DK3041490T3 - Sammensætninger, som indeholder en svækket newcastle disease-virus, og fremgangsmåder til anvendelse til behandling af neoplasi - Google Patents
Sammensætninger, som indeholder en svækket newcastle disease-virus, og fremgangsmåder til anvendelse til behandling af neoplasi Download PDFInfo
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- DK3041490T3 DK3041490T3 DK14761317.8T DK14761317T DK3041490T3 DK 3041490 T3 DK3041490 T3 DK 3041490T3 DK 14761317 T DK14761317 T DK 14761317T DK 3041490 T3 DK3041490 T3 DK 3041490T3
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Claims (15)
1. Svækket Newcastle disease-virus (NDV) 73T-stamme, hvor vildtype-F-proteinspaltningsstedet (FPCS) med aminosyresekvensen 111G-R-R-Q-K-R/F117 er modificeret, og hvor den modificerede F-proteinspaltningssekvens (FPCS) omfatter en sekvens valgt fra gruppen bestående af: S116: 111H-N-R-T-K-S/F117; S116K: 111H-N-K-T-K-S/F117; S116M: 111H-N-R-M-K-S/F117; S116KM: 111H-N-K-M-K-S/F-I118; og R116: 111H-N-R-T-K-R/F-I118.
2. Svækket Newcastle disease-virus ifølge krav 1, hvor den modificerede FPCS er R116: 111H-N-R-T-K-R/F-I118.
3. Svækket Newcastle disease-virus ifølge krav 1 eller 2, hvor virusset omfatter en forstørret HN-L-intergenregion, som omfatter en ikke-kodende sekvens med en længde på mellem 50 og 300 nukleotider.
4. Svækket Newcastle disease-virus ifølge krav 3, hvor den ikke-kodende sekvens stammer fra et paramyxovirus type 1 (APMV-1), et respiratorisk syncytialvirus (RSV) eller en tilfældig sekvens.
5. Svækket Newcastle disease-virus ifølge krav 3 eller 4, hvor den ikke-kodende sekvens har en længde på 60, 102, 144 eller 198 nukleotider.
6. Svækket Newcastle disease-virus ifølge et hvilket som helst af kravene 1-5, hvor virusset omfatter en eller flere heterologe polynukleotidsekvenser, som er indsat ved P-M-forbindelsesstedet.
7. Svækket Newcastle disease-virus ifølge krav 6, hvor de heterologe polynukleotidsekvenser koder for et cytokin, en celleoverfladeligand og/eller et kemokin.
8. Svækket Newcastle disease-virus ifølge krav 7, hvor cytokinet er valgt fra gruppen bestående af GM-CSF, IL-2, IL-21, IL-15, IL-12 og IL-12p70.
9. Svækket Newcastle disease-virus ifølge krav 8, hvor cytokinet er human GM-CSF.
10. Svækket Newcastle disease-virus ifølge et hvilket som helst af kravene 1-9, hvor den modificerede FPCS er R116: 111H-N-R-T-K-R/F-I118, den ikke-kodende sekvens har en længde på 198 nt, og den heterologe polynukleotidsekvens koder for human GM-CSF.
11. Svækket Newcastle disease-virus ifølge et hvilket som helst af kravene 1-10 til anvendelse ved en fremgangsmåde til behandling af cancer.
12. Svækket Newcastle disease-virus til anvendelse ifølge krav 11, hvor virusset selektivt dræber tumorceller, hvor virusset kommer i kontakt med en tumorcelle.
13. Svækket Newcastle disease-virus til anvendelse ifølge krav 11, hvor virusset inducerer tumorregression hos et individ, hvor virusset kommer i kontakt med en tumorcelle.
14. Svækket Newcastle disease-virus til anvendelse ifølge krav 11-13, hvor canceren er en cancer valgt fra gruppen bestående af blærecancer, ovariecancer, hjernecancer, pancreascancer, prostatacancer, sarkom, lungecancer, brystcancer, cervixcancer, knoglecancer, levercancer, hovedhalscancer, mavecancer, nyrecancer, lymfom, leukæmi, thyreoideacancer, coloncancer, kolorektal cancer og melanom.
15. Svækket Newcastle disease-virus til anvendelse ifølge krav 11-14, hvor det svækkede Newcastle disease-virus tilføres intravenøst, systemisk, intraperitonealt eller intratumoralt.
