DK3198243T3 - Imaging flow cytometer using spatial-temporal transformation - Google Patents
Imaging flow cytometer using spatial-temporal transformation Download PDFInfo
- Publication number
- DK3198243T3 DK3198243T3 DK15847776.0T DK15847776T DK3198243T3 DK 3198243 T3 DK3198243 T3 DK 3198243T3 DK 15847776 T DK15847776 T DK 15847776T DK 3198243 T3 DK3198243 T3 DK 3198243T3
- Authority
- DK
- Denmark
- Prior art keywords
- spatial
- flow cytometer
- imaging flow
- temporal transformation
- temporal
- Prior art date
Links
- 238000003384 imaging method Methods 0.000 title 1
- 230000009466 transformation Effects 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
- G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F17/00—Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/144—Imaging characterised by its optical setup
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/1447—Spatial selection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/1447—Spatial selection
- G01N2015/145—Spatial selection by pattern of light, e.g. fringe pattern
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06113—Coherent sources; lasers
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462057799P | 2014-09-30 | 2014-09-30 | |
| PCT/US2015/053368 WO2016054293A1 (en) | 2014-09-30 | 2015-09-30 | Imaging flow cytometer using spatial-temporal transformation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3198243T3 true DK3198243T3 (da) | 2020-10-19 |
Family
ID=55631472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15847776.0T DK3198243T3 (da) | 2014-09-30 | 2015-09-30 | Imaging flow cytometer using spatial-temporal transformation |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10267736B2 (da) |
| EP (1) | EP3198243B1 (da) |
| CN (1) | CN107209041B (da) |
| DK (1) | DK3198243T3 (da) |
| ES (1) | ES2827022T3 (da) |
| WO (1) | WO2016054293A1 (da) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2906928A4 (en) | 2012-10-15 | 2016-11-09 | Nanocellect Biomedical Inc | SYSTEMS, DEVICES AND METHOD FOR SORTING PARTICLES |
| EP2943778B1 (en) | 2013-01-09 | 2020-10-28 | The Regents of The University of California | Apparatus and methods for fluorescence imaging using radiofrequency-multiplexed excitation |
| JP6691053B2 (ja) | 2014-03-18 | 2020-04-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | 無線周波数多重化を用いた並行フローサイトメーター |
| DK3198243T3 (da) | 2014-09-30 | 2020-10-19 | Univ California | Imaging flow cytometer using spatial-temporal transformation |
| EP4194801A1 (en) | 2015-02-24 | 2023-06-14 | The University of Tokyo | Dynamic high-speed high-sensitivity imaging device and imaging method |
| WO2017066404A1 (en) | 2015-10-13 | 2017-04-20 | Omega Biosystems Incorporated | Multi-modal fluorescence imaging flow cytometry system |
| CN108351289B (zh) | 2015-10-28 | 2021-11-26 | 国立大学法人东京大学 | 分析装置 |
| BR112018068866B1 (pt) | 2016-03-17 | 2022-11-29 | Bd Biosciences | Classificação de células utilizando um citômetro de fluxo de fluorescência de alto rendimento |
| US10337975B2 (en) * | 2016-05-06 | 2019-07-02 | Deutsches Rheuma-Forschungszentrum Berlin | Method and system for characterizing particles using a flow cytometer |
| EP4726370A2 (en) * | 2016-05-12 | 2026-04-15 | BD Biosciences | Fluorescence imaging flow cytometry with enhanced image resolution |
| JP6983418B2 (ja) * | 2016-05-19 | 2021-12-17 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 流動内の自動化された単一細胞の細胞学的分類のためのシステムおよび方法 |
| DK3469338T3 (da) * | 2016-06-10 | 2025-05-05 | Univ California | Billedbaserede systemer og fremgangsmåder til cellesortering |
