DK2968424T3 - Ikke-replikative transduktionspartikler og transduktionspartikelbaserede reportersystemer - Google Patents

Ikke-replikative transduktionspartikler og transduktionspartikelbaserede reportersystemer Download PDF

Info

Publication number
DK2968424T3
DK2968424T3 DK14775849.4T DK14775849T DK2968424T3 DK 2968424 T3 DK2968424 T3 DK 2968424T3 DK 14775849 T DK14775849 T DK 14775849T DK 2968424 T3 DK2968424 T3 DK 2968424T3
Authority
DK
Denmark
Prior art keywords
transduction
reporter systems
based reporter
replicative
particle
Prior art date
Application number
DK14775849.4T
Other languages
English (en)
Inventor
Heather Cox
Diego Ariel Rey
Nikol Deforest
Soni Shukla
Original Assignee
Geneweave Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geneweave Biosciences Inc filed Critical Geneweave Biosciences Inc
Application granted granted Critical
Publication of DK2968424T3 publication Critical patent/DK2968424T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/14—Streptococcus; Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/12—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)(1.13.12)
    • C12Y113/12007—Photinus-luciferin 4-monooxygenase (ATP-hydrolysing) (1.13.12.7), i.e. firefly-luciferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10141—Use of virus, viral particle or viral elements as a vector
    • C12N2795/10143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10151—Methods of production or purification of viral material
    • C12N2795/10152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10311—Siphoviridae
    • C12N2795/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2795/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10311—Siphoviridae
    • C12N2795/10351—Methods of production or purification of viral material
    • C12N2795/10352—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/305—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
    • G01N2333/31—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90241—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK14775849.4T 2013-03-13 2014-03-13 Ikke-replikative transduktionspartikler og transduktionspartikelbaserede reportersystemer DK2968424T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361779177P 2013-03-13 2013-03-13
US201361897040P 2013-10-29 2013-10-29
US201461939126P 2014-02-12 2014-02-12
PCT/US2014/026536 WO2014160418A2 (en) 2013-03-13 2014-03-13 Non-replicative transduction particles and transduction particle-based reporter systems

Publications (1)

Publication Number Publication Date
DK2968424T3 true DK2968424T3 (da) 2020-03-30

Family

ID=51625644

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14775849.4T DK2968424T3 (da) 2013-03-13 2014-03-13 Ikke-replikative transduktionspartikler og transduktionspartikelbaserede reportersystemer

Country Status (14)

