DK3000466T3 - Inhibitor til retinochoroidale sygdomme - Google Patents
Inhibitor til retinochoroidale sygdomme Download PDFInfo
- Publication number
- DK3000466T3 DK3000466T3 DK14800477.3T DK14800477T DK3000466T3 DK 3000466 T3 DK3000466 T3 DK 3000466T3 DK 14800477 T DK14800477 T DK 14800477T DK 3000466 T3 DK3000466 T3 DK 3000466T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitor
- use according
- salt
- benzoic acid
- retinochoroidal
- Prior art date
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Claims (15)
1. Inhibitor til anvendelse i en fremgangsmåde til behandling afen retinochoroidal sygdom omfattende (E)-4-(2-{3-[(lH-pyrazol-l-yl)methyl]-5,5,8,8-tetramethyl- 5,6,7,8-tetrahydronaphthalen-2-yl}vinyl)benzoesyre, en ester deraf, eller et salt deraf som en effektiv bestanddel, hvor behandlingen omfatter inhibering af ardannelse eller atrofi.
2. Inhibitoren til anvendelse ifølge krav 1, hvor behandlingen omfatter inhibering af ardannelse.
3. Inhibitoren til anvendelse ifølge krav 1 eller 2, hvor arret er et fibrøst bindevæv der forekommer på et epiretinalt-, intraretinalt-, og/eller subretinalt skadested med progressionen afen ophthalmisk inflammation.
4. Inhibitoren til anvendelse ifølge et hvilket som helst af kravene 1 til 3, hvor arret omfatter en retinal pigmentepitelcelle med ekstracellulær matrix omfattende kollagen.
5. Inhibitoren til anvendelse ifølge krav 1, hvor behandlingen omfatter forebyggende deformation eller disintegration af en vævsstruktur.
6. Inhibitoren til anvendelse ifølge krav 1, hvor behandlingen omfatter inhibering af dannelsen og atrofi af et retinochoroidalt ar i epiretinalt-, intraretinalt-, og/eller subretinalt væv.
7. Inhibitoren til anvendelse ifølge krav 1, hvor behandlingen omfatter inhibering af kollagenatrofi, og hvor kollagenatrofi er en retinal pigmentepitelcelle, en fibroblast, og/eller en glialcelle.
8. Inhibitoren til anvendelse ifølge et hvilket som helst af kravene 1-7, hvor den retinochoroidale sygdom er en vitreoretinal sygdom, fortrinsvis, hvor den vitreoretinale sygdom er diabetisk retinopati, alders-relateret makulær degeneration, retinal adskillelse, proliferative vitreoretinopati, uveitis, okulær infektion, retinopati af prematuritet, neovaskulær maculopati, eller retinochoroiditis.
9. Inhibitoren til anvendelse ifølge krav 1, hvor behandlingen omfatter inhibering af vævsgenopbygning der sker efter inflammation, blødning, infektion, kirurgi, eller skade i ophthalmisk væv.
10. Inhibitoren til anvendelse ifølge et hvilket som helst af kravene 1-9, hvor inhibitoren er formuleret til administration oralt, intravenøst, intramuskulært, intraperitolealt, perkutant, intratrachealt, intrakutant, subkutant, eller ved inddrypning.
11. Inhibitoren til anvendelse ifølge et hvilket som helst af kravene 1-10, hvor (E)-4-(2-{3-[(lH-pyrazol-l-yl)methyl]-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl}vinyl)benzoesyren, en ester deraf, eller et salt deraf er formuleret som en salve, injektion, tablet, granulat, fint granulat, pulver, kapsel, inhalationsmiddel, sirup, pille, flydende formulering, suspension, emulsion, perkutant absorptionsmiddel, stikpille, lotion, eller inddrypning.
