DK2970903T3 - Fotoreceptorer og fotoreceptor-progenitorer fremstillet fra pluripotente stamceller - Google Patents

Fotoreceptorer og fotoreceptor-progenitorer fremstillet fra pluripotente stamceller Download PDF

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Publication number
DK2970903T3
DK2970903T3 DK14764825.7T DK14764825T DK2970903T3 DK 2970903 T3 DK2970903 T3 DK 2970903T3 DK 14764825 T DK14764825 T DK 14764825T DK 2970903 T3 DK2970903 T3 DK 2970903T3
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photoreceptors
stem cells
pluripotent stem
photoreceptor progenitors
progenitors produced
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DK14764825.7T
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Robert P Lanza
Shi-Jiang Lu
Wei Wang
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Astellas Inst For Regenerative Medicine
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DK14764825.7T 2013-03-15 2014-03-14 Fotoreceptorer og fotoreceptor-progenitorer fremstillet fra pluripotente stamceller DK2970903T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361793168P 2013-03-15 2013-03-15
PCT/US2014/029790 WO2014145108A1 (en) 2013-03-15 2014-03-14 Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells

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US (5) US10307444B2 (da)
EP (2) EP4292600A3 (da)
JP (4) JP6581966B2 (da)
KR (3) KR20230058556A (da)
CN (2) CN118995611A (da)
AU (4) AU2014233403B2 (da)
CA (2) CA2906815A1 (da)
DK (1) DK2970903T3 (da)
ES (1) ES2970720T3 (da)
FI (1) FI2970903T3 (da)
HK (1) HK1222205A1 (da)
IL (5) IL294897B2 (da)
PT (1) PT2970903T (da)
WO (1) WO2014145108A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230058556A (ko) 2013-03-15 2023-05-03 아스텔라스 인스티튜트 포 리제너러티브 메디슨 만능 줄기 세포로부터 제조된 광수용기 및 광수용기 전구체
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
ES2980659T3 (es) * 2015-03-23 2024-10-02 Astellas Inst For Regenerative Medicine Ensayos mejorados de potencia de células de epitelio pigmentario retiniano (EPR) humano y progenitores de fotorreceptores
TWI711455B (zh) * 2015-05-13 2020-12-01 臺北榮民總醫院 多層視網膜細胞移植物
SG10201913250SA (en) 2015-08-18 2020-03-30 Astellas Inst For Regenerative Medicine Clinical formulations
KR102675213B1 (ko) * 2015-09-08 2024-06-13 스미토모 파마 가부시키가이샤 망막 색소 표피 세포의 제조 방법
CN105567635A (zh) * 2016-02-21 2016-05-11 中国医科大学附属第一医院 一种改良的Neurobasal B27培养基、制备方法及应用
CN116121189A (zh) 2016-03-30 2023-05-16 阿斯特利亚斯生物治疗股份公司 少突胶质细胞祖细胞组合物
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
WO2018149985A1 (en) * 2017-02-17 2018-08-23 Sorbonne Universite Feeder-free methods for obtaining retinal progenitors, retinal pigmented epithelial cells and neural retinal cells
GB201703058D0 (en) * 2017-02-24 2017-04-12 Ucl Business Plc Biomarkers
EP3594322A4 (en) 2017-03-08 2021-01-27 Sumitomo Dainippon Pharma Co., Ltd. METHOD FOR PRODUCING RETINAPIGMENT EPITHELIAL CELLS
CA3075877A1 (en) * 2017-09-14 2019-03-21 Riken Method for producing retinal tissues
WO2019054515A1 (ja) * 2017-09-14 2019-03-21 国立研究開発法人理化学研究所 背側化シグナル伝達物質又は腹側化シグナル伝達物質による錐体視細胞又は桿体視細胞の増加方法
WO2019078781A1 (en) 2017-10-17 2019-04-25 National University Of Singapore SYSTEMS AND METHODS FOR PRODUCING PHOTORECEPTOR PROGENITORS
KR102920569B1 (ko) 2018-04-20 2026-02-02 후지필름 셀룰러 다이내믹스, 인코포레이티드 안구 세포의 분화를 위한 방법 및 이의 용도
CN108795864B (zh) * 2018-05-24 2021-08-24 中山大学中山眼科中心 一种利用人诱导多能干细胞获得富含视锥及视杆细胞的类视网膜组织的方法
US20210315938A1 (en) * 2018-09-07 2021-10-14 Hebecell Corporation Methods and Compositions for Retinal Neuron Generation in Carrier-Free 3D Sphere Suspension Culture
IL281628B2 (en) * 2018-09-19 2025-06-01 Lineage Cell Therapeutics Inc Methods for differentiating pluripotent stem cells in dynamic suspension culture
CN109486766B (zh) * 2018-11-26 2021-05-07 中山大学 一种泪腺干细胞、泪腺干细胞的培养体系和培养方法
WO2020154533A1 (en) 2019-01-23 2020-07-30 Asterias Biotherapeutics, Inc. Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells
BR112022024031A2 (pt) * 2020-05-29 2023-01-31 Fujifilm Cellular Dynamics Inc Agregados de células duplas de epitélio pigmentado da retina e fotorreceptor, e métodos de uso dos mesmos
CA3180561A1 (en) * 2020-05-29 2021-12-02 Andrew DIAS Bilayer of retinal pigmented epithelium and photoreceptors and use thereof
WO2022134031A1 (zh) * 2020-12-25 2022-06-30 武汉睿健医药科技有限公司 一种光感受器神经元细胞的化学诱导方法
CN112608883B (zh) * 2020-12-25 2023-02-24 武汉睿健医药科技有限公司 一种光感受器神经元细胞的化学诱导方法
KR102525093B1 (ko) * 2021-04-16 2023-04-27 가톨릭대학교 산학협력단 사람 신경능 유래 코 하비갑개 줄기세포를 유효성분으로 포함하는 망막변성질환 예방 또는 치료용 약학적 조성물
CN113388582A (zh) * 2021-06-21 2021-09-14 香港再生医学有限公司 促使iPSC分化为外周神经干细胞的方法及培养基和系统

