DK3035849T3 - Lægemiddeleluering til beskyttelse in vivo af biosensor-analysander - Google Patents

Lægemiddeleluering til beskyttelse in vivo af biosensor-analysander Download PDF

Info

Publication number
DK3035849T3
DK3035849T3 DK14838292.2T DK14838292T DK3035849T3 DK 3035849 T3 DK3035849 T3 DK 3035849T3 DK 14838292 T DK14838292 T DK 14838292T DK 3035849 T3 DK3035849 T3 DK 3035849T3
Authority
DK
Denmark
Prior art keywords
vivo
protection
biosensor analysis
elution
pharmaceutical
Prior art date
Application number
DK14838292.2T
Other languages
English (en)
Inventor
Philip Huffstetler
Jeremy Emken
Todd Whitehurst
Original Assignee
Senseonics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senseonics Inc filed Critical Senseonics Inc
Application granted granted Critical
Publication of DK3035849T3 publication Critical patent/DK3035849T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14503Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14542Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4836Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3303Using a biosensor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3306Optical measuring means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/005Parameter used as control input for the apparatus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
DK14838292.2T 2013-08-21 2014-08-21 Lægemiddeleluering til beskyttelse in vivo af biosensor-analysander DK3035849T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361868179P 2013-08-21 2013-08-21
PCT/US2014/052010 WO2015027018A1 (en) 2013-08-21 2014-08-21 Drug elution for in vivo protection of bio-sensing analytes

Publications (1)

Publication Number Publication Date
DK3035849T3 true DK3035849T3 (da) 2019-09-30

Family

ID=52480960

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14838292.2T DK3035849T3 (da) 2013-08-21 2014-08-21 Lægemiddeleluering til beskyttelse in vivo af biosensor-analysander

Country Status (9)

Country Link
US (2) US9931068B2 (da)
EP (2) EP3427661B1 (da)
JP (1) JP6494044B2 (da)
KR (1) KR102373982B1 (da)
CN (1) CN105530867B (da)
AU (1) AU2014308844B2 (da)
CA (1) CA2922095C (da)
DK (1) DK3035849T3 (da)
WO (1) WO2015027018A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3397163B1 (en) 2015-12-30 2023-09-13 DexCom, Inc. Diffusion resistance layer for analyte sensors
JP6738042B2 (ja) * 2016-04-27 2020-08-12 大日本印刷株式会社 センサー装置、及びicカード
CN108968976B (zh) * 2017-05-31 2022-09-13 心脏起搏器股份公司 具有化学传感器的植入式医疗设备
US12004853B2 (en) 2017-07-26 2024-06-11 Cardiac Pacemakers, Inc. Systems and methods for disambiguation of posture
CN109381195B (zh) 2017-08-10 2023-01-10 心脏起搏器股份公司 包括电解质传感器融合的系统和方法
CN109419515B (zh) 2017-08-23 2023-03-24 心脏起搏器股份公司 具有分级激活的可植入化学传感器
CN109864746B (zh) 2017-12-01 2023-09-29 心脏起搏器股份公司 用于医学装置的多模式分析物传感器
CN109864747B (zh) 2017-12-05 2023-08-25 心脏起搏器股份公司 多模式分析物传感器光电子接口
US20200054251A1 (en) * 2018-08-20 2020-02-20 Senseonics, Incorporated Mediated drug release for reducing in vivo analyte indicator degradation
US11672860B2 (en) 2018-11-02 2023-06-13 Senseonics, Incorporated Drug eluting matrix on analyte indicator
US11826143B2 (en) 2018-12-05 2023-11-28 Senseonics, Incorporated Reduction of in vivo analyte signal degradation using multiple metals
ES3055960T3 (en) * 2019-02-22 2026-02-17 Senseonics Inc Mediation of in vivo analyte signal degradation
US12419551B2 (en) 2019-05-08 2025-09-23 Senseonics, Incorporated Mediation of in vivo analyte signal degradation
US11963761B2 (en) 2019-05-16 2024-04-23 Senseonics, Incorporated Mediation of in vivo analyte signal degradation
US20200375511A1 (en) * 2019-05-29 2020-12-03 Senseonics, Incorporated Tailored drug delivery vehicles for in vivo protection of analyte sensing compounds
CN110681053B (zh) * 2019-09-29 2022-11-22 山东大学齐鲁医院(青岛) 心外膜临时起搏导线组件
US11793430B2 (en) 2019-10-01 2023-10-24 Senseonics, Incorporated Use of additives, copolymers, and dopants for optical stability of analyte sensing components
KR20220115927A (ko) 2019-10-25 2022-08-19 세르카코르 래버러토리즈, 인크. 지표 화합물, 지표 화합물을 포함하는 장치, 및 이의 제조 및 사용 방법
WO2021097274A1 (en) 2019-11-13 2021-05-20 Senseonics, Incorporated Identification of degradative species
EP4058786B1 (en) * 2019-11-14 2024-11-06 Senseonics, Incorporated Mediation of in vivo analyte signal degradation
WO2022093786A1 (en) 2020-10-29 2022-05-05 Cardiac Pacemakers, Inc. Integrated thermo-photonic chemical sensor
JP2024510494A (ja) * 2021-03-19 2024-03-07 デックスコム・インコーポレーテッド 分析物センサ用薬物放出膜
AU2022261713B2 (en) 2021-04-19 2025-11-27 W. L. Gore & Associates, Inc. Electrochemical analyte biosensors, associated compositions of matter, and methods for making and using same
EP4391912A4 (en) * 2021-08-26 2025-06-18 Senseonics, Incorporated Mediation of in vivo analyte signal degradation
US12201421B2 (en) * 2021-10-08 2025-01-21 Medtronic Minimed, Inc. Immunosuppressant releasing coatings
EP4531805A1 (en) 2022-06-03 2025-04-09 Nano Precision Medical, Inc. Devices and methods to improve bioavailability of therapeutic agents

