DK307286A - Pyridinderivater, fremstilling deraf og farmaceutisk praeparat indeholdende forbindelserne - Google Patents

Pyridinderivater, fremstilling deraf og farmaceutisk praeparat indeholdende forbindelserne Download PDF

Info

Publication number: DK307286A
Authority: DK; Denmark
Prior art keywords: preparing; compounds; pharmaceutical preparations; sup; sub
Prior art date: 1985-07-02

Application number

DK307286A

Other languages

English (en)

Other versions

DK307286D0 (da

DK170819B1 (da

Inventor

Akira Nohara

Yoshitaka Maki

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-02

Filing date

1986-06-27

Publication date

1987-01-03

1986-06-27 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1986-06-27 Publication of DK307286D0 publication Critical patent/DK307286D0/da

1987-01-03 Publication of DK307286A publication Critical patent/DK307286A/da

1996-01-29 Application granted granted Critical

1996-01-29 Publication of DK170819B1 publication Critical patent/DK170819B1/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
208000007882 Gastritis Diseases 0.000 abstract 1
208000007107 Stomach Ulcer Diseases 0.000 abstract 1
208000025865 Ulcer Diseases 0.000 abstract 1
230000001079 digestive effect Effects 0.000 abstract 1
208000000718 duodenal ulcer Diseases 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
201000005917 gastric ulcer Diseases 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
231100000397 ulcer Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK307286A 1985-07-02 1986-06-27 Substituerede 2-[(3,4-dialkoxypyrid-2-yl)metyltio eller metylsulfinyl]benzimidazoler, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende en sådan forbindelse DK170819B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP14639585		1985-07-02
JP14639585		1985-07-02
JP16045785		1985-07-19
JP16045785		1985-07-19

Publications (3)

Publication Number	Publication Date
DK307286D0 DK307286D0 (da)	1986-06-27
DK307286A true DK307286A (da)	1987-01-03
DK170819B1 DK170819B1 (da)	1996-01-29

Family

ID=26477257

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK307286A DK170819B1 (da)	1985-07-02	1986-06-27	Substituerede 2-[(3,4-dialkoxypyrid-2-yl)metyltio eller metylsulfinyl]benzimidazoler, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende en sådan forbindelse

Country Status (11)

