DK3146042T3 - Rekombinant klassisk svinepestvirus (CSFV) med substitution i E2-proteinets TAV-epitop - Google Patents

Rekombinant klassisk svinepestvirus (CSFV) med substitution i E2-proteinets TAV-epitop

Info

Publication number
DK3146042T3
DK3146042T3 DK15724642.2T DK15724642T DK3146042T3 DK 3146042 T3 DK3146042 T3 DK 3146042T3 DK 15724642 T DK15724642 T DK 15724642T DK 3146042 T3 DK3146042 T3 DK 3146042T3
Authority
DK
Denmark
Prior art keywords
csfv
substitution
protein
fever virus
swine fever
Prior art date
Application number
DK15724642.2T
Other languages
English (en)
Inventor
Gregor Meyers
Sabine Wirtz
Original Assignee
Boehringer Ingelheim Vetmedica Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica Gmbh filed Critical Boehringer Ingelheim Vetmedica Gmbh
Application granted granted Critical
Publication of DK3146042T3 publication Critical patent/DK3146042T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24361—Methods of inactivation or attenuation
    • C12N2770/24362—Methods of inactivation or attenuation by genetic engineering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G01N2333/183—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus) or border disease virus
    • G01N2333/185—Flaviviruses or Group B arboviruses, e.g. yellow fever virus, japanese encephalitis, tick-borne encephalitis, dengue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK15724642.2T 2014-05-23 2015-05-22 Rekombinant klassisk svinepestvirus (CSFV) med substitution i E2-proteinets TAV-epitop DK3146042T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14169703 2014-05-23
PCT/EP2015/061473 WO2015177369A1 (en) 2014-05-23 2015-05-22 Recombinant classical swine fever virus (csfv) comprising substitution in the tav epitope of the e2 protein

Publications (1)

Publication Number Publication Date
DK3146042T3 true DK3146042T3 (da) 2019-09-30

Family

ID=50774696

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15724642.2T DK3146042T3 (da) 2014-05-23 2015-05-22 Rekombinant klassisk svinepestvirus (CSFV) med substitution i E2-proteinets TAV-epitop

Country Status (6)

Country Link
US (1) US9993544B2 (da)
EP (1) EP3146042B1 (da)
CN (1) CN106456741B (da)
DK (1) DK3146042T3 (da)
ES (1) ES2757927T3 (da)
WO (1) WO2015177369A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2757927T3 (es) * 2014-05-23 2020-04-30 Boehringer Ingelheim Vetmedica Gmbh Virus de la peste porcina clásica (VPPC) recombinante que comprende sustituciones en el epítopo TAV de la proteína E2
CN106928327B (zh) * 2017-04-01 2020-02-04 河南科技学院 猪瘟病毒配体表位多肽se242及其应用
CN108383895B (zh) * 2018-05-03 2021-04-27 河南省农业科学院 一条可与猪瘟病毒e2蛋白结合的亲和肽及其应用
KR20220009960A (ko) * 2019-04-18 2022-01-25 베링거 잉겔하임 베트메디카 (차이나) 코포레이션 리미티드 재조합 고전적 돼지 열병 바이러스
CN111718400B (zh) * 2020-06-15 2021-11-02 苏州世诺生物技术有限公司 猪瘟病毒重组抗原及其制备方法和应用
CN115073608B (zh) * 2022-03-22 2023-05-02 广东海大集团股份有限公司 一种猪瘟病毒e2的核酸-蛋白复合标记性疫苗
CN114835822B (zh) * 2022-04-22 2022-11-04 浙江洪晟生物科技股份有限公司 猪瘟病毒的多聚体疫苗及其制备方法
CN117947057B (zh) * 2024-03-26 2024-08-06 中国兽医药品监察所 一种用于预防猪瘟的mRNA纳米脂质体颗粒及其制备、检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0965639A1 (en) * 1998-06-05 1999-12-22 Boehringer Ingelheim Vetmedica Gmbh Attenuated pestiviruses
DE10145969A1 (de) * 2001-09-18 2003-04-10 Maltagen Forschung Gmbh Verfahren zum Herstellen eines Markerimpfstoffs gegen ein Säugervirus
DE102004025452A1 (de) * 2004-05-19 2006-01-19 Boehringer Ingelheim Vetmedica Gmbh Vakzine enthaltend BVDV
US8846055B2 (en) 2006-05-30 2014-09-30 The United States Of America, As Represented By The Secretary Of Agriculture Virulence determinant within the E2 structural glycoprotein of classical swine fever virus
EP2066342B1 (en) * 2006-09-22 2014-07-23 Intervet International BV Bovine Viral Diarrhea Virus mutant for use in a vaccine
WO2008073464A2 (en) * 2006-12-11 2008-06-19 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
UY31930A (es) * 2008-06-25 2010-01-29 Boheringer Ingelheim Pharma Kg Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante
EP2202298A1 (en) * 2008-12-23 2010-06-30 Stichting Dienst Landbouwkundig Onderzoek Recombinant classical swine fever virus (CSFV) comprising a modified E2 protein and methods for generating said recombinant CSFV
US20110150770A1 (en) * 2009-12-18 2011-06-23 Boehringer Ingelheim Vetmedica, Inc. Multivalent vaccine against porcine teschovirus and other disease causing organisms in swine
PH12012502273A1 (en) 2010-05-18 2013-02-04 Ceva Sante Animale Marker vaccine for classical swine fever
ES2757927T3 (es) 2014-05-23 2020-04-30 Boehringer Ingelheim Vetmedica Gmbh Virus de la peste porcina clásica (VPPC) recombinante que comprende sustituciones en el epítopo TAV de la proteína E2