| EP3513167B1 (en) | 2016-09-13 | 2023-05-24 | Becton, Dickinson and Company | Flow cytometer with optical equalization |
| DE102017201252A1 (de) * | 2017-01-26 | 2018-07-26 | Universität Ulm | Verfahren und Vorrichtung zur Untersuchung von Zellen |
| EP3707721B1 (en) * | 2017-11-10 | 2025-12-03 | Sartorius BioAnalytical Instruments, Inc | Live cell visualization and analysis |
| CN112041660B (zh) * | 2018-02-16 | 2024-12-13 | 加利福尼亚大学董事会 | 用于移动粒子三维成像的系统、装置与方法 |
| JP7369385B2 (ja) | 2018-06-13 | 2023-10-26 | シンクサイト株式会社 | サイトメトリーのための方法及びシステム |
| US11815507B2 (en) | 2018-08-15 | 2023-11-14 | Deepcell, Inc. | Systems and methods for particle analysis |
| US10611995B2 (en) | 2018-08-15 | 2020-04-07 | Deepcell, Inc. | Systems and methods for particle analysis |
| EP3850080B1 (en) | 2018-09-14 | 2025-11-05 | The Regents of the University of California | Cell sorting device and method |
| DE102018131059A1 (de) * | 2018-12-05 | 2020-06-10 | SIKA Dr. Siebert & Kühn GmbH & Co. KG | Strömungsmessverfahren und Strömungsmessvorrichtung zur optischen Strömungsmessung |
| US11284786B2 (en) * | 2019-03-07 | 2022-03-29 | ZSquare Ltd. | Spatial encoding system decoding system imaging system and methods thereof |
| CN113785187B (zh) * | 2019-03-22 | 2025-01-28 | 贝克顿·迪金森公司 | 使用射频多路复用激发数据对荧光成像进行光谱解混 |
| WO2021003369A1 (en) * | 2019-07-02 | 2021-01-07 | The Regents Of The University Of California | Magnetically modulated computational cytometer and methods of use |
| AU2019453241B2 (en) | 2019-07-02 | 2022-03-10 | Brentwood Industries, Inc. | Cooling tower splash bar hanger and related assembly |
| EP3997439A4 (en) | 2019-07-10 | 2023-07-19 | Becton, Dickinson and Company | Reconfigurable integrated circuits for adjusting cell sorting classification |
| AU2020361681A1 (en) | 2019-10-10 | 2022-05-05 | 1859, Inc. | Methods and systems for microfluidic screening |
| US11125675B2 (en) | 2019-10-18 | 2021-09-21 | Roger Lawrence Deran | Fluid suspended particle classifier |
| KR102927571B1 (ko) * | 2019-11-04 | 2026-02-19 | 시놉시스, 인크. | 리소그래피 마스크들의 보정에서의 마스크 제조 모델들의 사용 |
| JP7556557B2 (ja) | 2019-12-27 | 2024-09-26 | シンクサイト株式会社 | フローサイトメータ性能評価方法 |
| US11592386B2 (en) | 2020-02-26 | 2023-02-28 | Becton, Dickinson And Company | Light detection systems having a secondary light scatter detector and methods for using same |
| EP4130714A4 (en) * | 2020-04-01 | 2024-04-17 | ThinkCyte, Inc. | FLOW CYTOMETER |
| JPWO2021200960A1 (da) | 2020-04-01 | 2021-10-07 | ||
| JP2023527306A (ja) | 2020-05-19 | 2023-06-28 | ベクトン・ディキンソン・アンド・カンパニー | レーザービームの強度プロファイルを変調するための方法及びそのシステム |
| EP4610627A1 (en) | 2020-06-26 | 2025-09-03 | Becton Dickinson and Company | Dual excitation beams for irradiating a sample in a flow stream and methods for using same |
| US20230363707A1 (en) * | 2020-09-25 | 2023-11-16 | The Regents Of The University Of California | Devices and related methods for physiological examination |
| EP4230995A4 (en) * | 2020-10-15 | 2024-11-13 | ThinkCyte K.K. | FLOW CYTOMETER, CELL SORTER, METHOD FOR GENERATING OPTICAL INFORMATION AND PROGRAM |
| US12066368B2 (en) * | 2020-10-15 | 2024-08-20 | Robert R. Alfano | Compact optical virus detection analyzer of nano- and micro-size bio particles using light scattering and fluorescence |
| WO2023053679A1 (ja) * | 2021-09-30 | 2023-04-06 | シンクサイト株式会社 | フローサイトメータ |
| CN114067315B (zh) * | 2021-10-23 | 2022-11-29 | 广州市艾贝泰生物科技有限公司 | 细胞计数方法、装置、计算机设备和存储介质 |
| EP4453908A1 (en) * | 2021-12-23 | 2024-10-30 | Radiometer Medical ApS | Biological fluid analyser with light-setting-based cell classification |
