DK3110948T3 - Chymosinvarianter med forbedrede mælkekoaguleringsegenskaber - Google Patents
Chymosinvarianter med forbedrede mælkekoaguleringsegenskaber Download PDFInfo
- Publication number
- DK3110948T3 DK3110948T3 DK15707110.1T DK15707110T DK3110948T3 DK 3110948 T3 DK3110948 T3 DK 3110948T3 DK 15707110 T DK15707110 T DK 15707110T DK 3110948 T3 DK3110948 T3 DK 3110948T3
- Authority
- DK
- Denmark
- Prior art keywords
- milk clotting
- improved milk
- chymosin variants
- clotting properties
- properties
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
- A23C19/00—Cheese; Cheese preparations; Making thereof
- A23C19/02—Making cheese curd
- A23C19/04—Making cheese curd characterised by the use of specific enzymes of vegetable or animal origin
- A23C19/041—Proteolytic or milk clotting enzymes from plants or vegetables, e.g. papain, ficin, bromelain
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
- A23C9/1209—Proteolytic or milk coagulating enzymes, e.g. trypsine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6483—Chymosin (3.4.23.4), i.e. rennin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/23—Aspartic endopeptidases (3.4.23)
- C12Y304/23004—Chymosin (3.4.23.4), i.e. rennin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
- A23C19/00—Cheese; Cheese preparations; Making thereof
- A23C19/02—Making cheese curd
- A23C19/04—Making cheese curd characterised by the use of specific enzymes of vegetable or animal origin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Husbandry (AREA)
- Botany (AREA)
- Peptides Or Proteins (AREA)
- Dairy Products (AREA)
- Enzymes And Modification Thereof (AREA)
- Fodder In General (AREA)
- Beans For Foods Or Fodder (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14156707 | 2014-02-26 | ||
| EP14176664 | 2014-07-11 | ||
| PCT/EP2015/054020 WO2015128417A1 (en) | 2014-02-26 | 2015-02-26 | Variants of chymosin with improved milk-clotting properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3110948T3 true DK3110948T3 (da) | 2025-05-12 |
Family
ID=52596486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15707110.1T DK3110948T3 (da) | 2014-02-26 | 2015-02-26 | Chymosinvarianter med forbedrede mælkekoaguleringsegenskaber |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10982204B2 (da) |
| EP (2) | EP4627930A3 (da) |
| JP (3) | JP7098270B2 (da) |
| KR (2) | KR102344861B1 (da) |
| CN (2) | CN111944791A (da) |
| AU (2) | AU2015222149B2 (da) |
| BR (1) | BR112016017502B1 (da) |
| CA (1) | CA2938015A1 (da) |
| DK (1) | DK3110948T3 (da) |
| MX (2) | MX2016009937A (da) |
| NZ (1) | NZ722003A (da) |
| RU (2) | RU2739004C1 (da) |
| UA (1) | UA121380C2 (da) |
| WO (1) | WO2015128417A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ725398A (en) | 2012-05-25 | 2018-05-25 | Chr Hansen As | Variants of chymosin with improved milk-clotting properties |
| RU2739004C1 (ru) | 2014-02-26 | 2020-12-21 | Кхр. Хансен А/С | Варианты химозина с улучшенными молокосвертывающими свойствами |
| WO2016207214A1 (en) * | 2015-06-22 | 2016-12-29 | Chr. Hansen A/S | Variants of chymosin with improved properties |
| MX2018002366A (es) | 2015-08-31 | 2018-04-11 | Chr Hansen As | Variantes de quimosina con propiedades mejoradas. |
| DK3143879T3 (da) * | 2015-09-18 | 2025-04-22 | Dsm Ip Assets Bv | Yoghurt med reduceret modning |
| JP7395251B2 (ja) * | 2016-05-19 | 2023-12-11 | セーホーエル．ハンセン アクティーゼルスカブ | 改善された凝乳特性を有するキモシン変異体 |
| CA3024211A1 (en) | 2016-05-19 | 2017-11-23 | Chr. Hansen A/S | Variants of chymosin with improved milk-clotting properties |
| CN106754840B (zh) * | 2016-12-22 | 2019-06-21 | 江南大学 | 一种酶活及热稳定性改善的凝乳酶突变体 |
| MX2020007300A (es) | 2018-01-15 | 2020-09-25 | Chr Hansen As | Producto de leche fermentada y preparacion del mismo usando fosfolipasa. |
| CN113801867B (zh) * | 2021-11-18 | 2022-03-18 | 中国农业科学院生物技术研究所 | 骆驼凝乳酶原突变蛋白及其编码基因和应用 |
| WO2023194285A2 (en) | 2022-04-06 | 2023-10-12 | Chr. Hansen A/S | Aspartic protease, methods and uses thereof |
| WO2024189187A1 (en) | 2023-03-15 | 2024-09-19 | Dsm Ip Assets B.V. | Novel process for producing a fermented milk product and new fermented milk product so produced |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0123928A3 (en) | 1983-03-31 | 1986-02-05 | Codon Genetic Engineering Laboratories | Recombinant dna coding for a polypeptide displaying milk clotting activity |
| US5217891A (en) * | 1987-07-28 | 1993-06-08 | Chiron Corporation | DNA constructs containing a kluyveromyces α factor leader sequence for directing secretion of heterologous polypeptides |