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3854480A (en) * 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
BE789524A (fr) * 1971-09-30 1973-01-15 Alza Corp Dispositif de liberation de medicaments
US5512246A (en) 1989-09-21 1996-04-30 Anthony P. Russell Method and means for detecting polyhydroxyl compounds
US6051576A (en) * 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
CA2182228C (en) * 1994-01-28 2008-09-16 Paul Ashton Codrugs as a method of controlled drug delivery
US5517313A (en) 1995-02-21 1996-05-14 Colvin, Jr.; Arthur E. Fluorescent optical sensor
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5711861A (en) * 1995-11-22 1998-01-27 Ward; W. Kenneth Device for monitoring changes in analyte concentration
US6304766B1 (en) * 1998-08-26 2001-10-16 Sensors For Medicine And Science Optical-based sensing devices, especially for in-situ sensing in humans
ATE394662T1 (de) * 1998-08-26 2008-05-15 Sensors For Med & Science Inc Optisch basierte sensor-vorrichtungen
US6560471B1 (en) * 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US9492111B2 (en) * 2002-04-22 2016-11-15 Medtronic Minimed, Inc. Methods and materials for stabilizing analyte sensors
US7153265B2 (en) 2002-04-22 2006-12-26 Medtronic Minimed, Inc. Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance
KR20060004942A (ko) 2003-04-15 2006-01-16 센서즈 포 메드슨 앤드 사이언스 인코포레이티드 집적화된 안테나를 포함하는 인쇄 회로 장치 및 집적화된인쇄 회로 보드 안테나를 포함하는 이식 가능한 센서 처리시스템
AU2004293463A1 (en) * 2003-11-20 2005-06-09 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US8696564B2 (en) * 2004-07-09 2014-04-15 Cardiac Pacemakers, Inc. Implantable sensor with biocompatible coating for controlling or inhibiting tissue growth
CN101505723A (zh) * 2006-06-22 2009-08-12 南佛罗里达大学 胶原支架、具有其的医用植入物以及使用方法
CA2698573C (en) * 2007-09-07 2017-12-05 Qlt Plug Delivery, Inc. Drug cores for sustained release of therapeutic agents
WO2009035567A2 (en) * 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Insertion and extraction tools for lacrimal implants
BRPI0912482A2 (pt) 2008-05-14 2020-08-18 Otonomy, Inc composições de corticosteróide de liberação controlada e métodos para o tratamento de distúrbios auriculares
US20100249783A1 (en) * 2009-03-24 2010-09-30 Warsaw Orthopedic, Inc. Drug-eluting implant cover
NZ602010A (en) 2009-04-07 2013-11-29 Duocort Pharma Ab Improved glucocorticoid therapy
TW201041612A (en) * 2009-04-21 2010-12-01 Sensors For Med & Science Inc Protective shell for an in vivo sensor made from resorbable polymer
US9357951B2 (en) * 2009-09-30 2016-06-07 Dexcom, Inc. Transcutaneous analyte sensor
DK2534470T3 (da) * 2010-02-08 2016-12-05 Medtronic Minimed Inc Antioxidantbeskyttelse af en kemisk sensor
CN103533884B (zh) * 2011-03-15 2016-06-01 传感技术股份有限公司 氧化敏感性材料的集成催化保护
FR2986156B1 (fr) * 2012-01-30 2014-07-04 Rhenovia Pharma Dispositif transdermique pour l'administration controlee a un patient d'au moins un principe actif
US9693714B2 (en) * 2012-02-10 2017-07-04 Senseonics, Incorporated Digital ASIC sensor platform