Country Link
US (5) US9388453B2 (da)
EP (2) EP3699592B1 (da)
JP (2) JP6431035B2 (da)
KR (1) KR102127358B1 (da)
CN (2) CN110938671A (da)
AU (1) AU2014243796B2 (da)
BR (1) BR112015023108A8 (da)
CA (1) CA2905341C (da)
DK (1) DK2968424T3 (da)
ES (1) ES2780827T3 (da)
MX (2) MX360560B (da)
RU (1) RU2661101C2 (da)
SG (1) SG11201507463WA (da)
WO (1) WO2014160418A2 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102127358B1 (ko) 2013-03-13 2020-06-29 지니위브 바이오사이언시스, 인코포레이티드 비-복제 형질도입 입자 및 형질도입 입자-기반 리포터 시스템
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
US9540675B2 (en) 2013-10-29 2017-01-10 GeneWeave Biosciences, Inc. Reagent cartridge and methods for detection of cells
US9676641B2 (en) 2014-01-29 2017-06-13 Synphagen Llc Therapeutic phages and methods for delivery of nucleic acids for therapeutic uses
CN106414776B9 (zh) 2014-06-13 2020-06-26 经纬生物科技有限公司 细胞的不依赖于生长的检测
ES2778727T3 (es) * 2014-08-25 2020-08-11 Geneweave Biosciences Inc Partículas de transducción no replicativas y sistemas indicadores basados en partículas de transducción
US9879328B2 (en) * 2014-11-21 2018-01-30 GeneWeave Biosciences, Inc. Mechanisms of antimicrobial susceptibility
US10227661B2 (en) 2014-11-21 2019-03-12 GeneWeave Biosciences, Inc. Sequence-specific detection and phenotype determination
US10351893B2 (en) * 2015-10-05 2019-07-16 GeneWeave Biosciences, Inc. Reagent cartridge for detection of cells
US10718003B2 (en) 2015-12-31 2020-07-21 Roche Molecular Systems, Inc. Detecting an analyte in a flash and glow reaction
WO2017172645A2 (en) 2016-03-28 2017-10-05 The Charles Stark Draper Laboratory, Inc. Bacteriophage engineering methods
US11149319B2 (en) 2016-12-20 2021-10-19 Roche Molecular Systems, Inc. Systems and methods for detecting cells using engineered transduction particles
EP3562953A1 (en) 2016-12-30 2019-11-06 Quidel Corporation Phage-mediated immunoassay and methods for determining susceptibility of bacteria to antibiotic or probiotic agents
WO2018213301A1 (en) * 2017-05-15 2018-11-22 New York University Compositions and methods for non-antibiotic treating of bacterial infections by blocking or disrupting bacterial genes involved in virulence or viability
US11077444B2 (en) 2017-05-23 2021-08-03 Roche Molecular Systems, Inc. Packaging for a molecular diagnostic cartridge
US11008602B2 (en) 2017-12-20 2021-05-18 Roche Molecular Systems, Inc. Non-replicative transduction particles and transduction particle-based reporter systems
WO2019209982A1 (en) * 2018-04-24 2019-10-31 Laboratory Corporation Of America Holdings Indicator bacteriophage for selecting and monitoring for efficacy of therapeutics and methods for using same
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US10968491B2 (en) 2018-12-05 2021-04-06 GeneWeave Biosciences, Inc. Growth-independent detection of cells
WO2020136154A1 (en) * 2018-12-27 2020-07-02 F. Hoffmann-La Roche Ag Non-replicative transduction particles and transduction particle-based reporter systems for detection of acinetobacter baumannii
WO2020136153A1 (en) * 2018-12-29 2020-07-02 F. Hoffmann-La Roche Ag Use of sideromycins to limit cross-reactivity and improve bacterial identification in antibiotic susceptibility assays
US11572595B2 (en) * 2018-12-31 2023-02-07 Roche Molecular Systems, Inc. Non-replicative transduction particles with one or more non-native tail fibers and transduction particle-based reporter systems
WO2020245123A1 (en) 2019-06-06 2020-12-10 F. Hoffmann-La Roche Ag Use of peptidomimetic antimicrobial peptides to limit cross-reactivity and improve bacterial identification in antibiotic susceptibility assays
JP7781741B2 (ja) * 2019-08-26 2025-12-08 ラボラトリー コーポレイション オブ アメリカ ホールディングス 組換え繁殖欠損指標バクテリオファージを使用して微生物を検出するためのデバイスおよび方法
US20220356537A1 (en) * 2019-12-31 2022-11-10 Roche Molecular Systems, Inc. Quantitative pcr screening of inducible prophage from bacterial isolates
JP2024532062A (ja) * 2021-08-20 2024-09-05 ユニバーシティ オブ ピッツバーグ－オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 抗生物質耐性サンプルと抗生物質感受性サンプルとの識別

