændring af angrebsrater til neuroner i de auditive og ikke auditive baner involveret i den auditive tilstand.
15. Det computer læsbare lagrings medium ifølge patentkrav 12, hvis instruktioner endvidere omfatter: instruktioner til øgning af angrebsrater til neuroner i de auditive og ikke auditive baner involveret i den auditive tilstand, eller instruktioner til mindskning af angrebsrater til neuroner i de auditive og ikke auditive baner involveret i den auditive tilstand.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361800607P | 2013-03-15 | 2013-03-15 | |
| US201361803062P | 2013-03-18 | 2013-03-18 | |
| PCT/US2014/030765 WO2014145914A1 (en) | 2013-03-15 | 2014-03-17 | Personalized auditory-somatosensory stimulation to treat tinnitus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2968010T3 true DK2968010T3 (da) | 2018-05-22 |
Family
ID=51530260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14765204.4T DK2968010T3 (da) | 2013-03-15 | 2014-03-17 | Personlig auditiv somato-sensorisk stimulering for behandling af tinnitus |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9242067B2 (da) |
| EP (1) | EP2968010B1 (da) |
| JP (1) | JP6510486B2 (da) |
| CA (1) | CA2903630C (da) |
| DK (1) | DK2968010T3 (da) |
| ES (1) | ES2675330T3 (da) |
| WO (1) | WO2014145914A1 (da) |
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| US10265527B2 (en) | 2012-04-17 | 2019-04-23 | Regents Of The University Of Minnesota | Multi-modal synchronization therapy |
| EP3441109A1 (en) | 2013-05-30 | 2019-02-13 | Graham H. Creasey | Flexible dermal patch for a topical nerve stimulator system |
| US11229789B2 (en) | 2013-05-30 | 2022-01-25 | Neurostim Oab, Inc. | Neuro activator with controller |
| US12311114B2 (en) | 2013-08-30 | 2025-05-27 | Neuromod Devices Limited | Method and apparatus for treating a neurological disorder |
| WO2015073381A1 (en) | 2013-11-14 | 2015-05-21 | Epic Medical Concepts & Innovations, Inc. | Pneumatic somatosensory stimulation device and method |
| EP3188692A4 (en) | 2014-09-02 | 2018-05-02 | Cochlear Limited | Event detection in an implantable auditory prosthesis |
| CN104888346B (zh) * | 2014-12-21 | 2020-10-13 | 徐志强 | 对昏迷大脑进行神经刺激的方法及装置 |
| US11534608B2 (en) | 2015-01-04 | 2022-12-27 | Ist, Llc | Methods and apparatuses for transdermal stimulation of the outer ear |
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| US10183164B2 (en) * | 2015-08-27 | 2019-01-22 | Cochlear Limited | Stimulation parameter optimization |
| GB201609448D0 (en) | 2015-09-10 | 2016-07-13 | Obl S A | Medical device |
| PT3170479T (pt) * | 2015-11-17 | 2021-07-28 | Neuromod Devices Ltd | Aparelho e processo para tratar uma perturbação neurológica do sistema auditivo |
| PL3865102T3 (pl) * | 2015-11-17 | 2024-12-16 | Neuromod Devices Limited | Urządzenie i sposób leczenia zaburzeń neurologicznych układu słuchowego |
| US10701498B2 (en) * | 2016-06-07 | 2020-06-30 | Regents Of The University Of Minnesota | Systems and methods for treating tinnitus and enhancing hearing |
| US10198076B2 (en) | 2016-09-06 | 2019-02-05 | Neosensory, Inc. | Method and system for providing adjunct sensory information to a user |
| US10821027B2 (en) | 2017-02-08 | 2020-11-03 | Intermountain Intellectual Asset Management, Llc | Devices for filtering sound and related methods |
| WO2019060298A1 (en) | 2017-09-19 | 2019-03-28 | Neuroenhancement Lab, LLC | METHOD AND APPARATUS FOR NEURO-ACTIVATION |
| WO2019064175A2 (en) | 2017-09-29 | 2019-04-04 | Cochlear Limited | HEARING AID |
| WO2019094365A1 (en) | 2017-11-07 | 2019-05-16 | Neurostim Oab, Inc. | Non-invasive nerve activator with adaptive circuit |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11478603B2 (en) | 2017-12-31 | 2022-10-25 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| US10582286B2 (en) * | 2018-06-22 | 2020-03-03 | University Of South Florida | Method for treating debilitating hyperacusis |
| US11452839B2 (en) | 2018-09-14 | 2022-09-27 | Neuroenhancement Lab, LLC | System and method of improving sleep |
| EP3860703A1 (en) | 2018-10-01 | 2021-08-11 | Biovisics Medical, Inc. | System and methods for controlled electrical modulation for vision therapy |
| US11305118B2 (en) | 2018-11-30 | 2022-04-19 | Biovisics Medical, Inc. | Head worn apparatuses for vision therapy |
| US12465718B2 (en) | 2019-01-18 | 2025-11-11 | Ist, Llc | Methods and devices for modulation of integrated neural networks to influence composite sensory processes |
