DK3070174T3 - Opsporing af lægemidler på grundlag af in vitro-differentierede celler - Google Patents

Opsporing af lægemidler på grundlag af in vitro-differentierede celler Download PDF

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Publication number
DK3070174T3
DK3070174T3 DK16165848.9T DK16165848T DK3070174T3 DK 3070174 T3 DK3070174 T3 DK 3070174T3 DK 16165848 T DK16165848 T DK 16165848T DK 3070174 T3 DK3070174 T3 DK 3070174T3
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determination
differentiated cells
vitro differentiated
medicines based
vitro
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DK16165848.9T
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Heribert Bohlen
Kristina Tressat
Silke Schwengberg
Andreas Ehlich
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Ncardia Ag
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
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    • G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061—Muscle cells
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DK16165848.9T 2004-05-11 2005-05-11 Opsporing af lægemidler på grundlag af in vitro-differentierede celler DK3070174T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04011214 2004-05-11
EP10010425.6A EP2270196B1 (en) 2004-05-11 2005-05-11 Assay for drug discovery based on in vitro differentiated cells

Publications (1)

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DK3070174T3 true DK3070174T3 (da) 2020-01-27

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DK05740642.3T DK1745144T3 (da) 2004-05-11 2005-05-11 Analysefremgangsmåde til opsporing af lægemidler på grundlag af in vitro-differentierede celler
DK16165848.9T DK3070174T3 (da) 2004-05-11 2005-05-11 Opsporing af lægemidler på grundlag af in vitro-differentierede celler

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US (6) US8318488B1 (da)
EP (3) EP1745144B1 (da)
JP (2) JP4814875B2 (da)
AT (1) ATE490306T1 (da)
CA (1) CA2565858C (da)
DE (1) DE602005025106D1 (da)
DK (2) DK1745144T3 (da)
ES (3) ES2770067T3 (da)
WO (1) WO2005108598A1 (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1740945B1 (en) 2004-04-07 2018-09-19 Ncardia AG Non-invasive, in vitro functional tissue assay systems
DK1745144T3 (da) * 2004-05-11 2011-02-07 Axiogenesis Ag Analysefremgangsmåde til opsporing af lægemidler på grundlag af in vitro-differentierede celler
US8568761B2 (en) * 2005-07-15 2013-10-29 Cormatrix Cardiovascular, Inc. Compositions for regenerating defective or absent myocardium
CN101432626B (zh) 2006-04-04 2013-06-19 神谷来克斯公司 用于肌钙蛋白分析的高灵敏系统和方法
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
WO2008129560A2 (en) * 2007-04-20 2008-10-30 Stempeutics Research Private Limited An in vitro human embryonic model and a method thereof
JP5734869B2 (ja) * 2008-12-16 2015-06-17 オンコノバ・セラピューティックス・インコーポレーテッド ヒトにおける細胞毒性物質の有害作用に対する治療レジメンの有効性を決定する方法
US10386360B2 (en) 2009-03-13 2019-08-20 University Of Central Florida Research Foundation, Inc. Bio-microelectromechanical system transducer and associated methods
US8835168B2 (en) 2009-04-23 2014-09-16 University Of Central Florida Research Foundation, Inc. Synthetic mammalian neuromuscular junction and method of making
US9163216B1 (en) 2009-04-23 2015-10-20 University Of Central Florida Research Foundation, Inc. Method for culturing skeletal muscle for tissue engineering
US8815584B1 (en) 2009-04-23 2014-08-26 University Of Central Florida Research Foundation, Inc. Method of co-culturing mammalian muscle cells and motoneurons