12. Inhibitoren til anvendelse ifølge krav 11, hvor salven er en opthalmisk salve, fortrinsvis, hvor koncentrationen af(E)-4-(2-{3-[(lH-pyrazol-l-yl)methyl]- 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl}vinyl)benzoesyre, en ester deraf, eller et salt deraf i den ophthalmiske salve administreret til et individ er fra 0,00001 til 10% (vægt/vægt), fra 0,0001 til 3% (vægt/vægt), eller fra 0,001 til 1% (vægt/vægt).
13. Inhibitoren til anvendelse ifølge krav 10, hvor inhibitoren formuleres til administration ved inddrypning, fortrinsvis, hvor koncentrationen af (E)-4-(2-{3-[(lH-pyrazol-l-yl)methyl]-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl}vinyl)benzoesyre, en ester deraf, eller et salt deraf i inddrypningen administreret til et individ er fra 0,000001 til 10% (vægt/volumen), from 0,00001 til 3% (vægt/volumen), eller fra 0,0001% til 1% (vægt/volumen).
14. Inhibitoren til anvendelse ifølge krav 10, hvor inhibitoren er formuleret til administration oralt, fortrinsvis, hvor mængden af (E)-4-(2-{3-[(lH-pyrazol-l- yl)methyl]-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2- yl}vinyl)benzoesyre, en ester deraf, eller et salt deraf administreret oralt til et individ er fra 0,01 til 5000 mg, fra 0,1 til 2500 mg, eller fra 0,5 til 1000 mg.
15. Inhibitoren til anvendelse ifølge et hvilket som helst af kravene 1-14, hvor (E)-4-(2-{3-[( 1 H-pyrazol-l-yl)methyl]-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl}vinyl)benzoesyren, en ester deraf, eller et salt deraf formuleres til administration i én eller flere daglige doser.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013107706 | 2013-05-22 | ||
| PCT/JP2014/002667 WO2014188716A1 (ja) | 2013-05-22 | 2014-05-21 | 網脈絡膜障害の抑制剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3000466T3 true DK3000466T3 (da) | 2018-11-26 |
Family
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|---|---|---|---|
| DK14800477.3T DK3000466T3 (da) | 2013-05-22 | 2014-05-21 | Inhibitor til retinochoroidale sygdomme |
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| EP (2) | EP3446690B1 (da) |
| JP (2) | JP6407145B2 (da) |
| KR (1) | KR102303316B1 (da) |
| CN (1) | CN105377258B (da) |
| AU (1) | AU2014269762B2 (da) |
| BR (1) | BR112015029114B1 (da) |
| CA (1) | CA2913005C (da) |
| CY (1) | CY1121036T1 (da) |
| DK (1) | DK3000466T3 (da) |
| ES (2) | ES2694831T3 (da) |
| HR (1) | HRP20181876T1 (da) |
| LT (1) | LT3000466T (da) |
| MX (1) | MX362239B (da) |
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| PT (1) | PT3000466T (da) |
| RS (1) | RS58045B1 (da) |
| RU (1) | RU2672057C2 (da) |
| SI (1) | SI3000466T1 (da) |
| SM (1) | SMT201800593T1 (da) |
| WO (1) | WO2014188716A1 (da) |
| ZA (1) | ZA201508940B (da) |
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| EA026251B1 (ru) | 2010-09-01 | 2017-03-31 | Томас Джефферсон Юниверсити | Способ восстановления и регенерации мышц |
| KR102173932B1 (ko) | 2012-11-08 | 2020-11-04 | 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 | 각결막 장해의 치료제 |
| PL3000466T3 (pl) * | 2013-05-22 | 2019-04-30 | Univ Yamaguchi | Inhibitor dla zaburzeń siatkówkowo-naczyniówkowych |
| SG11201810658PA (en) | 2016-06-08 | 2018-12-28 | Clementia Pharmaceuticals Inc | Methods for treating heterotopic ossification |
| EA039050B1 (ru) | 2016-11-16 | 2021-11-26 | Клементиа Фармасьютикалс Инк. | Способы лечения множественного остеохондроматоза (мо) |
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