Family Cites Families (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE628679A (da) 1962-02-28
US3826574A (en) 1973-02-12 1974-07-30 Continental Distributors Nephelometer
US4057148A (en) 1974-06-25 1977-11-08 G. D. Searle & Co. Multiple sample support assembly and apparatus for facilitating radioimmunoassays and the like
CA1277931C (en) 1984-06-05 1990-12-18 Shimon Ulitzur Detection and/or identification of microorganisms in a test sample usingbioluminescence or other exogenous genetically-introduced marker
US4861709A (en) 1985-05-31 1989-08-29 Technicon Research A.G. Detection and/or identification of microorganisms in a test sample using bioluminescence or other exogenous genetically-introduced marker
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
WO1987000201A1 (en) 1985-07-05 1987-01-15 Whitehead Institute For Biomedical Research Epithelial cells expressing foreign genetic material
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
DE3540823C1 (de) 1985-11-16 1986-10-02 Laboratorium Prof. Dr. Rudolf Berthold, 7547 Wildbad Fotometrische Messstation
CA1339465C (en) 1986-04-30 1997-09-16 Richard J. Massey Electrochemiluminescent assays
US5221623A (en) 1986-07-22 1993-06-22 Boyce Thompson Institute For Plant Research, Inc. Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms
WO1988000617A1 (en) 1986-07-22 1988-01-28 Boyce Thompson Institute For Plant Research Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms
EP0378576B1 (en) 1987-09-11 1995-01-18 Whitehead Institute For Biomedical Research Transduced fibroblasts and uses therefor
WO1989005345A1 (en) 1987-12-11 1989-06-15 Whitehead Institute For Biomedical Research Genetic modification of endothelial cells
JP2917998B2 (ja) 1988-02-05 1999-07-12 ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ 修飾された肝細胞およびその用途
FR2641793B1 (fr) 1988-12-26 1993-10-01 Setratech Procede de recombinaison in vivo de sequences d'adn presentant des mesappariements de bases
US5139745A (en) 1990-03-30 1992-08-18 Block Medical, Inc. Luminometer
GB9017443D0 (en) 1990-08-09 1990-09-26 Amersham Int Plc Reporter bacteria for rapid microbial detection
JP3249516B2 (ja) 1990-10-31 2002-01-21 ソマティクス セラピー コーポレイション 遺伝子治療のためのレトロウイルスのベクター
US5188455A (en) 1990-11-13 1993-02-23 The Pennsylvania Research Corporation Apparatus for remote mixing of fluids
US5086233A (en) 1991-01-22 1992-02-04 Dynatech Corporation Luminometers with sample container displacement controlled by ramped abutment
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
US6300061B1 (en) 1992-02-07 2001-10-09 Albert Einstein College Of Medicine Of Yeshiva University Mycobacterial species-specific reporter mycobacteriophages
US5242660A (en) 1992-02-28 1993-09-07 Paul Hsei Sample preparation device
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
JPH0634546A (ja) 1992-07-17 1994-02-08 Tosoh Corp 蛍光検出器
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
AU687363B2 (en) 1993-03-19 1998-02-26 Ciba Corning Diagnostics Corp. Luminometer
US5494646A (en) 1993-04-14 1996-02-27 Seymour; Eugene H. Sampling device and sample adequacy system
AU6905294A (en) * 1993-04-29 1994-11-21 Albert Einstein College Of Medicine Of Yeshiva University Mycobacterial species-specific reporter mycobacteriophages
US5645801A (en) 1993-10-21 1997-07-08 Abbott Laboratories Device and method for amplifying and detecting target nucleic acids
US6054299A (en) 1994-04-29 2000-04-25 Conrad; Charles A. Stem-loop cloning vector and method
US5736388A (en) * 1994-12-30 1998-04-07 Chada; Sunil Bacteriophage-mediated gene transfer systems capable of transfecting eukaryotic cells
US5656424A (en) 1995-02-15 1997-08-12 Albert Einstein College Of Medicine, A Division Of Yeshiva University Identification of mycobacterium tuberculosis complex species
