DK3202908T3 - Gener involveret i produktionen af noscapin - Google Patents

Gener involveret i produktionen af noscapin Download PDF

Info

Publication number: DK3202908T3
Authority: DK; Denmark
Prior art keywords: noscapine; production; genes involved; genes; involved
Prior art date: 2012-03-13

Application number

DK17162348.1T

Other languages

English (en)

Inventor

Thilo Winzer

Ian Alexander Graham

Tracey Carol Walker

Original Assignee

Sun Pharmaceutical Industries Australia Pty Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-03-13

Filing date

2013-03-12

Publication date

2022-09-05

2013-03-12 Application filed by Sun Pharmaceutical Industries Australia Pty Ltd filed Critical Sun Pharmaceutical Industries Australia Pty Ltd

2022-09-05 Application granted granted Critical

2022-09-05 Publication of DK3202908T3 publication Critical patent/DK3202908T3/da

Links

AKNNEGZIBPJZJG-MSOLQXFVSA-N (-)-noscapine Chemical compound CN1CCC2=CC=3OCOC=3C(OC)=C2[C@@H]1[C@@H]1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-MSOLQXFVSA-N 0.000 title 1
AKNNEGZIBPJZJG-UHFFFAOYSA-N alpha-noscapine Natural products CN1CCC2=CC=3OCOC=3C(OC)=C2C1C1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-UHFFFAOYSA-N 0.000 title 1
PLPRGLOFPNJOTN-UHFFFAOYSA-N narcotine Natural products COc1ccc2C(OC(=O)c2c1OC)C3Cc4c(CN3C)cc5OCOc5c4OC PLPRGLOFPNJOTN-UHFFFAOYSA-N 0.000 title 1
229960004708 noscapine Drugs 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/21—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and the other dehydrogenated (1.14.21)
- C12Y114/21001—(S)-Stylopine synthase (1.14.21.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/21—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and the other dehydrogenated (1.14.21)
- C12Y114/21002—(S)-Cheilanthifoline synthase (1.14.21.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01117—(S)-Scoulerine 9-O-methyltransferase (2.1.1.117)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01052—Phosphoserine transaminase (2.6.1.52)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Nutrition Science (AREA)
Botany (AREA)
Cell Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

DK17162348.1T 2012-03-13 2013-03-12 Gener involveret i produktionen af noscapin DK3202908T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB1204407.9A GB201204407D0 (en)	2012-03-13	2012-03-13	Nucleic acid molecule
EP13721003.5A EP2804949B1 (en)	2012-03-13	2013-03-12	Genes involved in noscapine production

Publications (1)

Publication Number	Publication Date
DK3202908T3 true DK3202908T3 (da)	2022-09-05

Family

ID=46026457

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK17162348.1T DK3202908T3 (da)	2012-03-13	2013-03-12	Gener involveret i produktionen af noscapin
DK13721003.5T DK2804949T3 (da)	2012-03-13	2013-03-12	Gener involveret i noscapinproduktion

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK13721003.5T DK2804949T3 (da)	2012-03-13	2013-03-12	Gener involveret i noscapinproduktion

Country Status (9)

Country	Link
US (2)	US9447444B2 (da)
EP (3)	EP4123028A3 (da)
AU (3)	AU2013234139B2 (da)
CA (1)	CA2863742C (da)
DK (2)	DK3202908T3 (da)
ES (2)	ES2648967T3 (da)
GB (1)	GB201204407D0 (da)
NZ (4)	NZ729980A (da)
WO (1)	WO2013136057A2 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2011268698B2 (en)	2010-06-22	2015-03-05	Sun Pharmaceutical Industries (Australia) Pty Ltd	Methyltransferase nucleic acids and polypeptides
NZ604057A (en)	2010-07-22	2014-12-24	Glaxosmithkline Australia Pty Ltd	Plant cytochrome p450
GB201204407D0 (en) *	2012-03-13	2012-04-25	Glaxosmithkline Australia Pty Ltd	Nucleic acid molecule
EP3865580A1 (en)	2013-03-15	2021-08-18	The Board of Trustees of the Leland Stanford Junior University	Benzylisoquinoline alkaloids (bia) producing microbes, and methods of making and using the same
AU2014306345B2 (en) *	2013-08-16	2018-12-13	Willow Biosciences Inc.	Compositions and methods for making noscapine and synthesis intermediates thereof
WO2015066642A1 (en)	2013-11-04	2015-05-07	The Board Of Trustees Of The Leland Stanford Junior University	Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same
CA2946812C (en) *	2014-05-16	2023-10-10	The Unversity Of York	Cytochrome p450 fusion protein
US20160228483A1 (en)	2014-09-30	2016-08-11	Noramco, Inc.	Method for extraction and concentration of alkaloids using dimethyl ether
GB2547371A (en) *	2014-11-17	2017-08-16	Univ Leland Stanford Junior	Noscapinoid-producing microbes and methods of making and using the same
CN107614688B (zh)	2015-05-04	2023-02-28	小利兰·斯坦福大学托管委员会	产生苄基异喹啉生物碱(bia)前体的微生物及其制备和使用方法
ES2945359T3 (es)	2015-05-08	2023-06-30	Univ Leland Stanford Junior	Métodos para producir epimerasas y alcaloides de bencilisoquinolina
GB201511156D0 (en)	2015-06-24	2015-08-05	Glaxosmithkline Australia Pty Ltd And University Of York	Production of alkaloids
CN106119265B (zh) *	2016-06-30	2019-04-30	湖南美可达生物资源股份有限公司	博落回中参与血根碱与白屈菜红碱合成的细胞色素p450酶基因及其应用
EP3529355A4 (en)	2016-10-18	2020-07-08	Antheia, Inc.	PROCESSES FOR THE PRODUCTION OF NOR-OPIOID AND NAL-OPIOID BENZYLISOQUINOLINE ALKALOIDS
GB2579940B (en)	2017-08-03	2022-11-30	Antheia Inc	Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids
WO2020185626A1 (en)	2019-03-08	2020-09-17	The Board Of Trustees Of The Leland Stanford Junior University	Tropane alkaloid (ta) producing non-plant host cells, and methods of making and using the same

