DK3213056T3 - Fremgangsmåder til hurtig forberedelse af mærkede glycosylaminer og til analyse af glykosylerede biomolekyler, som giver samme baggrund - Google Patents

Fremgangsmåder til hurtig forberedelse af mærkede glycosylaminer og til analyse af glykosylerede biomolekyler, som giver samme baggrund Download PDF

Info

Publication number
DK3213056T3
DK3213056T3 DK15855907.0T DK15855907T DK3213056T3 DK 3213056 T3 DK3213056 T3 DK 3213056T3 DK 15855907 T DK15855907 T DK 15855907T DK 3213056 T3 DK3213056 T3 DK 3213056T3
Authority
DK
Denmark
Prior art keywords
glycosyled
biomolecules
procedures
analysis
same background
Prior art date
Application number
DK15855907.0T
Other languages
English (en)
Inventor
Matthew A Lauber
Darryl W Brousmiche
Stephan M Koza
Original Assignee
Waters Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Waters Technologies Corp filed Critical Waters Technologies Corp
Application granted granted Critical
Publication of DK3213056T3 publication Critical patent/DK3213056T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G01N2333/98—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/38—Post-translational modifications [PTMs] in chemical analysis of biological material addition of carbohydrates, e.g. glycosylation, glycation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK15855907.0T 2014-10-30 2015-10-28 Fremgangsmåder til hurtig forberedelse af mærkede glycosylaminer og til analyse af glykosylerede biomolekyler, som giver samme baggrund DK3213056T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462072747P 2014-10-30 2014-10-30
US201562107994P 2015-01-26 2015-01-26
PCT/US2015/057848 WO2016069764A1 (en) 2014-10-30 2015-10-28 Methods for the rapid preparation of labeled glycosylamines and for the analysis of glycosylated biomolecules producing the same

Publications (1)

Publication Number Publication Date
DK3213056T3 true DK3213056T3 (da) 2020-09-28

Family

ID=55858312

Family Applications (2)

Application Number Title Priority Date Filing Date
DK20188814.6T DK3748340T3 (da) 2014-10-30 2015-10-28 Fremgangsmåder til hurtig præparering af mærkede glykosylaminer og til analyse af glykosylerede biomolekyler, som fremstiller samme
DK15855907.0T DK3213056T3 (da) 2014-10-30 2015-10-28 Fremgangsmåder til hurtig forberedelse af mærkede glycosylaminer og til analyse af glykosylerede biomolekyler, som giver samme baggrund

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK20188814.6T DK3748340T3 (da) 2014-10-30 2015-10-28 Fremgangsmåder til hurtig præparering af mærkede glykosylaminer og til analyse af glykosylerede biomolekyler, som fremstiller samme

Country Status (6)