US5476768A (en) 1995-03-10 1995-12-19 Becton, Dickinson And Company Mycobacteriophage DSGA specific for the mycobacterium tuberculosis complex
DE19517940A1 (de) 1995-05-18 1996-11-21 Merck Patent Gmbh Nachweis von Listerien mittels rekombinanter Bakteriophagen
JP3080407B2 (ja) 1995-06-07 2000-08-28 ベクトン・ディッキンソン・アンド・カンパニー ファージに基づく抗生物質感受性試験のためのデバイスと方法
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
US5939262A (en) 1996-07-03 1999-08-17 Ambion, Inc. Ribonuclease resistant RNA preparation and utilization
US5677124A (en) 1996-07-03 1997-10-14 Ambion, Inc. Ribonuclease resistant viral RNA standards
US5905029A (en) 1997-02-19 1999-05-18 Fritz Berthold Method for rapid hygiene testing
US5989499A (en) 1997-05-02 1999-11-23 Biomerieux, Inc. Dual chamber disposable reaction vessel for amplification reactions
SE9702005D0 (sv) 1997-05-28 1997-05-28 Alphahelix Ab New reaction vessel and method for its use
AU8408998A (en) 1997-07-17 1999-02-10 Synermed International Inc. Assay for total and direct bilirubin
US6054312A (en) * 1997-08-29 2000-04-25 Selective Genetics, Inc. Receptor-mediated gene delivery using bacteriophage vectors
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US6003566A (en) 1998-02-26 1999-12-21 Becton Dickinson And Company Vial transferset and method
NZ507093A (en) 1998-04-08 2003-08-29 Commw Scient Ind Res Org Methods and means for reducing the phenotypic expression of a nucleic acid of interest in a plant
AR020078A1 (es) 1998-05-26 2002-04-10 Syngenta Participations Ag Metodo para alterar la expresion de un gen objetivo en una celula de planta
MXPA01003642A (es) 1998-10-09 2003-07-21 Ingene Inc Sintesis enzimatica de adnss.
BR9914773A (pt) 1998-10-09 2002-02-05 Ingene Inc Conjunto de elementos genéricos, método para a produção de dna de cordão único, transcrição de mrna, construção de ácido nucléico, transcrição de ssdna, vetor, sistema vetor, célula hospedeira, conjunto para a produção de uma sequência de ácido nucléico de cordão único, método para a produção in vivo ou in vitro de uma sequência de ácido nucléico de cordão único, transcrição de cdna de cordão único, ácido nucléico inibidor, molécula heteroduplex, e composição farmacêutica
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
DE60014987T2 (de) 1999-02-22 2005-11-10 Matsushita Electric Industrial Co., Ltd., Kadoma Verfahren zum Nachweis von Bakterien
WO2000061804A1 (en) 1999-04-14 2000-10-19 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US6271034B1 (en) 1999-07-08 2001-08-07 Albert Einstein College Of Medicine Of Yeshiva University One step allelic exchange in mycobacteria using in vitro generated conditional transducing phages
US6737266B1 (en) 1999-10-01 2004-05-18 3M Innovative Properties Company Devices and methods for microorganism detection
DE10100586C1 (de) 2001-01-09 2002-04-11 Ribopharma Ag Verfahren zur Hemmung der Expression eines Ziegens
US7160511B2 (en) 2000-02-18 2007-01-09 Olympus Corporation Liquid pipetting apparatus and micro array manufacturing apparatus
US8216797B2 (en) 2001-02-07 2012-07-10 Massachusetts Institute Of Technology Pathogen detection biosensor
GB0108830D0 (en) 2001-04-09 2001-05-30 Univ Nottingham Controlling DNA packaging
US6544729B2 (en) 2001-07-20 2003-04-08 University Of Tennessee Bioluminescent biosensor device
JP4849772B2 (ja) 2001-09-27 2012-01-11 ガンガゲン インコーポレーティッド 免疫原性が低いリシン欠損バクテリオファージ
US20030148335A1 (en) 2001-10-10 2003-08-07 Li Shen Detecting targets by unique identifier nucleotide tags
EP1436199A1 (en) 2001-10-19 2004-07-14 MonoGen, Inc. Specimen vial sealing apparatus and method
AU2002365188A1 (en) 2001-11-07 2003-07-30 Musc Foundation For Research Development Nucleic acid delivery and expression
NZ533051A (en) 2001-12-06 2006-10-27 Biocontrol Systems Inc Sample collection and testing system