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750196B1 (en) 1995-03-27 2004-06-15 Acorda Therapeutics Methods of treating disorders of the eye
US20030166276A1 (en) 2000-10-16 2003-09-04 Melissa Carpenter Cultures of human CNS neural stem cells
WO1999055838A1 (en) 1998-04-24 1999-11-04 University Of Nebraska Board Of Regents Compositions and methods for the characterization and transplantation of mammalian retinal stem cells
JP2003505023A (ja) 1999-07-16 2003-02-12 プレサイエント ニューロファーマ インコーポレイテッド 細胞治療用細胞の産生および調製の方法
WO2002074176A1 (en) 2001-03-16 2002-09-26 University Of Washington Methods for modulating neural activity in the retina
WO2002076386A2 (en) 2001-03-26 2002-10-03 Zymogenetics, Inc. Method of inducing proliferation of retinal stem cells
JP2006506970A (ja) 2002-07-12 2006-03-02 ユニバーシティ オブ ワシントン 神経細胞の延長されたインビトロ培養のための方法および系
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
BRPI0507074A (pt) 2004-01-23 2007-06-19 Advanced Cell Tech Inc modalidades aperfeiçoadas para o tratamento de doenças degenerativas da retina
EP1783205B1 (en) 2004-06-18 2024-02-21 Riken Method of inducing the differentiation of embryonic stem cells into nerve by serum-free suspension culture
CA2583473A1 (en) * 2004-10-05 2007-04-04 University Of Georgia Research Foundation, Inc. Neuronal progenitors from feeder-free human embryonic stem cell culture
US7541186B2 (en) 2006-02-22 2009-06-02 University Of Washington Method of generating human retinal progenitors from embryonic stem cells
US20100136537A1 (en) 2006-10-10 2010-06-03 The Regents Of The University Of Michigan Photoreceptor precursor cells
JP5441099B2 (ja) 2007-01-18 2014-03-12 独立行政法人理化学研究所 視細胞への分化誘導方法
WO2011028524A1 (en) 2009-08-24 2011-03-10 Wisconsin Alumni Research Foundation Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
KR101268741B1 (ko) * 2009-10-06 2013-06-04 김지연 줄기세포를 망막세포로 분화시키는 방법
JP5787370B2 (ja) 2009-11-05 2015-09-30 国立研究開発法人理化学研究所 幹細胞の分化誘導方法
EP2383333B1 (en) 2010-04-28 2015-05-27 Technische Universität Dresden Method for producing polarized retinal progenitor cells from pluripotent stem cells and their differentiation into retinal pigment epithelium cells
EP3636286A1 (en) 2011-05-18 2020-04-15 The Regents of The University of California Compositions and methods for treating retinal diseases
KR102111936B1 (ko) 2011-11-25 2020-05-18 스미또모 가가꾸 가부시끼가이샤 망막 조직 및 망막 관련 세포의 제조 방법
RU2696071C2 (ru) 2012-04-24 2019-07-30 Виселл Терапеутикс, Инк. Получение плюрипотентных клеток de novo
US9458428B2 (en) * 2012-06-05 2016-10-04 The Regents Of The University Of California Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells
WO2013183774A1 (ja) 2012-06-08 2013-12-12 住友化学株式会社 毛様体周縁部様構造体の製造方法
US20140004086A1 (en) 2012-06-29 2014-01-02 Tissue Genesis Inc. Formation of cell aggregates
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
KR20230058556A (ko) 2013-03-15 2023-05-03 아스텔라스 인스티튜트 포 리제너러티브 메디슨 만능 줄기 세포로부터 제조된 광수용기 및 광수용기 전구체
US20160175361A1 (en) 2014-03-14 2016-06-23 Advanced Cell Technology, Inc. Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
US20160175362A1 (en) 2014-03-14 2016-06-23 Ocata Therapeutics, Inc. Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