Country Link
US (2) US11371996B2 (da)
EP (3) EP3213056B1 (da)
JP (3) JP7055634B2 (da)
CN (2) CN115753702A (da)
DK (2) DK3748340T3 (da)
WO (1) WO2016069764A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6193237B2 (ja) 2011-09-28 2017-09-06 ウオーターズ・テクノロジーズ・コーポレイシヨン 強められたｍｓ信号を有するグリカンおよび他の生体分子の迅速蛍光タグ付け
US11352325B2 (en) 2011-09-28 2022-06-07 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
US10436790B2 (en) 2011-09-28 2019-10-08 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
DK3748340T3 (da) 2014-10-30 2022-04-19 Waters Technologies Corp Fremgangsmåder til hurtig præparering af mærkede glykosylaminer og til analyse af glykosylerede biomolekyler, som fremstiller samme
CN115536714B (zh) 2014-11-13 2026-04-24 沃特世科技公司 快速标记的n-聚糖的液相色谱校准方法
EP3472132A4 (en) 2016-06-21 2020-01-15 Waters Technologies Corporation FLUORESCENCE LABELING OF GLYCANS AND OTHER BIOMOLECULES BY REDUCING AMINATION FOR IMPROVED MASS SPECTROMETRY SIGNALS
EP3472621A4 (en) * 2016-06-21 2020-03-04 Waters Technologies Corporation Methods of electrospray ionization of glycans modified with amphipathic, strongly basic moieties
US11353461B2 (en) 2016-06-21 2022-06-07 Waters Technologies Corporation Methods of enhancing MS detection of tagged glycans
CN114839302A (zh) 2016-07-01 2022-08-02 沃特世科技公司 使用分子量截留过滤和过滤器上去糖基化从复杂基质快速制备标记的葡基胺的方法
EP4443155B1 (en) * 2016-07-28 2026-05-13 Waters Technologies Corporation Encapsulated pre-analytic workflows for flow-through devices, liquid chromatography and mass spectrometric analysis
US20180094293A1 (en) * 2016-10-03 2018-04-05 Waters Technologies Corporation Labeled glycan amino acid complexes useful in lc-ms analysis and methods of making the same
US11112411B2 (en) * 2017-03-31 2021-09-07 Alexion Pharmaceuticals, Inc. Method for simultaneous quantification of ALXN1210 and eculizumab in human serum or urine
CN109254101B (zh) * 2017-07-13 2021-07-09 中国科学院大连化学物理研究所 一种母乳酸性寡糖净化和分析方法
EP4653862A3 (en) * 2018-03-16 2026-01-14 Quest Diagnostics Investments LLC Methods for detecting chromogranin a by mass spectrometry
US11173418B2 (en) 2018-07-11 2021-11-16 Waters Technologies Corporation Materials and methods for trap-elute mixed mode chromatography
BR112022013481A2 (pt) * 2020-01-08 2022-09-13 Regeneron Pharma Uso de aminoácidos para aumentar o sinal em análises espectro de massa
US11835527B2 (en) * 2020-01-21 2023-12-05 Regeneron Pharmaceuticals, Inc. Deglycosylation methods for electrophoresis of glycosylated proteins
JP7521307B2 (ja) * 2020-07-31 2024-07-24 住友ベークライト株式会社 糖鎖を標識する方法及びキット
CN113295778A (zh) * 2021-04-02 2021-08-24 东莞太力生物工程有限公司 糖蛋白n-糖链分析方法
JP7576708B2 (ja) * 2021-08-27 2024-10-31 公益財団法人がん研究会 糖鎖の分析方法
US20250035553A1 (en) * 2023-07-28 2025-01-30 Waters Technologies Corporation Methods of multiplexed analyte characterization
WO2025047369A1 (ja) * 2023-08-29 2025-03-06 株式会社ファイトリピッド・テクノロジーズ 算出方法、プログラム、定量方法、および高速液体クロマトグラフタンデム質量分析装置
CN118032958A (zh) * 2023-12-02 2024-05-14 中国检验检疫科学研究院 一种基于GalN-AQC衍生化的硫酸软骨素的HPLC定量检测方法