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| PCT/EP2014/068619 WO2015032755A1 (en) | 2013-09-03 | 2014-09-02 | Compositions featuring an attenuated newcastle disease virus and methods of use for treating neoplasia |
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| DK14761317.8T DK3041490T3 (da) | 2013-09-03 | 2014-09-02 | Sammensætninger, som indeholder en svækket newcastle disease-virus, og fremgangsmåder til anvendelse til behandling af neoplasi |
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| KR101492643B1 (ko) | 2005-12-02 | 2015-02-12 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | 비-천연 표면 단백질을 제시하는 키메라 바이러스 및 그의용도 |
| ES2550179T3 (es) | 2009-02-05 | 2015-11-05 | Icahn School Of Medicine At Mount Sinai | Virus quiméricos de la enfermedad de Newcastle y usos de los mismos |
| EA038981B1 (ru) | 2013-03-14 | 2021-11-17 | Икан Скул Оф Медсин Эт Маунт Синай | Вирусы болезни ньюкасла и их применение |
| WO2015032755A1 (en) * | 2013-09-03 | 2015-03-12 | Medimmune Limited | Compositions featuring an attenuated newcastle disease virus and methods of use for treating neoplasia |
| WO2015127501A1 (en) | 2014-02-27 | 2015-09-03 | Viralytics Limited | Combination method for treatment of cancer |
| CN107847610B (zh) * | 2015-04-28 | 2022-02-01 | 塞维卡有限责任公司 | 基于piv5的扩增病毒样颗粒 |
| EP3778881A1 (en) | 2016-01-08 | 2021-02-17 | Replimune Limited | Modified oncolytic virus |
| EP3246410A1 (en) | 2016-05-19 | 2017-11-22 | Klinikum rechts der Isar der Technischen Universität München | Vsv/ndv hybrid viruses for oncolytic therapy of cancer |
| GB201700350D0 (en) | 2017-01-09 | 2017-02-22 | Replimune Ltd | Altered virus |
| KR101964610B1 (ko) * | 2017-03-13 | 2019-04-03 | 대한민국 | 신규한 종양용해성 바이러스 및 이의 용도 |
| JOP20190256A1 (ar) * | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| CN107254450A (zh) * | 2017-07-20 | 2017-10-17 | 扬州大学 | 克服鸡新城疫母源抗体影响的嵌合新城疫病毒疫苗载体候选株及构建方法 |
| CN108486279A (zh) * | 2017-09-21 | 2018-09-04 | 山东省农业科学院家禽研究所 | 一种基于荧光定量pcr技术检测鸽新城疫病毒的方法 |
| EP3552608A1 (en) * | 2018-04-09 | 2019-10-16 | Rapo Yerape B.H. Ltd | Increased activity of oncoloytic newcastle disease virus |
| US20200297787A1 (en) * | 2018-07-13 | 2020-09-24 | Icahn School Of Medicine At Mount Sinai | Apmv and uses thereof for the treatment of cancer |
| WO2020037215A1 (en) | 2018-08-17 | 2020-02-20 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease |
| CN110859968A (zh) * | 2019-11-21 | 2020-03-06 | 四川安可康生物医药有限公司 | 激活对肿瘤的系统免疫反应的基因生物药物 |
| CA3172423A1 (en) * | 2020-03-20 | 2021-03-22 | Alex WESSELHOEFT | Circular rna compositions and methods |
| CN115197949A (zh) * | 2021-04-13 | 2022-10-18 | 江苏康缘瑞翱生物医药科技有限公司 | 一种重组新城疫病毒rNDV-OX40L、其基因组、制备方法及其用途 |
| US20220396809A1 (en) * | 2021-06-03 | 2022-12-15 | University Of Guelph | Engineered newcastle disease virus vector and uses thereof |
| EP4661905A2 (en) * | 2023-02-06 | 2025-12-17 | Cyanvac LLC | Modified piv5 vaccine vectors: methods of making and uses |
| KR20250083186A (ko) * | 2023-11-29 | 2025-06-09 | 주식회사 카브 | 재조합 뉴캣슬병 바이러스 벡터를 포함하는 암 치료용 약제학적 조성물 |
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| US7724558B1 (en) * | 1999-03-19 | 2010-05-25 | Nec Corporation | Magnetic signal transmission line |
| AU7607900A (en) * | 1999-09-22 | 2001-04-24 | Mayo Foundation For Medical Education And Research | Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family |
| KR100801180B1 (ko) * | 2006-09-26 | 2008-02-05 | 주식회사 고려비엔피 | 약독화된 재조합 뉴캐슬병 바이러스 및 이를 함유하는뉴캐슬병 백신 |
| EP2085092A1 (en) * | 2008-01-29 | 2009-08-05 | Bayer Schering Pharma Aktiengesellschaft | Attenuated oncolytic paramyxoviruses encoding avian cytokines |
| US20090208495A1 (en) * | 2008-02-14 | 2009-08-20 | Bayer Schering Pharma Ag | Anti-tumor effective paramyxovirus |
| ES2550179T3 (es) * | 2009-02-05 | 2015-11-05 | Icahn School Of Medicine At Mount Sinai | Virus quiméricos de la enfermedad de Newcastle y usos de los mismos |
| EA038981B1 (ru) * | 2013-03-14 | 2021-11-17 | Икан Скул Оф Медсин Эт Маунт Синай | Вирусы болезни ньюкасла и их применение |
| WO2015032755A1 (en) * | 2013-09-03 | 2015-03-12 | Medimmune Limited | Compositions featuring an attenuated newcastle disease virus and methods of use for treating neoplasia |
| CN109099045A (zh) * | 2018-10-30 | 2018-12-28 | 浙江斯泰新材料科技股份有限公司 | 防松锁固型螺钉 |
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