US8385624B2 (en) 2009-05-13 2013-02-26 David J. Charlot Automated transient image cytometry
US8828721B1 (en) 2009-05-28 2014-09-09 University Of Central Florida Research Foundation, Inc. Method of myelinating isolated motoneurons
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
WO2011014740A2 (en) * 2009-07-31 2011-02-03 Chromocell Corporation Methods and composition for identifying and validating modulators of cell fate
DE102009041254A1 (de) * 2009-09-11 2011-06-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 80686 Spontan kontrahierende Fischzellaggregate, deren Verwendung und Verfahren zu deren Erzeugung
US9404140B1 (en) 2009-11-03 2016-08-02 The University Of Central Florida Research Foundation, Inc. Patterned cardiomyocyte culture on microelectrode array
EP2531910B1 (en) 2010-02-05 2015-04-08 University of Central Florida Research Foundation, Inc. Methods for identifying points of action in electrically active cells
US8615311B2 (en) * 2010-03-15 2013-12-24 Rutgers, The State University Of New Jersey Microelectorode array, methods for preparing the same and uses thereof
US9133496B2 (en) 2010-06-29 2015-09-15 Public University Corporation Nagoya City University Material for screening for compound acting on ion channel and use thereof
EP2591356A1 (en) * 2010-07-09 2013-05-15 Ecole Polytechnique Fédérale de Lausanne (EPFL) Method for in-vitro monitoring of neuronal disorders and use thereof
BR112013009888A2 (pt) * 2010-10-29 2021-07-20 F. Hoffmann - La Roche Ag método para determinar o risco de arritmia
WO2012098260A1 (en) 2011-01-21 2012-07-26 Axiogenesis Ag A non-viral system for the generation of induced pluripotent stem (ips) cells
WO2012108444A1 (ja) * 2011-02-07 2012-08-16 国立大学法人京都大学 心筋症特異的多能性幹細胞およびその用途
JP6388537B2 (ja) 2011-07-21 2018-09-12 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 患者由来の人工多能性幹細胞由来の心筋細胞および使用方法
US20150219622A1 (en) 2012-08-17 2015-08-06 University Of Central Florida Research Foundation, Inc. Methods, systems and compositions for functional in vitro cellular models of mammalian systems
EP2932238B1 (en) 2012-12-14 2018-02-28 Vala Sciences, Inc. Analysis of action potentials, transients, and ion flux in excitable cells
EP2951281B1 (en) 2013-01-30 2018-06-27 University of Central Florida Research Foundation, Inc. System and method for mimicking heart function
CN104237308B (zh) * 2013-06-09 2016-08-31 国家纳米科学中心 一种在体外筛选药物的方法
DE102013114671B4 (de) * 2013-12-20 2015-10-29 Universität Rostock Verfahren zur Erzeugung von Sinusknotenzellen ("Herz-Schrittmacherzellen") aus Stammzellen
JP6446059B2 (ja) * 2014-04-03 2018-12-26 アイメック・ヴェーゼットウェーＩｍｅｃ Ｖｚｗ 医薬スクーリングのための方法および装置
US10935541B2 (en) 2014-08-07 2021-03-02 University Of Central Florida Research Foundation, Inc. Devices and methods comprising neuromuscular junctions
CA3089957C (en) * 2017-02-04 2024-01-23 AnaBios Corporation System and methods for predicting drug-induced inotropic and pro-arrhythmia risk
US11474103B2 (en) * 2017-02-17 2022-10-18 Koniku Inc. Systems for detection
NL2019618B1 (en) 2017-09-22 2019-03-28 Ncardia B V In vitro method for providing stem cell derived cardiomyocytes
WO2019236828A1 (en) * 2018-06-08 2019-12-12 Lochbaum Eckhardt L Lee Cells with improved inward rectifier current
WO2020066396A1 (ja) 2018-09-28 2020-04-02 日本ゼオン株式会社 心毒性評価方法
CN110161111B (zh) * 2019-04-15 2021-09-07 广东工业大学 一种检测动物组织中β肾上腺素受体激动剂类药物的方法
WO2020232436A1 (en) 2019-05-16 2020-11-19 Brown University A human in vitro cardiotoxicity model
