DK3149163T3 - Prohæmostatiske proteiner til behandling af blødning - Google Patents

Prohæmostatiske proteiner til behandling af blødning Download PDF

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Publication number
DK3149163T3
DK3149163T3 DK15731411.3T DK15731411T DK3149163T3 DK 3149163 T3 DK3149163 T3 DK 3149163T3 DK 15731411 T DK15731411 T DK 15731411T DK 3149163 T3 DK3149163 T3 DK 3149163T3
Authority
DK
Denmark
Prior art keywords
bleeding
treatment
prohemostatic
proteins
prohemostatic proteins
Prior art date
Application number
DK15731411.3T
Other languages
English (en)
Inventor
Pieter H Reitsma
Mettine H A Bos
Daniël Verhoef
Original Assignee
Academisch Ziekenhuis Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academisch Ziekenhuis Leiden filed Critical Academisch Ziekenhuis Leiden
Application granted granted Critical
Publication of DK3149163T3 publication Critical patent/DK3149163T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK15731411.3T 2014-05-26 2015-05-26 Prohæmostatiske proteiner til behandling af blødning DK3149163T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14169895 2014-05-26
PCT/NL2015/050377 WO2015183085A1 (en) 2014-05-26 2015-05-26 Prohemostatic proteins for the treatment of bleeding

Publications (1)

Publication Number Publication Date
DK3149163T3 true DK3149163T3 (da) 2020-08-31

Family

ID=50774744

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15731411.3T DK3149163T3 (da) 2014-05-26 2015-05-26 Prohæmostatiske proteiner til behandling af blødning

Country Status (24)

Country Link
US (5) US10537618B2 (da)
EP (2) EP3744840A1 (da)
JP (3) JP6640198B2 (da)
KR (2) KR102245264B1 (da)
CN (1) CN106536566A (da)
AU (2) AU2015268149B2 (da)
CA (1) CA2949349A1 (da)
DK (1) DK3149163T3 (da)
EA (2) EA037991B1 (da)
ES (1) ES2813440T3 (da)
HR (1) HRP20201311T1 (da)
HU (1) HUE052098T2 (da)
IL (2) IL249132B (da)
LT (1) LT3149163T (da)
MA (2) MA51688A (da)
MX (2) MX378899B (da)
NZ (1) NZ727444A (da)
PL (1) PL3149163T3 (da)
PT (1) PT3149163T (da)
RS (1) RS60706B1 (da)
SG (2) SG11201609811TA (da)
SI (1) SI3149163T1 (da)
WO (1) WO2015183085A1 (da)
ZA (1) ZA201608017B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX378899B (es) * 2014-05-26 2025-03-10 Academisch Ziekenhuis Leiden Proteinas prohemostaticas para el tratamiento de hemorragias.
CN108486197B (zh) * 2018-03-06 2021-10-22 爱斯特（成都）生物制药股份有限公司 高纯度依度沙班中间体的制备方法
GB202408056D0 (en) * 2024-06-06 2024-07-24 Cambridge Entpr Ltd Anticoagulant protein molecules and uses thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703004A (en) 1984-01-24 1987-10-27 Immunex Corporation Synthesis of protein with an identification peptide
EP0785273A1 (en) 1990-11-26 1997-07-23 Genetics Institute, Inc. Paired basic amino acid converting enzyme and DNA sequence encoding it
US6797492B2 (en) 1991-05-17 2004-09-28 Merck & Co., Inc. Method for reducing the immunogenicity of antibody variable domains
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
DE4203965A1 (de) 1992-02-11 1993-08-12 Max Planck Gesellschaft Antidot fuer hirudin und synthetische thrombininhibitoren
AT404357B (de) 1995-06-13 1998-11-25 Immuno Ag Prothrombin-derivate
DE19605126A1 (de) 1996-02-12 1997-08-14 Basf Ag Thrombinmuteine als Antidot für Thrombininhibitoren
US6200955B1 (en) 1996-06-11 2001-03-13 Commonwealth Biotechnologies, Inc. Heparin binding peptides
US6624141B1 (en) 1999-03-17 2003-09-23 The Regents Of The University Of Michigan Protamine fragment compositions and methods of use
EP1728798A1 (en) 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
MX336958B (es) * 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
EP1820508A1 (en) * 2006-02-21 2007-08-22 CSL Behring GmbH Coagulation factor X polypeptides with modified activation properties
EP2481797A1 (en) * 2007-04-13 2012-08-01 Catalyst Biosciences, Inc. Modified factor VII polypeptides and uses thereof
EP2193196B1 (en) 2007-09-28 2016-07-13 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
TWI465247B (zh) * 2008-04-11 2014-12-21 Catalyst Biosciences Inc 經修飾的因子ｖｉｉ多肽和其用途
JP6163304B2 (ja) 2009-07-15 2017-07-12 ポートラ ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子インヒビターの解毒剤の単位用量処方物およびその使用方法
SG11201500579SA (en) * 2012-07-25 2015-02-27 Catalyst Biosciences Inc Modified factor x polypeptides and uses thereof
KR20150103205A (ko) 2013-01-31 2015-09-09 화이자 인코포레이티드 인자 Xa 억제를 길항하기 위한 조성물 및 방법
US10119101B2 (en) 2014-04-28 2018-11-06 Ecolab Usa Inc. Method of minimizing enzyme based aerosol mist using a pressure spray system
MX378899B (es) * 2014-05-26 2025-03-10 Academisch Ziekenhuis Leiden Proteinas prohemostaticas para el tratamiento de hemorragias.

