DK3204398T3 - Fremgangsmåder til fraseparering af gemcitabin-phosphat diastereoisomerer - Google Patents

Fremgangsmåder til fraseparering af gemcitabin-phosphat diastereoisomerer Download PDF

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Publication number
DK3204398T3
DK3204398T3 DK15782005.1T DK15782005T DK3204398T3 DK 3204398 T3 DK3204398 T3 DK 3204398T3 DK 15782005 T DK15782005 T DK 15782005T DK 3204398 T3 DK3204398 T3 DK 3204398T3
Authority
DK
Denmark
Prior art keywords
gemcitabin
procedures
pharmaceutical preparation
diastereoisomer
phosphate
Prior art date
Application number
DK15782005.1T
Other languages
English (en)
Inventor
Hugh Griffith
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NuCana plc filed Critical NuCana plc
Application granted granted Critical
Publication of DK3204398T3 publication Critical patent/DK3204398T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK15782005.1T 2014-10-06 2015-09-29 Fremgangsmåder til fraseparering af gemcitabin-phosphat diastereoisomerer DK3204398T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1417644.0A GB201417644D0 (en) 2014-10-06 2014-10-06 Method of separating phosphate diastereoisomers
PCT/GB2015/052839 WO2016055769A1 (en) 2014-10-06 2015-09-29 Methods of separating gemcitabine-phosphate diastereoisomers

Publications (1)

Publication Number Publication Date
DK3204398T3 true DK3204398T3 (da) 2020-06-02

Family

ID=51946917

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15782005.1T DK3204398T3 (da) 2014-10-06 2015-09-29 Fremgangsmåder til fraseparering af gemcitabin-phosphat diastereoisomerer

Country Status (30)

Country Link
US (1) US10669300B2 (da)
EP (2) EP3725794A1 (da)
JP (2) JP6893172B2 (da)
KR (1) KR102532498B1 (da)
CN (2) CN112552362A (da)
AU (2) AU2015329767B2 (da)
CA (1) CA2959977C (da)
CL (1) CL2017000819A1 (da)
CY (1) CY1123061T1 (da)
DK (1) DK3204398T3 (da)
EA (1) EA033118B1 (da)
ES (1) ES2793957T3 (da)
GB (1) GB201417644D0 (da)
HR (1) HRP20200849T1 (da)
HU (1) HUE050882T2 (da)
IL (1) IL251125B (da)
LT (1) LT3204398T (da)
MA (1) MA41039B1 (da)
ME (1) ME03730B (da)
MX (2) MX387346B (da)
MY (1) MY183302A (da)
PH (1) PH12017500586A1 (da)
PL (1) PL3204398T3 (da)
PT (1) PT3204398T (da)
RS (1) RS60634B1 (da)
SG (2) SG10201902952SA (da)
SI (1) SI3204398T1 (da)
SM (1) SMT202000410T1 (da)
WO (1) WO2016055769A1 (da)
ZA (1) ZA201701723B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) * 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
AU2013346515B2 (en) 2012-11-16 2017-05-25 NuCana plc Process for preparing nucleoside prodrugs
EA033046B1 (ru) 2014-06-25 2019-08-30 НУКАНА ПиЭлСи Состав, содержащий пролекарство гемцитабина
RS60968B1 (sr) 2014-06-25 2020-11-30 NuCana plc Prolekovi gemcitabina
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
CN106543252A (zh) 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 核苷氨基磷酸酯类前药的制备方法及其中间体
CN106543220A (zh) 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 氨基磷酸酯化合物及其制备方法和晶体
CN106478753A (zh) 2015-09-16 2017-03-08 博瑞生物医药（苏州）股份有限公司 一种nuc‑1031单一异构体的制备方法和用途
PH12018500691B1 (en) 2015-10-05 2022-08-10 NuCana plc Combination therapy
CA3007347C (en) 2015-12-11 2020-08-04 NuCana plc Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug nuc-1031
GB201522771D0 (en) * 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
WO2018019188A1 (zh) * 2016-07-23 2018-02-01 博瑞生物医药（苏州）股份有限公司 核苷氨基磷酸酯类前药的多晶型及其制备方法
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
CN107400156B (zh) * 2017-09-19 2020-01-31 北京大学 一种分离麦角甾烷型三萜25r-与25s-差向异构体的方法
CN115028594A (zh) * 2020-06-03 2022-09-09 吴卫东 恩替他滨药用前体化合物及其制备方法和医学用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1254092B1 (en) * 2000-02-11 2004-01-21 Degussa AG Resolution of dl-racemic mixtures
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
FR2954310B1 (fr) * 2009-12-18 2014-07-25 Univ Rouen Procede de dedoublement d'enantiomeres par evapocristallisation preferentielle
AU2013346515B2 (en) * 2012-11-16 2017-05-25 NuCana plc Process for preparing nucleoside prodrugs
WO2014204856A1 (en) 2013-06-17 2014-12-24 Catabasis Pharmaceuticals, Inc. Fatty acid anticancer derivatives and their uses
JP2017504572A (ja) * 2013-11-27 2017-02-09 アイデニクス・ファーマシューティカルズ・エルエルシー 肝臓癌治療のためのヌクレオチド類
RS60968B1 (sr) 2014-06-25 2020-11-30 NuCana plc Prolekovi gemcitabina
EA033046B1 (ru) * 2014-06-25 2019-08-30 НУКАНА ПиЭлСи Состав, содержащий пролекарство гемцитабина
US9834577B2 (en) 2014-07-22 2017-12-05 Laurus Labs Limited Process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
CN107835687A (zh) 2015-05-14 2018-03-23 努卡那有限公司 癌症治疗
PH12018500691B1 (en) 2015-10-05 2022-08-10 NuCana plc Combination therapy
CA3007347C (en) 2015-12-11 2020-08-04 NuCana plc Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug nuc-1031
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
SI3393478T1 (sl) 2015-12-23 2020-07-31 NuCana plc Kombinacijska terapija
KR102566461B1 (ko) 2015-12-23 2023-08-14 뉴카나 피엘씨 조합 요법