JP7543656B2 (ja) * 2020-02-19 2024-09-03 日本ゼオン株式会社 心毒性評価方法
US12504423B2 (en) 2020-10-16 2025-12-23 Brown University Human in vitro cardiotoxicity model
WO2022266431A1 (en) * 2021-06-18 2022-12-22 The Texas A&M University System Methods of processing adult neural cells from mammals and assays thereof
US12076437B2 (en) 2021-07-12 2024-09-03 Brown University Proangiogenic protein cocktails delivered in custom biomaterials to revascularize ischemic tissue
JP2024539519A (ja) * 2021-10-20 2024-10-28 エクシール， インク． 非ヒト霊長類の個別化されたゲノムアセンブリ及び人工多能性幹細胞株を前臨床評価に使用するための組成物及び方法
WO2024162286A1 (ja) * 2023-01-31 2024-08-08 富士フイルム株式会社 薬剤の評価方法、試薬およびキット

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6072402A (en) 1992-01-09 2000-06-06 Slc Technologies, Inc. Secure entry system with radio communications
GB2197915B (en) 1986-11-19 1990-11-14 Rolls Royce Plc Improvements in or relating to fluid bearings
US4931561A (en) 1987-07-29 1990-06-05 Koei Chemical Co., Ltd. Process for preparing nitriles
US4937190A (en) 1987-10-15 1990-06-26 Wisconsin Alumni Research Foundation Translation enhancer
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5096815A (en) 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
US5198346A (en) 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
ES2118066T3 (es) 1989-10-05 1998-09-16 Optein Inc Sintesis y aislamiento, exentos de celulas, de nuevos genes y polipeptidos.
ES2284161T3 (es) 1990-01-12 2007-11-01 Amgen Fremont Inc. Generacion de anticuerpos xenogenicos.
US5747334A (en) 1990-02-15 1998-05-05 The University Of North Carolina At Chapel Hill Random peptide library
DD299439B5 (de) 1990-05-11 1995-10-19 Inst Pflanzengenetik & Kultur Verfahren zur Untersuchung der Wirkung von chemischen Wirkstoffen und medizinisch-pharmazeutischen Praeparaten
AU667680B2 (en) 1991-08-07 1996-04-04 Albert Einstein College Of Medicine Of Yeshiva University Proliferation of hepatocyte precursors
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
GB9308271D0 (en) 1993-04-21 1993-06-02 Univ Edinburgh Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
AU694745B2 (en) 1993-09-10 1998-07-30 Trustees Of Columbia University In The City Of New York, The Uses of green fluorescent protein
US5602301A (en) 1993-11-16 1997-02-11 Indiana University Foundation Non-human mammal having a graft and methods of delivering protein to myocardial tissue
US6015671A (en) 1995-06-07 2000-01-18 Indiana University Foundation Myocardial grafts and cellular compositions
US5534404A (en) 1993-12-10 1996-07-09 Cytotherapeutics, Inc. Glucose responsive insulin secreting β-cell lines and method for producing same
WO1995021191A1 (en) 1994-02-04 1995-08-10 William Ward Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
US5563067A (en) 1994-06-13 1996-10-08 Matsushita Electric Industrial Co., Ltd. Cell potential measurement apparatus having a plurality of microelectrodes
DE4441327C1 (de) 1994-11-22 1995-11-09 Inst Pflanzengenetik & Kultur Embryonale Herzmuskelzellen, ihre Herstellung und ihre Verwendung
US5641644A (en) 1994-12-09 1997-06-24 Board Of Regents, The University Of Texas System Method and apparatus for the precise positioning of cells
US5565340A (en) 1995-01-27 1996-10-15 Clontech Laboratories, Inc. Method for suppressing DNA fragment amplification during PCR
US6110743A (en) 1995-02-10 2000-08-29 The Regents Of The University Of California Development and use of human pancreatic cell lines
GB9504446D0 (en) 1995-03-06 1995-04-26 Medical Res Council Improvements in or relating to gene expression
