DK2986330T3 - Implantater til at inducere blødt og hårdt væv-integration - Google Patents
Implantater til at inducere blødt og hårdt væv-integration Download PDFInfo
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- DK2986330T3 DK2986330T3 DK13718169.9T DK13718169T DK2986330T3 DK 2986330 T3 DK2986330 T3 DK 2986330T3 DK 13718169 T DK13718169 T DK 13718169T DK 2986330 T3 DK2986330 T3 DK 2986330T3
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- metal
- implant
- alloy
- flavonoid
- biocompatible implant
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- Engineering & Computer Science (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Claims (15)
1. Biokompatibelt implantat omfattende et eller flere metaller, metallegeringer, metaloxider eller en kombination deraf, hvor en antioxidantforbindelse valgt fra gruppen af flavonoider, methoxytryptopholer, en ester deraf, et farmaceutisk acceptabelt salt deraf, og en kombination deraf, er coatet til mindst en del af en metal-, metallegerings- eller metaloxidoverflade af nævnte biokompatible implantat, hvor antioxidanten er kovalent bundet til metal-, metallegerings- eller metaloxidoverfladen.
2. Det biokompatible implantat ifølge krav 1, hvor flavonoid-forbindelsen omfatter mindst én carbonylgruppe, og, hvor flavonoidet er valgt fra quercitrin, taxifolin, galangin, diosmetin, chrysin eller derivater deraf.
3. Det biokompatible implantat ifølge krav 1, hvor methoxytryptophol-forbindelsen er valgt fra 5-methoxytryptophol eller 6-methoxytryptophol.
4. Det biokompatible implantat ifølge et hvilket som helst af de foregående krav, hvor en linker er bundet til nævnte metal-, metallegering- eller metaloxidoverflade og til nævnte antioxidant, ester af sådan forbindelse, et farmaceutisk acceptabelt salt deraf eller en kombination deraf.
5. Det biokompatible implantat ifølge krav 4, hvor nævnte linker er valgt fra gruppen bestående af anhydrider, alkoholer, syrer, aminer, epoxier, isocyanater, silaner, thiol, alkyl, aryl, halogenerede grupper, og polymeriserbare grupper.
6. Det biokompatible implantat ifølge det foregående krav, hvor silanen er valgt fra 3-aminopropyltriethoxysilan eller triethoxysilanpropylsuccinsyre.
7. Det biokompatible implantat ifølge krav 5, hvor linkeren er en polyether.
8. Det biokompatible implantat ifølge et hvilket som helst af de foregående krav, hvor nævnte metal(ler), metallegering(er) eller metaloxid(er) er valgt fra gruppen bestående aftitanium, en legering elleret oxid deraf, zirkonium, en legering eller et oxid deraf, tantalum, en legering eller et oxid deraf, hafnium, en legering eller et oxid deraf, niobium, eller en legering eller et oxid deraf, chrom-vanadium legering og rustfrit stål.
9. Det biokompatible implantat ifølge krav 8, hvor nævnte metal, metallegering eller metaloxid er titanium.
10. Det biokompatible implantat ifølge et hvilket som helst af de foregående krav, hvor andre biomolekyler er til stede på en metal-, metallegering- eller metaloxidoverflade af implantatet, hvor nævnte biomolekyler er valgt fra gruppen bestående af naturlige biomolekyler, syntetiske biomolekyler, og rekombinante biomolekyler, cellefastgøringsfaktorer, biopolymerer, blodproteiner, enzymer, ekstracellulær matrix-proteiner og biomolekyler, vækstfaktorer og hormoner, nukleinsyrer, receptorer, syntetiske biomolekyler, vitaminer, lægemidler, iphosphonater, biologisk aktive ioner, fluorid, og markørbiomolekyler.
11. Fremgangsmåde til fremstilling af et biokompatibelt implantat ifølge et hvilket som helst af de foregående krav, omfattende at reagere en antioxidantforbindelse som defineret i et hvilket som helst af kravene 1-3 med overfladen af nævnte biokompatible implantat.
12. Fremgangsmåden ifølge krav 11, omfattende trinnene: a) at kemisk forbehandle overfladen af et implantat, b) et trin at reagere en linker som defineret i et hvilket som helst af kravene 4-7 med nævnte kemisk forbehandlede overflade opnået i trin a), og c) at reagere en antioxidantforbindelse som defineret i et hvilket som helst af kravene 1-3 med nævnte linker; eller alternativt, trinnene; a) at kemisk forbehandle overfladen af et implantat, b) et trin at reagere en linker som defineret i et hvilket som helst af kravene 4-7 med antioxidantforbindelsen som defineret i et hvilket som helst af kravene 1-3; og c) at reagere antioxidant-linker-konjugatet derved opnået med nævnte forbehandlede overflade opnået i trin a).
13. Fremgangsmåden ifølge krav 12, hvor efter at reagere antioxidantforbindelsen med linkeren, et reduktionstrin udføres.
14. Fremgangsmåden ifølge et hvilket som helst af kravene 12-13, hvor forbehandlingstrinnet vælges fra piranha-angreb, passivering, UV-bestråling, syreeller alkali-angreb.