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2016962A (en) 1932-09-27 1935-10-08 Du Pont Process for producing glucamines and related products
US4003912A (en) 1973-06-11 1977-01-18 Monsanto Company Dicarboximido-N-phenylsubstituted carbamates and derivatives
US4068528A (en) 1976-01-19 1978-01-17 Rheodyne Incorporated Two position rotary valve for injecting sample liquids into an analysis system
US4138398A (en) 1976-12-27 1979-02-06 The Upjohn Company Bis-cyclic ureas
JPS59161355A (ja) 1983-03-05 1984-09-12 Haruo Ogura 新規なアミノ基標識試薬化合物
JPS60192703A (ja) 1983-12-05 1985-10-01 Nippon Mejifuijitsukusu Kk 少なくとも１個の遊離ホルミル基を有する高分子化合物
JPS62195361A (ja) 1986-02-21 1987-08-28 Haruo Ogura 新規なアミノ基標識試薬化合物
US5296599A (en) 1991-09-19 1994-03-22 Millipore Corporation Activated carbamates compounds
US5531959A (en) 1994-01-31 1996-07-02 Hamilton Company Automated liquid handling and computer controlled system and method for solid phase chromatographic extractions
CA2143519A1 (en) 1994-03-11 1995-09-12 F. Hoffmann-La Roche Ag Beta-lactams
US5696599A (en) 1994-12-30 1997-12-09 Novell, Inc. Method and apparatus for modifying handshake data transmissions
JP3359203B2 (ja) 1995-10-04 2002-12-24 タカラバイオ株式会社 ペプチドのアミノ酸配列解析方法
TW358097B (en) 1996-05-24 1999-05-11 Hoffmann La Roche Beta-lactams and their process and pharmaceutical compositions
JP4085443B2 (ja) 1997-05-07 2008-05-14 株式会社島津製作所 アミノ酸の分析試薬及びアミノ酸の分析方法
JPH1180107A (ja) 1997-09-01 1999-03-26 Japan Tobacco Inc 骨形成促進剤及びアミド化合物
WO1999021580A1 (en) 1997-10-27 1999-05-06 The Regents Of The University Of California Reagents and immunoassay for the detection and quantitative determination of mycothiol and precursors thereof
CA2312945A1 (en) 1997-12-05 1999-06-17 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Method for identifying nucleic acids by electro-spray mass spectrometry
US6379971B1 (en) 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
CN1078615C (zh) 1998-08-06 2002-01-30 福州大学 中空纤维酶膜反应器连续制备异麦芽低聚糖的方法
JP3985359B2 (ja) 1998-09-18 2007-10-03 住友化学株式会社 レジスト組成物
FR2788518B1 (fr) 1999-01-14 2001-03-02 Centre Nat Rech Scient Nouveaux carbamates actives stables, leur procede de preparation et leur utilisation pour la preparation d'urees
JP2000329744A (ja) 1999-05-21 2000-11-30 Kao Corp 有機物の分析方法
US6468761B2 (en) 2000-01-07 2002-10-22 Caliper Technologies, Corp. Microfluidic in-line labeling method for continuous-flow protease inhibition analysis
US6716634B1 (en) 2000-05-31 2004-04-06 Agilent Technologies, Inc. Increasing ionization efficiency in mass spectrometry
US20020177239A1 (en) 2001-03-16 2002-11-28 Thomas Gregory Brian Anti-GPE antibodies, their uses, and analytical methods for GPE
US7074570B2 (en) 2001-05-23 2006-07-11 Ge Healthcare Bio-Sciences Ab Peptide fragmentation
US20050158708A1 (en) 2001-06-06 2005-07-21 Iris Alroy Methods and compositions related to tagging of membrane surface proteins
DE10133809A1 (de) 2001-07-11 2003-01-23 Bericap Gmbh & Co Kg Verschlussunterteil mit Haltesteg
JP4290003B2 (ja) 2001-09-14 2009-07-01 エレクトロフォレティクス リミテッド 質量標識体
JP4102062B2 (ja) 2001-12-19 2008-06-18 野村化学株式会社 アルミニウム測定方法
EP2336763A1 (en) 2002-02-14 2011-06-22 Ajinomoto Co., Inc. Method for analysis of compounds with amino group and analytical reagent thereof
US20070269895A1 (en) 2002-06-03 2007-11-22 The Institute For Systems Biology Methods for quantitative proteome analysis of glycoproteins
US7317111B2 (en) 2002-09-23 2008-01-08 Aries Associates, Inc. Green and orange fluorescent labels and their uses
HUE027607T2 (en) 2002-10-30 2016-10-28 Basf Se Amino-benzene sulfonic acid amides and their preparation
GB0306756D0 (en) 2003-03-24 2003-04-30 Xzillion Gmbh & Co Kg Mass labels