GB9505663D0 (en) 1995-03-21 1995-05-10 Stringer Bradley M J Genetically modified neural cells
DE19525285C2 (de) 1995-06-28 1999-04-15 Inst Pflanzengenetik & Kultur In vitro Testverfahren zum Nachweis Chemikalien-induzierter embryotoxischer/teratogener Effekte
DE19529371C3 (de) 1995-08-10 2003-05-28 Nmi Univ Tuebingen Mikroelektroden-Anordnung
US6166288A (en) 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
AU721375B2 (en) 1996-01-09 2000-06-29 Regents Of The University Of California, The Porcine embryonic stem-like cells, methods of making and using the cells to produce transgenic pigs
US5869243A (en) 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
US6333447B1 (en) 1996-03-29 2001-12-25 The General Hospital Corporation Transgenic model of heart failure
CN1254376A (zh) 1996-10-01 2000-05-24 杰龙公司 端粒酶逆转录酶
WO1998022819A1 (de) 1996-11-16 1998-05-28 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen In Reutlingen Stiftung Bürgerlichen Rechts Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung
DE19653685B4 (de) 1996-12-13 2006-06-01 Institut für Pflanzengenetik und Kulturpflanzenforschung In vitro Zellsystem vaskulärer glatter Muskulatur für pharmakologische und physiologische Untersuchungen
CA2281648A1 (en) 1997-02-13 1998-08-20 Memorial Sloan-Kettering Cancer Center Hybrid molecules for optically detecting changes in cellular microenvironments
JPH10292688A (ja) 1997-02-20 1998-11-04 Kouji Kagetani 扉の施解錠方法
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
DE19815128A1 (de) 1997-04-03 1998-10-08 Franz Wolfgang M Dr Transgenes Tiermodell für humane Kardiomyopathien
US6218597B1 (en) 1997-04-03 2001-04-17 University Technology Corporation Transgenic model and treatment for heart disease
GB9708526D0 (en) 1997-04-25 1997-06-18 Royal Free Hosp School Med Eukaryotic gene expression cassette and uses thereof
US5981268A (en) 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
DE19727962A1 (de) 1997-07-02 1999-01-14 Juergen Hescheler Fluoreszierende Proteine als zelltypspezifische Reporter
JP2001514883A (ja) 1997-08-12 2001-09-18 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド ヒトｆｒｉｚｚｌｅｄ様タンパク質
AU748334B2 (en) 1997-10-16 2002-05-30 Board Of Regents, The University Of Texas System Models and treatments for cardiac hypertrophy in relation with NF-AT3 function
US6610480B1 (en) 1997-11-10 2003-08-26 Genentech, Inc. Treatment and diagnosis of cardiac hypertrophy
AU1606999A (en) 1997-11-26 1999-06-15 Albert Einstein College Of Medicine Of Yeshiva University Mouse telomerase reverse transcriptase
US6080576A (en) 1998-03-27 2000-06-27 Lexicon Genetics Incorporated Vectors for gene trapping and gene activation
DE19843234A1 (de) 1998-09-09 2000-03-23 Inst Pflanzengenetik & Kultur Differenzierte Herzzellen mit pathologischen Merkmalen als in vitro-Modell für Herzerkrankungen
GB2342003A (en) 1998-09-21 2000-03-29 Riva Limited Telephone apparatus for handling anonymous calls
AU6056299A (en) 1998-09-21 2000-04-10 Musc Foundation For Research Development Non-hematopoietic cells, including cardiomyocytes and skeletal muscle cells, derived from hematopoietic stem cells and methods of making and using them
WO2000020625A1 (en) 1998-10-07 2000-04-13 The Board Of Trustees Of The University Of Arkansas In vitro and in vivo models for screening compounds to prevent glucocorticoid-induced bone destruction
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
CA2353309A1 (en) 1998-12-09 2000-06-15 Vistagen, Inc. Toxicity typing using embryoid bodies