15. Biokompatibelt implantat ifølge et hvilket som helst af kravene 1-14, til anvendelse i erstatning af knoglevæv og/eller genvinding af en funktion af legemet af et hvirveldyr, hvor erstatningen omfatter at implantere det biokompatible implantat.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2013/058116 WO2014169959A1 (en) | 2013-04-18 | 2013-04-18 | Implants for inducing soft and hard tissue integration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2986330T3 true DK2986330T3 (da) | 2019-01-28 |
Family
ID=48170463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13718169.9T DK2986330T3 (da) | 2013-04-18 | 2013-04-18 | Implantater til at inducere blødt og hårdt væv-integration |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9849212B2 (da) |
| EP (1) | EP2986330B1 (da) |
| BR (1) | BR112015026321B1 (da) |
| CA (1) | CA2910148C (da) |
| CY (1) | CY1121178T1 (da) |
| DK (1) | DK2986330T3 (da) |
| ES (1) | ES2706021T3 (da) |
| HR (1) | HRP20190041T1 (da) |
| HU (1) | HUE043049T2 (da) |
| LT (1) | LT2986330T (da) |
| PL (1) | PL2986330T3 (da) |
| PT (1) | PT2986330T (da) |
| RS (1) | RS58359B1 (da) |
| SI (1) | SI2986330T1 (da) |
| WO (1) | WO2014169959A1 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017023527A1 (en) * | 2015-08-03 | 2017-02-09 | Advanced Endovascular Therapeutics | Novel coatings for medical devices |
| IT201700081175A1 (it) * | 2017-07-18 | 2019-01-18 | Nobil Bio Ricerche Srl | Dispositivi implantari rivestiti |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356433A (en) * | 1991-08-13 | 1994-10-18 | Cordis Corporation | Biocompatible metal surfaces |
| US5607475A (en) | 1995-08-22 | 1997-03-04 | Medtronic, Inc. | Biocompatible medical article and method |
| US20060194008A1 (en) * | 1999-09-22 | 2006-08-31 | Princeton University | Devices with multiple surface functionality |
| SE523236C2 (sv) * | 2002-07-19 | 2004-04-06 | Astra Tech Ab | Ett implantat och ett förfarande för behandling av en implantatyta |
| US7083813B2 (en) * | 2002-11-06 | 2006-08-01 | The Quigley Corporation | Methods for the treatment of peripheral neural and vascular ailments |
| WO2007010342A1 (en) | 2005-07-15 | 2007-01-25 | Sahajanand Biotech Private Limited | Implantable medical devices comprising a flavonoid or derivative thereof for prevention of restenosis |
| WO2008119053A1 (en) | 2007-03-27 | 2008-10-02 | University Of Southern California | Device which enhances the biological activity of locally applied growth factors with particular emphasis on those used for bone repair |
| JP5474831B2 (ja) * | 2008-02-08 | 2014-04-16 | テルモ株式会社 | 生理活性物質管腔内制御送達用薬剤送達装置およびその作成方法 |
| EP2143451A1 (en) | 2008-07-11 | 2010-01-13 | Nobel Biocare Services AG | Bone implant application |
-
2013
- 2013-04-18 SI SI201331314T patent/SI2986330T1/sl unknown
- 2013-04-18 EP EP13718169.9A patent/EP2986330B1/en active Active
- 2013-04-18 PT PT13718169T patent/PT2986330T/pt unknown
- 2013-04-18 HU HUE13718169A patent/HUE043049T2/hu unknown
- 2013-04-18 CA CA2910148A patent/CA2910148C/en active Active
- 2013-04-18 RS RS20190009A patent/RS58359B1/sr unknown
- 2013-04-18 BR BR112015026321A patent/BR112015026321B1/pt not_active IP Right Cessation
- 2013-04-18 LT LTEP13718169.9T patent/LT2986330T/lt unknown
- 2013-04-18 US US14/785,253 patent/US9849212B2/en not_active Expired - Fee Related
- 2013-04-18 WO PCT/EP2013/058116 patent/WO2014169959A1/en not_active Ceased
- 2013-04-18 ES ES13718169T patent/ES2706021T3/es active Active
- 2013-04-18 DK DK13718169.9T patent/DK2986330T3/da active
- 2013-04-18 HR HRP20190041TT patent/HRP20190041T1/hr unknown
- 2013-04-18 PL PL13718169T patent/PL2986330T3/pl unknown
-
2019
- 2019-01-10 CY CY20191100023T patent/CY1121178T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2986330B1 (en) | 2018-10-17 |
| CA2910148A1 (en) | 2014-10-23 |
| PL2986330T3 (pl) | 2019-08-30 |
| PT2986330T (pt) | 2019-01-21 |
| US9849212B2 (en) | 2017-12-26 |
| LT2986330T (lt) | 2019-03-12 |
| BR112015026321B1 (pt) | 2019-12-03 |
| RS58359B1 (sr) | 2019-03-29 |
| WO2014169959A1 (en) | 2014-10-23 |
| EP2986330A1 (en) | 2016-02-24 |
| BR112015026321A2 (pt) | 2017-10-10 |
| CA2910148C (en) | 2020-08-18 |
| HRP20190041T1 (hr) | 2019-03-22 |
| SI2986330T1 (sl) | 2019-04-30 |
| US20160082147A1 (en) | 2016-03-24 |
| HUE043049T2 (hu) | 2019-07-29 |
| ES2706021T3 (es) | 2019-03-27 |
| CY1121178T1 (el) | 2020-05-29 |
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