DK3202908T3 - Gener involveret i produktionen af noscapin - Google Patents

Gener involveret i produktionen af noscapin Download PDF

Info

Publication number: DK3202908T3
Authority: DK; Denmark
Prior art keywords: noscapine; production; genes involved; genes; involved
Prior art date: 2012-03-13

Application number

DK17162348.1T

Other languages

English (en)

Inventor

Thilo Winzer

Ian Alexander Graham

Tracey Carol Walker

Original Assignee

Sun Pharmaceutical Industries Australia Pty Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-03-13

Filing date

2013-03-12

Publication date

2022-09-05

2013-03-12 Application filed by Sun Pharmaceutical Industries Australia Pty Ltd filed Critical Sun Pharmaceutical Industries Australia Pty Ltd

2022-09-05 Application granted granted Critical

2022-09-05 Publication of DK3202908T3 publication Critical patent/DK3202908T3/da

Links

AKNNEGZIBPJZJG-MSOLQXFVSA-N (-)-noscapine Chemical compound CN1CCC2=CC=3OCOC=3C(OC)=C2[C@@H]1[C@@H]1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-MSOLQXFVSA-N 0.000 title 1
AKNNEGZIBPJZJG-UHFFFAOYSA-N alpha-noscapine Natural products CN1CCC2=CC=3OCOC=3C(OC)=C2C1C1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-UHFFFAOYSA-N 0.000 title 1
PLPRGLOFPNJOTN-UHFFFAOYSA-N narcotine Natural products COc1ccc2C(OC(=O)c2c1OC)C3Cc4c(CN3C)cc5OCOc5c4OC PLPRGLOFPNJOTN-UHFFFAOYSA-N 0.000 title 1
229960004708 noscapine Drugs 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/21—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and the other dehydrogenated (1.14.21)
- C12Y114/21001—(S)-Stylopine synthase (1.14.21.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/21—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and the other dehydrogenated (1.14.21)
- C12Y114/21002—(S)-Cheilanthifoline synthase (1.14.21.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01117—(S)-Scoulerine 9-O-methyltransferase (2.1.1.117)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01052—Phosphoserine transaminase (2.6.1.52)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nutrition Science (AREA)
Cell Biology (AREA)
Botany (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

DK17162348.1T 2012-03-13 2013-03-12 Gener involveret i produktionen af noscapin DK3202908T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB1204407.9A GB201204407D0 (en)	2012-03-13	2012-03-13	Nucleic acid molecule
EP13721003.5A EP2804949B1 (en)	2012-03-13	2013-03-12	Genes involved in noscapine production

Publications (1)

Publication Number	Publication Date
DK3202908T3 true DK3202908T3 (da)	2022-09-05

Family

ID=46026457

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK17162348.1T DK3202908T3 (da)	2012-03-13	2013-03-12	Gener involveret i produktionen af noscapin
DK13721003.5T DK2804949T3 (da)	2012-03-13	2013-03-12	Gener involveret i noscapinproduktion

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK13721003.5T DK2804949T3 (da)	2012-03-13	2013-03-12	Gener involveret i noscapinproduktion

Country Status (9)

Country	Link
US (2)	US9447444B2 (da)
EP (3)	EP3202908B1 (da)
AU (3)	AU2013234139B2 (da)
CA (1)	CA2863742C (da)
DK (2)	DK3202908T3 (da)
ES (2)	ES2648967T3 (da)
GB (1)	GB201204407D0 (da)
NZ (4)	NZ729980A (da)
WO (1)	WO2013136057A2 (da)

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HUE044896T2 (hu)	2010-06-22	2019-11-28	Sun Pharmaceutical Industries Australia Pty Ltd	Metil-transzferáz nukleinsavak és polipeptidek
CA3044439C (en)	2010-07-22	2023-12-19	Sun Pharmaceutical Industries (Australia) Pty Ltd	Plant cytochrome p450
GB201204407D0 (en) *	2012-03-13	2012-04-25	Glaxosmithkline Australia Pty Ltd	Nucleic acid molecule
CN105247038B (zh)	2013-03-15	2021-08-27	小利兰·斯坦福大学托管委员会	产生苄基异喹啉生物碱(bia)的微生物及其制备和使用方法
US10793885B2 (en)	2013-08-16	2020-10-06	Willow Biosciences Inc.	Compositions and methods for making noscapine and synthesis intermediates thereof
CN112410379B (zh)	2013-11-04	2024-12-31	小利兰·斯坦福大学托管委员会	产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法
CA2946812C (en) *	2014-05-16	2023-10-10	The Unversity Of York	Cytochrome p450 fusion protein
US20160228483A1 (en)	2014-09-30	2016-08-11	Noramco, Inc.	Method for extraction and concentration of alkaloids using dimethyl ether
AU2015350229B2 (en) *	2014-11-17	2019-08-01	The Board Of Trustees Of The Leland Stanford Junior University	Noscapinoid-producing microbes and methods of making and using the same
EP3292203A4 (en)	2015-05-04	2019-10-09	The Board of Trustees of the Leland Stanford Junior University	BENZYL ISOCHINOLIN ALKALOID (BIA) Precursor Producing Microbicides and Method for the Preparation and Use Thereof
WO2016183023A1 (en)	2015-05-08	2016-11-17	The Board Of Trustees Of The Leland Stanford Junior University	Methods of producing epimerases and benzylisoquinoline alkaloids
GB201511156D0 (en)	2015-06-24	2015-08-05	Glaxosmithkline Australia Pty Ltd And University Of York	Production of alkaloids
CN106119265B (zh) *	2016-06-30	2019-04-30	湖南美可达生物资源股份有限公司	博落回中参与血根碱与白屈菜红碱合成的细胞色素p450酶基因及其应用
BR112019007884A2 (pt)	2016-10-18	2019-07-02	Antheia Inc	métodos para a produção de alcaloides nor-opioides e nal-opioides de benzilisoquinolina
GB2579940B (en)	2017-08-03	2022-11-30	Antheia Inc	Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids
CN113784758B (zh)	2019-03-08	2025-03-07	小利兰·斯坦福大学托管委员会	产生莨菪烷生物碱(ta)的非植物宿主细胞及其制备和使用方法