| US7390936B1 (en) * | 1999-08-23 | 2008-06-24 | Sembiosys Genetics Inc. | Commercial production of chymosin in plants |
| RU2192137C2 (ru) | 2000-08-07 | 2002-11-10 | Открытое акционерное общество "Уфамолагропром" | Способ производства сыра |
| EP1334182B2 (en) | 2000-11-06 | 2021-03-24 | Chr. Hansen A/S | Method of producing non-bovine chymosin and use hereof |
| CA2501295A1 (en) | 2002-10-02 | 2004-04-15 | Jack Nguyen | Methods of generating and screening for proteases with altered specificity |
| WO2004072225A2 (en) | 2003-02-12 | 2004-08-26 | Ramot At Tel Aviv University Ltd. | Transgenic fungi expressing bcl-2 and methods of using bcl-2 or portions thereof for improving biomass production, survival, longevity, stress resistance and pathogenicity of fungi |
| AU2004254352A1 (en) | 2003-06-27 | 2005-01-13 | Roberto Crea | Look-through mutagenesis |
| US7482148B2 (en) * | 2004-03-30 | 2009-01-27 | Sudershan Biotech Ltd. | Recombinant calf-chymosin and a process for producing the same |
| WO2008098973A1 (en) | 2007-02-13 | 2008-08-21 | Chr. Hansen A/S | Coagulation of milk |
| JP2010046034A (ja) | 2008-08-22 | 2010-03-04 | Toyota Central R&D Labs Inc | 変異体のスクリーニング方法 |
| EP2411512B1 (en) * | 2009-03-24 | 2013-11-20 | Meito Sangyo Co., Ltd. | Improved type milk-clotting protease derived from a microorganism |
| IN2012DN03825A (da) * | 2009-11-20 | 2015-08-28 | Danisco Us Inc | |
| US20130202576A1 (en) * | 2010-07-12 | 2013-08-08 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| EP2844751B1 (en) | 2012-05-03 | 2018-10-17 | DSM IP Assets B.V. | Improved chymosine enzyme variants |
| NZ725398A (en) | 2012-05-25 | 2018-05-25 | Chr Hansen As | Variants of chymosin with improved milk-clotting properties |
| CN103484488B (zh) * | 2013-09-16 | 2015-07-15 | 中国农业科学院生物技术研究所 | 优化的牛凝乳酶原基因及其分泌表达方法和应用 |
| RU2739004C1 (ru) | 2014-02-26 | 2020-12-21 | Кхр. Хансен А/С | Варианты химозина с улучшенными молокосвертывающими свойствами |
| UA125925C2 (uk) | 2015-02-10 | 2022-07-13 | Кр. Гансен А/С | Композиція для згортання молока, що містить суміш хімозинів, харчова та кормова композиції, що містять суміш хімозинів, застосування композиції для згортання молока, спосіб одержання продукту на основі молока та спосіб одержання ферментованого молочного продукту з використанням композиції для згортання молока |
| WO2016207214A1 (en) | 2015-06-22 | 2016-12-29 | Chr. Hansen A/S | Variants of chymosin with improved properties |
| MX2018002366A (es) | 2015-08-31 | 2018-04-11 | Chr Hansen As | Variantes de quimosina con propiedades mejoradas. |
| JP7395251B2 (ja) | 2016-05-19 | 2023-12-11 | セーホーエル．ハンセン アクティーゼルスカブ | 改善された凝乳特性を有するキモシン変異体 |
| CA3024211A1 (en) | 2016-05-19 | 2017-11-23 | Chr. Hansen A/S | Variants of chymosin with improved milk-clotting properties |
-
2015
- 2015-02-26 RU RU2020107148A patent/RU2739004C1/ru active
- 2015-02-26 AU AU2015222149A patent/AU2015222149B2/en active Active
- 2015-02-26 NZ NZ722003A patent/NZ722003A/en unknown
- 2015-02-26 JP JP2016553838A patent/JP7098270B2/ja active Active
- 2015-02-26 EP EP25169128.3A patent/EP4627930A3/en active Pending
- 2015-02-26 CA CA2938015A patent/CA2938015A1/en active Pending
- 2015-02-26 KR KR1020167026056A patent/KR102344861B1/ko active Active
- 2015-02-26 KR KR1020217042407A patent/KR102494645B1/ko active Active
- 2015-02-26 DK DK15707110.1T patent/DK3110948T3/da active
- 2015-02-26 EP EP15707110.1A patent/EP3110948B1/en active Active
- 2015-02-26 CN CN202010904707.0A patent/CN111944791A/zh active Pending
- 2015-02-26 UA UAA201607691A patent/UA121380C2/uk unknown
- 2015-02-26 RU RU2016132974A patent/RU2717770C2/ru active
- 2015-02-26 US US15/121,286 patent/US10982204B2/en active Active
- 2015-02-26 MX MX2016009937A patent/MX2016009937A/es unknown
- 2015-02-26 BR BR112016017502-6A patent/BR112016017502B1/pt active IP Right Grant
- 2015-02-26 CN CN201580009539.6A patent/CN106062187B/zh active Active
- 2015-02-26 WO PCT/EP2015/054020 patent/WO2015128417A1/en not_active Ceased
-
2016
- 2016-07-29 MX MX2022006692A patent/MX2022006692A/es unknown
-
2020
- 2020-03-05 JP JP2020038155A patent/JP7144470B2/ja active Active
-
2021
- 2021-04-15 US US17/231,956 patent/US11629343B2/en active Active
- 2021-12-17 AU AU2021286442A patent/AU2021286442B2/en active Active
-
2022
- 2022-01-07 US US17/571,413 patent/US11827913B2/en active Active
- 2022-05-25 JP JP2022085229A patent/JP2022122926A/ja active Pending
-
2023
- 2023-10-30 US US18/497,758 patent/US20240084281A1/en not_active Abandoned
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