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1288073C (en)	1985-03-07	1991-08-27	Paul G. Ahlquist	Rna transformation vector
US5569597A (en)	1985-05-13	1996-10-29	Ciba Geigy Corp.	Methods of inserting viral DNA into plant material
US5268463A (en)	1986-11-11	1993-12-07	Jefferson Richard A	Plant promoter α-glucuronidase gene construct
US5608142A (en)	1986-12-03	1997-03-04	Agracetus, Inc.	Insecticidal cotton plants
ES2187497T3 (es)	1990-04-12	2003-06-16	Syngenta Participations Ag	Promotores preferentemente en tejidos.
US5498830A (en)	1990-06-18	1996-03-12	Monsanto Company	Decreased oil content in plant seeds
US5399680A (en)	1991-05-22	1995-03-21	The Salk Institute For Biological Studies	Rice chitinase promoter
DE69230290T2 (de)	1991-08-27	2000-07-20	Novartis Ag, Basel	Proteine mit insektiziden eigenschaften gegen homopteran insekten und ihre verwendung im pflanzenschutz
US5814618A (en)	1993-06-14	1998-09-29	Basf Aktiengesellschaft	Methods for regulating gene expression
US5789156A (en)	1993-06-14	1998-08-04	Basf Ag	Tetracycline-regulated transcriptional inhibitors
US5608144A (en)	1994-08-12	1997-03-04	Dna Plant Technology Corp.	Plant group 2 promoters and uses thereof
US6521433B1 (en) *	1997-09-17	2003-02-18	E. I. Du Pont De Nemours And Company	cDNA sequences from plants that encode activities associated with isoflavone biosynthesis
EP1270727A1 (en) *	2001-06-11	2003-01-02	Institut für Pflanzenbiochemie	Salutaridinol 7-O-acetyltransferase and derivatives thereof
EP1512748A1 (en)	2003-09-03	2005-03-09	Johnson & Johnson Research Pty Limited	O-methyltransferases of tetrahydrobenzylisoquinoline alkaloid biosynthesis in papaver somniferum
US20060168696A1 (en)	2004-12-22	2006-07-27	Ceres, Inc.	Nucleotide sequences and corresponding polypeptides conferring modulated plant size and biomass and other characteristics
EP1632565A1 (en)	2004-08-12	2006-03-08	Johnson & Johnson Research Pty Limited	Modulation of alkaloid biosynthesis in plants and plants having altered alkaloid biosynthesis
WO2006138012A1 (en)	2005-06-17	2006-12-28	Ceres Inc.	P450 substrates and methods related thereto
US20070199090A1 (en)	2006-02-22	2007-08-23	Nestor Apuya	Modulating alkaloid biosynthesis
EP1837396A1 (en)	2006-03-23	2007-09-26	Institut für Pflanzenbiochemie-IPB	Salutaridine reductase and morphine biosynthesis
US8362322B2 (en)	2006-10-27	2013-01-29	Ceres, Inc.	Modulating lignin in plants
EP2169075B1 (en)	2007-06-12	2016-09-14	Kyoto University	Method for production of alkaloid
WO2009005647A2 (en) *	2007-06-27	2009-01-08	Bioverdant, Inc.	Compounds and process to prepare chiral intermediates for synthesis of paroxetine
US8124851B2 (en)	2007-11-12	2012-02-28	North Carolina State University	Alteration of tobacco alkaloid content through modification of specific cytochrome P450 genes
US9131649B2 (en)	2008-03-07	2015-09-15	Tasmanian Alkaloids Pty. Ltd	Papaver somniferum strain with high concentration of thebaine
AU2011268698B2 (en) *	2010-06-22	2015-03-05	Sun Pharmaceutical Industries (Australia) Pty Ltd	Methyltransferase nucleic acids and polypeptides
NZ604057A (en) *	2010-07-22	2014-12-24	Glaxosmithkline Australia Pty Ltd	Plant cytochrome p450
GB201204407D0 (en) *	2012-03-13	2012-04-25	Glaxosmithkline Australia Pty Ltd	Nucleic acid molecule

