DK3129023T3 - Potente opløselige epoxidhydrolase-inhibitorer - Google Patents
Potente opløselige epoxidhydrolase-inhibitorer Download PDFInfo
- Publication number
- DK3129023T3 DK3129023T3 DK15768180.0T DK15768180T DK3129023T3 DK 3129023 T3 DK3129023 T3 DK 3129023T3 DK 15768180 T DK15768180 T DK 15768180T DK 3129023 T3 DK3129023 T3 DK 3129023T3
- Authority
- DK
- Denmark
- Prior art keywords
- epoxide hydrolase
- soluble epoxide
- hydrolase inhibitors
- potential soluble
- potential
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461971410P | 2014-03-27 | 2014-03-27 | |
| PCT/US2015/023048 WO2015148954A1 (en) | 2014-03-27 | 2015-03-27 | Potent soluble epoxide hydrolase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3129023T3 true DK3129023T3 (da) | 2021-05-25 |
Family
ID=54196453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15768180.0T DK3129023T3 (da) | 2014-03-27 | 2015-03-27 | Potente opløselige epoxidhydrolase-inhibitorer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10377744B2 (da) |
| EP (1) | EP3129023B1 (da) |
| CN (2) | CN112898196B (da) |
| AU (1) | AU2015237245B2 (da) |
| BR (1) | BR112016021641A2 (da) |
| DK (1) | DK3129023T3 (da) |
| ES (1) | ES2871027T3 (da) |
| PL (1) | PL3129023T3 (da) |
| WO (1) | WO2015148954A1 (da) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020301161B2 (en) | 2019-06-25 | 2023-10-26 | Gilead Sciences, Inc. | FLT3L-Fc fusion proteins and methods of use |
| KR102902719B1 (ko) | 2019-10-18 | 2025-12-24 | 포티 세븐, 엘엘씨 | 골수이형성 증후군 및 급성 골수성 백혈병을 치료하기 위한 조합 치료 |
| CA3153636A1 (en) | 2019-10-31 | 2021-05-06 | Forty Seven, Inc. | Anti-cd47 and anti-cd20 based treatment of blood cancer |
| TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
| EP4445902A3 (en) | 2019-12-24 | 2024-12-18 | Carna Biosciences, Inc. | Diacylglycerol kinase modulating compounds |
| CN117964757A (zh) | 2020-02-14 | 2024-05-03 | 吉利德科学公司 | 与ccr8结合的抗体和融合蛋白及其用途 |
| US12110294B2 (en) | 2020-05-01 | 2024-10-08 | Gilead Sciences, Inc. | CD73 compounds |
| CN111574432A (zh) * | 2020-06-17 | 2020-08-25 | 安徽省逸欣铭医药科技有限公司 | 一种可溶性环氧水解酶和γ-氨基丁酸双重抑制剂及用途 |
| US20240024302A1 (en) * | 2020-10-26 | 2024-01-25 | Beth Israel Deaconess Medical Center, Inc. | SOLUBLE EPOXIDE HYDROLASE (sEH) INHIBITORS AND DUAL COX/sEH INHIBITORS FOR THE TREATMENT OF ARRHYTHMOGENIC CARDIOMYOPATHY |
| EP4063348A1 (en) | 2021-03-24 | 2022-09-28 | Universitat de Barcelona | Compounds as soluble epoxide hydrolase inhibitors |
| TW202302145A (zh) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症 |
| TW202313094A (zh) | 2021-05-18 | 2023-04-01 | 美商基利科學股份有限公司 | 使用ＦＬＴ３Ｌ—Ｆｃ融合蛋白之方法 |
| CN113264922A (zh) * | 2021-05-22 | 2021-08-17 | 深圳市术理科技有限公司 | 降解sEH的小分子化合物或其可药用的盐、制备方法及用途 |
| CN113402447B (zh) * | 2021-06-22 | 2022-10-18 | 沈阳药科大学 | 一种sEH抑制剂或其药学上可接受的组合物及其制备方法和应用 |
| EP4359415A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| WO2022271650A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| WO2022271659A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| US11932634B2 (en) | 2021-06-23 | 2024-03-19 | Gilead Sciences, Inc. | Diacylglycerol kinase modulating compounds |
| AU2022375782B2 (en) | 2021-10-28 | 2026-02-26 | Gilead Sciences, Inc. | Pyridizin-3(2h)-one derivatives |
| AU2022376954B2 (en) | 2021-10-29 | 2026-04-23 | Gilead Sciences, Inc. | Cd73 compounds |
| CA3237577A1 (en) | 2021-12-22 | 2023-06-29 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| AU2022419982B2 (en) | 2021-12-22 | 2026-04-16 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