GB2344670B (en) 1998-12-12 2003-09-03 Ibm System, apparatus and method for controlling access
US6377057B1 (en) 1999-02-18 2002-04-23 The Board Of Trustees Of The Leland Stanford Junior University Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential
AU4365800A (en) 1999-04-21 2000-11-02 Human Genome Sciences, Inc. Galectin 11
AU5632300A (en) 1999-07-07 2001-01-30 Regeneron Pharmaceuticals, Inc. Methods of inhibiting muscle atrophy
CA2382045A1 (en) * 1999-08-20 2001-03-01 Board Of Regents, The University Of Texas System Hdac4 and hdac5 in the regulation of cardiac gene expression
US20030059797A1 (en) 1999-08-27 2003-03-27 Elena Paley Animal model of and test for Alzheimer's disease
AU7445800A (en) 1999-09-27 2001-04-30 Chugai Seiyaku Kabushiki Kaisha Method of prolonging normal cell life span
EP1107003A1 (en) 1999-12-09 2001-06-13 Trophos Methods for screening compounds active on neurons
DE19962154A1 (de) * 1999-12-22 2001-07-12 Medigene Ag Krankhaft veränderte Herzmuskelzelle, ihre Herstellung und Verwendung
US20020142457A1 (en) 1999-12-28 2002-10-03 Akihiro Umezawa Cell having the potentiality of differentiation into cardiomyocytes
US6602711B1 (en) 2000-02-21 2003-08-05 Wisconsin Alumni Research Foundation Method of making embryoid bodies from primate embryonic stem cells
EP1309856A2 (de) 2000-03-01 2003-05-14 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen Verwendung eines elektrodenarrays
CA2402245A1 (en) 2000-03-10 2001-09-20 Advanced Research And Technology Institute, Inc. Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same
AU2001255467A1 (en) 2000-04-19 2001-11-07 Pierre C Van Rysselberghe Security systems for delivering goods and services
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
US7256042B2 (en) * 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
US7282366B2 (en) 2000-04-27 2007-10-16 Geron Corporation Hepatocytes for therapy and drug screening made from embryonic stem cells
AU2001261650A1 (en) 2000-05-15 2001-11-26 Geron Corporation Ovine tissue for xenotransplantation
JP2004504834A (ja) 2000-08-01 2004-02-19 イスム　リサーチ　ディベロップメント　カンパニー 胚性細胞の定方向分化
JP2002051782A (ja) 2000-08-09 2002-02-19 Sankyo Co Ltd 骨粗鬆症もしくは関節リウマチの治療または予防剤の試験方法
SE520984C2 (sv) 2000-08-10 2003-09-16 Volvo Technology Corp Metod och system för att låsa upp ett föremål
US7214371B1 (en) 2000-09-01 2007-05-08 Ben-Gurion University Of The Negev Research & Development Authority Tissue engineered biografts for repair of damaged myocardium
US6844184B2 (en) 2000-11-08 2005-01-18 Surface Logix, Inc. Device for arraying biomolecules and for monitoring cell motility in real-time
US20030027331A1 (en) 2000-11-30 2003-02-06 Yan Wen Liang Isolated homozygous stem cells, differentiated cells derived therefrom, and materials and methods for making and using same
JP4159358B2 (ja) 2000-12-27 2008-10-01 アクシオジェネシス アーゲー 分化中の胚幹細胞、成体幹細胞および胚生殖系細胞を細胞特異的および成長特異的に選択するためのシステム
GB0100119D0 (en) 2001-01-03 2001-02-14 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
US20040234972A1 (en) * 2001-03-20 2004-11-25 Owens Gary K. Method for identifying and purifying smooth muscle progenitor cells
US20030148296A1 (en) 2001-03-30 2003-08-07 Brown Harlan Roger Differential gene expression in cardiac hypertrophy
US20030032185A1 (en) 2001-05-03 2003-02-13 Sharkis Saul J. Method of making a homogeneous preparation of hematopoietic stem cells
DE10126371A1 (de) 2001-05-30 2003-02-27 Medigene Ag Verfahren zur Identifizierung von Substanzen gegen Herzmuskelzellen-Hypertrophie