US20050221337A1 (en) 2003-10-02 2005-10-06 Massachusetts Institute Of Technology Microarrays and microspheres comprising oligosaccharides, complex carbohydrates or glycoproteins
US20060127950A1 (en) 2004-04-15 2006-06-15 Massachusetts Institute Of Technology Methods and products related to the improved analysis of carbohydrates
EP1750126B1 (en) 2004-05-26 2015-09-16 Ajinomoto Co., Inc. Method and apparatus for analyzing aminofunctional compound
WO2006091214A2 (en) 2004-06-18 2006-08-31 Molecular Probes, Inc. Fluorescent isotope tags and their method of use
US7651847B2 (en) 2004-06-22 2010-01-26 The Regents Of The University Of California Methods of oligosaccharide profiling for the detection of cancer
CN1973047A (zh) 2004-06-22 2007-05-30 加利福尼亚大学董事会 用于检测癌症的寡糖分布法
JP4568551B2 (ja) 2004-07-28 2010-10-27 一晃 掛樋 糖たん白質糖鎖の分析方法及び非標識糖鎖の製造方法
US8047060B2 (en) 2005-01-31 2011-11-01 Waters Technologies Corporation Method and apparatus for sample injection in liquid chromatography
ES2337704T3 (es) 2005-04-26 2010-04-28 National Institute for Bioprocessing Research and Training Limited Estrategia automatizada de identificacion del perfil de glucosilacion.
US20070141723A1 (en) * 2005-12-16 2007-06-21 Sompuram Seshi A Immunohistochemistry staining controls
JP2007163423A (ja) 2005-12-16 2007-06-28 Ajinomoto Co Inc 質量分析計によるアミノ酸分析方法
EA029538B1 (ru) 2006-03-07 2018-04-30 Басф Энзаймс Ллк Полипептид, обладающий активностью альдолазы, полинуклеотид, кодирующий этот полипептид, и способы получения и применения полинуклеотида и полипептида
US8198063B1 (en) 2006-09-12 2012-06-12 Pro Zyme, Inc Rapid deglycosylation of glycoproteins
US20080201095A1 (en) 2007-02-12 2008-08-21 Yip Ping F Method for Calibrating an Analytical Instrument
JP5357059B2 (ja) 2007-02-28 2013-12-04 ウオーターズ・テクノロジーズ・コーポレイシヨン 拡散結合チタン構成要素を有する液体クロマトグラフィ装置
US7910319B2 (en) 2007-03-23 2011-03-22 Academia Sinica Glycoproteomic probes for fluorescent imaging fucosylated glycans in vivo
EP2135090A1 (en) 2007-04-16 2009-12-23 Momenta Pharmaceuticals, Inc. Proteolytic release of glycans
US7847245B2 (en) 2007-07-18 2010-12-07 Platomics, Inc. Multiplexing matrix-analyte stereo electronic interactions for high throughput shotgun metabolomics
US20100285593A1 (en) 2007-11-26 2010-11-11 Waters Technologies Corporation Internal standards and methods for use in quantitatively measuring analytes in a sample
WO2009100155A1 (en) * 2008-02-04 2009-08-13 Prozyme, Inc. Compounds and methods for rapid labeling of n-glycans
JP5305284B2 (ja) * 2008-03-26 2013-10-02 独立行政法人産業技術総合研究所 糖化合物の質量分析法
KR20110028295A (ko) * 2008-06-12 2011-03-17 스미토모 베이클리트 컴퍼니 리미티드 당쇄 시료 조제 방법, 당쇄 시료, 및 당쇄 분석법
US20090324635A1 (en) 2008-06-25 2009-12-31 Ferenc Korodi Caspofungin free of caspofungin impurity A
FR2939795B1 (fr) 2008-12-17 2010-12-17 Sanofi Aventis Procede de preparation d'esters actives
US8905075B2 (en) 2009-07-13 2014-12-09 Idex Health & Science Llc Rotary shear valve assembly with hard-on-hard seal surfaces
EP2306199A1 (en) 2009-09-29 2011-04-06 Academisch Ziekenhuis Leiden Acting Under The Name Leiden University Medical Center Reductive amination and analysis of carbohydrates using 2-picoline borane as reducing agent
EP2305692A1 (en) 2009-09-29 2011-04-06 Academisch Ziekenhuis Leiden Acting Under The Name Leiden University Medical Center Method for releasing and labelling O-glycans
US8912178B2 (en) 2010-05-19 2014-12-16 Xcovery Holdings Company, LLC mTOR selective kinase inhibitors
EP2583008A4 (en) 2010-06-16 2014-07-30 Waters Technologies Corp VALVE FOR HIGH-PRESSURE ANALYTICAL SYSTEM
WO2012037407A1 (en) 2010-09-17 2012-03-22 Prozyme, Inc. Isolation and deglycosylation of glycoproteins
WO2012083866A1 (en) 2010-12-22 2012-06-28 The Hong Kong Polytechnic University Quinoline derivatives as anti-cancer agents