| EP4623290A1 (en) * | 2022-11-23 | 2025-10-01 | Bionano Genomics, Inc. | Top hat illumination biological sample imaging devices, and methods of using the same |
| WO2024138130A1 (en) * | 2022-12-24 | 2024-06-27 | Celloptic, Inc. | System, apparatus, and method for improved imaging and holography |
| CN116673079A (zh) * | 2023-06-06 | 2023-09-01 | 武汉大学 | 一种三维聚焦的高通量微流控芯片及其应用和制作方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9612293A (pt) * | 1995-12-27 | 1999-07-13 | Toa Medical Electronics | Analisador de sangue não-invasivo |
| US6778263B2 (en) | 2000-08-25 | 2004-08-17 | Amnis Corporation | Methods of calibrating an imaging system using calibration beads |
| US6741730B2 (en) * | 2001-08-10 | 2004-05-25 | Visiongate, Inc. | Method and apparatus for three-dimensional imaging in the fourier domain |
| EP2085797B1 (en) | 2008-01-30 | 2016-06-01 | Palo Alto Research Center Incorporated | Producing Filters with Combined Transmission and/or Reflection Functions |
| CN101278829A (zh) * | 2008-05-26 | 2008-10-08 | 上海理工大学 | 便携式在体流式细胞仪 |
| CN102037343B (zh) * | 2008-06-12 | 2013-10-02 | 东卡莱罗纳大学 | 用于三维衍射成像的流式细胞仪系统及方法 |
| WO2010104993A2 (en) * | 2009-03-10 | 2010-09-16 | The Regents Of The University Of California | Fluidic flow cytometry devices and particle sensing based on signal-encoding |
| US9645010B2 (en) * | 2009-03-10 | 2017-05-09 | The Regents Of The University Of California | Fluidic flow cytometry devices and methods |
| CA2756045A1 (en) * | 2009-03-20 | 2010-09-23 | Biorad Laboratories, Inc. | Serial-line-scan-encoded multi-color fluorescence microscopy and imaging flow cytometry |
| US20110001963A1 (en) * | 2009-07-02 | 2011-01-06 | Durack Gary P | System and method for the measurement of multiple emissions from multiple parallel flow channels in a flow cytometry system |
| CN103237889B (zh) | 2010-08-16 | 2017-04-05 | 萨克生物研究学院 | 腺病毒组装方法 |
| US9074978B2 (en) * | 2011-07-12 | 2015-07-07 | The Regents Of The University Of California | Optical space-time coding technique in microfluidic devices |
| US9423335B2 (en) * | 2011-07-21 | 2016-08-23 | Invitrox, Inc. | Instrument and method for optical particle sensing |
| DK3198243T3 (da) | 2014-09-30 | 2020-10-19 | Univ California | Imaging flow cytometer using spatial-temporal transformation |
-
2015
- 2015-09-30 DK DK15847776.0T patent/DK3198243T3/da active
- 2015-09-30 WO PCT/US2015/053368 patent/WO2016054293A1/en not_active Ceased
- 2015-09-30 ES ES15847776T patent/ES2827022T3/es active Active
- 2015-09-30 EP EP15847776.0A patent/EP3198243B1/en active Active
- 2015-09-30 US US15/514,930 patent/US10267736B2/en active Active
- 2015-09-30 CN CN201580064914.7A patent/CN107209041B/zh active Active
-
2019
- 2019-03-27 US US16/367,071 patent/US10788425B2/en active Active
-
2020
- 2020-09-28 US US17/035,505 patent/US11774362B2/en active Active
-
2023
- 2023-08-24 US US18/455,148 patent/US12152992B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20170227466A1 (en) | 2017-08-10 |
| US12152992B2 (en) | 2024-11-26 |
| US20210181113A1 (en) | 2021-06-17 |
| EP3198243A1 (en) | 2017-08-02 |
| US10267736B2 (en) | 2019-04-23 |
| US10788425B2 (en) | 2020-09-29 |
| EP3198243B1 (en) | 2020-07-22 |
| CN107209041A (zh) | 2017-09-26 |
| WO2016054293A1 (en) | 2016-04-07 |
| US20240094129A1 (en) | 2024-03-21 |
| CN107209041B (zh) | 2019-11-05 |
| US20190219509A1 (en) | 2019-07-18 |
| ES2827022T3 (es) | 2021-05-19 |
| EP3198243A4 (en) | 2018-07-18 |
| US11774362B2 (en) | 2023-10-03 |
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