2012
- 2012-03-13 GB GBGB1204407.9A patent/GB201204407D0/en not_active Ceased
2013
- 2013-03-12 WO PCT/GB2013/050599 patent/WO2013136057A2/en not_active Ceased
- 2013-03-12 EP EP22177354.2A patent/EP4123028A3/en active Pending
- 2013-03-12 US US14/375,120 patent/US9447444B2/en active Active
- 2013-03-12 NZ NZ729980A patent/NZ729980A/en unknown
- 2013-03-12 AU AU2013234139A patent/AU2013234139B2/en active Active
- 2013-03-12 NZ NZ729979A patent/NZ729979A/en unknown
- 2013-03-12 NZ NZ723978A patent/NZ723978A/en unknown
- 2013-03-12 EP EP17162348.1A patent/EP3202908B1/en active Active
- 2013-03-12 DK DK17162348.1T patent/DK3202908T3/da active
- 2013-03-12 NZ NZ627373A patent/NZ627373A/en unknown
- 2013-03-12 ES ES13721003.5T patent/ES2648967T3/es active Active
- 2013-03-12 DK DK13721003.5T patent/DK2804949T3/da active
- 2013-03-12 EP EP13721003.5A patent/EP2804949B1/en active Active
- 2013-03-12 ES ES17162348T patent/ES2925868T3/es active Active
- 2013-03-12 CA CA2863742A patent/CA2863742C/en active Active
2016
- 2016-06-15 US US15/182,761 patent/US9862979B2/en active Active
2018
- 2018-07-13 AU AU2018205190A patent/AU2018205190B2/en active Active
2021
- 2021-05-20 AU AU2021203237A patent/AU2021203237B2/en active Active

Also Published As

Publication number	Publication date
AU2013234139B2 (en)	2018-05-10
DK2804949T3 (da)	2018-01-08
WO2013136057A3 (en)	2013-11-14
AU2018205190A1 (en)	2018-08-02
EP4123028A3 (en)	2023-04-19
ES2925868T3 (es)	2022-10-20
US9862979B2 (en)	2018-01-09
EP3202908A1 (en)	2017-08-09
US9447444B2 (en)	2016-09-20
CA2863742C (en)	2024-01-02
AU2013234139A1 (en)	2014-09-18
WO2013136057A2 (en)	2013-09-19
ES2648967T3 (es)	2018-01-09
AU2021203237B2 (en)	2024-04-04
AU2018205190B2 (en)	2021-03-11
US20160281121A1 (en)	2016-09-29
EP2804949B1 (en)	2017-10-18
CA2863742A1 (en)	2013-09-19
EP3202908B1 (en)	2022-07-20
NZ627373A (en)	2016-10-28
US20150004659A1 (en)	2015-01-01
NZ729980A (en)	2020-01-31
GB201204407D0 (en)	2012-04-25
NZ723978A (en)	2017-09-29
EP4123028A2 (en)	2023-01-25
AU2021203237A1 (en)	2021-06-10
NZ729979A (en)	2020-01-31
EP2804949A2 (en)	2014-11-26

Publication	Publication Date	Title
IL269045A (en)	2019-10-31	Aptamers and uses thereof
SMT201700130B (it)	2017-03-08	Diidratodicomposto di benzotiofeneeprocessoper la produzione dello stesso
LT3091141T (lt)	2018-08-10	Lengvesnės grindų plokštės iš mažiau medžiagų
BR112015002039A2 (pt)	2017-07-04	poliésteres
EP2789165A4 (en)	2015-08-05	Chroma quantization parameter extension
DK2928496T3 (da)	2019-11-11	Crispr-baseret genommodifikation og -regulering
DK2923081T3 (da)	2019-11-04	Vertikalakseturbine
FI20176131L (fi)	2017-12-18	Menetelmä biopolttoaineen tai
EP2873453A4 (en)	2016-03-23	STIRRERS
DE112013003850A5 (de)	2015-04-23	Effektpigmente
DK2894998T3 (da)	2020-03-02	Rotation af kegle
PL2885336T3 (pl)	2020-03-31	Poliestry
EP4512390C0 (en)	2026-01-28	DEGARELIX MANUFACTURING
EP2873686A4 (en)	2016-03-23	MIXED PELLET
DK2882938T3 (da)	2020-05-18	Turbinearrangement
FR2992364B1 (fr)	2014-07-25	Turbopompe
BR112014019020A2 (pt)	2017-06-20	Retardador hidrodinâmico
EP2650084C0 (en)	2023-09-13	TURBINE
DK3590960T3 (da)	2023-04-24	Igg-stimuleret remyelinisering af perifere nerver
FR2991392B1 (fr)	2016-01-15	Turbopompe
DK2934593T3 (da)	2020-02-17	Cabazitaxel composition
DK2928896T3 (da)	2017-11-06	Fast form af dihydro-pyrido-oxazin-derivat
FR2993389B1 (fr)	2015-02-27	Antifusible
EP2858642A4 (en)	2015-12-02	NOVEL IMINO SUGAR AND ITS APPLICATIONS
DE112013003862A5 (de)	2015-05-28	Spinndüsenvorrichtung