CN103918055B (zh) 2011-03-31 2016-08-17 Dh科技发展私人贸易有限公司 用于校准质谱仪的组合物、方法和试剂盒
EP2742347B1 (en) 2011-08-12 2020-03-04 Life Technologies Corporation Apparatuses, methods, computer program products, and kits for hi-throughput glycan analysis
US11352325B2 (en) 2011-09-28 2022-06-07 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
US10436790B2 (en) 2011-09-28 2019-10-08 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
JP6193237B2 (ja) 2011-09-28 2017-09-06 ウオーターズ・テクノロジーズ・コーポレイシヨン 強められたｍｓ信号を有するグリカンおよび他の生体分子の迅速蛍光タグ付け
US9177765B2 (en) 2011-11-29 2015-11-03 Thermo Finnigan Llc Method for automated checking and adjustment of mass spectrometer calibration
WO2013084236A1 (en) 2011-12-05 2013-06-13 Ben-Gurion University Of The Negev Research And Development Authority Diagnostic and therapeutic methods and their application in amyotrophic lateral sclerosis (als)
JP2013142566A (ja) 2012-01-10 2013-07-22 Sumitomo Bakelite Co Ltd 糖鎖試料の調製方法
US20150057243A1 (en) 2012-04-02 2015-02-26 Northern University Compositions and Methods for the Inhibition of Methyltransferases
WO2013192530A2 (en) 2012-06-21 2013-12-27 Children's Medical Center Corporation Methods and reagents for glycoproteomics
US20140030732A1 (en) 2012-07-25 2014-01-30 Agilent Technologies, Inc. Microfluidic hplc-chip for glycopeptide analysis with integrated hilic enrichment
DE102013212179A1 (de) * 2012-07-31 2014-02-06 Agilent Technologies, Inc. Derivatisierung von PNGase F-freigesetzter Glykane auf einem HPLC-Chip
EP2722673B1 (en) 2012-10-17 2017-07-12 Hexal AG Improved method of mapping glycans of glycoproteins
EP2741312A1 (en) 2012-12-05 2014-06-11 Tofwerk AG Method of calibrating mass-to-charge ratio measurements obtained from a mass spectrometer connected in fluid communication with an analysis system delivering a temporally changing sample
US9310344B2 (en) 2013-06-14 2016-04-12 Dionex Corporation HILIC/anion-exchange/cation-exchange multimodal media
US9169331B2 (en) 2012-12-21 2015-10-27 Dionex Corporation Separation of glycans by mixed-mode liquid chromatography
US20140227793A1 (en) * 2013-02-14 2014-08-14 California Institute Of Technology Compositions and methods for glycan sequencing
US20140274768A1 (en) 2013-03-14 2014-09-18 Van Andel Research Institute Glycoforms of MUC5AC and Endorepellin and Biomarkers for Mucinous Pancreatic Cysts
US9814329B2 (en) 2013-05-29 2017-11-14 Exxel Outdoors, Llc Quilt
WO2014194320A1 (en) 2013-05-31 2014-12-04 The Uab Research Foundation Chromatography mass spectrometry method and system
JP6169552B2 (ja) 2013-10-01 2017-07-26 Ｊｃｒファーマ株式会社 ２−アミノピリジンによる糖鎖の標識法
US10119944B2 (en) 2013-12-24 2018-11-06 Waters Technologies Corporation Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides
CN106604930B (zh) 2014-05-30 2021-10-29 新英格兰生物实验室公司 去糖基化试剂和方法
EP2975401B1 (en) 2014-07-18 2019-12-25 Hexal AG Improved method of mapping glycans of glycoproteins in serum samples
JP6774748B2 (ja) 2014-08-13 2020-10-28 ウオーターズ・テクノロジーズ・コーポレイシヨン 強められたｍｓ信号を有するグリカンおよび他の生体分子の迅速蛍光タグ付け
US9823225B2 (en) 2014-08-25 2017-11-21 Waters Technologies Corporation Injector sample dilution for a liquid chromatography system
US9816971B2 (en) 2014-09-08 2017-11-14 Waters Technologies Corporation Controllable injector sample dilution for a liquid chromatography system
DK3748340T3 (da) * 2014-10-30 2022-04-19 Waters Technologies Corp Fremgangsmåder til hurtig præparering af mærkede glykosylaminer og til analyse af glykosylerede biomolekyler, som fremstiller samme
GB2549404B (en) 2014-12-01 2020-08-12 Waters Technologies Corp System and method for performing a chromatography injection sequence using a single injection valve
WO2016112253A1 (en) 2015-01-09 2016-07-14 Children's Medical Center Corporation Methods of membrane-based proteomic sample preparation