ES2346424T3 (es) 2002-04-12 2010-10-15 Colorado School Of Mines Procedimiento de deteccion de bajas concentraciones de una bacteria diana que utiliza fagos para infectar celulas bacterianas diana.
US8216780B2 (en) 2002-04-12 2012-07-10 Microphage (Tm) Incorporated Method for enhanced sensitivity in bacteriophage-based diagnostic assays
US20050003346A1 (en) 2002-04-12 2005-01-06 Colorado School Of Mines Apparatus and method for detecting microscopic living organisms using bacteriophage
WO2004005553A1 (en) 2002-07-10 2004-01-15 Massachusetts Institute Of Technology Apparatus and method for isolating a nucleic acid from a sample
SE0203366L (sv) 2002-11-14 2003-11-04 Magnetic Biosolutions Sweden A Pipetteringsapparat
WO2004046321A2 (en) 2002-11-15 2004-06-03 Trustees Of Boston University Cis/trans riboregulators
US7291482B2 (en) * 2002-12-20 2007-11-06 E.I. Du Pont De Nemours And Company Mutations affecting plasmid copy number
US7125727B2 (en) 2003-01-29 2006-10-24 Protedyne Corporation Sample handling tool with piezoelectric actuator
FI20030867A7 (fi) 2003-06-10 2004-12-11 Wallac Oy Optinen mittausmenetelmä ja laboratoriomittauslaite
EP3718635A1 (en) 2003-07-31 2020-10-07 Handylab, Inc. Processing particle-containing samples
WO2005046579A2 (en) 2003-10-06 2005-05-26 Gangagen, Inc. Defined dose therapeutic phage
FR2860731B1 (fr) 2003-10-14 2006-01-21 Maxmat S A Appareil de mixage d'un analyseur chimique ou biochimique avec entrainement pendulaire d'une pipette
DE102004003434B4 (de) 2004-01-21 2006-06-08 Eppendorf Ag Pipettiervorrichtung mit einer Verdrängungseinrichtung und einer damit lösbar verbundenen Antriebseinrichtung
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US20060257991A1 (en) 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
AU2005324479A1 (en) * 2004-04-07 2006-07-20 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Reporter plasmid phage packaging system for detection of bacteria
US7674621B2 (en) 2004-05-21 2010-03-09 The United States Of America As Represented By The Department Of Health And Human Services Plasmids and phages for homologous recombination and methods of use
NZ551993A (en) 2004-07-06 2009-12-24 Mixis France Sa Generation of recombinant genes in a bacteriophage and a bacterial host cell.
US8182804B1 (en) 2004-09-13 2012-05-22 Trustees Of Boston University Engineered enzymatically active bacteriophages and methods of uses thereof
US20060068398A1 (en) 2004-09-24 2006-03-30 Cepheid Universal and target specific reagent beads for nucleic acid amplification
US7244612B2 (en) 2004-10-07 2007-07-17 University Of Wyoming Template reporter bacteriophage platform and multiple bacterial detection assays based thereon
KR100668310B1 (ko) 2004-11-01 2007-01-12 삼성전자주식회사 표적 세포 특이적 바이러스를 이용하여 표적 세포의존재를 검출하는 방법
WO2006083695A2 (en) 2005-01-28 2006-08-10 Parker-Hannifin Corporation Sampling probe, gripper and interface for laboratory sample management systems
US20110097702A1 (en) 2005-03-31 2011-04-28 Voorhees Kent J Methods and compositions for in situ detection of microorganisms on a surface
US8092990B2 (en) 2005-03-31 2012-01-10 Colorado School Of Mines Apparatus and method for detecting microscopic organisms using bacteriophage
WO2007053186A2 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
JP2009508490A (ja) 2005-09-15 2009-03-05 マイクロファージ・インコーポレーテッド バクテリオファージを用いた、微生物同定のための方法および装置
US20070072174A1 (en) 2005-09-28 2007-03-29 Sayler Gary S Bioreporter for detection of microbes
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US20070178450A1 (en) 2006-01-27 2007-08-02 Microphage (Tm) Incorporation Method and apparatus for determining level of microorganisms using bacteriophage
US20080003564A1 (en) 2006-02-14 2008-01-03 Iquum, Inc. Sample processing