Also Published As

Publication number Publication date
CN112552362A (zh) 2021-03-26
MX373944B (es) 2020-07-13
AU2015329767A1 (en) 2017-04-13
MX2017004446A (es) 2017-06-19
US10669300B2 (en) 2020-06-02
KR20170090413A (ko) 2017-08-07
GB201417644D0 (en) 2014-11-19
MX2020003758A (es) 2021-10-26
PH12017500586A1 (en) 2017-08-30
SMT202000410T1 (it) 2020-09-10
KR102532498B1 (ko) 2023-05-12
EP3204398B1 (en) 2020-05-13
RS60634B1 (sr) 2020-09-30
LT3204398T (lt) 2020-09-10
AU2020203714A1 (en) 2020-06-25
CA2959977C (en) 2024-01-02
MA41039B1 (fr) 2020-08-31
ZA201701723B (en) 2023-11-29
CA2959977A1 (en) 2016-04-14
MX387346B (es) 2025-03-18
WO2016055769A1 (en) 2016-04-14
EP3204398A1 (en) 2017-08-16
CL2017000819A1 (es) 2017-11-03
EA201790794A1 (ru) 2017-07-31
ES2793957T3 (es) 2020-11-17
CN107108682A (zh) 2017-08-29
EA033118B1 (ru) 2019-08-30
PL3204398T3 (pl) 2020-11-16
SG11201701885UA (en) 2017-04-27
BR112017006855A2 (pt) 2017-12-12
MY183302A (en) 2021-02-18
US20170226147A1 (en) 2017-08-10
CN107108682B (zh) 2020-12-18
JP2017530172A (ja) 2017-10-12
CY1123061T1 (el) 2021-10-29
EP3725794A1 (en) 2020-10-21
IL251125B (en) 2020-07-30
HUE050882T2 (hu) 2021-01-28
AU2015329767B2 (en) 2020-03-12
JP6893172B2 (ja) 2021-06-23
JP6967625B2 (ja) 2021-11-17
IL251125A0 (en) 2017-04-30
SI3204398T1 (sl) 2020-09-30
SG10201902952SA (en) 2019-05-30
PT3204398T (pt) 2020-05-28
AU2020203714B2 (en) 2021-07-22
ME03730B (me) 2021-01-20
JP2020128392A (ja) 2020-08-27
HRP20200849T1 (hr) 2020-10-30

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