Also Published As

Publication number Publication date
WO2015177369A1 (en) 2015-11-26
US9993544B2 (en) 2018-06-12
EP3146042B1 (en) 2019-07-10
EP3146042A1 (en) 2017-03-29
ES2757927T3 (es) 2020-04-30
CN106456741B (zh) 2020-07-21
CN106456741A (zh) 2017-02-22
US20170119870A1 (en) 2017-05-04

Similar Documents

Publication Publication Date Title
IL280459A (en) Phosphoramidates for the treatment of hepatitis b virus
DK3146042T3 (da) Rekombinant klassisk svinepestvirus (CSFV) med substitution i E2-proteinets TAV-epitop
IL248392A0 (en) Human antibodies to middle east respiratory syndrome -coronavirus spike protein
HUE061253T2 (hu) Antitestek OX40 ellen és azok felhasználásai
IL256785A (en) Chimeric polypeptide assembly and methods of making and using the same
HUE055331T2 (hu) Pro/látens-miosztatin elleni ellenanyagok és alkalmazásuk
DK3197472T3 (da) Rekombinante phe-frie proteiner til anvendelse i behandlingen af phenylketonuri
EP3639849C0 (en) VACCINE AGAINST ATTENUATED AFRICAN SWINE FEVER VIRUS
DK3805376T3 (da) Modificeret virus
HUE048284T2 (hu) Anti-CD40 antitestek és alkalmazásuk
HUE055311T2 (hu) Módosított FGF-21 polipeptidek és azok felhasználása
IL247221B (en) Antibodies binding dengue virus, compositions comprising same and uses thereof
HUE052541T2 (hu) Immunogén WT-1 peptidek és eljárások azok alkalmazására
HUE054201T2 (hu) PD-1-CD28 fúziós fehérjék és gyógyászatban való alkalmazásuk
LT3240895T (lt) Kompozicijos ir būdai, skirti baltymų glikozilinimui
HUE042054T2 (hu) UspA2-fehérjekonstrukciók és alkalmazásuk
HUE052577T2 (hu) Rekombináns GLUT1 adeno-asszociált vírusvektor-szerkezetek és kapcsolódó eljárások GLUT1 expresszió helyreállítására
DK3199179T3 (da) Formulering af rekombinant fusionsprotein
IL261140B (en) Anti-tnfalpha-antibodies and functional fragments thereof
BR112017009792A2 (pt) anticorpos anti-pdgf-b e métodos de uso
HUE059655T2 (hu) Új anti-humán GPVI antitestek és felhasználásuk
EP3442549C0 (en) BIFIDOBACTERIA TO INCREASE THE LEAN MASS OF A BODY
IL261031A (en) Anti-tnfalpha-antibodies and functional fragments thereof
KR20180084995A (ko) Fmdv 및 e2 융합 단백질 및 이의 용도
LT3110837T (lt) Tatk-cdkl5 sulieti baltymai, kompozicijos, sudėtys ir jų panaudojimas