Country	Link
US (1)	US4738975A (da)
EP (1)	EP0208452B1 (da)
JP (1)	JPH0674270B2 (da)
KR (1)	KR930010495B1 (da)
CN (1)	CN1018642B (da)
AT (1)	ATE67494T1 (da)
CA (1)	CA1339819C (da)
DE (1)	DE3681518D1 (da)
DK (1)	DK170819B1 (da)
HU (1)	HUT43589A (da)
IE (1)	IE59049B1 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK171989B1 (da) *	1987-08-04	1997-09-08	Takeda Chemical Industries Ltd	Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
AU2817989A (en) *	1987-12-11	1989-07-05	Byk Gulden Lomberg Chemische Fabrik Gmbh	Novel benzimidazole derivatives
WO1990003373A1 (fr) *	1988-09-20	1990-04-05	Hisamitsu Pharmaceutical Co., Inc.	NOUVEAUX DERIVES DE DIBENZ[b,e]OXEPINE
SE8804629D0 (sv)	1988-12-22	1988-12-22	Ab Haessle	New therapeutically active compounds
IE64199B1 (en) *	1988-12-22	1995-07-12	Haessle Ab	Compound with gastric acid inhibitory effect and process for its preparation
SE8804628D0 (sv) *	1988-12-22	1988-12-22	Ab Haessle	New compounds
GR1001241B (el) *	1989-05-19	1993-06-30	Byk Gulden Lomberg Chem Fab	Μεθοδος αλκυλιωσεως.
US4965269A (en) *	1989-12-20	1990-10-23	Ab Hassle	Therapeutically active chloro substituted benzimidazoles
US5049674A (en) *	1989-12-20	1991-09-17	Aktiebolaget Hassle	Therapeutically active fluoro substituted benzimidazoles
US5274099A (en) *	1989-12-20	1993-12-28	Aktiebolaget Hassle	Therapeutically active fluoro substituted benzimidazoles
SE9002206D0 (sv)	1990-06-20	1990-06-20	Haessle Ab	New compounds
WO1991019712A1 (en) *	1990-06-20	1991-12-26	Aktiebolaget Astra	Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use
AT394368B (de) *	1990-08-07	1992-03-25	Byk Gulden Lomberg Chem Fab	Verfahren zur herstellung von 3,4-dialkoxypyridinen
US5312824A (en) *	1990-10-17	1994-05-17	Takeda Chemical Industries, Ltd.	Certain 2-[(4-difluoromethoxy-2-pyridyl)-methylthio or methylsulfinyl-5-benzimidazoles useful for treating peptic ulcers
US5298525A (en) *	1992-11-23	1994-03-29	University Technologies International, Inc.	Diabetes prevention and treatment
TW280770B (da)	1993-10-15	1996-07-11	Takeda Pharm Industry Co Ltd
AU6551198A (en) *	1997-05-30	1998-12-30	Dr. Reddy's Research Foundation	Novel benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them
DE69934505T2 (de)	1998-05-18	2007-10-04	Takeda Pharmaceutical Co. Ltd.	Im munde zerfallende tablette enthaltend ein benzimidazole
DE19951960C2 (de) *	1999-10-28	2002-06-27	Gruenenthal Gmbh	Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
US6544556B1 (en)	2000-09-11	2003-04-08	Andrx Corporation	Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
CN1243749C (zh) *	2001-09-18	2006-03-01	泽里新药工业株式会社	苯并咪唑衍生物
WO2005020954A2 (en) *	2003-09-03	2005-03-10	Agi Therapeutics Limited	Proton pump inhibitor formulations, and methods of preparing and using such formulations
US8486450B2 (en)	2005-12-28	2013-07-16	Takeda Pharmaceutical Company Limited	Method of producing solid preparation disintegrating in the oral cavity
EP2124884B1 (en)	2006-12-22	2019-07-10	Ironwood Pharmaceuticals, Inc.	Compositions comprising bile acid sequestrants for treating esophageal disorders
WO2012027331A1 (en)	2010-08-27	2012-03-01	Ironwood Pharmaceuticals, Inc.	Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
CA2898362C (en)	2013-01-15	2020-09-01	Ironwood Pharmaceuticals, Inc.	Gastro-retentive sustained-release oral dosage form of a bile acid sequestrant
US20180015118A1 (en)	2015-02-03	2018-01-18	Ironwood Pharmaceuticals, Inc.	Methods of treating upper gastrointestinal disorders in ppi refractory gerd
US20170042806A1 (en)	2015-04-29	2017-02-16	Dexcel Pharma Technologies Ltd.	Orally disintegrating compositions
WO2017145146A1 (en)	2016-02-25	2017-08-31	Dexcel Pharma Technologies Ltd.	Compositions comprising proton pump inhibitors
US10076494B2 (en)	2016-06-16	2018-09-18	Dexcel Pharma Technologies Ltd.	Stable orally disintegrating pharmaceutical compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE416649B (sv) *	1974-05-16	1981-01-26	Haessle Ab	Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) *	1978-04-14	1979-10-15	Haessle Ab	Magsyrasekretionsmedel
US4359465A (en) *	1980-07-28	1982-11-16	The Upjohn Company	Methods for treating gastrointestinal inflammation
ZA825106B (en) *	1981-08-13	1983-04-27	Haessle Ab	Novel pharmaceutical compositions
US4472409A (en) *	1981-11-05	1984-09-18	Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung	2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
SE8300736D0 (sv) *	1983-02-11	1983-02-11	Haessle Ab	Novel pharmacologically active compounds
HU195220B (en) *	1983-05-03	1988-04-28	Byk Gulden Lomberg Chem Fqb	Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
IL76839A (en) *	1984-10-31	1988-08-31	Byk Gulden Lomberg Chem Fab	Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same