WO2007115378A1 (en) 2006-04-11 2007-10-18 Minifab (Australia) Pty Ltd Microfluidic package housing
US20070292397A1 (en) 2006-06-19 2007-12-20 Mcnulty Amy K Method for the detection and neutralization of bacteria
WO2008049036A2 (en) 2006-10-17 2008-04-24 Zymera, Inc. Enzyme detection system with caged substrates
CA2667771A1 (en) 2006-10-31 2008-05-29 Microphage Incorporated Method and apparatus for enhanced bacteriophage-based diagnostic assays by selective inhibition of potential cross reactive organisms
US20080153096A1 (en) 2006-11-02 2008-06-26 Vectrant Technologies Inc. Cartridge for conducting diagnostic assays
ITPD20060419A1 (it) 2006-11-13 2008-05-14 Federico Nalesso Dispositivo per il trattamento manutentivo di cateteri venosi centrali
US8355132B2 (en) 2007-04-06 2013-01-15 Qiagen Gaithersburg, Inc. Sample adequacy measurement system having a plurality of sample tubes and using turbidity light scattering techniques
CA2684311A1 (en) * 2007-04-18 2008-10-30 Cornell University Microorganism detection method and apparatus
US8483174B2 (en) 2007-04-20 2013-07-09 Qualcomm Incorporated Method and apparatus for providing gateway relocation
US8454895B2 (en) 2007-05-03 2013-06-04 Nanyang Technological University Online contaminant detection and removal system
AU2008265989B8 (en) 2007-06-15 2012-01-12 Microphage Incorporated Method of detection of microorganisms with enhanced bacteriophage amplification
GB0712844D0 (en) 2007-07-02 2007-08-08 Univ Leuven Kath Colorimetric assay for the visual detection of primary and secondary amines
US8314222B2 (en) * 2007-10-05 2012-11-20 Sapphire Energy, Inc. System for capturing and modifying large pieces of genomic DNA and constructing organisms with chloroplasts
US20090155838A1 (en) 2007-11-28 2009-06-18 Smart Tube, Inc. Devices, systems and methods for the collection, stimulation, stabilization, and analysis of a biological sample
US8619257B2 (en) 2007-12-13 2013-12-31 Kimberley-Clark Worldwide, Inc. Recombinant bacteriophage for detection of nosocomial infection
US8153119B2 (en) 2007-12-18 2012-04-10 Trustees Of Boston University Engineered enzymatically active bacteriophage and methods for dispersing biofilms
US8329889B2 (en) 2008-02-15 2012-12-11 Trustees Of Boston University In vivo gene sensors
EP2276852B1 (en) 2008-05-14 2015-11-04 Guild Associates, Inc. Phage-mediated bioluminescent detection of yersinia pestis
DK2291640T3 (da) 2008-05-20 2019-03-11 Univ Health Network Anordning og fremgangsmåde til fluorescens-baseret billeddannelse og monitorering
US20120134975A1 (en) 2008-08-13 2012-05-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Biological targeting compositions and methods of using the same
CN102317777B (zh) 2008-12-16 2015-01-07 生物梅里埃有限公司 用于在固体或半固体介质上表征微生物的方法
US8645115B2 (en) 2008-12-22 2014-02-04 Trustees Of Boston University Modular nucleic acid-based circuits for counters, binary operations, memory and logic
EP2398775B1 (en) 2009-02-18 2019-04-24 Cornell University Coupled recognition/detection system for in vivo and in vitro use
US20110183314A1 (en) 2010-01-26 2011-07-28 Microphage Incorporated Bacteriophage-based microorganism diagnostic assay using speed or acceleration of bacteriophage reproduction
TW201217783A (en) 2010-09-15 2012-05-01 Mbio Diagnostics Inc System and method for detecting multiple molecules in one assay
CN104023834B (zh) 2011-05-04 2016-09-28 卢米耐克斯公司 用于集成的样品制备、反应和检测的设备与方法
EP2723884B2 (en) 2011-06-22 2024-09-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for detecting the presence of carbapenemase-producing bacteria in a sample
US9234227B2 (en) 2011-09-26 2016-01-12 Sample6 Technologies, Inc. Recombinant phage and methods
KR102127358B1 (ko) 2013-03-13 2020-06-29 지니위브 바이오사이언시스, 인코포레이티드 비-복제 형질도입 입자 및 형질도입 입자-기반 리포터 시스템
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles

Also Published As

Publication number Publication date
US10227663B2 (en) 2019-03-12
ES2780827T3 (es) 2020-08-27
CA2905341A1 (en) 2014-10-02
KR102127358B1 (ko) 2020-06-29
US10227662B2 (en) 2019-03-12
AU2014243796B2 (en) 2018-07-19
CN110938671A (zh) 2020-03-31
EP2968424A4 (en) 2017-01-25
BR112015023108A2 (pt) 2017-11-21
EP2968424A2 (en) 2016-01-20
US20160281179A1 (en) 2016-09-29
MX380248B (es) 2025-03-12
CN105378060A (zh) 2016-03-02
HK1218429A1 (zh) 2017-02-17
MX360560B (es) 2018-11-07
US9388453B2 (en) 2016-07-12
EP3699592B1 (en) 2026-04-29
US20170327910A1 (en) 2017-11-16
MX2015011446A (es) 2016-03-15
JP6708721B2 (ja) 2020-06-10
JP2016520290A (ja) 2016-07-14
AU2014243796A1 (en) 2015-10-08
RU2661101C2 (ru) 2018-07-11
BR112015023108A8 (pt) 2018-01-23
SG11201507463WA (en) 2015-10-29
CA2905341C (en) 2021-08-24
CN105378060B (zh) 2019-12-10
US9771622B2 (en) 2017-09-26
JP2019030328A (ja) 2019-02-28
US20160281180A1 (en) 2016-09-29
NZ712344A (en) 2021-03-26
US20150104787A1 (en) 2015-04-16
KR20150131199A (ko) 2015-11-24
WO2014160418A2 (en) 2014-10-02
EP3699592A1 (en) 2020-08-26
JP6431035B2 (ja) 2018-11-28
US9752200B2 (en) 2017-09-05
WO2014160418A3 (en) 2015-03-19
EP2968424B1 (en) 2020-01-22
RU2015143713A (ru) 2017-04-20
US20170321289A1 (en) 2017-11-09

Similar Documents

Publication Publication Date Title
DK2968424T3 (da) Ikke-replikative transduktionspartikler og transduktionspartikelbaserede reportersystemer
CY2025017I1 (el) Αιθερες αρυλιου και χρησεις εξ αυτων
IL284727B (en) Noise suppression methods and apparatus
SG11201701273PA (en) Non-replicative transduction particles and transduction particle-based reporter systems
IL251558B (en) Systems and methods for resource consumption analytics
EP2949343A4 (en) THREE-TONE CONNEXONE AND USE THEREOF
SG11201604906QA (en) Cloud-based transactions methods and systems
DK3010841T3 (da) Systemer og fremgangsmåder til ordrebehandling
CL2016000743A1 (es) Pellets alimenticios y métodos y sistemas relacionados
DK3003039T3 (da) Methyl/fluor-pyridinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser og fluor-pyrimidinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser
DK3063144T3 (da) Antiparasitære og pesticid-isoxazolinforbindelser
DK2962100T3 (da) Tuberkulosebiomarkører og anvendelser deraf
DK3030549T3 (da) Pyridazinonforbindelser og anvendelser deraf
IL243728A0 (en) Heterobicycloaryl rorc2 inhibitors and methods of use thereof
DK3029038T3 (da) Tetrazolinonforbindelse og anvendelse deraf
EP2957073A4 (en) Queue monitoring and visualization
IL259565A (en) Systems and methods for sharing content
EP3640854C0 (en) IMPROVEMENTS FOR COUNTING DEVICES
IL258856A (en) Solabegron zwitterion and uses thereof
DK2951208T3 (da) Anti-cd83 antistoffer og anvendelse deraf
DK3077510T3 (da) Antisense-forbindelser og anvendelser deraf
EP3051144A4 (en) COMPRESSORS AND CHARGERS
GB2527460B (en) Systems and methods for evaluating physical performance
BR112015024661A2 (pt) silo e silo elevado
FI10723U1 (fi) Matemaattiset opetusvälineet