DK3119887T3 - Forbedrede korte interfererende ribonukleinsyremolekyler - Google Patents
Forbedrede korte interfererende ribonukleinsyremolekyler Download PDFInfo
- Publication number
- DK3119887T3 DK3119887T3 DK15711195.6T DK15711195T DK3119887T3 DK 3119887 T3 DK3119887 T3 DK 3119887T3 DK 15711195 T DK15711195 T DK 15711195T DK 3119887 T3 DK3119887 T3 DK 3119887T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid molecules
- ribonucleic acid
- short interfering
- interfering ribonucleic
- improved short
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1450312 | 2014-03-20 | ||
| PCT/EP2015/056012 WO2015140330A1 (en) | 2014-03-20 | 2015-03-20 | Improved small interfering ribonucleic acid molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3119887T3 true DK3119887T3 (da) | 2019-05-20 |
Family
ID=52697435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15711195.6T DK3119887T3 (da) | 2014-03-20 | 2015-03-20 | Forbedrede korte interfererende ribonukleinsyremolekyler |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20170137808A1 (da) |
| EP (1) | EP3119887B1 (da) |
| DK (1) | DK3119887T3 (da) |
| ES (1) | ES2727078T3 (da) |
| WO (1) | WO2015140330A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201516685D0 (en) * | 2015-09-21 | 2015-11-04 | Varghese Oommen P And Oommen Oommen P | Nucleic acid molecules with enhanced activity |
| US11260134B2 (en) | 2016-09-29 | 2022-03-01 | National University Corporation Tokyo Medical And Dental University | Double-stranded nucleic acid complex having overhang |
| WO2023207615A1 (zh) * | 2022-04-26 | 2023-11-02 | 南京明德新药研发有限公司 | 一类含由天然核苷酸组成突出端的双链RNAi化合物 |
| CN119614573B (zh) * | 2024-12-25 | 2026-04-21 | 厦门大学 | 用于动物活体Zbp1基因敲低的小干扰RNA及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040259247A1 (en) * | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| EP2305812A3 (en) * | 2002-11-14 | 2012-06-06 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
| WO2005079533A2 (en) * | 2004-02-17 | 2005-09-01 | University Of Massachusetts | Methods and compositions for mediating gene silencing |
| DK1888749T3 (da) * | 2005-06-01 | 2015-01-05 | Polyplus Transfection | Oligonukleotider til RNA-interferens samt biologiske anvendelser deraf |
| EP2152870A2 (en) * | 2007-05-02 | 2010-02-17 | Sirna Therapeutics Inc. | Rna interference mediated inhibition of cyclic nucleotide type 4 phosphodiesterase (pde4b) gene expression using short interfering nucleic acid (sina) |
| CA2746527A1 (en) * | 2008-09-22 | 2010-03-25 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| EP2756845B1 (en) * | 2009-04-03 | 2017-03-15 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA |
| DK2631291T3 (da) * | 2010-10-22 | 2019-06-11 | Olix Pharmaceuticals Inc | Nukleinsyremolekyler, der inducerer rna-interferens, og anvendelser deraf |
-
2015
- 2015-03-20 US US15/127,616 patent/US20170137808A1/en not_active Abandoned
- 2015-03-20 EP EP15711195.6A patent/EP3119887B1/en active Active
- 2015-03-20 DK DK15711195.6T patent/DK3119887T3/da active
- 2015-03-20 WO PCT/EP2015/056012 patent/WO2015140330A1/en not_active Ceased
- 2015-03-20 ES ES15711195T patent/ES2727078T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2727078T3 (es) | 2019-10-14 |
| WO2015140330A1 (en) | 2015-09-24 |
| EP3119887A1 (en) | 2017-01-25 |
| EP3119887B1 (en) | 2019-02-20 |
| US20170137808A1 (en) | 2017-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3341482T3 (da) | Kunstige nukleinsyremolekyler | |
| PL3118311T3 (pl) | Antysensowny kwas nukleinowy | |
| HUE049405T2 (hu) | Nukleáz-közvetített DNS-összeállítás | |
| DK3094731T3 (da) | Saccharidmodificerede nukleinsyremolekyler | |
| SG11201704681QA (en) | Artificial nucleic acid molecules | |
| DK3234132T3 (da) | Ligand-modificerede dobbeltstrengede nukleinsyrer | |
| DK4023249T3 (da) | Nukleinsyrevacciner | |
| EP3171975C0 (en) | CATALYSTS | |
| DK3351633T3 (da) | Antisense-nukleinsyre | |
| EP3286549A4 (en) | BIOSENSOR | |
| DK3105250T3 (da) | Multispecifikke iga-bindingsmolekyler | |
| EP3227659C0 (en) | THAWING PROCESSES | |
| DE112015005628A5 (de) | Steckverbinder | |
| EP3156789C0 (en) | BIOSENSOR | |
| DK3242685T3 (da) | Cxcr4-bindende molekyler | |
| DK3237432T3 (da) | Proteinfremstilling | |
| IL254413B (en) | Cell-free production of ribonucleic acid | |
| DK2952752T3 (da) | Afbøjnings-rørbøjning | |
| EP3387414A4 (en) | BIOSENSOR | |
| EP3371575A4 (en) | BIOSENSOR | |
| DE202014104222U8 (de) | Steckverbinder | |
| SG11201507104WA (en) | Novel nucleic acid molecules | |
| EP3141244C0 (en) | EMULSIONS COMPRISING SILICIC ACID | |
| DK3125867T3 (da) | Hyperosmolær hyaluronsyresammensætning | |
| DK3119887T3 (da) | Forbedrede korte interfererende ribonukleinsyremolekyler |