1986
- 1986-06-18 US US06/875,702 patent/US4738975A/en not_active Expired - Lifetime
- 1986-06-23 IE IE167586A patent/IE59049B1/en not_active IP Right Cessation
- 1986-06-23 EP EP19860304803 patent/EP0208452B1/en not_active Expired - Lifetime
- 1986-06-23 AT AT86304803T patent/ATE67494T1/de not_active IP Right Cessation
- 1986-06-23 DE DE8686304803T patent/DE3681518D1/de not_active Expired - Fee Related
- 1986-06-26 KR KR1019860005148A patent/KR930010495B1/ko not_active Expired - Fee Related
- 1986-06-27 DK DK307286A patent/DK170819B1/da not_active IP Right Cessation
- 1986-06-30 CA CA000512760A patent/CA1339819C/en not_active Expired - Fee Related
- 1986-07-01 HU HU862745A patent/HUT43589A/hu not_active IP Right Cessation
- 1986-07-02 CN CN86104636A patent/CN1018642B/zh not_active Expired
- 1986-07-02 JP JP61156824A patent/JPH0674270B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IE861675L (en)	1987-01-02
US4738975A (en)	1988-04-19
EP0208452A3 (en)	1988-03-30
JPH0674270B2 (ja)	1994-09-21
ATE67494T1 (de)	1991-10-15
EP0208452A2 (en)	1987-01-14
IE59049B1 (en)	1993-12-15
KR870001195A (ko)	1987-03-12
HUT43589A (en)	1987-11-30
DK307286D0 (da)	1986-06-27
CN86104636A (zh)	1987-01-28
JPS62116576A (ja)	1987-05-28
CA1339819C (en)	1998-04-14
DE3681518D1 (de)	1991-10-24
KR930010495B1 (ko)	1993-10-25
EP0208452B1 (en)	1991-09-18
DK170819B1 (da)	1996-01-29
CN1018642B (zh)	1992-10-14

Legal Events

Date	Code	Title	Description
1996-01-29	B1	Patent granted (law 1993)
2003-02-03	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK307286D0 (da)	1986-06-27	Pyridinderivater, fremstilling deraf og farmaceutisk praeparat indeholdende forbindelserne
IE851976L (en)	1986-02-16	Pyridyl methylthiobenzimidazole derivatives
FI833047A0 (fi)	1983-08-25	Mellanprodukter foer framstaellning av omeprazol
ATE73796T1 (de)	1992-04-15	Benzimidazolderivate und deren herstellung.
DK519985D0 (da)	1985-11-12	Quinoloncarboxylsyrederivater, fremgangsmaade til fremstilling deraf og antibakterielt middel indeholdende saadanne derivater
MY102277A (en)	1992-05-15	Quinoline compounds
SE8601852L (sv)	1986-10-24	Cyklopentyletrar och deras framstellning och farmaceutiska beredning
DK180985A (da)	1985-10-25	Cyklopentylaetere, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende saadanne aetere
IE860987L (en)	1986-10-17	Triazole derivatives
FI853868L (fi)	1986-04-06	Pyridinderivat, foerfarande foer framstaellning av dessa och farmaceutiska foereningar innehaollande dessa.
NO821083L (no)	1982-10-04	Fremgangsmaate for fremstilling av terapeutisk aktive morfantridin-derivater
ATE42554T1 (de)	1989-05-15	Pyridin-derivate und deren herstellung.
ZA811904B (en)	1982-05-26	1-aroyl-2-phenylamino-2-imidazolines,their preparation and drugs containing these compounds
ES8306149A1 (es)	1983-05-01	Un procedimiento para la preparacion de nuevos derivados de 2-fenoti-zinsulfonamida.
SE8801907D0 (sv)	1988-05-20	Novel pharmacological compounds
TH3203A (th)	1986-04-01	อนุพันธ์ของพิริดีนและการผลิตสารดังกล่าว
ATE32893T1 (de)	1988-03-15	Spirobenzofuranone, deren herstellung und verwendung.