WO2004005882A2 (en) 2001-06-18 2004-01-15 Psychiatric Genomics, Inc. Multi-parameter high throughput screening assays (mphts)
US20030108895A1 (en) 2001-06-25 2003-06-12 Field Loren J. Methods and cell populations for identifying and validating genomic targets, and for drug screening
WO2003001202A1 (en) 2001-06-25 2003-01-03 Cardion Ag Methods and cell populations for identifying and validating genomic targets, and for drug screening
CA2351156A1 (en) 2001-07-04 2003-01-04 Peter W. Zandstra A bioprocess for the generation of pluripotent cell derived cells and tissues
GB2393734B (en) 2001-07-12 2005-07-27 Geron Corp Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
JP5479661B2 (ja) 2001-07-24 2014-04-23 イーエス・セル・インターナショナル・ピーティーイー・リミテッド 幹細胞の分化を誘導する方法
AU2002356043A1 (en) 2001-08-14 2003-03-03 Washington University In St. Louis Systems and methods for screening pharmaceutical chemicals
JP2005500847A (ja) 2001-08-24 2005-01-13 アドバンスド セル テクノロジー、インコーポレイテッド 分化誘導薬の同定のためのスクリーニング検定及び細胞治療用の分化細胞の調製
AU2002338732A1 (en) 2001-09-19 2003-04-01 Medigene Ag Extracellular regulated kinase 2 (erk2)
US6706686B2 (en) 2001-09-27 2004-03-16 The Regents Of The University Of Colorado Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
US20030082153A1 (en) 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
MXPA04005010A (es) 2001-11-26 2005-04-08 Advanced Cell Tech Inc METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS.
US6743962B2 (en) 2002-01-31 2004-06-01 Chevron U.S.A. Inc. Preparation of high octane alkylate from Fischer-Tropsch olefins
CA2385734A1 (en) 2002-03-04 2003-09-04 Board Of Regents, The University Of Texas System Transgenic cardiomyoctes with controlled proliferation and differentiation
EP1485479A2 (en) 2002-03-19 2004-12-15 The University Of Sheffield Stem cell culture
GB2387501A (en) 2002-04-11 2003-10-15 Andrew Nicholas Door intercom system with remote screening/access control via a mobile phone
AU2003233219A1 (en) 2002-04-30 2003-11-17 Board Of Regents, The University Of Texas System Ssh based methods for identifying and isolating unique nucleic acid sequences
GB0215044D0 (en) 2002-06-28 2002-08-07 Sciona Ltd Sampling kits, devices and uses thereof
US7611852B2 (en) 2002-07-26 2009-11-03 Wisconsin Alumni Research Foundation Functional cardiomyocytes from human embryonic stem cells
US7627535B2 (en) 2002-12-13 2009-12-01 Newspaper Delivery Technologies, Inc. Method and apparatus for supporting delivery, sale and billing of perishable and time-sensitive goods such as newspapers, periodicals and direct marketing and promotional materials
WO2004113515A2 (en) 2003-06-20 2004-12-29 Axiogenesis Ag Tissue modeling in embryonic stem (es) cell system
AU2004256209B2 (en) 2003-07-08 2010-04-08 Axiogenesis Ag Novel method for the preparation of embryoid bodies (EBs) and uses thereof
CA2559791A1 (en) 2003-07-08 2005-01-20 Axiogenesis Ag Secreted proteins as markers for cell differentiation
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
EP1740945B1 (en) 2004-04-07 2018-09-19 Ncardia AG Non-invasive, in vitro functional tissue assay systems
GB0410011D0 (en) 2004-05-05 2004-06-09 Novartis Forschungsstiftung Neural cell differentiation method
DK1745144T3 (da) 2004-05-11 2011-02-07 Axiogenesis Ag Analysefremgangsmåde til opsporing af lægemidler på grundlag af in vitro-differentierede celler
CN101864392B (zh) 2005-12-13 2016-03-23 国立大学法人京都大学 核重新编程因子

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