Also Published As

Publication number Publication date
KR20160045844A (ko) 2016-04-27
KR102373982B1 (ko) 2022-03-14
CN105530867B (zh) 2018-11-13
EP3035849B1 (en) 2019-07-31
US9931068B2 (en) 2018-04-03
WO2015027018A1 (en) 2015-02-26
CA2922095C (en) 2021-12-28
EP3427661B1 (en) 2020-05-13
US20150057509A1 (en) 2015-02-26
EP3035849A1 (en) 2016-06-29
AU2014308844B2 (en) 2019-07-04
US20180220940A1 (en) 2018-08-09
EP3427661A1 (en) 2019-01-16
JP6494044B2 (ja) 2019-04-03
EP3035849A4 (en) 2017-04-19
AU2014308844A1 (en) 2016-03-10
CA2922095A1 (en) 2015-02-26
CN105530867A (zh) 2016-04-27
JP2016530009A (ja) 2016-09-29

Similar Documents

Publication Publication Date Title
DK3035849T3 (da) Lægemiddeleluering til beskyttelse in vivo af biosensor-analysander
PT3030262T (pt) Composição farmacêutica de associação
DK2818482T3 (da) Farmaceutisk sammensætning til behandling af cancer
DK2824114T3 (da) Farmaceutisk sammensætning til behandling af cancer
DK2804587T3 (da) Formulering og fremgangsmåde til øgning af lægemidlers biotilgængelighed
DK3008168T3 (da) Sc-celler og sammensætninger og fremgangsmåde til dannelse deraf
DK3608325T3 (da) Polycykliske-carbamoylpyridonforbindelser og deres farmaceutiske anvendelse
DK3019200T3 (da) Oligonukleotid-ligand-konjugater og fremgangsmåde til fremstiling deraf
HUE042654T2 (hu) Eljárás genetikai variációk nem-invazív megállapítására
DK2972351T3 (da) Forbedrede analysemetoder
HUE040111T2 (hu) Vegyületek és alkalmazási eljárásaik
LT2968221T (lt) S-ketamino hidrochlorido farmacinė kompozicija
EP2935546A4 (en) BIORAFFINATION OF RAW TALL OIL
DK3079719T3 (da) ANTI-SIGLEC-8-antistoffer og fremgangsmåder til anvendelse deraf
DK2970389T3 (da) Farmaceutiske forbindelser
EP2970569A4 (en) PERSISTENT CARBENE AND COMPOSITIONS WITH IT
BR112013014644A2 (pt) composição farmacêutica e complexo
BR112015011111A2 (pt) proteína multifuncional e formulação farmacêutica
DK3025586T3 (da) Sammensætning til bekæmpelse af plantesygdomme og anvendelse deraf
DK2964767T3 (da) Toksingener og fremgangsmåder til anvendelse deraf
DK2897594T3 (da) Farmaceutisk sammensætning
BR112014026357A2 (pt) composição e sistema
DK2849760T3 (da) Fremgangsmåder til oligonukleotid-chelatkompleks
DK3434276T3 (da) Fremgangsmåde og farmaceutisk sammensætning til anvendelse i behandlingen af kræft
DK2988733T3 (da) Farmaceutisk sammensætning indeholdende krystallin macitentan