| EP4493554A1 (en) | 2022-03-17 | 2025-01-22 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| WO2023183817A1 (en) | 2022-03-24 | 2023-09-28 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| TWI876305B (zh) | 2022-04-05 | 2025-03-11 | 美商基利科學股份有限公司 | 用於治療結腸直腸癌之組合療法 |
| CR20240451A (es) | 2022-04-21 | 2024-12-04 | Gilead Sciences Inc | Compuestos de modulación de kras g12d |
| PE20250758A1 (es) | 2022-07-01 | 2025-03-13 | Gilead Sciences Inc | Compuestos de cd73 |
| WO2024064668A1 (en) | 2022-09-21 | 2024-03-28 | Gilead Sciences, Inc. | FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY |
| WO2024097063A1 (en) * | 2022-11-02 | 2024-05-10 | Eicosis, Llc | Polymorphic forms of a soluble epoxide hydrolase inhibitor and formulations thereof |
| WO2024105225A1 (en) | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain |
| CN120225509A (zh) | 2022-12-22 | 2025-06-27 | 吉利德科学公司 | Prmt5抑制剂及其用途 |
| CN118206542B (zh) * | 2023-03-22 | 2025-06-27 | 沈阳药科大学 | 一种化合物及其制备方法和在制备sEH抑制剂与PPARs激动剂中的应用 |
| AU2024252725A1 (en) | 2023-04-11 | 2025-11-06 | Gilead Sciences, Inc. | Kras modulating compounds |
| PE20260121A1 (es) | 2023-04-21 | 2026-01-16 | Gilead Sciences Inc | Inhibidores de prmt5 y usos de los mismos |
| AU2024306338A1 (en) | 2023-06-30 | 2026-01-08 | Gilead Sciences, Inc. | Kras modulating compounds |
| WO2025024811A1 (en) | 2023-07-26 | 2025-01-30 | Gilead Sciences, Inc. | Parp7 inhibitors |
| KR20260046403A (ko) | 2023-07-26 | 2026-04-07 | 길리애드 사이언시즈, 인코포레이티드 | Parp7 저해제 |
| AU2024337913A1 (en) | 2023-09-08 | 2026-03-26 | Gilead Sciences, Inc. | Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds |
| US20250101042A1 (en) | 2023-09-08 | 2025-03-27 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| US20250154172A1 (en) | 2023-11-03 | 2025-05-15 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025235691A1 (en) * | 2024-05-08 | 2025-11-13 | Eicosis, Llc | Soluble epoxide hydrolase inhibitors and methods of use therof |
| WO2025245003A1 (en) | 2024-05-21 | 2025-11-27 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2026006549A1 (en) * | 2024-06-26 | 2026-01-02 | Eicosis, Llc | Methods for treating or preventing occular diseases |
| WO2026039365A1 (en) | 2024-08-12 | 2026-02-19 | Gilead Sciences, Inc. | Kras modulating compounds |
| WO2026089992A1 (en) | 2024-10-21 | 2026-04-30 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| CN119528936B (zh) * | 2024-11-22 | 2025-10-17 | 深圳安泰维生物医药有限公司 | 一种巴洛沙韦衍生物及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5445956A (en) | 1993-08-13 | 1995-08-29 | The Regents Of The University Of California | Recombinant soluble epoxide hydrolase |
| US8815951B2 (en) | 1996-08-13 | 2014-08-26 | The Regents Of The University Of California | Inhibitors of epoxide hydrolases for the treatment of inflammation |
| PT1539753E (pt) | 2002-09-16 | 2009-12-10 | Glaxo Group Ltd | Compostos de pirazolo(3,4-b)piridina e sua utilização como inibidores da fosfodiesterase |
| JP2007532484A (ja) | 2004-03-16 | 2007-11-15 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 可溶性エポキシド加水分解酵素の阻害剤およびエポキシエイコサノイドを用いて腎症を緩和する方法 |
| EP1814875A4 (en) | 2004-10-20 | 2010-02-17 | Univ California | IMPROVED INHIBITORS OF SOLUBLE EPOXY HYDROLASE |
| AR059826A1 (es) | 2006-03-13 | 2008-04-30 | Univ California | Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble |
| CN101535259A (zh) * | 2006-10-20 | 2009-09-16 | 亚瑞特医疗公司 | 作为可溶性环氧化物水解酶抑制剂的苯基脲化合物 |
| MX2009004089A (es) * | 2006-10-20 | 2009-07-10 | Arete Therapeutics Inc | Inhibidores de epoxido hidrolasa soluble. |