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HUE044896T2 (hu)	2010-06-22	2019-11-28	Sun Pharmaceutical Industries Australia Pty Ltd	Metil-transzferáz nukleinsavak és polipeptidek
CA3044439C (en)	2010-07-22	2023-12-19	Sun Pharmaceutical Industries (Australia) Pty Ltd	Plant cytochrome p450
GB201204407D0 (en) *	2012-03-13	2012-04-25	Glaxosmithkline Australia Pty Ltd	Nucleic acid molecule

2012
- 2012-03-13 GB GBGB1204407.9A patent/GB201204407D0/en not_active Ceased
2013
- 2013-03-12 CA CA2863742A patent/CA2863742C/en active Active
- 2013-03-12 NZ NZ729980A patent/NZ729980A/en unknown
- 2013-03-12 EP EP17162348.1A patent/EP3202908B1/en active Active
- 2013-03-12 NZ NZ723978A patent/NZ723978A/en unknown
- 2013-03-12 EP EP13721003.5A patent/EP2804949B1/en active Active
- 2013-03-12 ES ES13721003.5T patent/ES2648967T3/es active Active
- 2013-03-12 ES ES17162348T patent/ES2925868T3/es active Active
- 2013-03-12 NZ NZ729979A patent/NZ729979A/en unknown
- 2013-03-12 WO PCT/GB2013/050599 patent/WO2013136057A2/en not_active Ceased
- 2013-03-12 DK DK17162348.1T patent/DK3202908T3/da active
- 2013-03-12 NZ NZ627373A patent/NZ627373A/en unknown
- 2013-03-12 EP EP22177354.2A patent/EP4123028A3/en active Pending
- 2013-03-12 DK DK13721003.5T patent/DK2804949T3/da active
- 2013-03-12 US US14/375,120 patent/US9447444B2/en active Active
- 2013-03-12 AU AU2013234139A patent/AU2013234139B2/en active Active
2016
- 2016-06-15 US US15/182,761 patent/US9862979B2/en active Active
2018
- 2018-07-13 AU AU2018205190A patent/AU2018205190B2/en active Active
2021
- 2021-05-20 AU AU2021203237A patent/AU2021203237B2/en active Active

Also Published As

Publication number	Publication date
AU2013234139B2 (en)	2018-05-10
US20150004659A1 (en)	2015-01-01
NZ729980A (en)	2020-01-31
NZ729979A (en)	2020-01-31
EP4123028A2 (en)	2023-01-25
WO2013136057A2 (en)	2013-09-19
AU2013234139A1 (en)	2014-09-18
ES2925868T3 (es)	2022-10-20
EP2804949B1 (en)	2017-10-18
WO2013136057A3 (en)	2013-11-14
CA2863742A1 (en)	2013-09-19
NZ723978A (en)	2017-09-29
DK2804949T3 (da)	2018-01-08
CA2863742C (en)	2024-01-02
GB201204407D0 (en)	2012-04-25
NZ627373A (en)	2016-10-28
US20160281121A1 (en)	2016-09-29
AU2018205190A1 (en)	2018-08-02
EP4123028A3 (en)	2023-04-19
EP2804949A2 (en)	2014-11-26
AU2021203237B2 (en)	2024-04-04
AU2021203237A1 (en)	2021-06-10
US9447444B2 (en)	2016-09-20
US9862979B2 (en)	2018-01-09
EP3202908A1 (en)	2017-08-09
ES2648967T3 (es)	2018-01-09
AU2018205190B2 (en)	2021-03-11
EP3202908B1 (en)	2022-07-20

Publication	Publication Date	Title
DK3202908T3 (da)	2022-09-05	Gener involveret i produktionen af noscapin
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BR112015002039A2 (pt)	2017-07-04	poliésteres
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PL2885336T3 (pl)	2020-03-31	Poliestry
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EP2650084C0 (en)	2023-09-13	TURBINE
DK2820042T3 (da)	2019-10-28	Igg-stimuleret remyelinisering af perifere nerver
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