| US11471680B2 (en) | 2019-04-10 | 2022-10-18 | Biovisics, Inc. | Systems and interfaces for ocular therapy |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
| EP4464367A3 (en) | 2019-06-14 | 2025-01-22 | i-LUMEN Scientific, Inc. | Wearable medical device |
| CA3144957A1 (en) | 2019-06-26 | 2020-12-30 | Neurostim Technologies Llc | Non-invasive nerve activator with adaptive circuit |
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| WO2021126921A1 (en) | 2019-12-16 | 2021-06-24 | Neurostim Solutions, Llc | Non-invasive nerve activator with boosted charge delivery |
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| WO2021262789A1 (en) | 2020-06-23 | 2021-12-30 | Bose Corporation | Haptic tinnitus therapeutic system |
| US11159901B1 (en) * | 2020-07-20 | 2021-10-26 | Thomas Kendall McLennan | Tinnitus treatment using sine wave clusters |
| US11497675B2 (en) * | 2020-10-23 | 2022-11-15 | Neosensory, Inc. | Method and system for multimodal stimulation |
| KR102451956B1 (ko) * | 2020-11-03 | 2022-10-07 | 한림대학교 산학협력단 | 음악을 이용하여 청능 훈련을 수행하는 전자 장치, 방법, 및 컴퓨터 프로그램 |
| EP4197587A1 (en) * | 2021-12-17 | 2023-06-21 | CereGate GmbH | Auditory neural interface device |
| US11862147B2 (en) | 2021-08-13 | 2024-01-02 | Neosensory, Inc. | Method and system for enhancing the intelligibility of information for a user |
| US12589243B2 (en) | 2022-10-21 | 2026-03-31 | I-Lumen Scientific, Inc. | Ocular devices and controller interfaces for ocular therapy |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7520851B2 (en) | 1999-03-17 | 2009-04-21 | Neurominics Pty Limited | Tinnitus rehabilitation device and method |
| AUPP927599A0 (en) | 1999-03-17 | 1999-04-15 | Curtin University Of Technology | Tinnitus rehabilitation device and method |
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| WO2006047264A1 (en) * | 2004-10-21 | 2006-05-04 | Advanced Neuromodulation Systems, Inc. | Peripheral nerve stimulation to treat auditory dysfunction |
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| US9089707B2 (en) * | 2008-07-02 | 2015-07-28 | The Board Of Regents, The University Of Texas System | Systems, methods and devices for paired plasticity |
| DE102008052078B4 (de) * | 2008-10-17 | 2011-06-01 | Forschungszentrum Jülich GmbH | Vorrichtung zur konditionierten desynchronisierenden Stimulation |
| RS56031B1 (sr) * | 2010-11-23 | 2017-09-29 | Nat Univ Ireland | Postupak i uređaj za zamenu čula |
| US20120203301A1 (en) | 2011-02-07 | 2012-08-09 | Advanced Neuromodulation Systems, Inc. | Methods using trigeminal nerve stimulation to treat neurological diseases |
| DE102011100065A1 (de) * | 2011-04-30 | 2012-10-31 | Cerbomed Gmbh | Vorrichtung zur kombinierten Aufbringung eines transkutanen elektrischen Stimulationsreizes und Abgabe eines akustischen Signals |
| US10265527B2 (en) | 2012-04-17 | 2019-04-23 | Regents Of The University Of Minnesota | Multi-modal synchronization therapy |
| EP2842530B1 (en) | 2013-08-30 | 2021-09-29 | Neuromod Devices Limited | Method and system for generation of customised sensory stimulus |
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2014
- 2014-03-17 JP JP2016503458A patent/JP6510486B2/ja active Active
- 2014-03-17 ES ES14765204.4T patent/ES2675330T3/es active Active
- 2014-03-17 WO PCT/US2014/030765 patent/WO2014145914A1/en not_active Ceased
- 2014-03-17 CA CA2903630A patent/CA2903630C/en active Active
- 2014-03-17 DK DK14765204.4T patent/DK2968010T3/da active
- 2014-03-17 US US14/217,090 patent/US9242067B2/en active Active
- 2014-03-17 EP EP14765204.4A patent/EP2968010B1/en active Active
-
2015
- 2015-12-21 US US14/977,416 patent/US9682232B2/en active Active
-
2017
- 2017-06-19 US US15/627,358 patent/US10569082B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2968010A1 (en) | 2016-01-20 |
| US20160106975A1 (en) | 2016-04-21 |
| EP2968010B1 (en) | 2018-01-31 |
| US9682232B2 (en) | 2017-06-20 |
| US10569082B2 (en) | 2020-02-25 |
| ES2675330T3 (es) | 2018-07-10 |
| US20140275737A1 (en) | 2014-09-18 |
| EP2968010A4 (en) | 2016-11-09 |
| JP2016512764A (ja) | 2016-05-09 |
| WO2014145914A1 (en) | 2014-09-18 |
| US20170281900A1 (en) | 2017-10-05 |
| CA2903630A1 (en) | 2014-09-18 |
| CA2903630C (en) | 2022-06-14 |
| US9242067B2 (en) | 2016-01-26 |
| JP6510486B2 (ja) | 2019-05-08 |
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