| WO2009062073A1 (en) | 2007-11-08 | 2009-05-14 | Regents Of The University Of California | Alleviating neuropathic pain with eets and seh inhibitors |
| WO2012054093A2 (en) * | 2010-01-29 | 2012-04-26 | The Regents Of The University Of California | Acyl piperidine inhibitors of soluble epoxide hydrolase |
| CN104136022A (zh) | 2012-02-01 | 2014-11-05 | 加利福尼亚大学董事会 | 使用seh抑制剂来治疗神经性疼痛 |
| US9034903B2 (en) | 2012-02-01 | 2015-05-19 | The Regents Of The University Of California | Acyl piperidine inhibitors of soluble epoxide hydrolase |
| EP2846825B1 (en) | 2012-03-14 | 2021-05-05 | The Regents of The University of California | Treatment of inflammatory disorders in non-human mammals |
| SG11201500005SA (en) * | 2012-07-10 | 2015-01-29 | Ares Trading Sa | Pyrimidine pyrazolyl derivatives |
-
2015
- 2015-03-27 DK DK15768180.0T patent/DK3129023T3/da active
- 2015-03-27 PL PL15768180T patent/PL3129023T3/pl unknown
- 2015-03-27 AU AU2015237245A patent/AU2015237245B2/en active Active
- 2015-03-27 CN CN202110081723.9A patent/CN112898196B/zh active Active
- 2015-03-27 EP EP15768180.0A patent/EP3129023B1/en active Active
- 2015-03-27 WO PCT/US2015/023048 patent/WO2015148954A1/en not_active Ceased
- 2015-03-27 US US15/128,933 patent/US10377744B2/en active Active
- 2015-03-27 ES ES15768180T patent/ES2871027T3/es active Active
- 2015-03-27 BR BR112016021641A patent/BR112016021641A2/pt not_active IP Right Cessation
- 2015-03-27 CN CN201580015513.2A patent/CN106163521B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN106163521B (zh) | 2021-02-09 |
| EP3129023B1 (en) | 2021-02-24 |
| CN106163521A (zh) | 2016-11-23 |
| US20170174665A1 (en) | 2017-06-22 |
| CN112898196B (zh) | 2024-12-27 |
| EP3129023A4 (en) | 2017-08-30 |
| US10377744B2 (en) | 2019-08-13 |
| CN112898196A (zh) | 2021-06-04 |
| WO2015148954A1 (en) | 2015-10-01 |
| ES2871027T3 (es) | 2021-10-28 |
| AU2015237245A1 (en) | 2016-08-25 |
| EP3129023A1 (en) | 2017-02-15 |
| BR112016021641A2 (pt) | 2017-08-15 |
| PL3129023T3 (pl) | 2021-08-16 |
| AU2015237245B2 (en) | 2019-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3541932A4 (en) | INHIBITORS OF CRISPR-CAS9 | |
| HUE042335T2 (hu) | ROR-gamma dihidropirrolopiridin inhibitorai | |
| PL3129023T3 (pl) | Silne inhibitory rozpuszczalnej hydrolazy epoksydowej | |
| LT3303334T (lt) | Tirozinkinazės inhibitoriai | |
| LT3137169T (lt) | Lizinui specifinės demetilazės-1 inhibitoriai | |
| DK3442972T3 (da) | Bromdomænehæmmere | |
| HUE046273T2 (hu) | Ciklopropilaminok mint LSD1 inhibitorok | |
| HUE045725T2 (hu) | Ciklopropilaminok mint LSD1 inhibitorok | |
| BR112016030697A2 (pt) | inibidores da desmetilase-1 específica da lisina | |
| PT3154989T (pt) | Inibidores de beta-lactamase | |
| DK3139982T3 (da) | Forstøver | |
| HUE058852T2 (hu) | Lizinspecifikus demetiláz-1 inhibitorai | |
| CU20160125A7 (es) | Inhibidores de diacilglicerol aciltransferasa 2 | |
| DK3191487T3 (da) | Spirocykliske cathepsin-c-inhibitorer | |
| EP3313828A4 (en) | METALLO-BETA-Lactamase INHIBITORS | |
| LT3160952T (lt) | Histono demetilazės inhibitoriai | |
| BR112017000042A2 (pt) | inibidores de desmetilase-1 lisina-específica | |
| EP3183255C0 (en) | SPIROPYRROLIDINES USEFUL AS MDM2 INHIBITORS | |
| HUE053905T2 (hu) | Porlasztókészülék | |
| DK3186242T3 (da) | Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere | |
| DK3114120T3 (da) | Tetrazolon-substituerede dihydropyridinon-mgat2-hæmmere | |
| MA43367A (fr) | Inhibiteurs de métallo-bêta-lactamases | |
| MA41022A (fr) | Ciblage lysosomial et utilisations correspondantes | |
| DK3139984T3 (da) | Forstøver | |
| DK3191013T3 (da) | Sinter-råemne |