Also Published As

Publication number Publication date
SG10201906329VA (en) 2019-08-27
ES2813440T3 (es) 2021-03-23
IL277377B (en) 2021-10-31
EP3744840A1 (en) 2020-12-02
AU2015268149B2 (en) 2021-03-11
WO2015183085A1 (en) 2015-12-03
JP2022134139A (ja) 2022-09-14
CA2949349A1 (en) 2015-12-03
PL3149163T3 (pl) 2020-12-28
IL277377A (en) 2020-11-30
EA202190813A1 (ru) 2021-12-31
ZA201608017B (en) 2019-04-24
AU2015268149A1 (en) 2016-12-08
JP2017522900A (ja) 2017-08-17
US20240390467A1 (en) 2024-11-28
RS60706B1 (sr) 2020-09-30
KR20170020332A (ko) 2017-02-22
US12083170B2 (en) 2024-09-10
SI3149163T1 (sl) 2020-10-30
EA201692161A1 (ru) 2017-08-31
MA51688A (fr) 2020-12-02
US20200138916A1 (en) 2020-05-07
MX2020013410A (es) 2021-02-26
EA037991B1 (ru) 2021-06-21
MX378899B (es) 2025-03-10
LT3149163T (lt) 2020-09-25
AU2021203838B2 (en) 2023-03-02
US10537618B2 (en) 2020-01-21
KR102351728B1 (ko) 2022-01-14
US20170157223A1 (en) 2017-06-08
IL249132B (en) 2020-09-30
JP2020062039A (ja) 2020-04-23
US11304995B2 (en) 2022-04-19
AU2021203838A1 (en) 2021-07-08
HUE052098T2 (hu) 2021-04-28
JP6640198B2 (ja) 2020-02-05
SG11201609811TA (en) 2016-12-29
NZ727444A (en) 2021-12-24
MA40042B1 (fr) 2020-08-31
NZ764611A (en) 2024-07-05
EP3149163A1 (en) 2017-04-05
BR112016027649A2 (pt) 2017-08-15
IL249132A0 (en) 2017-01-31
JP7535849B2 (ja) 2024-08-19
PT3149163T (pt) 2020-09-03
EP3149163B1 (en) 2020-06-03
US20200138917A1 (en) 2020-05-07
MX2016015567A (es) 2017-06-29
HRP20201311T1 (hr) 2020-12-11
US11357836B2 (en) 2022-06-14
CN106536566A (zh) 2017-03-22
KR102245264B1 (ko) 2021-04-28
US20220288172A1 (en) 2022-09-15
KR20210054573A (ko) 2021-05-13

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