Also Published As

Publication number Publication date
CN107110785A (zh) 2017-08-29
EP3213056A4 (en) 2018-08-08
DK3748340T3 (da) 2022-04-19
JP7055634B2 (ja) 2022-04-18
WO2016069764A1 (en) 2016-05-06
JP2023162207A (ja) 2023-11-08
US12158472B2 (en) 2024-12-03
JP2018501465A (ja) 2018-01-18
EP3748340A1 (en) 2020-12-09
JP7687847B2 (ja) 2025-06-03
EP4033223A1 (en) 2022-07-27
EP3748340B1 (en) 2022-04-06
EP4033223B1 (en) 2025-06-18
CN115753702A (zh) 2023-03-07
US11371996B2 (en) 2022-06-28
EP3213056B1 (en) 2020-08-12
US20220268779A1 (en) 2022-08-25
JP2021119345A (ja) 2021-08-12
JP7716450B2 (ja) 2025-07-31
EP3213056A1 (en) 2017-09-06
US20180188259A1 (en) 2018-07-05

Similar Documents

Publication Publication Date Title
DK3748340T3 (da) Fremgangsmåder til hurtig præparering af mærkede glykosylaminer og til analyse af glykosylerede biomolekyler, som fremstiller samme
EP3428031C0 (en) DRIVER ASSISTANCE DESIGN ANALYSIS SYSTEM
EP4091544C0 (en) BLOOD SAMPLE OPTIMIZATION DEVICE
DK3370867T3 (da) Prøvepræpareringsindretning
DK3538864T3 (da) Mikrotom
MA42847A (fr) Analyse de micro-moment
DK3072835T3 (da) Fremgangsmåde til fremføring
HUE050430T2 (hu) Fekális mikrobióta mintavételezési eljárás
BR112016016020A2 (pt) anticorpos dirigidos contra interleucina-33 (il-33)
EP3382398A4 (en) SAMPLE ANALYSIS DEVICE
EP3680332C0 (en) SAMPLE PREPARATION SYSTEM AND CARTRIDGE
EP3318873A4 (en) TEST SYSTEM
DK3197506T3 (da) Fremgangsmåde til tørring af et endoskops kanaler
SG10201508801PA (en) Hydrophilically modified fluorinated membrane (v)
DK3210276T3 (da) Fremgangsmåde til drift af et uafhængigt netværk
DK3280408T3 (da) Fremgangsmåde til fremstilling af dicycloplatin
EP3720425C0 (en) SAMPLING CAPSULE SYSTEM
DK3525672T3 (da) Grænseflade til åndedrætsprøvetagning
EP3312614C0 (en) SAMPLE ANALYZER
PT3630968T (pt) Enzimas para análise de glicanos
EP3596440C0 (en) Pipeline sampler
DK3528948T3 (da) Mikrofluidsystem
EP3108962C0 (de) Probenträger
EP3463414C0 (en) Protein interfaces
EP3454741A4 (en) TEST SYSTEM FOR AWARENESS-CHANGING SUBSTANCES