EP2796545A1 (en) 2013-04-26 2014-10-29 Université Pierre et Marie Curie (Paris 6) Methods for obtaining retinal progenitors, retinal pigmented epithelial cells and neural retinal cells
DK3037524T3 (da) 2013-08-23 2020-03-16 Sumitomo Chemical Co Fremgangsmåde til at fremstille nethindevæv og nethinderelaterede celler
CN120384050A (zh) 2013-11-11 2025-07-29 住友化学株式会社 用于制备视网膜色素上皮细胞的方法
EP3081637B1 (en) 2013-12-11 2019-05-08 Sumitomo Chemical Company, Limited Method for manufacturing ciliary marginal zone-like structure
US10435667B2 (en) 2014-01-16 2019-10-08 The Johns Hopkins University Methods for forming three-dimensional human retinal tissue in vitro
AU2014378349B2 (en) 2014-01-17 2021-06-03 Riken Method for manufacturing ciliary margin stem cells
GB201402692D0 (en) 2014-02-16 2014-04-02 Univ Newcastle Synthetic retina
JP6682446B2 (ja) 2014-10-24 2020-04-15 大日本住友製薬株式会社 網膜組織の製造方法
US10363256B2 (en) 2015-03-27 2019-07-30 University Of Washington Methods for treatment of retinal disease by photoreceptor gene expression modulation
JP6884354B2 (ja) 2015-09-08 2021-06-09 大日本住友製薬株式会社 網膜組織の製造方法
US11371003B2 (en) 2016-02-05 2022-06-28 Wisconsin Alumni Research Foundation Photoreceptor scaffold for in vitro modeling and transplantation therapy
CA3019357A1 (en) 2016-04-04 2017-10-12 Biotime, Inc. Pluripotent stem cell-derived 3d retinal tissue and uses thereof
SG11201809201UA (en) 2016-04-22 2018-11-29 Sumitomo Dainippon Pharma Co Ltd Method for producing retinal tissue
JP7048585B2 (ja) 2016-09-22 2022-04-05 ソルボンヌ・ユニヴェルシテ 網膜変性疾患の処置に使用するための光遺伝学的に形質転換した光受容体前駆細胞
US10973855B2 (en) 2016-10-10 2021-04-13 Small Kent W Methods for treating macular degeneration
CN109996873A (zh) 2016-11-25 2019-07-09 国立研究开发法人理化学研究所 移植用细胞群及其制造方法
WO2018132802A1 (en) 2017-01-13 2018-07-19 The Johns Hopkins University Retina regeneration with a tissue-and-technology prosthesis
WO2018149985A1 (en) 2017-02-17 2018-08-23 Sorbonne Universite Feeder-free methods for obtaining retinal progenitors, retinal pigmented epithelial cells and neural retinal cells
GB201703058D0 (en) 2017-02-24 2017-04-12 Ucl Business Plc Biomarkers
US12534706B2 (en) 2017-07-20 2026-01-27 Riken Method for maturation of retinal tissue containing continuous epithelium
CA3071648A1 (en) 2017-07-31 2019-02-07 Biotime, Inc. Compositions and methods for restoring or preventing loss of vision caused by disease or traumatic injury
US20200368234A1 (en) 2017-08-10 2020-11-26 University Of Washington Photoreceptor gene modulator photoregulin 3 for treatment of retinal disease
CA3075877A1 (en) 2017-09-14 2019-03-21 Riken Method for producing retinal tissues
WO2019054515A1 (ja) 2017-09-14 2019-03-21 国立研究開発法人理化学研究所 背側化シグナル伝達物質又は腹側化シグナル伝達物質による錐体視細胞又は桿体視細胞の増加方法
GB201800546D0 (en) 2018-01-12 2018-02-28 Ucl Business Plc Treatment
US12497591B2 (en) 2018-03-07 2025-12-16 Sorbonne Universite Compositions and methods for efficient amplification of retinal progenitors cells
US20210228741A1 (en) 2018-04-27 2021-07-29 University Of Washington Methods and compositions to stimulate retinal regeneration
EP3790959A1 (en) 2018-05-09 2021-03-17 The Regents of the University of Colorado, A Body Corporate Stem cell-derived cell cultures, stem cell-derived three-dimensional tissue products, and methods of making and using the same

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